Detailed information for compound 1648516

Basic information

Technical information
  • TDR Targets ID: 1648516
  • Name: 1-(1-propylbenzimidazol-2-yl)-N,N-bis[(1-prop ylbenzimidazol-2-yl)methyl]methanamine
  • MW: 533.71 | Formula: C33H39N7
  • H donors: 0 H acceptors: 3 LogP: 5.89 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCn1c(CN(Cc2nc3c(n2CCC)cccc3)Cc2nc3c(n2CCC)cccc3)nc2c1cccc2
  • InChi: 1S/C33H39N7/c1-4-19-38-28-16-10-7-13-25(28)34-31(38)22-37(23-32-35-26-14-8-11-17-29(26)39(32)20-5-2)24-33-36-27-15-9-12-18-30(27)40(33)21-6-3/h7-18H,4-6,19-24H2,1-3H3
  • InChiKey: KIHQMDIBTPBWQM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(1-propyl-2-benzimidazolyl)-N,N-bis[(1-propyl-2-benzimidazolyl)methyl]methanamine
  • tris[(1-propylbenzimidazol-2-yl)methyl]amine
  • NCI60_040275
  • NSC716501

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0025 0.0014 0.0011
Schistosoma mansoni peter pan-related 0.0025 0.0014 0.0014
Brugia malayi hypothetical protein 0.0025 0.0014 0.0011
Entamoeba histolytica hypothetical protein 0.0042 0.0139 0.9037
Schistosoma mansoni hypothetical protein 0.0025 0.0014 0.0014
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0134 0.0121
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1372 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0146 0.0133
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0134 0.0351
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0488 0.3448 0.3445
Onchocerca volvulus RING finger protein 141 homolog 0.0025 0.0014 0.0011
Brugia malayi RING zinc finger protein 0.0025 0.0014 0.0011
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0043 0.0146 1
Schistosoma mansoni zinc finger protein 0.0025 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0003
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0003 0.0003
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0488 0.3448 0.3445
Loa Loa (eye worm) hypothetical protein 0.0079 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0488 0.3448 0.3448
Echinococcus multilocularis muscleblind protein 1 0.0166 0.1062 0.1059
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0003 0.0003
Brugia malayi RING finger protein 20 0.0025 0.0014 0.0011
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0134 0.0121
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0201 0.0198
Loa Loa (eye worm) hypothetical protein 0.0488 0.3448 0.3448
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0043 0.0146 0.0386
Loa Loa (eye worm) acetyltransferase 0.0164 0.1045 0.1045
Leishmania major hypothetical protein, conserved 0.0488 0.3448 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0043 0.0146 1
Echinococcus granulosus geminin 0.0385 0.2682 0.268
Echinococcus granulosus zinc finger protein Ran binding 0.0488 0.3448 0.3445
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0025 0.0014 0.0011
Onchocerca volvulus 0.1372 1 1
Schistosoma mansoni ap endonuclease 0.0043 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0014
Brugia malayi brahma associated protein 60 kDa 0.1372 1 1
Onchocerca volvulus 0.0025 0.0014 0.0011
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0351 0.0348
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0488 0.3448 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0488 0.3448 0.3448
Echinococcus multilocularis SWI:SNF matrix associated 0.1372 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.0992 0.0988
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0014
Echinococcus granulosus ring finger protein 113a 0.0025 0.0015 0.0011
Leishmania major hypothetical protein, conserved 0.0488 0.3448 1
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0025 0.0014 0.0011
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0488 0.3448 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0146 0.0133
Schistosoma mansoni hypothetical protein 0.1372 1 1
Brugia malayi hypothetical protein 0.0025 0.0014 0.0011
Leishmania major hypothetical protein, conserved 0.0488 0.3448 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0043 0.0146 1
Brugia malayi SWIB/MDM2 domain containing protein 0.1372 1 1
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0025 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0014
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0488 0.3448 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0146
Brugia malayi Bromodomain containing protein 0.0087 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0049 0.0195 0.0195
Entamoeba histolytica hypothetical protein 0.0042 0.0139 0.9037
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0003 0.0003
Echinococcus multilocularis ring and YY1 binding protein 0.0488 0.3448 0.3445
Onchocerca volvulus 0.0488 0.3448 0.3445
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0043 0.0146 0.0143
Chlamydia trachomatis SWIB complex protein 0.1372 1 0.5
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0043 0.0146 0.9592
Echinococcus granulosus zinc finger protein 0.0026 0.0021 0.0017
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1372 1 1
Schistosoma mansoni zinc finger protein 0.0488 0.3448 0.3448
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0025 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0043 0.0146 0.0386
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0134 0.0121
Schistosoma mansoni ring finger protein 151 0.0025 0.0014 0.0014
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0146 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0003 0.0003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0003 0.0003
Schistosoma mansoni bromodomain containing protein 0.0074 0.0381 0.0381
Schistosoma mansoni hypothetical protein 0.1372 1 1
Echinococcus granulosus muscleblind protein 0.0166 0.1062 0.1059
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0003
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0134 0.0121
Schistosoma mansoni brg-1 associated factor 0.1372 1 1
Schistosoma mansoni hypothetical protein 0.0385 0.2682 0.2682
Echinococcus granulosus cell growth regulator with ring finger domain 0.0025 0.0014 0.0011
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0488 0.3448 0.3445
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0152 0.0138
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0902 0.6517 0.6515
Loa Loa (eye worm) hypothetical protein 0.0488 0.3448 0.3448
Echinococcus multilocularis 0.0025 0.0014 0.0011
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0003 0.0003
Onchocerca volvulus 0.0025 0.0014 0.0011
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0003 0.0003
Schistosoma mansoni coup transcription factor 0.0023 0.0003 0.0003
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0152 1
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1372 1 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0201 0.0187
Brugia malayi Muscleblind-like protein 0.0166 0.1062 0.1059
Brugia malayi hypothetical protein 0.0025 0.0014 0.0011
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0152 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0139 0.0135
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0003 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0043 0.0146 0.0386
Loa Loa (eye worm) hypothetical protein 0.0488 0.3448 0.3448
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0488 0.3448 1
Trichomonas vaginalis conserved hypothetical protein 0.1372 1 1
Brugia malayi YY1-associated factor 2 0.0488 0.3448 0.3445
Loa Loa (eye worm) RING finger protein 20 0.0025 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0166 0.1062 0.1062
Echinococcus multilocularis muscleblind protein 0.0166 0.1062 0.1059
Echinococcus multilocularis zinc finger protein Ran binding 0.0488 0.3448 0.3445
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0134 0.0351
Schistosoma mansoni ap endonuclease 0.0043 0.0146 0.0146
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0164 0.1045 0.1042
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0488 0.3448 0.3445
Schistosoma mansoni peter pan-related 0.0025 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0014
Brugia malayi Inositol-1 0.0041 0.0134 0.0131
Loa Loa (eye worm) brahma associated protein 0.1372 1 1
Brugia malayi hypothetical protein 0.0025 0.0014 0.0011
Echinococcus multilocularis SWI:SNF matrix associated 0.1372 1 1
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0134 0.0131
Leishmania major hypothetical protein, conserved 0.0488 0.3448 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0211 0.0211
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0025 0.0014 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0488 0.3448 1
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0003 0.0003
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0488 0.3448 0.3445
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1372 1 1
Onchocerca volvulus Putative RING finger protein 207 0.0025 0.0014 0.0011
Loa Loa (eye worm) inositol-1 0.0041 0.0134 0.0134
Brugia malayi hypothetical protein 0.0025 0.0014 0.0011
Entamoeba histolytica hypothetical protein 0.0042 0.0139 0.9037
Schistosoma mansoni hypothetical protein 0.0025 0.0015 0.0015
Echinococcus granulosus ring and YY1 binding protein 0.0488 0.3448 0.3445
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0134 0.0351
Echinococcus multilocularis geminin 0.0385 0.2682 0.268
Onchocerca volvulus Protein neuralized homolog 0.0025 0.0014 0.0011
Trypanosoma cruzi WLM domain containing protein, putative 0.0488 0.3448 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0014 0.0014
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1372 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0201 0.0187
Trypanosoma cruzi hypothetical protein, conserved 0.0488 0.3448 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0003 0.0003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0003 0.0003
Trypanosoma cruzi WLM domain containing protein, putative 0.0488 0.3448 1
Onchocerca volvulus 0.0488 0.3448 0.3445
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0201 0.0187
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0488 0.3448 0.3438
Echinococcus granulosus RING finger protein 185 0.0025 0.0014 0.0011
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0016 0.0012
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0488 0.3448 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0126 0.0123
Schistosoma mansoni inositol monophosphatase 0.0041 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0014
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0134 0.0131
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0488 0.3448 0.3445
Schistosoma mansoni hypothetical protein 0.1372 1 1
Schistosoma mansoni rnf5 0.0025 0.0014 0.0014
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0488 0.3448 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0016 0.0016
Loa Loa (eye worm) RiNg Finger protein family member 0.0025 0.0015 0.0015
Echinococcus multilocularis ring finger protein 170 0.0025 0.0014 0.0011
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0488 0.3448 1
Schistosoma mansoni TRABID protein (C64 family) 0.0488 0.3448 0.3448
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0025 0.0014 0.0011
Brugia malayi hypothetical protein 0.0042 0.0139 0.0135
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0146 0.0133
Onchocerca volvulus 0.0025 0.0014 0.0011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0043 0.0146 0.0146
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0488 0.3448 0.3445
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0014
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0134 0.0351
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0201 0.0187
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0385 0.2682 0.2682
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0003
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0488 0.3448 1
Brugia malayi Neuralized family protein 0.0025 0.0014 0.0011
Echinococcus multilocularis SWI:SNF matrix associated 0.1372 1 1
Brugia malayi hypothetical protein 0.0025 0.0014 0.0011
Echinococcus granulosus Zinc finger RanBP2 type 0.0488 0.3448 0.3445
Entamoeba histolytica hypothetical protein 0.0042 0.0139 0.9037
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0025 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0003 0.0003
Echinococcus multilocularis ring finger protein 113a 0.0025 0.0015 0.0011
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0025 0.0014 0.0011
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0025 0.0014 0.0011
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1372 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0042 0.0139 0.0139
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0003 0.0003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0043 0.0146 0.0386
Echinococcus multilocularis zinc finger protein 0.0026 0.0021 0.0017
Brugia malayi acetyltransferase, GNAT family protein 0.0164 0.1045 0.1042
Brugia malayi Bromodomain containing protein 0.0047 0.0175 0.0172
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0003
Onchocerca volvulus 0.0025 0.0014 0.0011
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0126 0.0123
Onchocerca volvulus 0.0488 0.3448 0.3445
Onchocerca volvulus 0.0025 0.0014 0.0011
Brugia malayi B-box zinc finger family protein 0.0025 0.0014 0.0011
Echinococcus granulosus ring finger protein 170 0.0025 0.0014 0.0011
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0005 0.0005
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0351 0.0348
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1372 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0488 0.3448 0.3448
Schistosoma mansoni mind bomb 0.0025 0.0014 0.0014
Echinococcus multilocularis RING finger protein 185 0.0025 0.0014 0.0011
Chlamydia trachomatis DNA topoisomerase I 0.1372 1 0.5
Toxoplasma gondii exonuclease III APE 0.0043 0.0146 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0003 0.0003
Toxoplasma gondii ran binding protein 0.0488 0.3448 0.3438
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0043 0.0146 0.0143
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0139 0.0139
Trypanosoma brucei hypothetical protein, conserved 0.0488 0.3448 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0016 0.0012
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0025 0.0014 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0488 0.3448 1
Schistosoma mansoni hypothetical protein 0.0025 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0014
Brugia malayi Zinc finger, C2H2 type family protein 0.0025 0.0014 0.0011
Schistosoma mansoni fusion 0.0488 0.3448 0.3448
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0025 0.0014 0.0011
Brugia malayi Zinc finger protein 183 homolog 0.0025 0.0015 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0166 0.1062 0.1062
Brugia malayi exodeoxyribonuclease III family protein 0.0043 0.0146 0.0143
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0488 0.3448 0.3445
Echinococcus granulosus SWI:SNF matrix associated 0.1372 1 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0164 0.1045 0.1045
Brugia malayi PHD-finger family protein 0.0032 0.0065 0.0061
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0134 0.8724
Onchocerca volvulus 0.0488 0.3448 0.3445
Plasmodium vivax hypothetical protein, conserved 0.1372 1 1
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0025 0.0015 0.0001
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1372 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0201 0.0187
Schistosoma mansoni RNA binding protein 0.0488 0.3448 0.3448
Leishmania major hypothetical protein, conserved 0.0488 0.3448 1
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0025 0.0014 0.0011
Onchocerca volvulus 0.0025 0.0014 0.0011
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0003 0.0003
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0488 0.3448 0.3438
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0103 0.5
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0043 0.0146 0.9592
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0014
Treponema pallidum exodeoxyribonuclease (exoA) 0.0043 0.0146 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0139 0.0135
Schistosoma mansoni inositol monophosphatase 0.0041 0.0134 0.0134
Schistosoma mansoni zinc finger protein 0.0026 0.0021 0.0021

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -6.117 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.697 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.676 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.656 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.645 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.594 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.519 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.377 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.306 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.292 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.106 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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