Detailed information for compound 1654605

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 480.818 | Formula: C21H13ClN6O6
  • H donors: 0 H acceptors: 8 LogP: 1.26 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)C(=O)C(=O)N2CCn1nnc(c1)CN1C(=O)C(=O)c2c1ccc(c2)[N+](=O)[O-]
  • InChi: 1S/C21H13ClN6O6/c22-11-1-3-16-14(7-11)18(29)20(31)26(16)6-5-25-9-12(23-24-25)10-27-17-4-2-13(28(33)34)8-15(17)19(30)21(27)32/h1-4,7-9H,5-6,10H2
  • InChiKey: LUZSDRQFMIXWOK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis g protein coupled receptor 0.0038 0.0667 0.0628
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0038 0.0667 0.0611
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Onchocerca volvulus 0.0038 0.0667 0.0196
Mycobacterium tuberculosis Probable oxidoreductase 0.0105 0.2778 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 1 1
Brugia malayi hypothetical protein 0.0027 0.0314 0.0314
Onchocerca volvulus 0.0334 1 1
Giardia lamblia Cathepsin B precursor 0.0123 0.3349 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0954 0.0954
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0249 0.7338 0.7322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0175 0.4983 0.4953
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0777 0.0739
Entamoeba histolytica cysteine protease, putative 0.0175 0.4983 0.4953
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0038 0.0667 0.0628
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Echinococcus multilocularis apoptotic protease activating factor 1 0.0054 0.1163 0.1126
Echinococcus granulosus biogenic amine 5HT receptor 0.0038 0.0667 0.0611
Loa Loa (eye worm) hypothetical protein 0.005 0.1066 0.1066
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Entamoeba histolytica cysteine protease, putative 0.0175 0.4983 0.4953
Brugia malayi nuclear receptor RXR 0.0047 0.0954 0.0954
Echinococcus granulosus biogenic amine 5HT receptor 0.0038 0.0667 0.0611
Echinococcus multilocularis cathepsin b 0.0249 0.7338 0.7326
Trypanosoma cruzi cysteine peptidase, putative 0.0334 1 1
Leishmania major cathepsin L-like protease 0.0334 1 1
Brugia malayi cathepsin L-like precursor 0.0225 0.6579 0.6579
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.008 0.2012 0.2012
Entamoeba histolytica cysteine protease, putative 0.0175 0.4983 0.4953
Echinococcus granulosus hypothetical protein 0.0038 0.0667 0.0611
Brugia malayi Melatonin receptor type 1A 0.0038 0.0667 0.0667
Entamoeba histolytica cysteine protease, putative 0.0066 0.1563 0.1512
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0066 0.1563 0.1512
Loa Loa (eye worm) hypothetical protein 0.0047 0.0954 0.0954
Brugia malayi glutathione reductase 0.0041 0.0777 0.0777
Onchocerca volvulus 0.0038 0.0667 0.0196
Loa Loa (eye worm) hypothetical protein 0.0066 0.1563 0.1563
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0066 0.1563 0.1563
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0099 0.261 0.2566
Schistosoma mansoni hypothetical protein 0.0038 0.0667 0.0611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0099 0.261 0.258
Onchocerca volvulus 0.0038 0.0667 0.0196
Schistosoma mansoni opsin-like receptor 0.0038 0.0667 0.0611
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0082 0.0082
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0334 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0047 0.0954 0.09
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0062 0.1415 0.1415
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0099 0.261 0.261
Loa Loa (eye worm) hypothetical protein 0.0099 0.261 0.261
Brugia malayi Tachykinin-like peptides receptor 99D 0.0038 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0038 0.0667 0.0611
Echinococcus multilocularis fmrfamide receptor 0.0038 0.0667 0.0628
Brugia malayi tailless protein 0.0047 0.0954 0.0954
Entamoeba histolytica cysteine protease, putative 0.0175 0.4983 0.4953
Schistosoma mansoni nuclear hormone receptor 0.0099 0.261 0.2566
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Onchocerca volvulus 0.0334 1 1
Schistosoma mansoni neuropeptide receptor 0.0038 0.0667 0.0611
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.1563 0.1563
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0334 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.008 0.2012 0.1965
Echinococcus multilocularis serotonin receptor 0.0038 0.0667 0.0628
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0022 0.0154 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.1563 0.1512
Trypanosoma cruzi metacaspase 5, putative 0.008 0.2012 0.2012
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0225 0.6579 0.6579
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0099 0.261 0.2566
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0667 0.0628
Loa Loa (eye worm) hypothetical protein 0.0225 0.6579 0.6579
Loa Loa (eye worm) hypothetical protein 0.0156 0.4404 0.4404
Loa Loa (eye worm) G-protein coupled receptor 0.0038 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0053 0.1131 0.1131
Brugia malayi nuclear hormone receptor family member nhr-6 0.0047 0.0954 0.0954
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0053 0.1131 0.1078
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0066 0.1563 0.1512
Plasmodium vivax serine-repeat antigen (SERA) 0.0066 0.1563 0.1563
Trypanosoma brucei metacaspase MCA2 0.008 0.2012 0.2012
Schistosoma mansoni nuclear receptor 0.0047 0.0954 0.09
Echinococcus granulosus cathepsin l1 0.0225 0.6579 0.6559
Loa Loa (eye worm) hypothetical protein 0.0027 0.0314 0.0314
Brugia malayi cathepsin Z-like cysteine proteinase 0.0066 0.1563 0.1563
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0038 0.0667 0.0628
Onchocerca volvulus Bile acid receptor homolog 0.0099 0.261 0.2238
Loa Loa (eye worm) hypothetical protein 0.0047 0.0954 0.0954
Echinococcus multilocularis voltage gated potassium channel 0.002 0.0113 0.0072
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0058 0.1294 0.1243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0099 0.261 0.261
Schistosoma mansoni hypothetical protein 0.0019 0.0082 0.0022
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Schistosoma mansoni neuropeptide receptor 0.0038 0.0667 0.0611
Entamoeba histolytica cysteine protease, putative 0.0175 0.4983 0.4953
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0175 0.4983 0.4953
Echinococcus granulosus nuclear receptor nhr 48 0.0047 0.0954 0.09
Toxoplasma gondii cathepsin CPC2 0.0066 0.1563 0.1563
Schistosoma mansoni caspase-7 (C14 family) 0.0134 0.3701 0.3663
Loa Loa (eye worm) steroid hormone receptor 0.0099 0.261 0.261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 1 1
Brugia malayi ecdysteroid receptor 0.0099 0.261 0.261
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0062 0.1415 0.1364
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0066 0.1563 0.1512
Schistosoma mansoni cathepsin C 0.0066 0.1563 0.1512
Trichomonas vaginalis conserved hypothetical protein 0.008 0.2012 0.1965
Brugia malayi hypothetical protein 0.0053 0.1131 0.1131
Brugia malayi nuclear hormone receptor 0.0047 0.0954 0.0954
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0038 0.0667 0.0628
Entamoeba histolytica cysteine protease, putative 0.0175 0.4983 0.4953
Entamoeba histolytica hypothetical protein 0.0066 0.1563 0.1512
Schistosoma mansoni amine GPCR 0.0038 0.0667 0.0611
Giardia lamblia Hypothetical protein 0.0066 0.1563 0.457
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0099 0.261 0.258
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0038 0.0667 0.0611
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0038 0.0667 0.0628
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0026 0.0279 0.0221
Trypanosoma cruzi major cysteine proteinase, putative 0.0066 0.1563 0.1563
Echinococcus multilocularis GPCR, family 2 0.0019 0.0082 0.004
Brugia malayi G protein-coupled receptor F59B2.13 0.0038 0.0667 0.0667
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0099 0.261 0.261
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0334 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0038 0.0667 0.0667
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0038 0.0667 0.0611
Entamoeba histolytica cysteine proteinase 2 0.0175 0.4983 0.4953
Brugia malayi Serotonin receptor 0.0038 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0024 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.1563 0.1512
Loa Loa (eye worm) hypothetical protein 0.008 0.2012 0.2012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.1563 0.1512
Brugia malayi cathepsin F-like cysteine proteinase 0.0108 0.2895 0.2895
Giardia lamblia Cysteine protease 0.0066 0.1563 0.457
Brugia malayi photoreceptor-specific nuclear receptor 0.0099 0.261 0.261
Echinococcus multilocularis neuropeptide Y receptor 0.0038 0.0667 0.0628
Echinococcus multilocularis G protein coupled receptor 139 0.0038 0.0667 0.0628
Echinococcus granulosus g protein coupled receptor 0.0038 0.0667 0.0611
Schistosoma mansoni neuropeptide f receptor 76f 0.0038 0.0667 0.0611
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.002 0.0113 0.0113
Echinococcus multilocularis caspase 2 0.0134 0.3701 0.3674
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0066 0.1563 0.1512
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0038 0.0667 0.0628
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0038 0.0667 0.0611
Loa Loa (eye worm) hypothetical protein 0.0066 0.1563 0.1563
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0058 0.1294 0.1243
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Brugia malayi hypothetical protein 0.0022 0.0154 0.0154
Brugia malayi nuclear receptor NHR-67 0.0047 0.0954 0.0954
Onchocerca volvulus 0.0038 0.0667 0.0196
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0099 0.261 0.2566
Brugia malayi hypothetical protein 0.0184 0.5269 0.5269
Plasmodium vivax glutathione reductase, putative 0.0041 0.0777 0.0777
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0038 0.0667 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0099 0.261 0.261
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0099 0.261 0.2238
Plasmodium falciparum cysteine proteinase falcipain 3 0.0334 1 1
Brugia malayi hypothetical protein 0.0156 0.4404 0.4404
Brugia malayi Dopamine receptor protein 1 0.0038 0.0667 0.0667
Loa Loa (eye worm) TYRA-2 protein 0.0038 0.0667 0.0667
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0066 0.1563 0.1512
Echinococcus granulosus orexin receptor type 2 0.0038 0.0667 0.0611
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Giardia lamblia Cathepsin L precursor 0.0066 0.1563 0.457
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0667 0.0611
Brugia malayi Nuclear hormone receptor E75 0.0047 0.0954 0.0954
Echinococcus granulosus neuropeptides capa receptor 0.0038 0.0667 0.0611
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0082 0.0022
Leishmania major cathepsin L-like protease 0.0334 1 1
Leishmania major metacaspase, putative 0.008 0.2012 0.2012
Echinococcus multilocularis orexin receptor type 2 0.0038 0.0667 0.0628
Echinococcus multilocularis g-protein coupled receptor 0.0038 0.0667 0.0628
Onchocerca volvulus 0.0334 1 1
Entamoeba histolytica hypothetical protein 0.0022 0.0154 0.0096
Plasmodium vivax serine-repeat antigen (SERA) 0.0066 0.1563 0.1563
Schistosoma mansoni zinc finger protein 0.0047 0.0954 0.09
Brugia malayi cathepsin F-like cysteine proteinase 0.0066 0.1563 0.1563
Brugia malayi sulfakinin receptor protein 0.0184 0.5269 0.5269
Plasmodium falciparum metacaspase 1 0.008 0.2012 0.2012
Entamoeba histolytica cysteine protease, putative 0.0175 0.4983 0.4953
Echinococcus granulosus expressed protein 0.002 0.0106 0.0047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0954 0.09
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0113 0.0054
Loa Loa (eye worm) hypothetical protein 0.0054 0.1163 0.1163
Schistosoma mansoni coup transcription factor 0.0099 0.261 0.2566
Loa Loa (eye worm) hypothetical protein 0.0099 0.261 0.261
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0047 0.0954 0.09
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0038 0.0667 0.0628
Brugia malayi hypothetical protein 0.0038 0.0667 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 1 1
Trypanosoma brucei metacaspase 5, putative 0.008 0.2012 0.2012
Schistosoma mansoni transcription factor LCR-F1 0.0022 0.0154 0.0096
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0099 0.261 0.261
Brugia malayi nuclear receptor NHR-88 0.0047 0.0954 0.0954
Brugia malayi hypothetical protein 0.0038 0.0667 0.0667
Echinococcus granulosus peptide allatostatin:somatostatin 0.0038 0.0667 0.0611
Echinococcus granulosus alpha 1A adrenergic receptor 0.0038 0.0667 0.0611
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Loa Loa (eye worm) neuropeptide F receptor 0.0038 0.0667 0.0667
Schistosoma mansoni amine GPCR 0.0038 0.0667 0.0611
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0019 0.0059 0.0059
Brugia malayi Integrin beta pat-3 precursor 0.0175 0.4998 0.4998
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.008 0.2012 0.1965
Leishmania major cysteine peptidase A (CPA) 0.0334 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0038 0.0667 0.0611
Trypanosoma cruzi cysteine peptidase, putative 0.0334 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0047 0.0954 0.0916
Echinococcus granulosus FTZ F1 alpha 0.0099 0.261 0.2566
Plasmodium falciparum glutathione reductase 0.0041 0.0777 0.0777
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 1 1
Trichomonas vaginalis conserved hypothetical protein 0.008 0.2012 0.1965
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Brugia malayi calpain family protein 1 0.0024 0.0245 0.0245
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.002 0.0106 0.0106
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0066 0.1563 0.1512
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.008 0.2012 0.1965
Loa Loa (eye worm) neuropeptide F receptor 0.0038 0.0667 0.0667
Brugia malayi cathepsin B-like cysteine proteinase 0.0249 0.7338 0.7338
Plasmodium falciparum serine repeat antigen 8 0.0066 0.1563 0.1563
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0099 0.261 0.261
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0038 0.0667 0.0611
Loa Loa (eye worm) hypothetical protein 0.0053 0.1131 0.1131
Brugia malayi Cathepsin L-like precursor 0.0334 1 1
Brugia malayi nuclear receptor RXR 0.0053 0.1131 0.1131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0667 0.0611
Brugia malayi Cathepsin L-like precursor 0.0225 0.6579 0.6579
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 1 1
Trypanosoma brucei metacaspase MCA3 0.008 0.2012 0.2012
Entamoeba histolytica cysteine protease, putative 0.0066 0.1563 0.1512
Plasmodium vivax vivapain-2 0.0334 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0047 0.0954 0.0954
Brugia malayi larval opioid receptor 0.0038 0.0667 0.0667
Echinococcus granulosus calpain A 0.0026 0.0279 0.0221
Brugia malayi hypothetical protein 0.0038 0.0667 0.0667
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.008 0.2012 0.1965
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0667 0.0611
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0099 0.261 0.2566
Echinococcus multilocularis neuropeptide Y receptor 0.0038 0.0667 0.0628
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0334 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0038 0.0667 0.0628
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0094 0.2446 0.8342
Onchocerca volvulus 0.0038 0.0667 0.0196
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0094 0.2446 0.8342
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0019 0.0059 0.0059
Mycobacterium tuberculosis Probable dehydrogenase 0.0094 0.2446 0.8342
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.008 0.2012 0.2012
Brugia malayi Cathepsin L-like precursor 0.0334 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0777 0.0777
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0038 0.0667 0.0611
Trichomonas vaginalis conserved hypothetical protein 0.008 0.2012 0.1965
Schistosoma mansoni amine GPCR 0.0038 0.0667 0.0611
Brugia malayi steroid hormone receptor 0.0099 0.261 0.261
Echinococcus granulosus neuropeptide receptor 0.0038 0.0667 0.0611
Schistosoma mansoni growth hormone secretagogue receptor 0.0038 0.0667 0.0611
Echinococcus multilocularis dro:myosuppressin receptor 0.0038 0.0667 0.0628
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0038 0.0667 0.0628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0099 0.261 0.261
Brugia malayi putative neuropeptide receptor 0.0038 0.0667 0.0667
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.008 0.2012 0.1965
Echinococcus multilocularis caspase 8 0.008 0.2012 0.1979
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0099 0.261 0.2566
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.1563 0.1563
Trypanosoma brucei trypanothione reductase 0.0041 0.0777 0.0777
Onchocerca volvulus Cathepsin F homolog 0.0334 1 1
Brugia malayi calpain family protein 1 0.0024 0.0245 0.0245
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0066 0.1563 0.457
Loa Loa (eye worm) hypothetical protein 0.0053 0.1131 0.1131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0099 0.261 0.261
Plasmodium falciparum metacaspase-like protein 0.008 0.2012 0.2012
Toxoplasma gondii peptidylprolyl isomerase 0.002 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Echinococcus granulosus neuropeptide receptor 0.0038 0.0667 0.0611
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0019 0.0059 0.0018
Entamoeba histolytica cysteine protease, putative 0.0334 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0667 0.0628
Schistosoma mansoni nuclear receptor 0.0047 0.0954 0.09
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.1563 0.1512
Giardia lamblia Cathepsin B precursor 0.0066 0.1563 0.457
Echinococcus granulosus caspase 0.0175 0.4992 0.4963
Onchocerca volvulus 0.0038 0.0667 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0099 0.261 0.261
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0082 0.0082
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0094 0.2446 0.8342
Trichomonas vaginalis conserved hypothetical protein 0.008 0.2012 0.1965
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0099 0.261 0.2566
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0667 0.0611
Onchocerca volvulus 0.0038 0.0667 0.0196
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0066 0.1563 0.1563
Echinococcus multilocularis integrin beta 2 0.013 0.3567 0.354
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Onchocerca volvulus 0.0038 0.0667 0.0196
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Echinococcus granulosus tm gpcr rhodopsin 0.0038 0.0667 0.0611
Loa Loa (eye worm) cysteine protease 0.0334 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0334 1 1
Plasmodium falciparum serine repeat antigen 5 0.0066 0.1563 0.1563
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0334 1 1
Echinococcus multilocularis expressed protein 0.002 0.0106 0.0065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0099 0.261 0.2566
Trypanosoma cruzi metacaspase 5, putative 0.008 0.2012 0.2012
Echinococcus granulosus dro:myosuppressin receptor 0.0038 0.0667 0.0611
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0099 0.261 0.261
Echinococcus multilocularis calpain A 0.0026 0.0279 0.0239
Echinococcus multilocularis neuropeptide receptor 0.0038 0.0667 0.0628
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0066 0.1563 0.1563
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0334 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0099 0.261 0.258
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0099 0.261 0.261
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0047 0.0954 0.0954
Brugia malayi putative neuropeptide receptor NPR1 0.0038 0.0667 0.0667
Entamoeba histolytica hypothetical protein 0.0022 0.0154 0.0096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0334 1 1
Brugia malayi conserved hypotetical protein 0.0047 0.0954 0.0954
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0099 0.261 0.261
Schistosoma mansoni hypothetical protein 0.0019 0.0082 0.0022
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0038 0.0667 0.0667
Brugia malayi AKH receptor 0.0038 0.0667 0.0667
Onchocerca volvulus 0.0038 0.0667 0.0196
Trichomonas vaginalis rotamase, putative 0.002 0.0091 0.0032
Toxoplasma gondii cathepsin B 0.0123 0.3349 0.3349
Echinococcus granulosus fmrfamide receptor 0.0038 0.0667 0.0611
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0667 0.0611
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0082 0.004
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.002 0.0091 0.0091
Plasmodium vivax unspecified product 0.0066 0.1563 0.1563
Trypanosoma cruzi metacaspase, putative 0.008 0.2012 0.2012
Schistosoma mansoni thyroid hormone receptor 0.0099 0.261 0.2566
Entamoeba histolytica cysteine proteinase, putative 0.0175 0.4983 0.4953
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0954 0.0916
Echinococcus multilocularis cathepsin L 0.0175 0.4983 0.4962
Echinococcus multilocularis survival motor neuron protein 1 0.0156 0.4404 0.4381
Brugia malayi Cathepsin L-like cysteine proteinase 0.0225 0.6579 0.6579
Brugia malayi Papain family cysteine protease containing protein 0.0175 0.4983 0.4983
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Echinococcus granulosus caspase 8 0.008 0.2012 0.1965
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0066 0.1563 0.1512
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0249 0.7338 0.7322
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0062 0.1415 0.1415
Onchocerca volvulus 0.0334 1 1
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0019 0.0059 0.0059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0667 0.0611
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Schistosoma mansoni hypothetical protein 0.0032 0.048 0.0423
Echinococcus granulosus neuropeptides capa receptor 0.0038 0.0667 0.0611
Trypanosoma cruzi cysteine peptidase, putative 0.0175 0.4983 0.4983
Brugia malayi Dopamine receptor 0.0038 0.0667 0.0667
Echinococcus multilocularis serotonin receptor 0.0038 0.0667 0.0628
Plasmodium falciparum serine repeat antigen 9 0.0066 0.1563 0.1563
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0066 0.1563 0.1563
Echinococcus granulosus cathepsin L 0.0066 0.1563 0.1512
Brugia malayi hypothetical protein 0.0038 0.0667 0.0667
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0038 0.0667 0.0667
Brugia malayi cathepsin L-like cysteine proteinase 0.0066 0.1563 0.1563
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0954 0.0954
Loa Loa (eye worm) hypothetical protein 0.0099 0.261 0.261
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0038 0.0667 0.0611
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0038 0.0667 0.0667
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0777 0.0777
Loa Loa (eye worm) fibroinase 0.0334 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0954 0.0954
Giardia lamblia Cathepsin B precursor 0.0066 0.1563 0.457
Schistosoma mansoni voltage-gated potassium channel 0.0067 0.1583 0.1533
Loa Loa (eye worm) hypothetical protein 0.0225 0.6579 0.6579
Plasmodium vivax hypothetical protein, conserved 0.008 0.2012 0.2012
Loa Loa (eye worm) hypothetical protein 0.0066 0.1563 0.1563
Brugia malayi fibroinase precursor 0.0066 0.1563 0.1563
Trypanosoma cruzi cysteine proteinase, putative 0.0175 0.4983 0.4983
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0066 0.1563 0.1512
Echinococcus multilocularis neuropeptide receptor A26 0.0038 0.0667 0.0628
Onchocerca volvulus 0.0334 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0667 0.0628
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0123 0.3349 0.3309
Toxoplasma gondii preprocathepsin c precursor, putative 0.0066 0.1563 0.1563
Loa Loa (eye worm) melatonin receptor type 1A 0.0038 0.0667 0.0667
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.002 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0047 0.0954 0.0954
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0038 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0108 0.2895 0.2895
Brugia malayi follicle stimulating hormone receptor 0.0038 0.0667 0.0667
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.002 0.0091 0.0091
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0038 0.0667 0.0628
Loa Loa (eye worm) hypothetical protein 0.0334 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.1563 0.1563
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0667 0.0611
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0027 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0249 0.7338 0.7338
Loa Loa (eye worm) hypothetical protein 0.0108 0.2895 0.2895
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0066 0.1563 0.1563
Trypanosoma cruzi metacaspase, putative 0.008 0.2012 0.2012
Trypanosoma cruzi cysteine peptidase, putative 0.0334 1 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0105 0.2778 1
Brugia malayi Cathepsin L-like precursor 0.0334 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0175 0.4983 0.4953
Trypanosoma cruzi cruzipain precursor, putative 0.0108 0.2895 0.2895
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0047 0.0954 0.0498
Schistosoma mansoni biogenic amine (5HT) receptor 0.0038 0.0667 0.0611
Loa Loa (eye worm) cathepsin B 0.0123 0.3349 0.3349
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0038 0.0667 0.0628
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.008 0.2012 0.1965
Onchocerca volvulus 0.0038 0.0667 0.0196
Echinococcus granulosus caspase 2 0.0134 0.3701 0.3663
Schistosoma mansoni RAR-like nuclear receptor 0.0099 0.261 0.2566
Trypanosoma cruzi metacaspase, putative 0.008 0.2012 0.2012
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0026 0.0279 0.0221
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.002 0.0106 0.0106
Plasmodium falciparum serine repeat antigen 1 0.0066 0.1563 0.1563
Echinococcus granulosus allatostatin A receptor 0.0038 0.0667 0.0611
Toxoplasma gondii cathepsin CPC1 0.0066 0.1563 0.1563
Giardia lamblia Cysteine protease 0.0066 0.1563 0.457
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0066 0.1563 0.1512
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0667 0.0611
Entamoeba histolytica cysteine protease, putative 0.0175 0.4983 0.4953
Entamoeba histolytica hypothetical protein 0.0022 0.0154 0.0096
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0334 1 1
Schistosoma mansoni hypothetical protein 0.0042 0.0786 0.0731
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0066 0.1563 0.1512
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0026 0.0279 0.0239
Schistosoma mansoni hypothetical protein 0.0022 0.0154 0.0096
Schistosoma mansoni opsin-like receptor 0.0038 0.0667 0.0611
Plasmodium vivax vivapain-2 0.0334 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0175 0.4983 0.4953
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0334 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0105 0.2778 1
Onchocerca volvulus 0.0038 0.0667 0.0196
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0019 0.0059 0.0059
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0777 0.0777
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Echinococcus granulosus cysteine protease 0.0175 0.4983 0.4953
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0066 0.1563 0.1512
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0019 0.0059 0.0059
Entamoeba histolytica cysteine protease, putative 0.0175 0.4983 0.4953
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0066 0.1563 0.1563
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Entamoeba histolytica cysteine protease, putative 0.0175 0.4983 0.4953
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0053 0.1131 0.1078
Schistosoma mansoni biogenic amine receptor 0.0038 0.0667 0.0611
Plasmodium vivax unspecified product 0.0108 0.2895 0.2895
Onchocerca volvulus Cathepsin L homolog 0.0066 0.1563 0.1137
Brugia malayi Papain family cysteine protease containing protein 0.0175 0.4983 0.4983
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.1563 0.1512
Echinococcus granulosus tm gpcr rhodopsin 0.0038 0.0667 0.0611
Trypanosoma brucei metacaspase 0.008 0.2012 0.2012
Echinococcus granulosus cathepsin L 0.0175 0.4983 0.4953
Schistosoma mansoni amine GPCR 0.0038 0.0667 0.0611
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0777 0.0722
Entamoeba histolytica cysteine proteinase, putative 0.0334 1 1
Echinococcus multilocularis caspase 3 0.0095 0.2455 0.2423
Toxoplasma gondii thioredoxin reductase 0.0041 0.0777 0.0777
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0667 0.0611
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0019 0.0059 0.0059
Schistosoma mansoni voltage-gated potassium channel 0.0067 0.1583 0.1533
Loa Loa (eye worm) hypothetical protein 0.0047 0.0954 0.0954
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0066 0.1563 0.1563
Schistosoma mansoni amine GPCR 0.0038 0.0667 0.0611
Brugia malayi ORL1-like opioid receptor 0.0038 0.0667 0.0667
Schistosoma mansoni neuropeptide receptor 0.0038 0.0667 0.0611
Entamoeba histolytica cysteine proteinase 1, putative 0.0175 0.4983 0.4953
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 1 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.2895 0.2895
Schistosoma mansoni retinoic acid receptor RXR 0.0099 0.261 0.2566
Leishmania major cathepsin L-like protease 0.0334 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0099 0.261 0.261
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0047 0.0954 0.0916
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0667 0.0628
Schistosoma mansoni cathepsin F (C01 family) 0.0334 1 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.261 0.261
Schistosoma mansoni biogenic amine (5HT) receptor 0.0038 0.0667 0.0611
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0038 0.0667 0.0196
Entamoeba histolytica cysteine proteinase, putative 0.0175 0.4983 0.4953
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0066 0.1563 0.1512
Echinococcus granulosus neuropeptide Y receptor 0.0038 0.0667 0.0611
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0099 0.261 0.261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0099 0.261 0.261
Onchocerca volvulus Neuropeptide F receptor homolog 0.0038 0.0667 0.0196
Echinococcus multilocularis neuropeptide receptor 0.0038 0.0667 0.0628
Onchocerca volvulus Cathepsin L homolog 0.0334 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0066 0.1563 0.1512
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0667 0.0611
Echinococcus granulosus cathepsin L cysteine protease 0.0175 0.4983 0.4953
Echinococcus granulosus g-protein coupled receptor 0.0038 0.0667 0.0611
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0667 0.0628
Echinococcus multilocularis cysteine protease 0.0334 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0175 0.4983 0.4983
Giardia lamblia Cathepsin L precursor 0.0066 0.1563 0.457
Brugia malayi Cathepsin L-like precursor 0.0334 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0175 0.4983 0.4983
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0667 0.0611
Onchocerca volvulus 0.0225 0.6579 0.6407
Loa Loa (eye worm) nuclear hormone receptor 0.0047 0.0954 0.0954
Echinococcus granulosus cathepsin l1 0.0334 1 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.261 0.261
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0082 0.0082
Onchocerca volvulus 0.0038 0.0667 0.0196
Brugia malayi hypothetical protein 0.0038 0.0667 0.0667
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.002 0.0091 0.0091
Brugia malayi hypothetical protein 0.0054 0.1163 0.1163
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0047 0.0954 0.09
Onchocerca volvulus 0.0038 0.0667 0.0196
Loa Loa (eye worm) hypothetical protein 0.0066 0.1563 0.1563
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0038 0.0667 0.0611
Echinococcus multilocularis somatostatin receptor 0.0038 0.0667 0.0628
Echinococcus granulosus cathepsin b 0.0249 0.7338 0.7322
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0038 0.0667 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0066 0.1563 0.1512
Entamoeba histolytica cysteine protease, putative 0.0066 0.1563 0.1512
Loa Loa (eye worm) hypothetical protein 0.0066 0.1563 0.1563
Schistosoma mansoni hypothetical protein 0.0019 0.0082 0.0022
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0038 0.0667 0.0667
Brugia malayi Cell death protein 3 precursor 0.0134 0.3701 0.3701
Schistosoma mansoni hypothetical protein 0.0019 0.0082 0.0022
Schistosoma mansoni caspase-3 (C14 family) 0.0175 0.4992 0.4963
Echinococcus granulosus voltage gated potassium channel 0.002 0.0113 0.0054
Onchocerca volvulus 0.0334 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0053 0.1131 0.1078
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.008 0.2012 0.1965
Echinococcus granulosus tachykinin peptides receptor 99D 0.0038 0.0667 0.0611
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0066 0.1563 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0175 0.4983 0.4953
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0099 0.261 0.261
Echinococcus multilocularis G-protein coupled receptor, putative 0.0038 0.0667 0.0628
Giardia lamblia Cysteine protease 0.0066 0.1563 0.457
Onchocerca volvulus 0.0038 0.0667 0.0196
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.008 0.2012 0.1965
Echinococcus multilocularis g protein coupled receptor 0.0038 0.0667 0.0628
Loa Loa (eye worm) hypothetical protein 0.0042 0.0786 0.0786
Brugia malayi Kelch motif family protein 0.0027 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0225 0.6579 0.6559
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0667 0.0611
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0099 0.261 0.258
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.002 0.0113 0.0072
Leishmania major cathepsin L-like protease 0.0334 1 1
Schistosoma mansoni rotamase 0.002 0.0106 0.0047
Loa Loa (eye worm) hypothetical protein 0.0022 0.0157 0.0157
Brugia malayi cathepsin Z-like cysteine proteinase 0.0066 0.1563 0.1563
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0022 0.0154 0.0096
Schistosoma mansoni myosin xvIII 0.0038 0.0667 0.0611
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0066 0.1563 0.1563
Loa Loa (eye worm) ctsf protein 0.0334 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0066 0.1563 0.1512
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0667 0.0611
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0047 0.0954 0.0916
Schistosoma mansoni integrin beta subunit 0.0103 0.2727 0.2684
Schistosoma mansoni histamine h1 receptor 0.0038 0.0667 0.0611
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0047 0.0954 0.0916
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0175 0.4983 0.4953
Schistosoma mansoni caspase-7 (C14 family) 0.0175 0.4992 0.4963
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0954 0.09
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0334 1 1
Brugia malayi hypothetical protein 0.0038 0.0667 0.0667
Giardia lamblia Cathepsin L precursor 0.0066 0.1563 0.457
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0099 0.261 0.2566
Loa Loa (eye worm) hypothetical protein 0.002 0.0113 0.0113
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0066 0.1563 0.1563
Echinococcus multilocularis cysteine protease 0.0334 1 1
Loa Loa (eye worm) DR-78 0.0047 0.0954 0.0954
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0053 0.1131 0.1131
Brugia malayi neuropeptide F receptor 0.0038 0.0667 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 1 1
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0019 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0099 0.261 0.261
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0175 0.4983 0.4953
Echinococcus granulosus survival motor neuron protein 1 0.0156 0.4404 0.4371
Brugia malayi RE15519p 0.0038 0.0667 0.0667
Schistosoma mansoni steroid hormone receptor ad4bp 0.0099 0.261 0.2566
Loa Loa (eye worm) calpain family protein 1 0.0018 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0038 0.0667 0.0611
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0954 0.09
Onchocerca volvulus Protein ultraspiracle homolog 0.0099 0.261 0.2238
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0099 0.261 0.261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.1563 0.1512
Echinococcus granulosus cathepsin L cysteine proteinase 0.0334 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0047 0.0954 0.0954
Echinococcus granulosus G protein coupled receptor 139 0.0038 0.0667 0.0611
Echinococcus multilocularis g protein coupled receptor 0.0038 0.0667 0.0628
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0099 0.261 0.2566
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0082 0.0022
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0066 0.1563 0.1563
Brugia malayi Nuclear hormone receptor-like 1 0.0099 0.261 0.261
Brugia malayi neuropeptide F receptor 0.0038 0.0667 0.0667
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0062 0.1415 0.1379
Schistosoma mansoni adenoreceptor 0.0038 0.0667 0.0611
Brugia malayi hypothetical protein 0.0047 0.0954 0.0954
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0038 0.0667 0.0667
Plasmodium falciparum serine repeat antigen 6 0.0066 0.1563 0.1563
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.008 0.2012 0.1965
Echinococcus multilocularis cathepsin L 0.0066 0.1563 0.1527
Echinococcus multilocularis neuropeptides capa receptor 0.0038 0.0667 0.0628
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0038 0.0667 0.0667
Onchocerca volvulus Cathepsin L homolog 0.0334 1 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0024 0.0245 0.0186
Loa Loa (eye worm) glutathione reductase 0.0041 0.0777 0.0777
Schistosoma mansoni biogenic amine receptor 0.0038 0.0667 0.0611
Trypanosoma brucei cysteine peptidase C (CPC) 0.0123 0.3349 0.3349
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0123 0.3349 0.3309
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0099 0.261 0.258
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0667 0.0628
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0105 0.2778 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0667 0.0628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0175 0.4983 0.4983
Loa Loa (eye worm) hypothetical protein 0.0134 0.3701 0.3701
Echinococcus granulosus caspase 3 0.0095 0.2455 0.241
Loa Loa (eye worm) hypothetical protein 0.0066 0.1563 0.1563
Brugia malayi Cathepsin L-like precursor 0.0108 0.2895 0.2895
Schistosoma mansoni alpha-1 adrenergic receptor 0.0038 0.0667 0.0611
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0099 0.261 0.2566
Echinococcus granulosus neuropeptide receptor A26 0.0038 0.0667 0.0611
Brugia malayi Serotonin receptor 0.0038 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Echinococcus granulosus GPCR family 2 0.0019 0.0082 0.0022
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0082 0.004
Trichomonas vaginalis rotamase, putative 0.002 0.0106 0.0047
Brugia malayi G-protein coupled receptor 0.0038 0.0667 0.0667
Echinococcus multilocularis allatostatin A receptor 0.0038 0.0667 0.0628
Trypanosoma cruzi major cysteine proteinase, putative 0.0066 0.1563 0.1563
Giardia lamblia Cathepsin L precursor 0.0066 0.1563 0.457
Giardia lamblia Cysteine protease 0.0066 0.1563 0.457
Echinococcus granulosus 7TM GPCR rhodopsin 0.0038 0.0667 0.0611
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0038 0.0667 0.0611
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0026 0.0279 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.1563 0.1512
Brugia malayi hypothetical protein 0.0038 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Trypanosoma cruzi cysteine peptidase, putative 0.0334 1 1
Giardia lamblia Encystation-specific protease 0.0066 0.1563 0.457
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0047 0.0954 0.0498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0099 0.261 0.261
Echinococcus granulosus cathepsin b 0.0249 0.7338 0.7322
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0061 0.1393 0.1393
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0667 0.0611
Loa Loa (eye worm) hypothetical protein 0.0047 0.0954 0.0954
Giardia lamblia Cathepsin B precursor 0.0066 0.1563 0.457
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0334 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0334 1 1
Brugia malayi Thioredoxin reductase 0.0041 0.0777 0.0777
Brugia malayi Papain family cysteine protease containing protein 0.0334 1 1
Plasmodium falciparum serine repeat antigen 3 0.0066 0.1563 0.1563
Schistosoma mansoni cathepsin S (C01 family) 0.0066 0.1563 0.1512
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0066 0.1563 0.1563
Echinococcus granulosus neuropeptide s receptor 0.0038 0.0667 0.0611
Brugia malayi nuclear hormone receptor 0.0099 0.261 0.261
Brugia malayi orphan nuclear receptor NR2E1 0.0047 0.0954 0.0954
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0175 0.4992 0.4963
Schistosoma mansoni hypothetical protein 0.0054 0.1163 0.111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 1 1
Schistosoma mansoni cathepsin B (C01 family) 0.0066 0.1563 0.1512
Schistosoma mansoni cathepsin s 0.0108 0.2895 0.2853
Loa Loa (eye worm) hypothetical protein 0.0099 0.261 0.261
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0066 0.1563 0.457
Onchocerca volvulus 0.0066 0.1563 0.1137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0334 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.002 0.0113 0.0054
Onchocerca volvulus 0.0047 0.0954 0.0498
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0047 0.0954 0.09
Brugia malayi nuclear receptor NHR-88 0.0099 0.261 0.261
Giardia lamblia Cathepsin L precursor 0.0066 0.1563 0.457
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0108 0.2895 0.2895
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0334 1 1
Brugia malayi hypothetical protein 0.0047 0.0954 0.0954
Plasmodium falciparum serine repeat antigen 7 0.0066 0.1563 0.1563
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0175 0.4992 0.4972
Plasmodium falciparum serine repeat antigen 4 0.0066 0.1563 0.1563
Entamoeba histolytica cysteine protease, putative 0.0175 0.4983 0.4953
Schistosoma mansoni thyroid hormone receptor 0.0099 0.261 0.2566
Brugia malayi latrophilin 2 splice variant baaae 0.0042 0.0786 0.0786
Entamoeba histolytica cysteine protease, putative 0.0066 0.1563 0.1512
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0038 0.0667 0.0611
Giardia lamblia Cathepsin L-like protease 0.0066 0.1563 0.457
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0047 0.0954 0.0916
Echinococcus granulosus apoptotic protease activating factor 1 0.0054 0.1163 0.111
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0106 0.0047
Loa Loa (eye worm) hypothetical protein 0.0165 0.469 0.469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0061 0.1393 0.1393
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0066 0.1563 0.1512
Brugia malayi Calcitonin receptor-like protein seb-1 0.0061 0.1393 0.1393
Brugia malayi Steroid receptor seven-up type 2 0.0099 0.261 0.261
Brugia malayi hypothetical protein 0.0038 0.0667 0.0667
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0038 0.0667 0.0611
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0099 0.261 0.2566
Onchocerca volvulus 0.0038 0.0667 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.1563 0.1512
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0047 0.0954 0.0954
Onchocerca volvulus 0.0047 0.0954 0.0498
Entamoeba histolytica cysteine proteinase, putative 0.0334 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0032 0.048 0.048
Trypanosoma cruzi metacaspase, putative 0.008 0.2012 0.2012
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0038 0.0667 0.0628
Loa Loa (eye worm) hypothetical protein 0.0099 0.261 0.261
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0249 0.7338 0.7338
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0066 0.1563 0.1563
Entamoeba histolytica cysteine proteinase, putative 0.0225 0.6579 0.6559
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Leishmania major trypanothione reductase 0.0041 0.0777 0.0777
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0066 0.1563 0.1512
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0066 0.1563 0.1563
Echinococcus multilocularis sex peptide receptor 0.0038 0.0667 0.0628
Plasmodium vivax unspecified product 0.0175 0.4983 0.4983
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.008 0.2012 0.1965
Giardia lamblia Cathepsin B precursor 0.0123 0.3349 1
Onchocerca volvulus 0.0038 0.0667 0.0196
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0038 0.0667 0.0611
Echinococcus granulosus ecdysone induced protein 78C 0.0099 0.261 0.2566
Onchocerca volvulus Cell death protein 3 homolog 0.0134 0.3701 0.3383
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0082
Brugia malayi G protein-coupled receptor 0.0038 0.0667 0.0667
Brugia malayi hypothetical protein 0.0053 0.1131 0.1131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0667 0.0611
Echinococcus multilocularis neuropeptide FF receptor 2 0.0038 0.0667 0.0628
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0066 0.1563 0.1563
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0667 0.0611
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0099 0.261 0.2566
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0066 0.1563 0.457
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 1 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0066 0.1563 0.1512
Onchocerca volvulus 0.0099 0.261 0.2238
Loa Loa (eye worm) hypothetical protein 0.0225 0.6579 0.6579
Leishmania major cathepsin L-like protease 0.0334 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0038 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0184 0.5269 0.5269
Echinococcus granulosus integrin beta 2 0.013 0.3567 0.3528
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Leishmania major cathepsin L-like protease 0.0334 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0175 0.4983 0.4983
Brugia malayi Cathepsin L-like precursor 0.0225 0.6579 0.6579
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0667 0.0611
Giardia lamblia Cathepsin L precursor 0.0066 0.1563 0.457
Entamoeba histolytica cysteine protease, putative 0.0175 0.4983 0.4953
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0099 0.261 0.2566
Plasmodium falciparum serine repeat antigen 2 0.0066 0.1563 0.1563
Schistosoma mansoni nuclear receptor nhr-48 0.0047 0.0954 0.09
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0066 0.1563 0.1512
Plasmodium falciparum thioredoxin reductase 0.0041 0.0777 0.0777
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 1 1
Brugia malayi ecdysone receptor 0.0047 0.0954 0.0954
Plasmodium vivax metacaspase 1, putative 0.008 0.2012 0.2012
Schistosoma mansoni neuropeptide F-like receptor 0.0038 0.0667 0.0611
Echinococcus granulosus g protein coupled receptor 0.0038 0.0667 0.0611
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0334 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0038 0.0667 0.0611
Brugia malayi G-protein coupled receptor 0.0038 0.0667 0.0667
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0667 0.0628
Entamoeba histolytica cysteine protease, putative 0.0066 0.1563 0.1512
Entamoeba histolytica hypothetical protein 0.0022 0.0154 0.0096
Brugia malayi GnHR receptor homolog 0.0038 0.0667 0.0667
Schistosoma mansoni cathepsin F (C01 family) 0.0225 0.6579 0.6559
Loa Loa (eye worm) hypothetical protein 0.0047 0.0954 0.0954
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0099 0.261 0.261
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0038 0.0667 0.0611
Loa Loa (eye worm) G-protein coupled receptor 0.0038 0.0667 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Schistosoma mansoni neuropeptide receptor 0.0038 0.0667 0.0611
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0249 0.7338 0.7322
Trichomonas vaginalis conserved hypothetical protein 0.008 0.2012 0.1965
Echinococcus granulosus 7tm_1 domain containing protein 0.0038 0.0667 0.0611
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0066 0.1563 0.1563
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0066 0.1563 0.1512
Echinococcus multilocularis caspase 0.0175 0.4992 0.4972
Brugia malayi Cathepsin L-like precursor 0.0334 1 1
Echinococcus multilocularis cathepsin b 0.0249 0.7338 0.7326
Echinococcus granulosus tm gpcr rhodopsin 0.0038 0.0667 0.0611
Schistosoma mansoni biogenic amine receptor 0.0038 0.0667 0.0611
Mycobacterium tuberculosis Probable reductase 0.0094 0.2446 0.8342
Brugia malayi hypothetical protein 0.0038 0.0667 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0225 0.6579 0.6559
Echinococcus granulosus serotonin receptor 0.0038 0.0667 0.0611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 1 1
Plasmodium vivax vivapain-3 0.0175 0.4983 0.4983
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0334 1 1
Trypanosoma cruzi cysteine protease, putative 0.0175 0.4983 0.4983
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0094 0.2446 0.8342
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.008 0.2012 0.2012
Schistosoma mansoni survival motor neuron protein 0.0032 0.048 0.0423
Loa Loa (eye worm) hypothetical protein 0.0047 0.0954 0.0954
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0066 0.1563 0.1563
Echinococcus granulosus g protein coupled receptor 0.0038 0.0667 0.0611
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0038 0.0667 0.0628
Schistosoma mansoni hypothetical protein 0.0038 0.0667 0.0611
Echinococcus multilocularis ecdysone induced protein 78C 0.0099 0.261 0.258
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0038 0.0667 0.0611
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Brugia malayi Nuclear hormone receptor E75 0.0047 0.0954 0.0954
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0334 1 1
Echinococcus granulosus sex peptide receptor 0.0038 0.0667 0.0611
Schistosoma mansoni opsin-like receptor 0.0038 0.0667 0.0611
Echinococcus multilocularis fmrfamide receptor 0.0038 0.0667 0.0628
Schistosoma mansoni hypothetical protein 0.0038 0.0667 0.0611
Onchocerca volvulus 0.0054 0.1163 0.0717
Leishmania major cathepsin L-like protease 0.0334 1 1
Onchocerca volvulus 0.0038 0.0667 0.0196
Loa Loa (eye worm) hypothetical protein 0.0053 0.1131 0.1131
Loa Loa (eye worm) hypothetical protein 0.0047 0.0954 0.0954
Brugia malayi cathepsin L precursor 0.0066 0.1563 0.1563
Echinococcus granulosus somatostatin receptor 0.0038 0.0667 0.0611
Brugia malayi Dopamine receptor protein 2 0.0038 0.0667 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 1 1
Toxoplasma gondii cathepsin CPL 0.0334 1 1
Plasmodium vivax vivapain-1 0.0175 0.4983 0.4983
Schistosoma mansoni neuropeptide F-like receptor 0.0038 0.0667 0.0611
Entamoeba histolytica cysteine protease, putative 0.0175 0.4983 0.4953
Loa Loa (eye worm) hypothetical protein 0.0047 0.0954 0.0954
Giardia lamblia Cathepsin L-like protease 0.0066 0.1563 0.457
Loa Loa (eye worm) hypothetical protein 0.0061 0.1393 0.1393
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0108 0.2895 0.2895
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.1131 0.1131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Entamoeba histolytica cysteine protease, putative 0.0066 0.1563 0.1512
Echinococcus granulosus Nuclear hormone receptor HR96 0.0047 0.0954 0.09
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0165 0.469 0.4422
Trypanosoma cruzi cysteine peptidase, putative 0.0108 0.2895 0.2895
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0667 0.0611
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0334 1 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0123 0.3349 0.3349
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0667 0.0611
Loa Loa (eye worm) calpain family protein 1 0.0024 0.0245 0.0245
Onchocerca volvulus 0.0334 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0334 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.1131 0.1131
Loa Loa (eye worm) integrin beta-2 0.0175 0.4998 0.4998
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0066 0.1563 0.457
Giardia lamblia Cathepsin B precursor 0.0066 0.1563 0.457
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0038 0.0667 0.0628
Schistosoma mansoni hypothetical protein 0.0038 0.0667 0.0611
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0099 0.261 0.261
Echinococcus multilocularis cathepsin L cysteine protease 0.0334 1 1
Brugia malayi N-terminal motif family protein 0.0165 0.469 0.469
Echinococcus multilocularis neuropeptide s receptor 0.0038 0.0667 0.0628
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0091 0.0032
Giardia lamblia Hypothetical protein 0.0066 0.1563 0.457
Loa Loa (eye worm) hypothetical protein 0.0047 0.0954 0.0954
Plasmodium falciparum cysteine proteinase falcipain 1 0.0175 0.4983 0.4983
Loa Loa (eye worm) hypothetical protein 0.0053 0.1131 0.1131
Giardia lamblia Cathepsin B precursor 0.0066 0.1563 0.457
Giardia lamblia Cathepsin B precursor 0.0123 0.3349 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0099 0.261 0.258
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0053 0.1131 0.1094
Leishmania major cathepsin L-like protease 0.0334 1 1
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0113 0.0054
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0667
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0038 0.0667 0.0628
Schistosoma mansoni cathepsin F (C01 family) 0.0334 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0123 0.3349 0.3349
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0066 0.1563 0.1512
Trichomonas vaginalis conserved hypothetical protein 0.008 0.2012 0.1965
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0066 0.1563 0.1563
Echinococcus granulosus thyroid hormone receptor alpha 0.0047 0.0954 0.09
Echinococcus multilocularis FTZ F1 alpha 0.0099 0.261 0.258
Trypanosoma brucei Metacaspase-4 0.008 0.2012 0.2012
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.008 0.2012 0.2012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0099 0.261 0.258
Echinococcus multilocularis cathepsin L cysteine protease 0.0334 1 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0249 0.7338 0.7322

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 11 % Growth inhibition of human A549 cells at 10 uM after 48 hrs by SRB assay ChEMBL. 22818042

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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