Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0616 | 0.0616 |
Schistosoma mansoni | brg-1 associated factor | 0.0068 | 1 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0068 | 1 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0024 | 0.2575 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2575 | 0.2575 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0068 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0068 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0024 | 0.2575 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0024 | 0.2575 | 0.2087 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0068 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0068 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0068 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0024 | 0.2575 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0024 | 0.2575 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0024 | 0.2575 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0024 | 0.2575 | 0.2087 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.2575 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0024 | 0.2575 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0068 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 1 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0068 | 1 | 1 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0024 | 0.2575 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0013 | 0.0616 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0024 | 0.2575 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0068 | 1 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0068 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0068 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2575 | 0.2575 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.0616 | 0.0616 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0024 | 0.2575 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0024 | 0.2575 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0024 | 0.2575 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0024 | 0.2575 | 0.2087 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0024 | 0.2575 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0068 | 1 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0024 | 0.2575 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2575 | 0.2575 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2575 | 0.2575 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0068 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0068 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0068 | 1 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0024 | 0.2575 | 0.2087 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.2575 | 1 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0068 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.2575 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0024 | 0.2575 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0024 | 0.2575 | 0.2087 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2575 | 0.2575 |
Onchocerca volvulus | 0.0068 | 1 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.2575 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0616 | 0.0616 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.2575 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 16 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis CIP 103471 | ChEMBL. | 9873650 |
MIC (functional) | > 16 ug ml-1 | Antimycobacterial activity against Mycobacterium avium CIP 103317 | ChEMBL. | 9873650 |
MIC (functional) | > 16 ug ml-1 | Antibacterial activity against Mycobacterium smegmatis CIP 103599. | ChEMBL. | 9873650 |
MIC (functional) | > 16 ug ml-1 | Antimycobacterial activity against Mycobacterium gordonae CIP 6427 | ChEMBL. | 9873650 |
MIC (functional) | > 16 ug ml-1 | Compound was tested for anti-mycobacterial activity against Mycobacterium marinum CIP 6423. | ChEMBL. | 9873650 |
MIC (functional) | = 16 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis CIP 103471 | ChEMBL. | 9873650 |
MTD50 (functional) | = 1 ug ml-1 | In vitro cytotoxicity against VERO cells. | ChEMBL. | 9873650 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.