Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.3682 | 0.3627 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.1954 | 0.2041 |
Echinococcus multilocularis | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Schistosoma mansoni | plexin | 0.0164 | 0.8075 | 0.8727 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.9241 | 0.9234 |
Echinococcus multilocularis | plexin a4 | 0.0194 | 1 | 1 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0069 | 0.1954 | 0.1885 |
Onchocerca volvulus | 0.0164 | 0.8075 | 0.8727 | |
Entamoeba histolytica | protein kinase domain containing protein | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0182 | 0.9241 | 0.9234 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Onchocerca volvulus | 0.0182 | 0.9241 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.8075 | 0.8059 |
Brugia malayi | Plexin repeat family protein | 0.0164 | 0.8075 | 0.8059 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.9241 | 0.9234 |
Brugia malayi | Sema domain containing protein | 0.0069 | 0.1954 | 0.1885 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Schistosoma mansoni | hypothetical protein | 0.0096 | 0.3682 | 0.3928 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0182 | 0.9241 | 0.9234 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.9241 | 0.9234 |
Brugia malayi | Sema domain containing protein | 0.0069 | 0.1954 | 0.1885 |
Echinococcus multilocularis | semaphorin 5B | 0.0069 | 0.1954 | 0.1885 |
Onchocerca volvulus | 0.0069 | 0.1954 | 0.2041 | |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0182 | 0.9241 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0182 | 0.9241 | 0.9234 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0182 | 0.9241 | 0.9234 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0182 | 0.9241 | 1 |
Echinococcus granulosus | plexin a4 | 0.0194 | 1 | 1 |
Loa Loa (eye worm) | plexin A | 0.0194 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Brugia malayi | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Echinococcus granulosus | semaphorin 1A | 0.0069 | 0.1954 | 0.1885 |
Loa Loa (eye worm) | serotonin transporter b | 0.0182 | 0.9241 | 0.9234 |
Echinococcus granulosus | semaphorin 5B | 0.0069 | 0.1954 | 0.1885 |
Schistosoma mansoni | plexin | 0.0096 | 0.3682 | 0.3928 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Schistosoma mansoni | semaphorin 5-related | 0.0069 | 0.1954 | 0.2041 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0069 | 0.1954 | 0.1885 |
Echinococcus multilocularis | serotonin transporter | 0.0182 | 0.9241 | 0.9234 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0182 | 0.9241 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.1954 | 0.2041 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0038 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.473 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.988 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.954 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.888 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.873 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.82 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.817 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.799 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.78 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.762 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.