TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 531.53 | Formula: C25H28F3N7O3
H donors: 4 H acceptors: 5 LogP: 1.38 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(F)(F)F.CC(Nc1cccc2c1oc(n2)c1cc(cnc1N)c1cnn(c1)C1CCNCC1)C
InChi: 1S/C23H27N7O.C2HF3O2/c1-14(2)28-19-4-3-5-20-21(19)31-23(29-20)18-10-15(11-26-22(18)24)16-12-27-30(13-16)17-6-8-25-9-7-17;3-2(4,5)1(6)7/h3-5,10-14,17,25,28H,6-9H2,1-2H3,(H2,24,26);(H,6,7)
InChiKey: WBGQBUYDSRMRCH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	MET proto-oncogene, receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, putative	0.0409	0.2772	0.2753
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0232	0.0193
Trypanosoma cruzi	cysteine peptidase, putative	0.0756	0.5203	0.519
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0756	0.5203	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0756	0.5203	1
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.004	0.004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0972	0.0972
Echinococcus granulosus	hypothetical protein	0.0151	0.0972	0.0936
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0151	0.0972	0.0972
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0151	0.0972	0.0972
Brugia malayi	RNA binding protein	0.0059	0.0326	0.0267
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0177	0.0138
Giardia lamblia	Cathepsin B precursor	0.0565	0.3863	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0519	0.3546	0.3506
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0172	0.1115	0.1822
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0756	0.5203	1
Entamoeba histolytica	cysteine protease, putative	0.0409	0.2772	0.5137
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0066	0.0066
Entamoeba histolytica	cysteine protease, putative	0.0409	0.2772	0.5137
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0631	0.0631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0756	0.5203	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0172	0.1115	0.1115
Trypanosoma cruzi	cysteine peptidase, putative	0.0756	0.5203	0.519
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0061	0.0061
Onchocerca volvulus		0.0151	0.0972	0.1772
Schistosoma mansoni	zinc finger protein	0.0016	0.0027	0.0027
Echinococcus granulosus	GPCR family 2	0.0047	0.0247	0.0208
Onchocerca volvulus		0.0519	0.3546	0.6777
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0756	0.5203	0.5184
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0047	0.0247	0.0208
Onchocerca volvulus		0.0151	0.0972	0.1772
Echinococcus granulosus	neuropeptide Y receptor	0.0151	0.0972	0.0936
Echinococcus granulosus	cathepsin b	0.1442	1	1
Brugia malayi	G-protein coupled receptor	0.0151	0.0972	0.0917
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0756	0.5203	1
Echinococcus multilocularis	fmrfamide receptor	0.0151	0.0972	0.0936
Trypanosoma cruzi	major cysteine proteinase, putative	0.0172	0.1115	0.1091
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0972	0.0972
Loa Loa (eye worm)	G-protein coupled receptor	0.0151	0.0972	0.0972
Echinococcus granulosus	somatostatin receptor	0.0151	0.0972	0.0936
Onchocerca volvulus		0.0756	0.5203	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0972	0.0936
Schistosoma mansoni	cathepsin F (C01 family)	0.0519	0.3546	0.3546
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0151	0.0972	0.0917
Echinococcus granulosus	neuropeptide receptor A26	0.0151	0.0972	0.0936
Brugia malayi	hypothetical protein	0.0151	0.0972	0.0917
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0151	0.0972	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Echinococcus multilocularis	GPCR, family 2	0.0047	0.0247	0.0208
Echinococcus multilocularis	cathepsin L	0.0409	0.2772	0.2744
Entamoeba histolytica	cysteine protease, putative	0.0409	0.2772	0.5137
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0047	0.0247	0.0208
Onchocerca volvulus		0.0151	0.0972	0.1772
Schistosoma mansoni	tar DNA-binding protein	0.0059	0.0326	0.0326
Echinococcus granulosus	neuropeptide FF receptor 2	0.0151	0.0972	0.0936
Echinococcus multilocularis	serotonin receptor	0.0151	0.0972	0.0936
Brugia malayi	Cathepsin L-like precursor	0.0519	0.3546	0.3506
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0972	0.0972
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0232	0.0193
Trypanosoma cruzi	cruzipain precursor, putative	0.0237	0.1572	0.155
Loa Loa (eye worm)	cathepsin B	0.0565	0.3863	0.3863
Echinococcus multilocularis	transient receptor potential cation channel	0.0165	0.1069	0.1033
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0151	0.0972	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0151	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0151	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0172	0.1115	0.1115
Onchocerca volvulus		0.0151	0.0972	0.1772
Brugia malayi	Cathepsin L-like precursor	0.0756	0.5203	0.5174
Entamoeba histolytica	cysteine proteinase 2	0.0409	0.2772	0.5137
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0151	0.0972	0.0972
Echinococcus multilocularis	orexin receptor type 2	0.0151	0.0972	0.0936
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0756	0.5203	1
Echinococcus granulosus	neuropeptide s receptor	0.0151	0.0972	0.0936
Plasmodium vivax	unspecified product	0.0237	0.1572	0.1119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0972	0.0972
Schistosoma mansoni	hypothetical protein	0.0151	0.0972	0.0972
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0047	0.0247	0.0208
Echinococcus multilocularis	g protein coupled receptor	0.0151	0.0972	0.0936
Echinococcus granulosus	cysteine protease	0.0409	0.2772	0.2744
Brugia malayi	hypothetical protein	0.0151	0.0972	0.0917
Brugia malayi	ORL1-like opioid receptor	0.0151	0.0972	0.0917
Schistosoma mansoni	amine GPCR	0.0151	0.0972	0.0972
Onchocerca volvulus		0.0151	0.0972	0.1772
Onchocerca volvulus		0.0756	0.5203	1
Onchocerca volvulus		0.0151	0.0972	0.1772
Loa Loa (eye worm)	hypothetical protein	0.0237	0.1572	0.1572
Echinococcus multilocularis	cathepsin L	0.0172	0.1115	0.108
Entamoeba histolytica	cysteine proteinase, putative	0.0519	0.3546	0.6685
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0204	0.0165
Schistosoma mansoni	hypothetical protein	0.0047	0.0247	0.0247
Brugia malayi	AKH receptor	0.0151	0.0972	0.0917
Echinococcus multilocularis	neuropeptide s receptor	0.0151	0.0972	0.0936
Schistosoma mansoni	neuropeptide receptor	0.0151	0.0972	0.0972
Onchocerca volvulus		0.0151	0.0972	0.1772
Echinococcus granulosus	g protein coupled receptor	0.0151	0.0972	0.0936
Schistosoma mansoni	tar DNA-binding protein	0.0059	0.0326	0.0326
Schistosoma mansoni	cathepsin s	0.0237	0.1572	0.1572
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0151	0.0972	0.0917
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	0.0972	0.0936
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Loa Loa (eye worm)	ctsf protein	0.0756	0.5203	0.5203
Echinococcus granulosus	g protein coupled receptor	0.0151	0.0972	0.0936
Schistosoma mansoni	cathepsin C	0.0172	0.1115	0.1115
Entamoeba histolytica	cysteine protease, putative	0.0172	0.1115	0.1822
Brugia malayi	Latrophilin receptor protein 2	0.0047	0.0247	0.0187
Echinococcus granulosus	transient receptor potential cation channel	0.0165	0.1067	0.1031
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0756	0.5203	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0232	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0519	0.3546	0.3546
Schistosoma mansoni	neuropeptide F-like receptor	0.0151	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Echinococcus granulosus	cathepsin L cysteine protease	0.0409	0.2772	0.2744
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0232	0.0193
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0756	0.5203	1
Brugia malayi	hypothetical protein	0.0151	0.0972	0.0917
Schistosoma mansoni	zinc finger protein	0.002	0.0058	0.0058
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0151	0.0972	0.0972
Echinococcus granulosus	g protein coupled receptor	0.0151	0.0972	0.0936
Trypanosoma cruzi	cysteine peptidase, putative	0.0756	0.5203	0.519
Echinococcus multilocularis	neuropeptide Y receptor	0.0151	0.0972	0.0936
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0756	0.5203	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0151	0.0972	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Entamoeba histolytica	cysteine protease, putative	0.0756	0.5203	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0102	0.0631	0.0574
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0151	0.0972	0.0936
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0565	0.3863	0.3863
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0151	0.0972	0.0972
Echinococcus multilocularis	cathepsin b	0.1442	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Leishmania major	cathepsin L-like protease	0.0756	0.5203	1
Onchocerca volvulus		0.0756	0.5203	1
Echinococcus multilocularis	somatostatin receptor	0.0151	0.0972	0.0936
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.2772	0.5304
Loa Loa (eye worm)	plexin A	0.0025	0.0088	0.0088
Onchocerca volvulus		0.0756	0.5203	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0151	0.0972	0.0936
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0059	0.0326	0.0326
Echinococcus multilocularis	g-protein coupled receptor	0.0151	0.0972	0.0936
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0151	0.0972	0.0936
Onchocerca volvulus		0.0151	0.0972	0.1772
Brugia malayi	Bromodomain containing protein	0.004	0.0195	0.0135
Echinococcus multilocularis	zinc finger protein	0.002	0.0058	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0018	0.004	0.004
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0172	0.1115	0.1115
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Onchocerca volvulus		0.0151	0.0972	0.1772
Leishmania major	cathepsin L-like protease	0.0756	0.5203	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Loa Loa (eye worm)	TYRA-2 protein	0.0151	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0756	0.5203	0.5184
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0151	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Entamoeba histolytica	cysteine protease, putative	0.0409	0.2772	0.5137
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0756	0.5203	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0247	0.0247
Echinococcus multilocularis	serotonin receptor	0.0151	0.0972	0.0936
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	0.016	0.1033	0.1033
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0151	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0151	0.0972	0.0917
Brugia malayi	PHD-finger family protein	0.0026	0.0097	0.0036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0756	0.5203	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0972	0.0936
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0151	0.0972	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Loa Loa (eye worm)	melatonin receptor type 1A	0.0151	0.0972	0.0972
Schistosoma mansoni	growth hormone secretagogue receptor	0.0151	0.0972	0.0972
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0151	0.0972	0.0972
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0151	0.0972	0.0936
Echinococcus multilocularis	neuropeptide receptor	0.0151	0.0972	0.0936
Entamoeba histolytica	cysteine proteinase, putative	0.0756	0.5203	1
Brugia malayi	Papain family cysteine protease containing protein	0.0172	0.1115	0.1061
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1442	1	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0151	0.0972	0.0917
Onchocerca volvulus		0.0151	0.0972	0.1772
Onchocerca volvulus		0.0151	0.0972	0.1772
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0756	0.5203	1
Brugia malayi	Papain family cysteine protease containing protein	0.0172	0.1115	0.1061
Onchocerca volvulus	Cathepsin L homolog	0.0756	0.5203	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0172	0.1115	0.1115
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0151	0.0972	0.0936
Brugia malayi	Papain family cysteine protease containing protein	0.0756	0.5203	0.5174
Onchocerca volvulus	Cathepsin L homolog	0.0756	0.5203	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0151	0.0972	0.0972
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0172	0.1115	0.1115
Loa Loa (eye worm)	hypothetical protein	0.0756	0.5203	0.5203
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0151	0.0972	0.0972
Entamoeba histolytica	cysteine proteinase, putative	0.0409	0.2772	0.5137
Echinococcus multilocularis	neuropeptides capa receptor	0.0151	0.0972	0.0936
Echinococcus granulosus	neuropeptides capa receptor	0.0151	0.0972	0.0936
Echinococcus multilocularis	ankyrin repeat protein	0.016	0.1033	0.0997
Trypanosoma cruzi	cysteine protease, putative	0.0409	0.2772	0.2753
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0756	0.5203	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0047	0.0247	0.0247
Echinococcus multilocularis	neuropeptide receptor	0.0151	0.0972	0.0936
Echinococcus granulosus	cathepsin l1	0.0756	0.5203	0.5184
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0232	0.0232
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0972	0.0972
Brugia malayi	Papain family cysteine protease containing protein	0.0409	0.2772	0.2728
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0565	0.3863	0.7411
Brugia malayi	Cathepsin L-like precursor	0.0237	0.1572	0.1521
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0151	0.0972	0.0936
Onchocerca volvulus	Cathepsin F homolog	0.0756	0.5203	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0151	0.0972	0.0936
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0756	0.5203	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.2772	0.4054
Echinococcus multilocularis	fmrfamide receptor	0.0151	0.0972	0.0936
Schistosoma mansoni	hypothetical protein	0.0151	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.1442	1	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0151	0.0972	0.0936
Plasmodium vivax	vivapain-3	0.0409	0.2772	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.0172	0.1115	0.205
Schistosoma mansoni	bromodomain containing protein	0.0066	0.0377	0.0377
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0151	0.0972	0.0936
Loa Loa (eye worm)	TAR-binding protein	0.0059	0.0326	0.0326
Entamoeba histolytica	cysteine protease, putative	0.0172	0.1115	0.1822
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Brugia malayi	hypothetical protein	0.0151	0.0972	0.0917
Brugia malayi	follicle stimulating hormone receptor	0.0151	0.0972	0.0917
Brugia malayi	Cathepsin L-like precursor	0.0756	0.5203	0.5174
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0756	0.5203	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0756	0.5203	0.5184
Schistosoma mansoni	hypothetical protein	0.0102	0.0631	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0519	0.3546	0.3546
Brugia malayi	hypothetical protein	0.0151	0.0972	0.0917
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.008	0.008
Brugia malayi	TAR-binding protein	0.0059	0.0326	0.0267
Schistosoma mansoni	cathepsin S (C01 family)	0.0172	0.1115	0.1115
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0172	0.1115	0.1115
Entamoeba histolytica	cysteine protease, putative	0.0409	0.2772	0.5137
Loa Loa (eye worm)	cysteine protease	0.0756	0.5203	0.5203
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0172	0.1115	0.1115
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Leishmania major	cysteine peptidase A (CPA)	0.0756	0.5203	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0972	0.0936
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0172	0.1115	0.1061
Loa Loa (eye worm)	hypothetical protein	0.0172	0.1115	0.1115
Schistosoma mansoni	amine GPCR	0.0151	0.0972	0.0972
Onchocerca volvulus		0.0756	0.5203	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0756	0.5203	1
Brugia malayi	hypothetical protein	0.0041	0.0204	0.0144
Echinococcus granulosus	biogenic amine 5HT receptor	0.0151	0.0972	0.0936
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0151	0.0972	0.0972
Entamoeba histolytica	cysteine protease, putative	0.0409	0.2772	0.5137
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0756	0.5203	1
Toxoplasma gondii	cathepsin CPL	0.0756	0.5203	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0237	0.1572	0.155
Loa Loa (eye worm)	hypothetical protein	0.0172	0.1115	0.1115
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0151	0.0972	0.0972
Brugia malayi	Serotonin receptor	0.0151	0.0972	0.0917
Schistosoma mansoni	neuropeptide F-like receptor	0.0151	0.0972	0.0972
Schistosoma mansoni	hypothetical protein	0.0151	0.0972	0.0972
Entamoeba histolytica	cysteine protease, putative	0.0409	0.2772	0.5137
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Echinococcus multilocularis	plexin a4	0.0025	0.0088	0.0048
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0756	0.5203	1
Echinococcus granulosus	plexin a4	0.0025	0.0088	0.0048
Echinococcus granulosus	neuropeptide receptor	0.0151	0.0972	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Echinococcus granulosus	sex peptide receptor	0.0151	0.0972	0.0936
Echinococcus granulosus	allatostatin A receptor	0.0151	0.0972	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0177	0.0138
Brugia malayi	cathepsin L-like precursor	0.0519	0.3546	0.3506
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0756	0.5203	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0172	0.1115	0.1115
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0172	0.1115	0.1061
Plasmodium vivax	unspecified product	0.0409	0.2772	0.4054
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0151	0.0972	0.0972
Echinococcus granulosus	cathepsin L	0.0409	0.2772	0.2744
Brugia malayi	Serotonin receptor	0.0151	0.0972	0.0917
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0494	0.3372	0.3346
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	0.0972	0.0936
Brugia malayi	hypothetical protein	0.0151	0.0972	0.0917
Entamoeba histolytica	cysteine protease, putative	0.0409	0.2772	0.5137
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.004	0.004
Schistosoma mansoni	tar DNA-binding protein	0.0059	0.0326	0.0326
Brugia malayi	Melatonin receptor type 1A	0.0151	0.0972	0.0917
Onchocerca volvulus		0.0151	0.0972	0.1772
Echinococcus multilocularis	neuropeptides capa receptor	0.0151	0.0972	0.0936
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0756	0.5203	1
Entamoeba histolytica	cysteine protease, putative	0.0172	0.1115	0.1822
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.2772	0.5304
Entamoeba histolytica	cysteine proteinase 1, putative	0.0409	0.2772	0.5137
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1442	1	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0172	0.1115	0.1061
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0756	0.5203	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0151	0.0972	0.0936
Brugia malayi	cathepsin L precursor	0.0172	0.1115	0.1061
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0565	0.3863	0.6722
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.015	0.0963	0.0908
Onchocerca volvulus		0.0756	0.5203	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0172	0.1115	0.1115
Brugia malayi	Dopamine receptor protein 2	0.0151	0.0972	0.0917
Echinococcus granulosus	neuropeptide receptor	0.0151	0.0972	0.0936
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0232	0.0232
Trypanosoma cruzi	cysteine proteinase, putative	0.0409	0.2772	0.2753
Leishmania major	cathepsin L-like protease	0.0756	0.5203	1
Brugia malayi	hypothetical protein	0.0151	0.0972	0.0917
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0756	0.5203	1
Brugia malayi	Papain family cysteine protease containing protein	0.0409	0.2772	0.2728
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0756	0.5203	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0151	0.0972	0.0972
Entamoeba histolytica	cysteine protease, putative	0.0409	0.2772	0.5137
Echinococcus multilocularis	neuropeptide receptor A26	0.0151	0.0972	0.0936
Schistosoma mansoni	neuropeptide receptor	0.0151	0.0972	0.0972
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0756	0.5203	1
Schistosoma mansoni	opsin-like receptor	0.0151	0.0972	0.0972
Echinococcus multilocularis	allatostatin A receptor	0.0151	0.0972	0.0936
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0151	0.0972	0.0917
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.3546	0.5946
Giardia lamblia	Cathepsin B precursor	0.0565	0.3863	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0151	0.0972	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Schistosoma mansoni	hypothetical protein	0.0041	0.0204	0.0204
Brugia malayi	G-protein coupled receptor	0.0151	0.0972	0.0917
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	0.0972	0.0936
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0756	0.5203	1
Schistosoma mansoni	opsin-like receptor	0.0151	0.0972	0.0972
Entamoeba histolytica	cysteine protease, putative	0.0409	0.2772	0.5137
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0237	0.1572	0.1572
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1442	1	1
Schistosoma mansoni	plexin	0.0021	0.0061	0.0061
Schistosoma mansoni	hypothetical protein	0.0151	0.0972	0.0972
Brugia malayi	fibroinase precursor	0.0172	0.1115	0.1061
Echinococcus granulosus	tm gpcr rhodopsin	0.0151	0.0972	0.0936
Entamoeba histolytica	cysteine proteinase, putative	0.0409	0.2772	0.5137
Echinococcus granulosus	cathepsin l1	0.0519	0.3546	0.352
Brugia malayi	RNA recognition motif domain containing protein	0.0059	0.0326	0.0267
Brugia malayi	Cathepsin L-like precursor	0.0756	0.5203	0.5174
Echinococcus multilocularis	tar DNA binding protein	0.0059	0.0326	0.0288
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0151	0.0972	0.0936
Entamoeba histolytica	cysteine proteinase, putative	0.0756	0.5203	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0172	0.1115	0.1115
Brugia malayi	hypothetical protein	0.0151	0.0972	0.0917
Brugia malayi	larval opioid receptor	0.0151	0.0972	0.0917
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.004	0.004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0756	0.5203	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0756	0.5203	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0151	0.0972	0.0972
Echinococcus granulosus	serotonin receptor	0.0151	0.0972	0.0936
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0151	0.0972	0.0936
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0972	0.0936
Onchocerca volvulus		0.0151	0.0972	0.1772
Echinococcus granulosus	7tm_1 domain containing protein	0.0151	0.0972	0.0936
Echinococcus multilocularis	cathepsin b	0.1442	1	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0047	0.0247	0.0208
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0756	0.5203	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0151	0.0972	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Brugia malayi	neuropeptide F receptor	0.0151	0.0972	0.0917
Echinococcus granulosus	7TM GPCR rhodopsin	0.0151	0.0972	0.0936
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0232	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0237	0.1572	0.1572
Brugia malayi	cathepsin F-like cysteine proteinase	0.0172	0.1115	0.1061
Echinococcus granulosus	tm gpcr rhodopsin	0.0494	0.3372	0.3346
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0227	0.0227
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0151	0.0972	0.0936
Schistosoma mansoni	neuropeptide receptor	0.0151	0.0972	0.0972
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0151	0.0972	0.0936
Trypanosoma cruzi	major cysteine proteinase, putative	0.0172	0.1115	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Brugia malayi	cathepsin L-like cysteine proteinase	0.0172	0.1115	0.1061
Brugia malayi	neuropeptide F receptor	0.0151	0.0972	0.0917
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0972	0.0972
Schistosoma mansoni	amine GPCR	0.0151	0.0972	0.0972
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0151	0.0972	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0172	0.1115	0.1115
Schistosoma mansoni	hypothetical protein	0.0022	0.0066	0.0066
Entamoeba histolytica	hypothetical protein	0.0172	0.1115	0.1822
Echinococcus granulosus	cathepsin L	0.0172	0.1115	0.108
Onchocerca volvulus		0.0151	0.0972	0.1772
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0756	0.5203	1
Brugia malayi	plexin A	0.0025	0.0088	0.0027
Brugia malayi	cathepsin F-like cysteine proteinase	0.0237	0.1572	0.1521
Entamoeba histolytica	cysteine proteinase, putative	0.0409	0.2772	0.5137
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Echinococcus multilocularis	cysteine protease	0.0756	0.5203	0.5184
Brugia malayi	Calcitonin receptor-like protein seb-1	0.015	0.0963	0.0908
Schistosoma mansoni	biogenic amine receptor	0.0151	0.0972	0.0972
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0151	0.0972	0.1772
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	0.0972	0.0936
Leishmania major	cathepsin L-like protease	0.0756	0.5203	1
Echinococcus granulosus	fmrfamide receptor	0.0151	0.0972	0.0936
Onchocerca volvulus		0.0151	0.0972	0.1772
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Echinococcus multilocularis	cysteine protease	0.0756	0.5203	0.5184
Echinococcus multilocularis	G protein coupled receptor 139	0.0151	0.0972	0.0936
Entamoeba histolytica	cysteine protease, putative	0.0172	0.1115	0.1822
Brugia malayi	putative neuropeptide receptor	0.0151	0.0972	0.0917
Schistosoma mansoni	amine GPCR	0.0151	0.0972	0.0972
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1442	1	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0172	0.1115	0.1115
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Schistosoma mansoni	hypothetical protein	0.0047	0.0247	0.0247
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1442	1	1
Brugia malayi	Bromodomain containing protein	0.0078	0.0463	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0213	0.0213
Onchocerca volvulus		0.0151	0.0972	0.1772
Plasmodium vivax	vivapain-2	0.0756	0.5203	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.008	0.004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0756	0.5203	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0972	0.0936
Schistosoma mansoni	cathepsin F (C01 family)	0.0756	0.5203	0.5203
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0151	0.0972	0.0936
Echinococcus granulosus	tar DNA binding protein	0.0059	0.0326	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Loa Loa (eye worm)	RNA binding protein	0.0059	0.0326	0.0326
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0409	0.2772	0.2772
Brugia malayi	hypothetical protein	0.0151	0.0972	0.0917
Brugia malayi	RE15519p	0.0151	0.0972	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0432	0.0432
Brugia malayi	G protein-coupled receptor	0.0151	0.0972	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Schistosoma mansoni	hypothetical protein	0.0016	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0756	0.5203	1
Schistosoma mansoni	tar DNA-binding protein	0.0059	0.0326	0.0326
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0756	0.5203	1
Entamoeba histolytica	cysteine protease, putative	0.0172	0.1115	0.1822
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Brugia malayi	Cathepsin L-like precursor	0.0519	0.3546	0.3506
Schistosoma mansoni	biogenic amine receptor	0.0151	0.0972	0.0972
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0204	0.0165
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0151	0.0972	0.0972
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	0.0972	0.0936
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	0.0972	0.0936
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0972	0.0972
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0409	0.2772	0.2772
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0972	0.0936
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0151	0.0972	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0237	0.1572	0.1572
Echinococcus granulosus	cathepsin b	0.1442	1	1
Echinococcus granulosus	orexin receptor type 2	0.0151	0.0972	0.0936
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	0.0972	0.0972
Echinococcus granulosus	biogenic amine 5HT receptor	0.0151	0.0972	0.0936
Echinococcus multilocularis	neuropeptide Y receptor	0.0151	0.0972	0.0936
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0172	0.1115	0.1115
Plasmodium vivax	vivapain-1	0.0409	0.2772	0.4054
Schistosoma mansoni	histamine h1 receptor	0.0151	0.0972	0.0972
Brugia malayi	hypothetical protein	0.0151	0.0972	0.0917
Echinococcus granulosus	ankyrin repeat protein	0.016	0.1033	0.0997
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0172	0.1115	0.1115
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.008	0.004
Brugia malayi	Dopamine receptor protein 1	0.0151	0.0972	0.0917
Brugia malayi	G protein-coupled receptor F59B2.13	0.0151	0.0972	0.0917
Brugia malayi	Dopamine receptor	0.0151	0.0972	0.0917
Toxoplasma gondii	cathepsin B	0.0565	0.3863	0.6722
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0409	0.2772	0.2772
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Schistosoma mansoni	neuropeptide receptor	0.0151	0.0972	0.0972
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0172	0.1115	0.1115
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0756	0.5203	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0409	0.2772	0.4054
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0565	0.3863	0.7411
Loa Loa (eye worm)	hypothetical protein	0.004	0.0195	0.0195
Schistosoma mansoni	hypothetical protein	0.0047	0.0247	0.0247
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0756	0.5203	1
Echinococcus multilocularis	g protein coupled receptor	0.0151	0.0972	0.0936
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.004	0.004
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0047	0.0247	0.0187
Brugia malayi	GnHR receptor homolog	0.0151	0.0972	0.0917
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0151	0.0972	0.1772
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	0.0972	0.0936
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0565	0.3863	0.3846
Leishmania major	cathepsin L-like protease	0.0756	0.5203	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Echinococcus multilocularis	g protein coupled receptor	0.0151	0.0972	0.0936
Brugia malayi	Cathepsin L-like precursor	0.0756	0.5203	0.5174
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.3546	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0172	0.1115	0.1822
Schistosoma mansoni	biogenic amine receptor	0.0151	0.0972	0.0972
Entamoeba histolytica	cysteine proteinase, putative	0.0409	0.2772	0.5137
Schistosoma mansoni	cathepsin F (C01 family)	0.0756	0.5203	0.5203
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0756	0.5203	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0151	0.0972	0.0936
Leishmania major	cathepsin L-like protease	0.0756	0.5203	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Giardia lamblia	Cathepsin B precursor	0.0565	0.3863	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0151	0.0972	0.0972
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0756	0.5203	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0151	0.0972	0.0972
Trypanosoma cruzi	cysteine peptidase, putative	0.0756	0.5203	0.519
Loa Loa (eye worm)	hypothetical protein	0.0519	0.3546	0.3546
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0062	0.0351	0.0313
Echinococcus multilocularis	sex peptide receptor	0.0151	0.0972	0.0936
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0756	0.5203	1
Schistosoma mansoni	hypothetical protein	0.0047	0.0247	0.0247
Loa Loa (eye worm)	fibroinase	0.0756	0.5203	0.5203
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0151	0.0972	0.0936
Echinococcus granulosus	zinc finger protein	0.002	0.0058	0.0018
Echinococcus granulosus	neuropeptides capa receptor	0.0151	0.0972	0.0936
Entamoeba histolytica	cysteine protease, putative	0.0409	0.2772	0.5137
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0756	0.5203	0.5184
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0756	0.5203	0.5203
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0062	0.0351	0.0313
Brugia malayi	sulfakinin receptor protein	0.0151	0.0972	0.0917
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0972	0.0936
Entamoeba histolytica	cysteine protease, putative	0.0409	0.2772	0.5137
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Schistosoma mansoni	adenoreceptor	0.0151	0.0972	0.0972
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0756	0.5203	1
Schistosoma mansoni	amine GPCR	0.0151	0.0972	0.0972
Echinococcus granulosus	tm gpcr rhodopsin	0.0151	0.0972	0.0936
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0172	0.1115	0.1822
Brugia malayi	Papain family cysteine protease containing protein	0.0172	0.1115	0.1061
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0232	0.0172
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0151	0.0972	0.0972
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0237	0.1572	0.1521
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0151	0.0972	0.0936
Loa Loa (eye worm)	hypothetical protein	0.015	0.0963	0.0963
Brugia malayi	Cathepsin L-like precursor	0.0756	0.5203	0.5174
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0756	0.5203	0.5203
Plasmodium vivax	vivapain-2	0.0756	0.5203	1
Schistosoma mansoni	opsin-like receptor	0.0151	0.0972	0.0972
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0519	0.3546	0.3528
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0409	0.2772	0.2753
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.015	0.0963	0.0963
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0151	0.0972	0.0972
Schistosoma mansoni	tar DNA-binding protein	0.0059	0.0326	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Leishmania major	cathepsin L-like protease	0.0756	0.5203	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0409	0.2772	0.2753
Onchocerca volvulus		0.0172	0.1115	0.205
Onchocerca volvulus		0.0151	0.0972	0.1772
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.2772	0.4054
Echinococcus granulosus	neuropeptide Y receptor	0.0151	0.0972	0.0936
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0151	0.0972	0.0972
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0756	0.5203	1
Brugia malayi	Cathepsin L-like precursor	0.0756	0.5203	0.5174
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0151	0.0972	0.0936
Entamoeba histolytica	cysteine protease, putative	0.0409	0.2772	0.5137
Onchocerca volvulus		0.0756	0.5203	1
Loa Loa (eye worm)	hypothetical protein	0.0172	0.1115	0.1115
Schistosoma mansoni	myosin xvIII	0.0151	0.0972	0.0972
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0151	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0151	0.0972	0.0936
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0232	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0151	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0972	0.0972
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0756	0.5203	0.5184
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	0.0972	0.0936
Trypanosoma cruzi	cruzipain precursor, putative	0.0756	0.5203	0.519
Echinococcus granulosus	G protein coupled receptor 139	0.0151	0.0972	0.0936
Echinococcus multilocularis	cathepsin L cysteine protease	0.0756	0.5203	0.5184
Leishmania major	cathepsin L-like protease	0.0756	0.5203	1
Loa Loa (eye worm)	hypothetical protein	0.0172	0.1115	0.1115
Echinococcus granulosus	g-protein coupled receptor	0.0151	0.0972	0.0936

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.13 uM	Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis	ChEMBL.	22579487

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2032157

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1652534