Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | brg-1 associated factor | 0.0081 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0081 | 1 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0081 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0029 | 0.2659 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0081 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0029 | 0.2659 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0081 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0563 | 0.0563 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.2659 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.2659 | 1 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0029 | 0.2659 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2659 | 0.2659 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0029 | 0.2659 | 0.2221 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0081 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0081 | 1 | 0.5 |
Brugia malayi | YY1-associated factor 2 | 0.0029 | 0.2659 | 0.2221 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.2659 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0081 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 0.0563 | 0.0563 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0081 | 1 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0081 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.2659 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0.0563 | 0.5 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0029 | 0.2659 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0029 | 0.2659 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0029 | 0.2659 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.2659 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.2659 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0029 | 0.2659 | 1 |
Onchocerca volvulus | 0.0081 | 1 | 1 | |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0081 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0081 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0029 | 0.2659 | 0.2221 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0029 | 0.2659 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2659 | 0.2659 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0029 | 0.2659 | 0.2221 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.2659 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.2659 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0029 | 0.2659 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0081 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0081 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0081 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0029 | 0.2659 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0563 | 0.0563 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0081 | 1 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0081 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0029 | 0.2659 | 0.2221 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2659 | 0.2659 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2659 | 0.2659 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2659 | 0.2659 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0081 | 1 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0029 | 0.2659 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 16 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis CIP 103471 | ChEMBL. | 9873650 |
MIC (functional) | > 16 ug ml-1 | Antimycobacterial activity against Mycobacterium avium CIP 103317 | ChEMBL. | 9873650 |
MIC (functional) | > 16 ug ml-1 | Antibacterial activity against Mycobacterium smegmatis CIP 103599. | ChEMBL. | 9873650 |
MIC (functional) | > 16 ug ml-1 | Antimycobacterial activity against Mycobacterium gordonae CIP 6427 | ChEMBL. | 9873650 |
MIC (functional) | > 16 ug ml-1 | Antimycobacterial activity against Mycobacterium marinum CIP 6423 | ChEMBL. | 9873650 |
MIC (functional) | > 16 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis CIP 103471 | ChEMBL. | 9873650 |
MTD50 (functional) | 0 ug ml-1 | Compound was tested for cytotoxicity against VERO cells; Not determined | ChEMBL. | 9873650 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.