Detailed information for compound 1660584

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 341.161 | Formula: C12H13BrN4O3
  • H donors: 4 H acceptors: 5 LogP: -0.97 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ncc(c2c1ncn2[C@@H]1C=C([C@H]([C@H]1O)O)CO)Br
  • InChi: 1S/C12H13BrN4O3/c13-6-2-15-12(14)8-9(6)17(4-16-8)7-1-5(3-18)10(19)11(7)20/h1-2,4,7,10-11,18-20H,3H2,(H2,14,15)/t7-,10-,11+/m1/s1
  • InChiKey: PDMBCGAGDFHPGP-ONOSFVFSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosylhomocysteinase-like 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni adenosylhomocysteinase Get druggable targets OG5_130931 All targets in OG5_130931
Schistosoma mansoni adenosylhomocysteinase Get druggable targets OG5_130931 All targets in OG5_130931
Schistosoma japonicum Putative adenosylhomocysteinase 3, putative Get druggable targets OG5_130931 All targets in OG5_130931
Schistosoma mansoni adenosylhomocysteinase Get druggable targets OG5_130931 All targets in OG5_130931
Schistosoma japonicum IPR000043,S-adenosyl-L-homocysteine hydrolase,domain-containing Get druggable targets OG5_130931 All targets in OG5_130931
Schistosoma japonicum ko:K01251 adenosylhomocysteinase [EC3.3.1.1], putative Get druggable targets OG5_130931 All targets in OG5_130931
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) adenosylhomocysteinase-like 1 483 aa 480 aa 43.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ran 0.0021 0.0275 0.0269
Toxoplasma gondii adenosylhomocysteinase, putative 0.0097 0.1983 0.1964
Schistosoma mansoni hypothetical protein 0.045 1 1
Schistosoma mansoni bromodomain containing 0.001 0.0024 0.0018
Brugia malayi Bromodomain containing protein 0.0063 0.1211 0.1211
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0729 0.0723
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Schistosoma mansoni adenosylhomocysteinase 0.0195 0.4222 0.4218
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0021
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Schistosoma mansoni bromodomain containing protein 0.0012 0.0063 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Echinococcus multilocularis SWI:SNF matrix associated 0.045 1 1
Echinococcus multilocularis SWI:SNF matrix associated 0.045 1 1
Brugia malayi Flap endonuclease-1 0.0026 0.0388 0.0388
Loa Loa (eye worm) adenosylhomocysteinase 0.0097 0.1983 0.1981
Leishmania major hypothetical protein, conserved 0.0063 0.123 0.3551
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.016 0.3422 0.342
Echinococcus granulosus Zinc finger RanBP2 type 0.016 0.3422 0.342
Leishmania major hypothetical protein, conserved 0.016 0.3422 1
Echinococcus granulosus protein kinase C binding protein 1 0.001 0.0024 0.0021
Entamoeba histolytica bromodomain-containing protein 0.0032 0.0506 0.2527
Chlamydia trachomatis DNA topoisomerase I 0.045 1 0.5
Brugia malayi RNA binding protein 0.0051 0.0939 0.0939
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.001 0.0006 0.0006
Brugia malayi polybromodomain protein 0.001 0.0024 0.0024
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0049 0.0891 0.0889
Trypanosoma brucei hypothetical protein, conserved 0.0063 0.123 0.3551
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0012 0.0063 0.006
Trichomonas vaginalis bromodomain containing protein, putative 0.0032 0.0506 0.05
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.006
Entamoeba histolytica hypothetical protein 0.001 0.0024 0.0089
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Plasmodium falciparum adenosylhomocysteinase 0.0097 0.1983 0.1964
Echinococcus granulosus bromodomain containing protein 8 0.001 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0021
Echinococcus multilocularis zinc finger protein Ran binding 0.016 0.3422 0.342
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.016 0.3422 1
Onchocerca volvulus Bromodomain adjacent to zinc finger domain protein 1A homolog 0.001 0.0024 0.0018
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0168 0.0425
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.001 0.0024 0.0021
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0388 0.1074
Onchocerca volvulus 0.016 0.3422 0.3418
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.001 0.0006 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Giardia lamblia Histone acetyltransferase GCN5 0.0073 0.1436 1
Trichomonas vaginalis D-aminoacylase, putative 0.0063 0.123 0.1225
Echinococcus granulosus thyrotropin releasing hormone receptor 0.024 0.5226 0.5225
Schistosoma mansoni TRABID protein (C64 family) 0.016 0.3422 0.3418
Echinococcus granulosus Bromodomain containing protein 0.001 0.0024 0.0021
Brugia malayi MH2 domain containing protein 0.0447 0.9941 0.9941
Loa Loa (eye worm) MH2 domain-containing protein 0.0447 0.9941 0.9941
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0275 0.0272
Echinococcus multilocularis tar DNA binding protein 0.0051 0.0939 0.0936
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0006 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Echinococcus granulosus Bromodomain containing protein 0.001 0.0024 0.0021
Entamoeba histolytica bromodomain-containing protein 0.001 0.0024 0.0089
Schistosoma mansoni Smad4 0.0014 0.0099 0.0093
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0049 0.0891 0.0889
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0729 0.0723
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Brugia malayi Bromodomain containing protein 0.001 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0063 0.1211 0.1209
Echinococcus granulosus smad 0.003 0.0481 0.0478
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0083 0.167 0.1651
Trichomonas vaginalis bromodomain containing protein, putative 0.0041 0.0729 0.0723
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0406 0.8995 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Trichomonas vaginalis hypothetical protein 0.001 0.0024 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Trypanosoma cruzi WLM domain containing protein, putative 0.016 0.3422 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Leishmania major hypothetical protein, conserved 0.016 0.3422 1
Schistosoma mansoni flap endonuclease-1 0.0024 0.0331 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0097 0.1983 0.1978
Onchocerca volvulus 0.0063 0.123 0.1225
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.016 0.3422 1
Trichomonas vaginalis D-aminoacylase, putative 0.0063 0.123 0.1225
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0003
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0168 0.0162
Echinococcus granulosus histone acetyltransferase KAT2B 0.0083 0.167 0.1668
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Schistosoma mansoni smad1 5 8 and 0.003 0.0481 0.0475
Entamoeba histolytica hypothetical protein 0.0065 0.127 0.6393
Schistosoma mansoni CREB-binding protein 2 0.001 0.0024 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Schistosoma mansoni smad1 5 8 and 0.003 0.0481 0.0475
Echinococcus granulosus TGF beta signal transducer SmadC 0.003 0.0481 0.0478
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0063 0.123 0.1225
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0006 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0222 0.4834 0.4831
Trichomonas vaginalis bromodomain-containing protein 3, brd3, putative 0.001 0.0024 0.0018
Trichomonas vaginalis ran, putative 0.0021 0.0275 0.0269
Loa Loa (eye worm) hypothetical protein 0.0063 0.123 0.1228
Brugia malayi Bromodomain containing protein 0.0012 0.0063 0.0063
Echinococcus multilocularis CREB binding protein 0.001 0.0024 0.0021
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0063 0.1211 0.1206
Onchocerca volvulus Brd8 homolog 0.001 0.0024 0.0018
Brugia malayi CXXC zinc finger family protein 0.003 0.0479 0.0479
Leishmania major hypothetical protein, conserved 0.016 0.3422 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Echinococcus multilocularis tumor protein p63 0.0397 0.8795 0.8795
Schistosoma mansoni aldehyde dehydrogenase 0.0049 0.0891 0.0886
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0011 0.0045 0.0039
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0168 0.0425
Trichomonas vaginalis conserved hypothetical protein 0.045 1 1
Loa Loa (eye worm) G protein alpha subunit 3 0.001 0.0006 0.0003
Loa Loa (eye worm) bromodomain containing protein 0.001 0.0024 0.0021
Echinococcus granulosus beta LACTamase domain containing family member 0.0063 0.123 0.1228
Entamoeba histolytica adenosylhomocysteinase, putative 0.0097 0.1983 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0222 0.4834 0.4832
Brugia malayi Bromodomain containing protein 0.0063 0.1211 0.1211
Echinococcus multilocularis Bromodomain containing protein 0.0032 0.0506 0.0503
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.045 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0049 0.0891 0.0819
Loa Loa (eye worm) beta-lactamase 0.0063 0.123 0.1228
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Echinococcus granulosus bromodomain containing 2 0.0063 0.1211 0.1209
Entamoeba histolytica hypothetical protein 0.0024 0.0324 0.1609
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0003
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0006 0.0006
Brugia malayi SWIB/MDM2 domain containing protein 0.045 1 1
Brugia malayi TAZ zinc finger family protein 0.001 0.0024 0.0024
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.024 0.5226 0.5225
Schistosoma mansoni phd finger protein 0.001 0.0024 0.0018
Trichomonas vaginalis bromodomain containing protein, putative 0.001 0.0024 0.0018
Plasmodium falciparum importin beta, putative 0.0029 0.0449 0.0426
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0063 0.123 0.1203
Schistosoma mansoni hypothetical protein 0.001 0.0024 0.0018
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0097 0.1983 0.5766
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Brugia malayi beta-lactamase family protein 0.0063 0.123 0.123
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Onchocerca volvulus 0.001 0.0024 0.0018
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0324 0.0884
Entamoeba histolytica bromodomain-containing protein 0.001 0.0024 0.0089
Brugia malayi mothers against decapentaplegic homolog 3 0.0014 0.0099 0.0099
Mycobacterium ulcerans aldehyde dehydrogenase 0.0049 0.0891 0.3985
Mycobacterium tuberculosis Probable lipase LipD 0.0063 0.123 0.1203
Trichomonas vaginalis bromodomain containing protein, putative 0.001 0.0024 0.0018
Entamoeba histolytica bromodomain-containing protein 0.001 0.0024 0.0089
Loa Loa (eye worm) BRM protein 0.001 0.0024 0.0021
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Mycobacterium ulcerans hypothetical protein 0.0063 0.123 0.5853
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0275 0.0272
Schistosoma mansoni hypothetical protein 0.001 0.0024 0.0018
Schistosoma mansoni cpg binding protein 0.0032 0.0518 0.0512
Loa Loa (eye worm) hypothetical protein 0.0173 0.3717 0.3716
Echinococcus multilocularis adenosylhomocysteinase 0.0097 0.1983 0.1981
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0388 0.2583
Echinococcus multilocularis smad 0.003 0.0481 0.0478
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0097 0.1983 0.2056
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0083 0.167 0.1651
Echinococcus multilocularis bromodomain containing 2 0.0063 0.1211 0.1209
Trichomonas vaginalis bromodomain-containing protein, putative 0.0063 0.1211 0.1206
Onchocerca volvulus 0.045 1 1
Schistosoma mansoni adenosylhomocysteinase 0.0195 0.4222 0.4218
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.045 1 1
Echinococcus granulosus CREB binding protein 0.001 0.0024 0.0021
Onchocerca volvulus 0.001 0.0024 0.0018
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.016 0.3422 0.3406
Toxoplasma gondii ABC1 family protein 0.0063 0.123 0.1209
Onchocerca volvulus 0.0063 0.123 0.1225
Brugia malayi bromodomain containing protein 0.001 0.0024 0.0024
Loa Loa (eye worm) MH1 domain-containing protein 0.003 0.0481 0.0478
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0324 0.0318
Schistosoma mansoni hypothetical protein 0.031 0.6829 0.6827
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0168 0.0165
Trichomonas vaginalis penicillin-binding protein, putative 0.0063 0.123 0.1225
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0012 0.0063 0.006
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0021
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Schistosoma mansoni ap endonuclease 0.0017 0.0168 0.0162
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0388 0.1074
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0032 0.0506 0.05
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0006 0.0003
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0006 0.0006
Leishmania major S-adenosylhomocysteine hydrolase 0.0097 0.1983 0.5766
Onchocerca volvulus 0.0032 0.0506 0.05
Loa Loa (eye worm) hypothetical protein 0.016 0.3422 0.342
Trichomonas vaginalis hypothetical protein 0.001 0.0024 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0939 0.0933
Brugia malayi MH1 domain containing protein 0.0017 0.0172 0.0172
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Schistosoma mansoni transcription initiation factor tfiid 0.001 0.0024 0.0018
Echinococcus multilocularis global transcription activator snf2l2 0.001 0.0024 0.0021
Brugia malayi Bromodomain containing protein 0.001 0.0024 0.0024
Schistosoma mansoni polybromo-1 0.001 0.0024 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0021
Echinococcus granulosus mothers against decapentaplegic 2 0.0014 0.0099 0.0096
Loa Loa (eye worm) TAR-binding protein 0.0051 0.0939 0.0936
Brugia malayi hypothetical protein 0.0021 0.0272 0.0272
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.045 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.001 0.0024 0.0018
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0324 0.0318
Brugia malayi RNA recognition motif domain containing protein 0.0051 0.0939 0.0939
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0168 0.0425
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0083 0.167 0.1651
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.123 0.3551
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Brugia malayi hypothetical protein 0.0065 0.127 0.127
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.016 0.3422 0.3418
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0222 0.4834 0.4832
Mycobacterium ulcerans aldehyde dehydrogenase 0.0049 0.0891 0.3985
Loa Loa (eye worm) transcription factor SMAD2 0.0447 0.9941 0.9941
Echinococcus multilocularis muscleblind protein 0.0173 0.3717 0.3716
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0275 0.0739
Echinococcus granulosus zinc finger protein 0.0012 0.0063 0.006
Echinococcus granulosus adenosylhomocysteinase 0.0097 0.1983 0.1981
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.001 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0021
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0058 0.1108 0.1105
Entamoeba histolytica hypothetical protein 0.0065 0.127 0.6393
Brugia malayi beta-lactamase 0.0063 0.123 0.123
Brugia malayi ATPase, AAA family protein 0.001 0.0024 0.0024
Brugia malayi YY1-associated factor 2 0.016 0.3422 0.3422
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0275 0.0252
Mycobacterium ulcerans aldehyde dehydrogenase 0.0049 0.0891 0.3985
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0273 0.5983 0.5982
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0097 0.1983 0.1978
Brugia malayi MH2 domain containing protein 0.003 0.0481 0.0481
Toxoplasma gondii exonuclease III APE 0.0017 0.0168 0.0145
Echinococcus multilocularis SWI:SNF matrix associated 0.045 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0172 0.0169
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.001 0.0006 0.0003
Brugia malayi hypothetical protein 0.001 0.0006 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0222 0.4834 0.4831
Echinococcus granulosus geminin 0.0324 0.7146 0.7145
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0063 0.123 0.1203
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0051 0.0939 0.0936
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.0168 0.5
Brugia malayi Adenosylhomocysteinase 0.0097 0.1983 0.1983
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0063 0.123 0.1228
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0388 0.0386
Echinococcus granulosus Nuclear pore complex protein Nup153 0.016 0.3422 0.342
Onchocerca volvulus 0.016 0.3422 0.3418
Leishmania major importin beta-1 subunit, putative 0.0024 0.0324 0.0884
Schistosoma mansoni transcription factor LCR-F1 0.0065 0.127 0.1264
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Mycobacterium ulcerans lipase LipD 0.0063 0.123 0.5853
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0168 0.0162
Mycobacterium ulcerans esterase/lipase LipP 0.0063 0.123 0.5853
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.016 0.3422 0.3406
Schistosoma mansoni zinc finger protein 0.0012 0.0063 0.0057
Trichomonas vaginalis bromodomain containing protein, putative 0.001 0.0024 0.0018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.1252 0.1246
Mycobacterium tuberculosis Probable lipase LipE 0.0063 0.123 0.1203
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0021
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.133 0.1309
Loa Loa (eye worm) CBP-B 0.001 0.0024 0.0021
Brugia malayi MH1 domain containing protein 0.003 0.0481 0.0481
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.016 0.3422 0.3422
Loa Loa (eye worm) brahma associated protein 0.045 1 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0073 0.1436 0.7235
Echinococcus granulosus Smad4 0.003 0.0481 0.0478
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0449 0.0446
Entamoeba histolytica bromodomain-containing protein 0.0032 0.0506 0.2527
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.001 0.0006 0.0003
Schistosoma mansoni ap endonuclease 0.0017 0.0168 0.0162
Schistosoma mansoni fusion 0.016 0.3422 0.3418
Mycobacterium tuberculosis Probable esterase LipL 0.0063 0.123 0.1203
Schistosoma mansoni bromodomain containing protein 0.0012 0.0063 0.0057
Toxoplasma gondii bromodomain-containing protein 0.0032 0.0506 0.0483
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0729 0.0723
Onchocerca volvulus 0.016 0.3422 0.3418
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0388 0.0383
Echinococcus granulosus zinc finger protein Ran binding 0.016 0.3422 0.342
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Echinococcus multilocularis bromodomain containing protein 8 0.001 0.0024 0.0021
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0388 0.1074
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0032 0.0506 0.05
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0063 0.123 0.123
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Brugia malayi Muscleblind-like protein 0.0173 0.3717 0.3717
Entamoeba histolytica Ran family GTPase 0.0021 0.0275 0.1359
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0014 0.0099 0.0093
Echinococcus multilocularis zinc finger protein 0.0012 0.0063 0.006
Brugia malayi polybromodomain protein 0.001 0.0024 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.016 0.3422 1
Schistosoma mansoni bromodomain containing protein 0.001 0.0024 0.0018
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Schistosoma mansoni RNA binding protein 0.016 0.3422 0.3418
Trypanosoma cruzi hypothetical protein, conserved 0.016 0.3422 1
Mycobacterium ulcerans beta-lactamase 0.0063 0.123 0.5853
Loa Loa (eye worm) hypothetical protein 0.016 0.3422 0.342
Loa Loa (eye worm) MH2 domain-containing protein 0.0014 0.0099 0.0096
Trichomonas vaginalis bromodomain containing protein, putative 0.001 0.0024 0.0018
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0083 0.167 0.1665
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.006
Echinococcus multilocularis mothers against decapentaplegic 5 0.003 0.0481 0.0478
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0097 0.1983 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.016 0.3422 0.3422
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Plasmodium vivax importin-beta 2, putative 0.0029 0.0449 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Schistosoma mansoni cpg binding protein 0.0032 0.0518 0.0512
Brugia malayi MH1 domain containing protein 0.003 0.0481 0.0481
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0222 0.4834 0.4832
Loa Loa (eye worm) hypothetical protein 0.016 0.3422 0.342
Schistosoma mansoni aldehyde dehydrogenase 0.0049 0.0891 0.0886
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0097 0.1983 0.5766
Schistosoma mansoni adenosylhomocysteinase 0.0097 0.1983 0.1978
Echinococcus multilocularis muscleblind protein 1 0.0173 0.3717 0.3716
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0063 0.123 0.5853
Entamoeba histolytica bromodomain-containing protein 0.0032 0.0506 0.2527
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Schistosoma mansoni hypothetical protein 0.045 1 1
Onchocerca volvulus 0.003 0.0479 0.0473
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0006 0.0003
Leishmania major hypothetical protein, conserved 0.016 0.3422 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Echinococcus multilocularis Smad4 0.003 0.0481 0.0478
Chlamydia trachomatis SWIB complex protein 0.045 1 0.5
Brugia malayi Bromodomain containing protein 0.001 0.0024 0.0024
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.001 0.0006 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Echinococcus granulosus SWI:SNF matrix associated 0.045 1 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.016 0.3422 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Schistosoma mansoni TGF-beta signal transducer Smad2 0.003 0.0481 0.0475
Echinococcus multilocularis mothers against decapentaplegic 2 0.0014 0.0099 0.0096
Plasmodium falciparum histone acetyltransferase GCN5 0.0073 0.1436 0.1416
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0388 0.0386
Schistosoma mansoni adenosylhomocysteinase 0.0097 0.1983 0.1978
Trichomonas vaginalis lymphoid specific helicase, putative 0.001 0.0024 0.0018
Echinococcus multilocularis TGF beta signal transducer SmadC 0.003 0.0481 0.0478
Loa Loa (eye worm) hypothetical protein 0.0014 0.0099 0.0096
Echinococcus granulosus mothers against decapentaplegic 5 0.003 0.0481 0.0478
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0049 0.0891 0.2553
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0003
Trypanosoma brucei hypothetical protein, conserved 0.016 0.3422 1
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0388 0.0366
Trichomonas vaginalis esterase, putative 0.0063 0.123 0.1225
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.001 0.0024 0.0018
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0049 0.0902 0.0897
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0275 0.0739
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Loa Loa (eye worm) MH1 domain-containing protein 0.0014 0.0099 0.0096
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0006 0.0003
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0275 0.0252
Schistosoma mansoni hypothetical protein 0.0324 0.7146 0.7144
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Brugia malayi BRM protein 0.001 0.0024 0.0024
Echinococcus multilocularis Bromodomain containing protein 0.001 0.0024 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Echinococcus granulosus Upstream activation factor subunit UAF30 0.045 1 1
Echinococcus multilocularis expressed protein 0.001 0.0006 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0065 0.127 0.1267
Brugia malayi acetyltransferase, GNAT family protein 0.0273 0.5983 0.5983
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Plasmodium vivax hypothetical protein, conserved 0.0063 0.123 0.1209
Loa Loa (eye worm) hypothetical protein 0.0063 0.123 0.1228
Schistosoma mansoni hypothetical protein 0.001 0.0024 0.0018
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.001 0.0006 0.0006
Schistosoma mansoni cpg binding protein 0.003 0.0479 0.0473
Mycobacterium tuberculosis Conserved protein 0.0063 0.123 0.1203
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0168 0.0145
Echinococcus multilocularis cpg binding protein 0.0032 0.0518 0.0516
Loa Loa (eye worm) hypothetical protein 0.0063 0.123 0.1228
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0168 0.0165
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.016 0.3422 0.342
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0063 0.123 0.1225
Leishmania major GTP-binding protein, putative 0.0021 0.0275 0.0739
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0495 0.0489
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.001 0.0006 0.0003
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.045 1 1
Echinococcus granulosus mothers against decapentaplegic 6 0.0014 0.0099 0.0096
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0449 0.0426
Echinococcus granulosus peregrin 0.001 0.0024 0.0021
Schistosoma mansoni zinc finger protein 0.016 0.3422 0.3418
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.045 1 1
Schistosoma mansoni smad1 5 8 and 0.003 0.0481 0.0475
Echinococcus granulosus importin subunit beta 1 0.0029 0.0449 0.0446
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0449 0.1251
Loa Loa (eye worm) nuclear factor I 0.0017 0.0172 0.0169
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0097 0.1983 0.5766
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0275 0.1778
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0324 0.0318
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0449 0.1251
Echinococcus multilocularis protein kinase C binding protein 1 0.001 0.0024 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Loa Loa (eye worm) bromodomain containing protein 0.0032 0.0506 0.0503
Loa Loa (eye worm) hypothetical protein 0.0173 0.3717 0.3716
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Schistosoma mansoni importin beta-1 0.0029 0.0449 0.0443
Trypanosoma cruzi WLM domain containing protein, putative 0.016 0.3422 1
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.016 0.3422 1
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.001 0.0006 0.0006
Echinococcus granulosus polybromo 1 0.001 0.0024 0.0021
Toxoplasma gondii ran binding protein 0.016 0.3422 0.3406
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.6829 0.6828
Onchocerca volvulus 0.016 0.3422 0.3418
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0017 0.0168 0.0819
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Echinococcus multilocularis geminin 0.0324 0.7146 0.7145
Brugia malayi MH2 domain containing protein 0.003 0.0481 0.0481
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.0029 0.0449 0.0446
Brugia malayi Bromodomain containing protein 0.001 0.0024 0.0024
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0065 0.127 0.1267
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Echinococcus multilocularis peregrin 0.001 0.0024 0.0021
Echinococcus granulosus global transcription activator snf2l2 0.001 0.0024 0.0021
Brugia malayi Smad1 0.003 0.0481 0.0481
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0011 0.0045 0.0039
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0275 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Brugia malayi Bromodomain containing protein 0.001 0.0024 0.0024
Mycobacterium tuberculosis Probable hydrolase 0.0063 0.123 0.1203
Brugia malayi beta-lactamase family protein 0.0063 0.123 0.123
Brugia malayi MH2 domain containing protein 0.0014 0.0099 0.0099
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0168 0.0165
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0388 0.0366
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.016 0.3422 1
Echinococcus multilocularis ring and YY1 binding protein 0.016 0.3422 0.342
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.001 0.0006 0.0006
Giardia lamblia Kinase, putative 0.0032 0.0506 0.3413
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0479 0.0476
Loa Loa (eye worm) MH2 domain-containing protein 0.003 0.0481 0.0478
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0275 0.0739
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0729 0.0723
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.001 0.0006 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Echinococcus multilocularis beta LACTamase domain containing family member 0.0063 0.123 0.1228
Loa Loa (eye worm) hypothetical protein 0.0063 0.123 0.1228
Schistosoma mansoni hypothetical protein 0.045 1 1
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0388 0.1934
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0097 0.1983 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Echinococcus multilocularis 0.001 0.0024 0.0021
Loa Loa (eye worm) Smad1 0.003 0.0481 0.0478
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Schistosoma mansoni smad 0.003 0.0481 0.0475
Echinococcus granulosus tar DNA binding protein 0.0051 0.0939 0.0936
Mycobacterium tuberculosis Conserved protein 0.0063 0.123 0.1203
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.001 0.0024 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Brugia malayi RNA, U transporter 1 0.0083 0.1665 0.1665
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.016 0.3422 1
Schistosoma mansoni smad 0.0014 0.0099 0.0093
Schistosoma mansoni Smad4 0.003 0.0481 0.0475
Trichomonas vaginalis bromodomain-containing protein, putative 0.0083 0.167 0.1665
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.001 0.0024 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0939 0.0933
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.001 0.0006 0.0006
Echinococcus granulosus histone acetyltransferase KAT2B 0.0262 0.5727 0.5726
Brugia malayi brahma associated protein 60 kDa 0.045 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0222 0.4834 0.4832
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.001 0.0024 0.0021
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.1108 0.1102
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0.0168 0.5
Loa Loa (eye worm) RNA binding protein 0.0051 0.0939 0.0936
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0222 0.4834 0.4831
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Mycobacterium tuberculosis Conserved protein 0.0063 0.123 0.1203
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0939 0.0933
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0006 0.0003
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.016 0.3422 0.342
Brugia malayi Importin beta-1 subunit 0.0029 0.0449 0.0449
Loa Loa (eye worm) acetyltransferase 0.0273 0.5983 0.5982
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.016 0.3422 1
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0097 0.1983 0.1964
Brugia malayi Bromodomain containing protein 0.001 0.0024 0.0024
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0222 0.4834 0.4834
Schistosoma mansoni adenosylhomocysteinase 0.0195 0.4222 0.4218
Echinococcus multilocularis PH interacting protein 0.001 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0063 0.123 0.1228
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0168 0.0145
Plasmodium vivax SET domain containing protein 0.0011 0.0039 0.0015
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0273 0.5983 0.598
Entamoeba histolytica hypothetical protein 0.0065 0.127 0.6393
Brugia malayi G-protein alpha subunit 0.001 0.0006 0.0006
Echinococcus multilocularis snurportin 1 0.031 0.6829 0.6828
Trichomonas vaginalis bromodomain and PHD finger-containing protein, putative 0.001 0.0024 0.0018
Schistosoma mansoni hypothetical protein 0.0065 0.127 0.1264
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0063 0.123 0.1203
Echinococcus granulosus cpg binding protein 0.0032 0.0518 0.0516
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Entamoeba histolytica ankyrin repeat protein, putative 0.001 0.0024 0.0089
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Echinococcus multilocularis polybromo 1 0.001 0.0024 0.0021
Brugia malayi MH1 domain containing protein 0.0017 0.0172 0.0172
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.045 1 1
Schistosoma mansoni brg-1 associated factor 0.045 1 1
Echinococcus granulosus CREB binding protein 0.001 0.0024 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0222 0.4834 0.4832
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Plasmodium falciparum flap endonuclease 1 0.0026 0.0388 0.0366
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0275 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Onchocerca volvulus 0.0063 0.123 0.1225
Plasmodium vivax hypothetical protein, conserved 0.045 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0063 0.123 0.1225
Echinococcus granulosus ring and YY1 binding protein 0.016 0.3422 0.342
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.016 0.3422 0.3422
Leishmania major hypothetical protein, conserved 0.016 0.3422 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.016 0.3422 1
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0065 0.127 0.6393
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0006 0.0003
Toxoplasma gondii aldehyde dehydrogenase 0.0049 0.0891 0.087
Schistosoma mansoni hypothetical protein 0.0324 0.7146 0.7144
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0168 0.0425
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0506 0.05
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0063 0.123 0.1225
Schistosoma mansoni Smad4 0.0014 0.0099 0.0093
Brugia malayi TAR-binding protein 0.0051 0.0939 0.0939
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.123 0.3551
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0097 0.1983 0.1964
Trypanosoma brucei hypothetical protein, conserved 0.016 0.3422 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Brugia malayi Bromodomain containing protein 0.001 0.0024 0.0024
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.024 0.5226 0.5223
Trichomonas vaginalis bromodomain-containing protein, putative 0.0063 0.1211 0.1206
Loa Loa (eye worm) hypothetical protein 0.0063 0.123 0.1228
Echinococcus granulosus flap endonuclease 1 0.0026 0.0388 0.0386
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0939 0.0933
Echinococcus multilocularis mothers against decapentaplegic 6 0.0014 0.0099 0.0096
Onchocerca volvulus 0.0058 0.1108 0.1102
Schistosoma mansoni hypothetical protein 0.001 0.0024 0.0018
Schistosoma mansoni hypothetical protein 0.016 0.3422 0.3418
Brugia malayi PHD-finger family protein 0.0012 0.0063 0.0063
Echinococcus granulosus muscleblind protein 0.0173 0.3717 0.3716
Schistosoma mansoni helicase 0.001 0.0024 0.0018
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0506 0.05
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0939 0.0933
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.016 0.3422 0.3422
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.045 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0017 0.0168 0.1022
Echinococcus granulosus PH interacting protein 0.001 0.0024 0.0021
Trichomonas vaginalis bromodomain-containing protein, putative 0.001 0.0024 0.0018
Echinococcus granulosus tumor protein p63 0.0397 0.8795 0.8795
Echinococcus granulosus expressed protein 0.001 0.0006 0.0003
Echinococcus multilocularis Zinc finger, RanBP2 type 0.016 0.3422 0.342
Schistosoma mansoni ran 0.0021 0.0275 0.0269
Echinococcus granulosus snurportin 1 0.031 0.6829 0.6828

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) >= 100 uM Cytotoxicity against human HeLa assessed as minimum compound concentration required to cause microscopically detectable alteration of normal cell morphology ChEMBL. 22795626
CC50 (ADMET) = 21.06 uM Cytotoxicity against human HepG2 cells ChEMBL. 26750250
IC50 (binding) = 2.7 nM Inhibition of S-adenosylhomocysteine hydrolase (unknown origin) ChEMBL. 26750250

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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