Detailed information for compound 1648515

Basic information

Technical information
  • TDR Targets ID: 1648515
  • Name: 1-(2-methoxyethyl)-3-[1-(2,3,4-trichloropheny l)ethylideneamino]thiourea
  • MW: 354.683 | Formula: C12H14Cl3N3OS
  • H donors: 2 H acceptors: 0 LogP: 3.56 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCNC(=S)N/N=C(/c1ccc(c(c1Cl)Cl)Cl)\C
  • InChi: 1S/C12H14Cl3N3OS/c1-7(17-18-12(20)16-5-6-19-2)8-3-4-9(13)11(15)10(8)14/h3-4H,5-6H2,1-2H3,(H2,16,18,20)/b17-7+
  • InChiKey: IUHHPRPBHKHHQJ-REZTVBANSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • MLS001033083
  • SMR000385530
  • T0514-7538

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0492 0.35 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0094 0.0094
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.005 0.005
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0025 0.0094 0.0094
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0492 0.35 1
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1382 1 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0098 0.0004
Schistosoma mansoni zinc finger protein 0.0025 0.0094 0.0094
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0025 0.0094 0.0094
Brugia malayi SWIB/MDM2 domain containing protein 0.1382 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0094 0.0094
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0025 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0492 0.35 0.35
Onchocerca volvulus 0.0025 0.0094 0.0094
Schistosoma mansoni zinc finger protein 0.0492 0.35 0.35
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2624 0.2624
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0492 0.35 0.35
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.005 0.005
Leishmania major GTP-binding protein, putative 0.0026 0.0098 0.0013
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0492 0.35 0.35
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0492 0.35 0.3438
Brugia malayi hypothetical protein 0.0182 0.1243 0.1243
Loa Loa (eye worm) hypothetical protein 0.0492 0.35 0.35
Loa Loa (eye worm) hypothetical protein 0.0041 0.0211 0.0211
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0165 0.0072
Echinococcus multilocularis SWI:SNF matrix associated 0.1382 1 1
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0492 0.35 1
Loa Loa (eye worm) hypothetical protein 0.006 0.035 0.035
Trypanosoma brucei hypothetical protein, conserved 0.0492 0.35 1
Echinococcus granulosus cell growth regulator with ring finger domain 0.0025 0.0094 0.0094
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0492 0.35 1
Leishmania major hypothetical protein, conserved 0.0492 0.35 1
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0025 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.1382 1 1
Echinococcus granulosus GPCR family 2 0.0019 0.005 0.005
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0098 0.0004
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0492 0.35 0.35
Echinococcus granulosus Zinc finger RanBP2 type 0.0492 0.35 0.35
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0094 0.0094
Trypanosoma cruzi WLM domain containing protein, putative 0.0492 0.35 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.1243 0.1243
Brugia malayi Zinc finger protein 183 homolog 0.0025 0.0094 0.0094
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1382 1 1
Brugia malayi YY1-associated factor 2 0.0492 0.35 0.35
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0025 0.0094 0.0094
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0025 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0041 0.0211 0.0211
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0492 0.35 1
Schistosoma mansoni RNA binding protein 0.0492 0.35 0.35
Loa Loa (eye worm) hypothetical protein 0.0025 0.0094 0.0094
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0492 0.35 0.3438
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0963 0.0963
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0165
Echinococcus granulosus ring finger protein 170 0.0025 0.0094 0.0094
Toxoplasma gondii ran binding protein 0.0492 0.35 0.3438
Onchocerca volvulus 0.0025 0.0094 0.0094
Onchocerca volvulus 0.0492 0.35 0.35
Loa Loa (eye worm) brahma associated protein 0.1382 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0094 0.0094
Schistosoma mansoni ran 0.0026 0.0098 0.0098
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0117 0.0024
Loa Loa (eye worm) hypothetical protein 0.0025 0.0094 0.0094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.035 0.035
Loa Loa (eye worm) hypothetical protein 0.0025 0.0094 0.0094
Onchocerca volvulus Putative RING finger protein 207 0.0025 0.0094 0.0094
Plasmodium falciparum importin beta, putative 0.0035 0.0165 0.0072
Loa Loa (eye worm) hypothetical protein 0.0492 0.35 0.35
Schistosoma mansoni hypothetical protein 0.0025 0.0094 0.0094
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0098 1
Onchocerca volvulus 0.0492 0.35 0.35
Echinococcus multilocularis SWI:SNF matrix associated 0.1382 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0094 0.0094
Schistosoma mansoni peter pan-related 0.0025 0.0094 0.0094
Echinococcus granulosus zinc finger protein Ran binding 0.0492 0.35 0.35
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1382 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1382 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.005
Schistosoma mansoni TRABID protein (C64 family) 0.0492 0.35 0.35
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0025 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0025 0.0094 0.0094
Brugia malayi RING finger protein 20 0.0025 0.0094 0.0094
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.005 0.005
Brugia malayi hypothetical protein 0.0025 0.0094 0.0094
Loa Loa (eye worm) glutaminase 2 0.033 0.232 0.232
Entamoeba histolytica Ran family GTPase 0.0026 0.0098 0.1881
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0019 0.005 0.005
Leishmania major hypothetical protein, conserved 0.0492 0.35 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1382 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0094 0.0094
Echinococcus granulosus neuropeptide s receptor 0.0558 0.3986 0.3986
Brugia malayi RING zinc finger protein 0.0025 0.0094 0.0094
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0025 0.0094 0.0094
Brugia malayi glutaminase DH11.1 0.033 0.232 0.232
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0492 0.35 1
Schistosoma mansoni hypothetical protein 0.0372 0.2624 0.2624
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.035 0.035
Brugia malayi Zinc finger, C2H2 type family protein 0.0025 0.0094 0.0094
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0492 0.35 0.35
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0025 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0019 0.005 0.005
Loa Loa (eye worm) glutaminase 0.033 0.232 0.232
Brugia malayi hypothetical protein 0.0025 0.0094 0.0094
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.3986 0.3986
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0963 0.0963
Schistosoma mansoni fusion 0.0492 0.35 0.35
Brugia malayi B-box zinc finger family protein 0.0025 0.0094 0.0094
Plasmodium vivax hypothetical protein, conserved 0.1382 1 1
Echinococcus multilocularis ring finger protein 113a 0.0025 0.0094 0.0094
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.005 0.005
Onchocerca volvulus 0.0492 0.35 0.35
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0165 0.021
Entamoeba histolytica hypothetical protein 0.0028 0.0117 1
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0492 0.35 0.35
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.3986 0.3986
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.3986 0.3986
Echinococcus multilocularis 0.0025 0.0094 0.0094
Echinococcus granulosus SWI:SNF matrix associated 0.1382 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0492 0.35 1
Echinococcus multilocularis snurportin 1 0.0372 0.2624 0.2624
Loa Loa (eye worm) hypothetical protein 0.0492 0.35 0.35
Schistosoma mansoni ring finger protein 151 0.0025 0.0094 0.0094
Echinococcus granulosus snurportin 1 0.0372 0.2624 0.2624
Echinococcus multilocularis SWI:SNF matrix associated 0.1382 1 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0492 0.35 0.35
Brugia malayi Latrophilin receptor protein 2 0.0019 0.005 0.005
Brugia malayi MH2 domain containing protein 0.0144 0.0963 0.0963
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.005 0.005
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0492 0.35 0.35
Echinococcus granulosus RING finger protein 185 0.0025 0.0094 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.0492 0.35 1
Echinococcus multilocularis RING finger protein 185 0.0025 0.0094 0.0094
Schistosoma mansoni rnf5 0.0025 0.0094 0.0094
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0098 0.0004
Onchocerca volvulus 0.0492 0.35 0.35
Brugia malayi Importin beta-1 subunit 0.0035 0.0165 0.0165
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0098 0.0098
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0098 0.0098
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0025 0.0094 0.0094
Brugia malayi hypothetical protein 0.0025 0.0094 0.0094
Onchocerca volvulus 0.0025 0.0094 0.0094
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0098 0.0098
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0492 0.35 1
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0117 0.0024
Onchocerca volvulus 0.0025 0.0094 0.0094
Trichomonas vaginalis ran, putative 0.0026 0.0098 0.0004
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0165 0.0165
Schistosoma mansoni ran 0.0026 0.0098 0.0098
Leishmania major hypothetical protein, conserved 0.0492 0.35 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0211 0.0211
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0025 0.0094 0.0094
Mycobacterium ulcerans glutaminase 0.033 0.232 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.035 0.035
Schistosoma mansoni hypothetical protein 0.1382 1 1
Echinococcus multilocularis ring and YY1 binding protein 0.0492 0.35 0.35
Echinococcus granulosus ring and YY1 binding protein 0.0492 0.35 0.35
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0117 0.0069
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1382 1 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.005 0.005
Brugia malayi Neuralized family protein 0.0025 0.0094 0.0094
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1382 1 1
Schistosoma mansoni peter pan-related 0.0025 0.0094 0.0094
Schistosoma mansoni glutaminase 0.033 0.232 0.232
Brugia malayi hypothetical protein 0.0025 0.0094 0.0094
Schistosoma mansoni mind bomb 0.0025 0.0094 0.0094
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0492 0.35 0.35
Onchocerca volvulus 0.1382 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0165 0.021
Echinococcus multilocularis ring finger protein 170 0.0025 0.0094 0.0094
Brugia malayi hypothetical protein 0.0025 0.0094 0.0094
Brugia malayi hypothetical protein 0.0025 0.0094 0.0094
Onchocerca volvulus 0.0025 0.0094 0.0094
Trichomonas vaginalis glutaminase, putative 0.033 0.232 0.2247
Echinococcus granulosus importin subunit beta 1 0.0035 0.0165 0.0165
Leishmania major hypothetical protein, conserved 0.0492 0.35 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0165 0.0072
Onchocerca volvulus 0.0182 0.1243 0.1243
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0098 0.0013
Chlamydia trachomatis SWIB complex protein 0.1382 1 0.5
Loa Loa (eye worm) RiNg Finger protein family member 0.0025 0.0094 0.0094
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0098 0.0013
Loa Loa (eye worm) hypothetical protein 0.0492 0.35 0.35
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0025 0.0094 0.0094
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1382 1 1
Brugia malayi brahma associated protein 60 kDa 0.1382 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0492 0.35 1
Onchocerca volvulus Protein neuralized homolog 0.0025 0.0094 0.0094
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0098 0.0013
Loa Loa (eye worm) hypothetical protein 0.0025 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.1382 1 1
Schistosoma mansoni hypothetical protein 0.0492 0.35 0.35
Schistosoma mansoni hypothetical protein 0.0019 0.005 0.005
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0025 0.0094 0.0094
Schistosoma mansoni importin beta-1 0.0035 0.0165 0.0165
Trypanosoma cruzi hypothetical protein, conserved 0.0492 0.35 1
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0025 0.0094 0.0094
Leishmania major importin beta-1 subunit, putative 0.0028 0.0117 0.0069
Onchocerca volvulus 0.0025 0.0094 0.0094
Brugia malayi RNA, U transporter 1 0.0099 0.0634 0.0634
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1382 1 1
Chlamydia trachomatis DNA topoisomerase I 0.1382 1 0.5
Echinococcus granulosus ring finger protein 113a 0.0025 0.0094 0.0094
Loa Loa (eye worm) RING finger protein 20 0.0025 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0019 0.005 0.005
Schistosoma mansoni brg-1 associated factor 0.1382 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0117 0.0024
Echinococcus multilocularis zinc finger protein Ran binding 0.0492 0.35 0.35
Trypanosoma cruzi WLM domain containing protein, putative 0.0492 0.35 1
Leishmania major hypothetical protein, conserved 0.0492 0.35 1
Onchocerca volvulus RING finger protein 141 homolog 0.0025 0.0094 0.0094

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5805 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID485386, AID504448, AID504454, AID504459] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.