Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Cannabinoid CB1 receptor | Starlite/ChEMBL | References |
Mus musculus | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | pyruvate dehydrogenase | 0.0034 | 0.2482 | 0.2482 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.6314 | 0.7866 |
Echinococcus granulosus | transketolase | 0.0061 | 0.6314 | 0.6314 |
Entamoeba histolytica | phospholipase D, putative | 0.0086 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8027 | 1 |
Treponema pallidum | transketolase | 0.0038 | 0.316 | 1 |
Trichomonas vaginalis | transketolase, putative | 0.0061 | 0.6314 | 1 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0034 | 0.2482 | 0.1172 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0034 | 0.2482 | 0.1172 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8027 | 1 |
Leishmania major | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0034 | 0.2482 | 0.3932 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0034 | 0.2482 | 0.1172 |
Leishmania major | transketolase | 0.0061 | 0.6314 | 1 |
Toxoplasma gondii | transketolase | 0.0061 | 0.6314 | 1 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0034 | 0.2482 | 0.1172 |
Toxoplasma gondii | pyruvate dehydrogenase E1 component, beta subunit, putative | 0.0034 | 0.2482 | 0.1172 |
Entamoeba histolytica | transketolase, putative | 0.0061 | 0.6314 | 0.5096 |
Echinococcus granulosus | phospholipase D1 | 0.0086 | 1 | 1 |
Mycobacterium tuberculosis | Transketolase Tkt (TK) | 0.0061 | 0.6314 | 1 |
Brugia malayi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor | 0.0034 | 0.2482 | 0.2482 |
Entamoeba histolytica | transketolase, putative | 0.0061 | 0.6314 | 0.5096 |
Schistosoma mansoni | transketolase | 0.0061 | 0.6314 | 0.5096 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0034 | 0.2482 | 0.1172 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.003 | 0.1973 | 0.1973 |
Trypanosoma brucei | pyruvate dehydrogenase E1 beta subunit, putative | 0.0034 | 0.2482 | 0.1172 |
Chlamydia trachomatis | transketolase | 0.0061 | 0.6314 | 1 |
Trypanosoma cruzi | transketolase, putative | 0.0061 | 0.6314 | 1 |
Plasmodium falciparum | transketolase | 0.0038 | 0.316 | 1 |
Echinococcus multilocularis | pyruvate dehydrogenase | 0.0034 | 0.2482 | 0.2482 |
Giardia lamblia | Transketolase | 0.0038 | 0.316 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | transketolase | 0.0061 | 0.6314 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.2482 | 0.3092 |
Mycobacterium leprae | Probable transketolase Tkt (TK) | 0.0061 | 0.6314 | 1 |
Onchocerca volvulus | 0.0022 | 0.0829 | 1 | |
Brugia malayi | pyruvate dehydrogenase E1 component beta subunit, mitochondrial | 0.0034 | 0.2482 | 0.2482 |
Entamoeba histolytica | phospholipase D active site domain-containing protein | 0.0073 | 0.8027 | 0.7375 |
Echinococcus multilocularis | transketolase | 0.0061 | 0.6314 | 0.6314 |
Echinococcus granulosus | transketolase | 0.0061 | 0.6314 | 0.6314 |
Entamoeba histolytica | transketolase, putative | 0.0038 | 0.316 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.5702 | 0.7103 |
Schistosoma mansoni | transketolase | 0.0061 | 0.6314 | 0.5096 |
Brugia malayi | pyruvate dehydrogenase E1 component beta subunit, putative | 0.0034 | 0.2482 | 0.2482 |
Toxoplasma gondii | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0034 | 0.2482 | 0.1172 |
Leishmania major | pyruvate dehydrogenase E1 beta subunit, putative | 0.0034 | 0.2482 | 0.3932 |
Echinococcus multilocularis | phospholipase D1 | 0.0086 | 1 | 1 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0034 | 0.2482 | 0.1172 |
Schistosoma mansoni | phospholipase D | 0.0086 | 1 | 1 |
Plasmodium vivax | transketolase, putative | 0.0038 | 0.316 | 1 |
Echinococcus multilocularis | transketolase | 0.0061 | 0.6314 | 0.6314 |
Loa Loa (eye worm) | 2-oxoisovalerate dehydrogenase subunit beta | 0.0034 | 0.2482 | 0.3092 |
Echinococcus granulosus | phospholipase D | 0.0076 | 0.8562 | 0.8562 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0034 | 0.2482 | 0.1172 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.5702 | 0.7103 |
Entamoeba histolytica | transketolase, putative | 0.0061 | 0.6314 | 0.5096 |
Mycobacterium ulcerans | transketolase | 0.0061 | 0.6314 | 1 |
Echinococcus multilocularis | phospholipase D | 0.0076 | 0.8562 | 0.8562 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PD-HE1Beta | 0.0034 | 0.2482 | 0.1172 |
Brugia malayi | transketolase | 0.0061 | 0.6314 | 0.6314 |
Trypanosoma brucei | transketolase, putative | 0.0061 | 0.6314 | 1 |
Entamoeba histolytica | phospholipase D, putative | 0.0086 | 1 | 1 |
Trypanosoma cruzi | transketolase, putative | 0.0061 | 0.6314 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.2482 | 0.3092 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.8 nM | Binding affinity towards rat forebrain cannabinoid receptor 1 using [3H]CP-55,940 | ChEMBL. | 16190764 |
Ki (binding) | = 2.2 nM | Binding affinity towards mouse spleen cannabinoid receptor 2 using [3H]CP-55,940 | ChEMBL. | 16190764 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.