Detailed information for compound 1648514

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 386.286 | Formula: C19H20BrN3O
  • H donors: 0 H acceptors: 1 LogP: 4.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cccc2c1n(CC)c(=N)n2CC(=O)c1ccc(cc1)Br
  • InChi: 1S/C19H20BrN3O/c1-3-13-6-5-7-16-18(13)22(4-2)19(21)23(16)12-17(24)14-8-10-15(20)11-9-14/h5-11,21H,3-4,12H2,1-2H3
  • InChiKey: GTTVKNOBAKSFOI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aurora kinase B Starlite/ChEMBL No references
Homo sapiens BR serine/threonine kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum serine/threonine protein kinase, putative,protein kinase, putative Get druggable targets OG5_126655 All targets in OG5_126655
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, CAMK CAMKL Get druggable targets OG5_126655 All targets in OG5_126655
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Candida albicans protein serine/threonine kinase Get druggable targets OG5_126655 All targets in OG5_126655
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum hypothetical protein Get druggable targets OG5_126655 All targets in OG5_126655
Candida albicans bud neck kinase Get druggable targets OG5_126655 All targets in OG5_126655
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126655 All targets in OG5_126655
Candida albicans similar to S. cerevisiae HSL1 (YKL101W) serine/threonine-protein kinase involved in cell cycle control Get druggable targets OG5_126655 All targets in OG5_126655
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii histone kinase SNF1, putative Get druggable targets OG5_126655 All targets in OG5_126655
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum OSK4, putative Get druggable targets OG5_126655 All targets in OG5_126655
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine kinase SAD 1 Get druggable targets OG5_126655 All targets in OG5_126655
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_126655 All targets in OG5_126655
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative Get druggable targets OG5_126655 All targets in OG5_126655
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense serine/threonine protein kinase, putative,protein kinase, putative Get druggable targets OG5_126655 All targets in OG5_126655
Schistosoma japonicum HD domain-containing protein 2 homolog, putative Get druggable targets OG5_126655 All targets in OG5_126655
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Brugia malayi hypothetical protein Get druggable targets OG5_126655 All targets in OG5_126655
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans similar to S. cerevisiae HSL1 (YKL101W) serine/threonine-protein kinase involved in cell cycle control Get druggable targets OG5_126655 All targets in OG5_126655
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Leishmania braziliensis serine/threonine protein kinase, putative,protein kinase, putative Get druggable targets OG5_126655 All targets in OG5_126655
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei SNF1-related protein kinases, putative Get druggable targets OG5_126655 All targets in OG5_126655
Trypanosoma congolense SNF1-related protein kinases, putative Get druggable targets OG5_126655 All targets in OG5_126655
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126655 All targets in OG5_126655
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126655 All targets in OG5_126655
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi putative serine/threonine kinase SADA gamma Get druggable targets OG5_126655 All targets in OG5_126655
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Echinococcus multilocularis serine:threonine kinase SAD 1 Get druggable targets OG5_126655 All targets in OG5_126655
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Theileria parva 5'-AMP-activated protein kinase, putative Get druggable targets OG5_126655 All targets in OG5_126655
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana serine/threonine protein kinase, putative,protein kinase, putative Get druggable targets OG5_126655 All targets in OG5_126655
Trypanosoma cruzi SNF1-related protein kinases, putative Get druggable targets OG5_126655 All targets in OG5_126655
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani 5'-AMP-activated protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126655 All targets in OG5_126655
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126655 All targets in OG5_126655
Plasmodium vivax serine/threonine protein kinase KIN, putative Get druggable targets OG5_126655 All targets in OG5_126655
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126655 All targets in OG5_126655
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126655 All targets in OG5_126655
Leishmania donovani SNF1-related protein kinases, putative Get druggable targets OG5_126655 All targets in OG5_126655
Candida albicans protein serine/threonine kinase Get druggable targets OG5_126655 All targets in OG5_126655
Schistosoma japonicum ko:K07198 5'-AMP-activated protein kinase, catalytic alpha subunit, putative Get druggable targets OG5_126655 All targets in OG5_126655
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Candida albicans bud neck kinase Get druggable targets OG5_126655 All targets in OG5_126655
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum serine/threonine protein kinase KIN Get druggable targets OG5_126655 All targets in OG5_126655
Schistosoma japonicum MAP/microtubule affinity-regulating kinase 4, putative Get druggable targets OG5_126655 All targets in OG5_126655
Giardia lamblia Kinase, CAMK CAMKL Get druggable targets OG5_126655 All targets in OG5_126655
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative Get druggable targets OG5_126655 All targets in OG5_126655
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08796 BR serine/threonine kinase, putative Get druggable targets OG5_126655 All targets in OG5_126655
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus 5' AMP activated protein kinase catalytic Get druggable targets OG5_126655 All targets in OG5_126655
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative,SNF1-related protein kinases, putative Get druggable targets OG5_126655 All targets in OG5_126655
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126655 All targets in OG5_126655
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126655 All targets in OG5_126655
Echinococcus multilocularis 5' AMP activated protein kinase catalytic Get druggable targets OG5_126655 All targets in OG5_126655
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative,SNF1-related protein kinases, putative Get druggable targets OG5_126655 All targets in OG5_126655
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase, putative,SNF1-related protein kinases, putative Get druggable targets OG5_126655 All targets in OG5_126655
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative Get druggable targets OG5_126655 All targets in OG5_126655
Plasmodium knowlesi serine/threonine protein kinase KIN, putative Get druggable targets OG5_126655 All targets in OG5_126655
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase domain containing protein 0.0069 0.0195 1
Trypanosoma brucei hypothetical protein, conserved 0.0527 0.3375 1
Trypanosoma cruzi hypothetical protein, conserved 0.0527 0.3375 1
Echinococcus granulosus zinc finger protein Ran binding 0.0527 0.3375 0.337
Leishmania major hypothetical protein, conserved 0.0527 0.3375 1
Schistosoma mansoni hypothetical protein 0.1481 1 1
Toxoplasma gondii ran binding protein 0.0527 0.3375 0.337
Schistosoma mansoni protein kinase 0.0069 0.0195 0.0187
Chlamydia trachomatis SWIB complex protein 0.1481 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0527 0.3375 0.3375
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0527 0.3375 1
Plasmodium vivax hypothetical protein, conserved 0.1481 1 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0527 0.3375 1
Echinococcus multilocularis SWI:SNF matrix associated 0.1481 1 1
Trypanosoma brucei aurora B kinase 0.0069 0.0195 0.0555
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0195 0.0187
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0527 0.3375 0.337
Brugia malayi putative serine/threonine kinase SADA gamma 0.0042 0.0008 0.0008
Loa Loa (eye worm) brahma associated protein 0.1481 1 1
Entamoeba histolytica protein kinase, putative 0.0069 0.0195 1
Schistosoma mansoni zinc finger protein 0.0527 0.3375 0.337
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0069 0.0195 0.0187
Chlamydia trachomatis DNA topoisomerase I 0.1481 1 0.5
Leishmania major hypothetical protein, conserved 0.0527 0.3375 1
Brugia malayi serine/threonine protein kinase 6 0.0069 0.0195 0.0195
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1481 1 1
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0042 0.0008 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0195 0.0187
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0195 0.0187
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0527 0.3375 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0527 0.3375 1
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0527 0.3375 0.337
Echinococcus multilocularis SWI:SNF matrix associated 0.1481 1 1
Onchocerca volvulus 0.1481 1 1
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0069 0.0195 0.0187
Schistosoma mansoni hypothetical protein 0.1481 1 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1481 1 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0527 0.3375 0.3375
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0069 0.0195 1
Leishmania major hypothetical protein, conserved 0.0527 0.3375 1
Loa Loa (eye worm) AUR protein kinase 0.0069 0.0195 0.0195
Trypanosoma cruzi hypothetical protein, conserved 0.0527 0.3375 1
Schistosoma mansoni hypothetical protein 0.0527 0.3375 0.337
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0527 0.3375 0.3375
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0527 0.3375 0.337
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0527 0.3375 0.3375
Loa Loa (eye worm) AUR protein kinase 0.0069 0.0195 0.0195
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0527 0.3375 0.3375
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0527 0.3375 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0527 0.3375 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0069 0.0195 1
Leishmania major protein kinase, putative 0.0069 0.0195 0.0555
Echinococcus multilocularis SWI:SNF matrix associated 0.1481 1 1
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0069 0.0195 0.0187
Toxoplasma gondii aurora kinase 0.0069 0.0195 0.0187
Schistosoma mansoni fusion 0.0527 0.3375 0.337
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0042 0.0008 0.0008
Leishmania major hypothetical protein, conserved 0.0527 0.3375 1
Loa Loa (eye worm) hypothetical protein 0.0527 0.3375 0.3375
Loa Loa (eye worm) hypothetical protein 0.0527 0.3375 0.3375
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0195 0.0187
Schistosoma mansoni hypothetical protein 0.1481 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1481 1 1
Plasmodium falciparum serine/threonine protein kinase, putative 0.0069 0.0195 0.0187
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0527 0.3375 0.337
Loa Loa (eye worm) hypothetical protein 0.0527 0.3375 0.3375
Echinococcus granulosus ring and YY1 binding protein 0.0527 0.3375 0.337
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0069 0.0195 1
Echinococcus granulosus SWI:SNF matrix associated 0.1481 1 1
Leishmania major hypothetical protein, conserved 0.0527 0.3375 1
Trypanosoma brucei hypothetical protein, conserved 0.0527 0.3375 1
Loa Loa (eye worm) hypothetical protein 0.0527 0.3375 0.3375
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1481 1 1
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0527 0.3375 0.337
Schistosoma mansoni RNA binding protein 0.0527 0.3375 0.337
Echinococcus multilocularis zinc finger protein Ran binding 0.0527 0.3375 0.337
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0195 0.0187
Brugia malayi SWIB/MDM2 domain containing protein 0.1481 1 1
Trypanosoma cruzi aurora B kinase, putative 0.0069 0.0195 0.0555
Schistosoma mansoni brg-1 associated factor 0.1481 1 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1481 1 1
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1481 1 1
Brugia malayi brahma associated protein 60 kDa 0.1481 1 1
Brugia malayi serine/threonine-protein kinase 6 0.0069 0.0195 0.0195
Entamoeba histolytica protein kinase, putative 0.0069 0.0195 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0527 0.3375 1
Loa Loa (eye worm) AUR protein kinase 0.0069 0.0195 0.0195
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0042 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0042 0.0008 0.0008
Echinococcus granulosus Zinc finger RanBP2 type 0.0527 0.3375 0.337
Giardia lamblia Aurora kinase 0.0069 0.0195 1
Trypanosoma cruzi hypothetical protein, conserved 0.0527 0.3375 1
Schistosoma mansoni TRABID protein (C64 family) 0.0527 0.3375 0.337
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1481 1 1
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0527 0.3375 1
Brugia malayi YY1-associated factor 2 0.0527 0.3375 0.3375
Entamoeba histolytica protein kinase , putative 0.0069 0.0195 1
Echinococcus granulosus aurora kinase A 0.0069 0.0195 0.0187
Echinococcus multilocularis aurora kinase A 0.0069 0.0195 0.0187
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1481 1 1
Brugia malayi serine/threonine kinase 12 0.0069 0.0195 0.0195
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1481 1 1
Echinococcus multilocularis ring and YY1 binding protein 0.0527 0.3375 0.337
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0527 0.3375 1

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 5.6 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK12 ChEMBL. No reference
Ki (functional) = 5.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: KIAA1811 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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