TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 390.432 | Formula: C23H22N2O4
H donors: 1 H acceptors: 2 LogP: 3.54 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1OC)C1CC(=NN1C(=O)C)c1ccc2c(c1O)cccc2
InChi: 1S/C23H22N2O4/c1-14(26)25-20(16-9-11-21(28-2)22(12-16)29-3)13-19(24-25)18-10-8-15-6-4-5-7-17(15)23(18)27/h4-12,20,27H,13H2,1-3H3
InChiKey: NBYYSHWZVCHIJM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	hypothetical protein, conserved	0.0307	0.3438	1
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0465	0.0465
Schistosoma mansoni	hypothetical protein	0.0052	0.0431	0.0431
Schistosoma mansoni	hypothetical protein	0.0863	1	1
Schistosoma mansoni	brg-1 associated factor	0.0863	1	1
Loa Loa (eye worm)	hypothetical protein	0.0307	0.3438	0.3438
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0137	0.0137
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0451	0.0451
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0202	0.2201	1
Loa Loa (eye worm)	hypothetical protein	0.0256	0.283	0.283
Schistosoma mansoni	hypothetical protein	0.0084	0.0802	0.0802
Trypanosoma brucei	protein kinase, putative	0.0055	0.0465	0.131
Echinococcus granulosus	integrin beta 2	0.0288	0.3211	0.3199
Onchocerca volvulus		0.0307	0.3438	0.3332
Loa Loa (eye worm)	pax transcription factor protein 2	0.026	0.2884	0.2884
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0863	1	1
Brugia malayi	Integrin beta pat-3 precursor	0.0393	0.4453	0.4453
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0196	0.0196
Echinococcus granulosus	zinc finger protein Ran binding	0.0307	0.3438	0.3427
Echinococcus multilocularis	mitogen activated protein kinase	0.0055	0.0465	0.0449
Onchocerca volvulus		0.0032	0.0196	0.0037
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0137	0.012
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0153	0.0153
Trypanosoma cruzi	hypothetical protein, conserved	0.0307	0.3438	1
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0055	0.0465	0.131
Loa Loa (eye worm)	hypothetical protein	0.0307	0.3438	0.3438
Echinococcus multilocularis	lamin dm0	0.0029	0.0159	0.0143
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0055	0.0465	0.0449
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0274	0.0274
Loa Loa (eye worm)	brahma associated protein	0.0863	1	1
Loa Loa (eye worm)	hypothetical protein	0.0307	0.3438	0.3438
Echinococcus multilocularis	integrin alpha ps	0.0059	0.0515	0.0499
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0062	0.0062
Giardia lamblia	DINP protein human, muc B family	0.0021	0.0062	0.1326
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0159	0.0159
Schistosoma mansoni	hypothetical protein	0.0017	0.0017	0.0017
Schistosoma mansoni	single-minded	0.0047	0.0374	0.0374
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0055	0.0465	0.1353
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.0465	0.131
Schistosoma mansoni	TRABID protein (C64 family)	0.0307	0.3438	0.3438
Echinococcus granulosus	single minded 2	0.0035	0.0229	0.0213
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0196	0.0179
Brugia malayi	intermediate filament protein	0.0029	0.0159	0.0159
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0307	0.3438	1
Leishmania major	DNA polymerase eta, putative	0.0021	0.0062	0.0179
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0062	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0017	0.0017
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0159	0.0159
Echinococcus multilocularis	SWI:SNF matrix associated	0.0863	1	1
Onchocerca volvulus		0.0307	0.3438	0.3332
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0055	0.0465	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0202	0.2201	0.2201
Trypanosoma brucei	DNA polymerase eta, putative	0.0021	0.0062	0.013
Trypanosoma cruzi	WLM domain containing protein, putative	0.0307	0.3438	1
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0863	1	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0062	0.013
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0159	0.0159
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0062	0.0062
Leishmania major	hypothetical protein, conserved	0.0307	0.3438	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.025	0.025
Trypanosoma cruzi	hypothetical protein, conserved	0.0307	0.3438	1
Toxoplasma gondii	ran binding protein	0.0307	0.3438	0.3427
Echinococcus granulosus	expressed conserved protein	0.019	0.2056	0.2043
Schistosoma mansoni	DNA polymerase eta	0.0021	0.0062	0.0062
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0307	0.3438	0.3427
Schistosoma mansoni	fusion	0.0307	0.3438	0.3438
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0062	0.013
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0137	0.012
Trypanosoma cruzi	WLM domain containing protein, putative	0.0307	0.3438	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0062	0.013
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0062	0.013
Echinococcus multilocularis	musashi	0.0029	0.0159	0.0143
Giardia lamblia	Kinase, NEK	0.0016	0.0006	0.0126
Schistosoma mansoni	hypothetical protein	0.0084	0.0802	0.0802
Brugia malayi	YY1-associated factor 2	0.0307	0.3438	0.3438
Onchocerca volvulus		0.0863	1	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0196	0.0196
Brugia malayi	hypoxia-induced factor 1	0.0147	0.1544	0.1544
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0307	0.3438	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0431	0.0431
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.01	0.0995	0.0995
Brugia malayi	hypothetical protein	0.0062	0.0544	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0451	0.0451
Echinococcus granulosus	ring and YY1 binding protein	0.0307	0.3438	0.3427
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0307	0.3438	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0274	0.0258
Schistosoma mansoni	lamin	0.0029	0.0159	0.0159
Echinococcus granulosus	Niemann Pick C1 protein	0.0289	0.3225	0.3213
Onchocerca volvulus		0.0052	0.0431	0.0275
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0062	0.013
Echinococcus granulosus	mitogen activated protein kinase 3	0.0055	0.0465	0.0449
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0062	0.0062
Echinococcus multilocularis	expressed conserved protein	0.019	0.2056	0.2043
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0431	0.0431
Echinococcus multilocularis	geminin	0.0183	0.1976	0.1962
Echinococcus granulosus	survival motor neuron protein 1	0.0256	0.283	0.2818
Brugia malayi	MAP kinase sur-1	0.0055	0.0465	0.0465
Echinococcus granulosus	Protein patched homolog 1	0.0087	0.0839	0.0824
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0062	0.013
Echinococcus multilocularis	dna polymerase eta	0.0021	0.0062	0.0045
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0018	0.0023	0.0023
Entamoeba histolytica	hypothetical protein	0.0039	0.0274	0.0994
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0137	0.012
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0062	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0196	0.018
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0863	1	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0274	0.0994
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0055	0.0465	0.131
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0062	0.013
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.0017	0.0017
Echinococcus granulosus	dna polymerase eta	0.0021	0.0062	0.0045
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0062	0.0544	0.0544
Schistosoma mansoni	hypothetical protein	0.0863	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0137	0.0351
Echinococcus granulosus	Niemann Pick C1 protein	0.0202	0.2201	0.2188
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0062	0.013
Brugia malayi	SWIB/MDM2 domain containing protein	0.0863	1	1
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0017	0.005
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.025	0.025
Echinococcus granulosus	lamin	0.0029	0.0159	0.0143
Trypanosoma cruzi	hypothetical protein, conserved	0.0307	0.3438	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0062	0.013
Schistosoma mansoni	RNA binding protein	0.0307	0.3438	0.3438
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0465	0.0465
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0159	0.0159
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0274	0.0258
Schistosoma mansoni	hypothetical protein	0.0039	0.0274	0.0274
Trichomonas vaginalis	DNA polymerase eta, putative	0.0021	0.0062	0.0062
Schistosoma mansoni	hypothetical protein	0.0037	0.025	0.025
Echinococcus multilocularis	zinc finger protein Ran binding	0.0307	0.3438	0.3427
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0196	0.018
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0151	0.0151
Leishmania major	hypothetical protein, conserved	0.0307	0.3438	1
Loa Loa (eye worm)	hypothetical protein	0.0307	0.3438	0.3438
Loa Loa (eye worm)	hypothetical protein	0.0106	0.107	0.107
Echinococcus multilocularis	integrin beta 2	0.0288	0.3211	0.3199
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0062	0.013
Schistosoma mansoni	hypothetical protein	0.0028	0.0151	0.0151
Plasmodium vivax	SET domain protein, putative	0.0032	0.0196	0.0179
Echinococcus granulosus	integrin alpha ps	0.0028	0.0151	0.0134
Echinococcus granulosus	Zinc finger RanBP2 type	0.0307	0.3438	0.3427
Schistosoma mansoni	patched 1	0.0087	0.0839	0.0839
Brugia malayi	Kelch motif family protein	0.0062	0.0544	0.0544
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0062	0.0179
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0307	0.3438	0.3332
Loa Loa (eye worm)	integrin alpha pat-2	0.0131	0.1359	0.1359
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0062	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.0839	0.0839
Echinococcus granulosus	integrin alpha 3	0.0028	0.0151	0.0134
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.0465	0.131
Giardia lamblia	Kinase, NEK	0.0016	0.0006	0.0126
Onchocerca volvulus		0.0307	0.3438	0.3332
Trypanosoma cruzi	DNA polymerase eta, putative	0.0021	0.0062	0.013
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0465	0.0465
Schistosoma mansoni	integrin alpha-ps	0.0059	0.0515	0.0515
Echinococcus multilocularis	integrin alpha ps	0.0059	0.0515	0.0499
Loa Loa (eye worm)	hypothetical protein	0.01	0.0995	0.0995
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0062	0.0045
Echinococcus granulosus	intermediate filament protein	0.0029	0.0159	0.0143
Leishmania major	hypothetical protein, conserved	0.0307	0.3438	1
Brugia malayi	brahma associated protein 60 kDa	0.0863	1	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0055	0.0465	0.0449
Brugia malayi	isocitrate dehydrogenase	0.0017	0.0017	0.0017
Trichomonas vaginalis	set domain proteins, putative	0.0256	0.2835	0.2835
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0465	0.0465
Echinococcus multilocularis	SWI:SNF matrix associated	0.0863	1	1
Mycobacterium ulcerans	putative regulatory protein	0.0035	0.0229	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0196	0.0196
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0307	0.3438	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0307	0.3438	0.3438
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0863	1	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0202	0.2201	0.2188
Plasmodium vivax	hypothetical protein, conserved	0.0863	1	1
Schistosoma mansoni	hypothetical protein	0.0183	0.1976	0.1976
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0196	0.018
Brugia malayi	PAS domain containing protein	0.0047	0.0374	0.0374
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0307	0.3438	0.3438
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0839	0.0839
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0055	0.0465	0.1353
Echinococcus granulosus	integrin alpha ps	0.0059	0.0515	0.0499
Giardia lamblia	Kinase	0.0016	0.0006	0.0126
Entamoeba histolytica	hypothetical protein	0.0039	0.0274	0.0994
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0196	0.0196
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0182	0.0166
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.0465	0.0465
Echinococcus multilocularis	lamin	0.0029	0.0159	0.0143
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0021	0.0062	0.0062
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0006	0.0006
Trypanosoma brucei	unspecified product	0.0021	0.0062	0.013
Brugia malayi	Integrin alpha pat-2 precursor	0.0059	0.0515	0.0515
Schistosoma mansoni	integrin alpha-ps	0.0031	0.018	0.018
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0062	0.0179
Brugia malayi	Niemann-Pick C1 protein precursor	0.0202	0.2201	0.2201
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0062	0.013
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0137	0.0351
Schistosoma mansoni	lamin	0.0029	0.0159	0.0159
Onchocerca volvulus		0.026	0.2884	0.2768
Schistosoma mansoni	hypothetical protein	0.0307	0.3438	0.3438
Brugia malayi	Pre-SET motif family protein	0.0225	0.2469	0.2469
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0062	0.0045
Onchocerca volvulus		0.0307	0.3438	0.3332
Schistosoma mansoni	hypothetical protein	0.0863	1	1
Onchocerca volvulus		0.0035	0.0229	0.0071
Echinococcus granulosus	sterol regulatory element binding protein	0.0087	0.0839	0.0824
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0062	0.0045
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0307	0.3438	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.018	0.018
Echinococcus multilocularis	Niemann Pick C1 protein	0.0289	0.3225	0.3213
Loa Loa (eye worm)	hypothetical protein	0.0307	0.3438	0.3438
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0147	0.1544	0.1544
Echinococcus multilocularis	ring and YY1 binding protein	0.0307	0.3438	0.3427
Brugia malayi	hypothetical protein	0.0256	0.283	0.283
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0087	0.0839	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0031	0.018	0.018
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.0017	0.0017
Echinococcus multilocularis	transfer RNA-Lys	0.0035	0.0229	0.0213
Onchocerca volvulus		0.0256	0.2835	0.2719
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0196	0.0196
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0062	0.0062
Trypanosoma brucei	hypothetical protein, conserved	0.0307	0.3438	1
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.0017	0.0017
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0205	0.2238	0.2238
Trichomonas vaginalis	conserved hypothetical protein	0.0863	1	1
Schistosoma mansoni	aryl hydrocarbon receptor	0.0047	0.0374	0.0374
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0863	1	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0017	0.0017
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0307	0.3438	1
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0307	0.3438	0.3427
Brugia malayi	hypothetical protein	0.0027	0.0137	0.0137
Brugia malayi	MH2 domain containing protein	0.0129	0.1338	0.1338
Schistosoma mansoni	integrin beta subunit	0.0226	0.2483	0.2483
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0307	0.3438	0.3427
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0451	0.0451
Brugia malayi	hypothetical protein	0.0039	0.0274	0.0274
Chlamydia trachomatis	SWIB complex protein	0.0863	1	0.5
Schistosoma mansoni	hypothetical protein	0.0084	0.0802	0.0802
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0062	0.013
Schistosoma mansoni	integrin alpha	0.0059	0.0515	0.0515
Echinococcus granulosus	geminin	0.0183	0.1976	0.1962
Echinococcus multilocularis	integrin alpha ps	0.0028	0.0151	0.0134
Echinococcus granulosus	SWI:SNF matrix associated	0.0863	1	1
Echinococcus multilocularis	protein patched	0.0087	0.0839	0.0824
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0307	0.3438	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0307	0.3438	0.3438
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0017	0.0017
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0062	0.0062
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0062	0.013
Entamoeba histolytica	hypothetical protein	0.0039	0.0274	0.0994
Trypanosoma brucei	hypothetical protein, conserved	0.0307	0.3438	1
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0863	1	1
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0055	0.0465	0.131
Brugia malayi	CHE-14 protein	0.0087	0.0839	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1689	0.1689
Leishmania major	hypothetical protein, conserved	0.0307	0.3438	1
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0307	0.3438	0.3427
Chlamydia trachomatis	DNA topoisomerase I	0.0863	1	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.1338	0.1338
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0062	0.013
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0863	1	1
Brugia malayi	Pax transcription factor protein 2	0.026	0.2884	0.2884
Schistosoma mansoni	hypothetical protein	0.0017	0.0017	0.0017
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0225	0.2469	0.2469
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0789	0.9125	0.9124
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0017	0.0017
Loa Loa (eye worm)	integrin beta-2	0.0393	0.4453	0.4453
Brugia malayi	hypothetical protein	0.0159	0.1689	0.1689
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0307	0.3438	0.3438
Brugia malayi	Pre-SET motif family protein	0.0032	0.0196	0.0196
Schistosoma mansoni	zinc finger protein	0.0307	0.3438	0.3438
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0863	1	1
Echinococcus granulosus	mitogen activated protein kinase	0.0055	0.0465	0.0449
Echinococcus granulosus	lamin dm0	0.0029	0.0159	0.0143
Schistosoma mansoni	hypothetical protein	0.0084	0.0802	0.0802
Giardia lamblia	Kinase, CMGC MAPK	0.0055	0.0465	1
Leishmania major	hypothetical protein, conserved	0.0027	0.0137	0.0398
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0137	0.012
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0137	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0544	0.0544
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.1338	0.1338
Echinococcus multilocularis	integrin alpha 3	0.0028	0.0151	0.0134
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0307	0.3438	0.3427
Echinococcus multilocularis	sterol regulatory element binding protein	0.0087	0.0839	0.0824
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0062	0.013
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0451	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0062	0.0062
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0062	1
Brugia malayi	bHLH-PAS transcription factor	0.0035	0.0229	0.0229
Echinococcus multilocularis	survival motor neuron protein 1	0.0256	0.283	0.2818
Schistosoma mansoni	hypothetical protein	0.0017	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0183	0.1976	0.1976
Echinococcus multilocularis	SWI:SNF matrix associated	0.0863	1	1
Echinococcus multilocularis	protein dispatched 1	0.0099	0.0984	0.0969
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0062	0.013

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1986440

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1649596