TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 437.558 | Formula: C23H27N5O2S
H donors: 1 H acceptors: 4 LogP: 3.06 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N#CC1(CC1)NC(=O)[C@@H]1CCCC[C@H]1C(=O)N1CCN(CC1)c1nc2c(s1)cccc2
InChi: 1S/C23H27N5O2S/c24-15-23(9-10-23)26-20(29)16-5-1-2-6-17(16)21(30)27-11-13-28(14-12-27)22-25-18-7-3-4-8-19(18)31-22/h3-4,7-8,16-17H,1-2,5-6,9-14H2,(H,26,29)/t16-,17-/m1/s1
InChiKey: ZZFJAPGUVYMXSJ-IAGOWNOFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin S	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References
Canis familiaris	Cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Dictyostelium discoideum	cathepsin L-like proteinase	Cathepsin K	330 aa	319 aa	38.6 %
Onchocerca volvulus		Cathepsin K	330 aa	297 aa	32.7 %
Dictyostelium discoideum	hypothetical protein	Cathepsin K	330 aa	350 aa	33.7 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin K	330 aa	359 aa	25.9 %
Plasmodium knowlesi	dipeptidyl aminopeptidase 1, putative	Cathepsin K	330 aa	277 aa	26.0 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin K	330 aa	328 aa	32.0 %
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Cathepsin K	330 aa	280 aa	27.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %
Babesia bovis	cathepsin C precursor, putative	Cathepsin K	330 aa	268 aa	25.7 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin K	330 aa	379 aa	24.5 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin K	330 aa	304 aa	24.7 %
Toxoplasma gondii	cathepsin CPC1	Cathepsin K	330 aa	384 aa	23.4 %
Trypanosoma cruzi	cysteine protease, putative	Cathepsin K	330 aa	311 aa	31.8 %
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Cathepsin K	330 aa	287 aa	29.6 %
Schistosoma japonicum	Disco-interacting protein 2 homolog B, putative	Cathepsin K	330 aa	342 aa	36.0 %
Onchocerca volvulus		Cathepsin K	330 aa	321 aa	42.1 %
Plasmodium yoelii	cysteine proteinase precursor	Cathepsin K	330 aa	345 aa	30.4 %
Echinococcus multilocularis	cathepsin L	Cathepsin K	330 aa	326 aa	32.2 %
Echinococcus granulosus	cathepsin L	Cathepsin K	330 aa	316 aa	32.0 %
Babesia bovis	cysteine protease 2	Cathepsin K	330 aa	343 aa	30.0 %
Plasmodium vivax	unspecified product	Cathepsin K	330 aa	354 aa	28.8 %
Echinococcus multilocularis	cathepsin b	Cathepsin K	330 aa	295 aa	26.1 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin K	330 aa	269 aa	26.4 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin K	330 aa	324 aa	24.7 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium vivax	vivapain-3	Cathepsin K	330 aa	304 aa	36.5 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin K	330 aa	388 aa	24.2 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin K	330 aa	329 aa	35.9 %
Echinococcus granulosus	cathepsin L cysteine protease	Cathepsin K	330 aa	331 aa	46.8 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin K	330 aa	268 aa	28.0 %
Giardia lamblia	Cathepsin L precursor	Cathepsin K	330 aa	291 aa	33.7 %
Schistosoma japonicum	ko:K01365 cathepsin L [EC3.4.22.15], putative	Cathepsin K	330 aa	330 aa	41.5 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin K	330 aa	354 aa	31.6 %
Drosophila melanogaster	CG6347 gene product from transcript CG6347-RA	Cathepsin K	330 aa	343 aa	35.6 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin K	330 aa	363 aa	25.1 %
Plasmodium yoelii	cathepsin c precursor	Cathepsin K	330 aa	292 aa	22.9 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin K	330 aa	268 aa	28.0 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin K	330 aa	268 aa	28.0 %
Theileria parva	cysteine proteinase, putative	Cathepsin K	330 aa	316 aa	29.4 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin K	330 aa	276 aa	26.8 %
Giardia lamblia	Cathepsin L precursor	Cathepsin K	330 aa	270 aa	26.3 %
Onchocerca volvulus		Cathepsin K	330 aa	310 aa	41.9 %
Brugia malayi	Papain family cysteine protease containing protein	Cathepsin K	330 aa	308 aa	32.8 %
Plasmodium falciparum	cysteine proteinase falcipain 1	Cathepsin K	330 aa	348 aa	33.0 %
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Cathepsin K	330 aa	299 aa	25.1 %
Onchocerca volvulus	Cathepsin L homolog	Cathepsin K	330 aa	316 aa	45.3 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin K	330 aa	347 aa	25.1 %
Theileria parva	cysteine proteinase, putative	Cathepsin K	330 aa	330 aa	32.4 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin K	330 aa	363 aa	25.1 %
Echinococcus granulosus	cysteine protease	Cathepsin K	330 aa	331 aa	45.6 %
Loa Loa (eye worm)	hypothetical protein	Cathepsin K	330 aa	277 aa	27.4 %
Onchocerca volvulus		Cathepsin K	330 aa	319 aa	42.0 %
Echinococcus granulosus	cathepsin b	Cathepsin K	330 aa	295 aa	26.1 %
Plasmodium vivax	serine-repeat antigen 3 (SERA)	Cathepsin K	330 aa	291 aa	23.7 %
Onchocerca volvulus		Cathepsin K	330 aa	272 aa	28.7 %
Echinococcus granulosus	cathepsin b	Cathepsin K	330 aa	269 aa	24.2 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin K	330 aa	296 aa	25.7 %
Plasmodium berghei	berghepain-1	Cathepsin K	330 aa	344 aa	30.5 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin K	330 aa	268 aa	28.0 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin K	330 aa	369 aa	24.7 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin K	330 aa	355 aa	26.5 %
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Cathepsin K	330 aa	265 aa	26.0 %
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Cathepsin K	330 aa	318 aa	27.0 %
Giardia lamblia	Cathepsin L precursor	Cathepsin K	330 aa	289 aa	24.6 %
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	Cathepsin K	330 aa	318 aa	30.2 %
Giardia lamblia	Cathepsin L precursor	Cathepsin K	330 aa	290 aa	31.0 %
Onchocerca volvulus		Cathepsin K	330 aa	311 aa	37.6 %
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Cathepsin K	330 aa	269 aa	25.3 %
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Cathepsin K	330 aa	274 aa	27.7 %
Plasmodium knowlesi	knowpain-1	Cathepsin K	330 aa	351 aa	28.8 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin K	330 aa	329 aa	35.9 %
Echinococcus multilocularis	cathepsin b	Cathepsin K	330 aa	284 aa	25.4 %
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	Cathepsin K	330 aa	319 aa	45.1 %
Plasmodium vivax	vivapain-1	Cathepsin K	330 aa	354 aa	28.8 %
Brugia malayi	cathepsin B-like cysteine proteinase	Cathepsin K	330 aa	380 aa	23.2 %
Theileria parva	cysteine proteinase, putative	Cathepsin K	330 aa	331 aa	26.6 %
Giardia lamblia	Cathepsin L-like protease	Cathepsin K	330 aa	266 aa	27.1 %
Babesia bovis	papain family cysteine protease containing protein	Cathepsin K	330 aa	331 aa	31.4 %
Schistosoma mansoni	cathepsin S (C01 family)	Cathepsin K	330 aa	316 aa	35.8 %
Dictyostelium discoideum	hypothetical protein	Cathepsin K	330 aa	339 aa	35.1 %
Neospora caninum	hypothetical protein	Cathepsin K	330 aa	381 aa	24.9 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin K	330 aa	363 aa	25.1 %
Onchocerca volvulus	Protein MCM10 homolog	Cathepsin K	330 aa	302 aa	35.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine protease, putative	0.0061	0.2216	0.4054
Loa Loa (eye worm)	cathepsin B	0.0075	0.3093	0.3093
Loa Loa (eye worm)	cysteine protease	0.0113	0.5467	0.5467
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0186	1	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.2216	0.4054
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0113	0.5467	0.5467
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0113	0.5467	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.5467	0.5467
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.2216	0.2216
Entamoeba histolytica	cysteine protease, putative	0.0061	0.2216	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.5467	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0077	0.325	0.325
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0113	0.5467	0.5467
Schistosoma mansoni	cathepsin s	0.0036	0.067	0.067
Leishmania major	cathepsin L-like protease	0.0113	0.5467	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0036	0.067	0.067
Brugia malayi	Cathepsin L-like precursor	0.0113	0.5467	0.5467
Loa Loa (eye worm)	hypothetical protein	0.0077	0.325	0.325
Brugia malayi	Cathepsin L-like precursor	0.0113	0.5467	0.5467
Onchocerca volvulus		0.0077	0.325	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0061	0.2216	0.4054
Onchocerca volvulus		0.0113	0.5467	1
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.2216	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.5467	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.5467	0.5467
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.5467	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.5467	1
Brugia malayi	Papain family cysteine protease containing protein	0.0113	0.5467	0.5467
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0113	0.5467	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.1223	0.1223
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0077	0.325	0.325
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.5467	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0061	0.2216	0.2216
Brugia malayi	Cathepsin L-like precursor	0.0077	0.325	0.325
Trypanosoma cruzi	cysteine proteinase, putative	0.0061	0.2216	0.2216
Echinococcus granulosus	cathepsin L	0.0061	0.2216	0.2216
Leishmania major	cathepsin L-like protease	0.0113	0.5467	1
Brugia malayi	cathepsin L-like precursor	0.0077	0.325	0.325
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.2216	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.5467	1
Plasmodium vivax	vivapain-1	0.0061	0.2216	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.2216	0.4054
Toxoplasma gondii	cathepsin CPL	0.0113	0.5467	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.5467	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.325	0.325
Entamoeba histolytica	cysteine proteinase, putative	0.0077	0.325	0.5946
Trypanosoma cruzi	cruzipain precursor, putative	0.0113	0.5467	0.5467
Plasmodium vivax	unspecified product	0.0036	0.067	0.1225
Onchocerca volvulus	Cathepsin L homolog	0.0113	0.5467	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0075	0.3093	0.5658
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0036	0.067	0.067
Echinococcus granulosus	cathepsin l1	0.0077	0.325	0.325
Loa Loa (eye worm)	hypothetical protein	0.0036	0.067	0.067
Entamoeba histolytica	cysteine protease, putative	0.0061	0.2216	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.0113	0.5467	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	0.325	0.5946
Echinococcus multilocularis	cathepsin L cysteine protease	0.0113	0.5467	0.5467
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.5467	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.1223	0.1223
Giardia lamblia	Cathepsin B precursor	0.0075	0.3093	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.067	0.067
Echinococcus multilocularis	cathepsin b	0.0186	1	1
Echinococcus granulosus	cathepsin b	0.0186	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.5467	1
Leishmania major	cathepsin L-like protease	0.0113	0.5467	1
Brugia malayi	Cathepsin L-like precursor	0.0077	0.325	0.325
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0113	0.5467	0.5467
Loa Loa (eye worm)	hypothetical protein	0.0036	0.067	0.067
Schistosoma mansoni	cathepsin F (C01 family)	0.0113	0.5467	0.5467
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.1477	0.1477
Onchocerca volvulus		0.0113	0.5467	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.2216	0.4054
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0113	0.5467	0.5467
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.5467	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.5467	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.5467	1
Echinococcus granulosus	cysteine protease	0.0061	0.2216	0.2216
Leishmania major	cysteine peptidase A (CPA)	0.0113	0.5467	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.2216	0.4054
Entamoeba histolytica	cysteine proteinase 1, putative	0.0061	0.2216	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.5467	1
Plasmodium vivax	vivapain-2	0.0113	0.5467	1
Leishmania major	cathepsin L-like protease	0.0113	0.5467	1
Entamoeba histolytica	cysteine proteinase, putative	0.0113	0.5467	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	0.325	0.5946
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0075	0.3093	0.3093
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.5467	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.2216	0.4054
Plasmodium vivax	vivapain-2	0.0113	0.5467	1
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.2216	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.2216	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	1	1
Giardia lamblia	Cathepsin B precursor	0.0075	0.3093	1
Leishmania major	cathepsin L-like protease	0.0113	0.5467	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.5467	1
Onchocerca volvulus		0.0113	0.5467	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.1223	0.1223
Echinococcus granulosus	cathepsin b	0.0186	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.5467	0.5467
Entamoeba histolytica	cysteine protease, putative	0.0061	0.2216	0.4054
Leishmania major	cathepsin L-like protease	0.0113	0.5467	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.2216	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	1	1
Plasmodium vivax	vivapain-3	0.0061	0.2216	0.4054
Leishmania major	cathepsin L-like protease	0.0113	0.5467	1
Entamoeba histolytica	cysteine proteinase, putative	0.0113	0.5467	1
Loa Loa (eye worm)	hypothetical protein	0.0186	1	1
Loa Loa (eye worm)	ctsf protein	0.0113	0.5467	0.5467
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.5467	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0113	0.5467	1
Giardia lamblia	Cathepsin B precursor	0.0075	0.3093	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.5467	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.5467	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.5467	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.5467	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.5467	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.5467	1
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.2216	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0061	0.2216	0.4054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0061	0.2216	0.2216
Onchocerca volvulus		0.0113	0.5467	1
Brugia malayi	Papain family cysteine protease containing protein	0.0061	0.2216	0.2216
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.2216	0.2216
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.5467	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.1223	0.1223
Echinococcus multilocularis	cysteine protease	0.0113	0.5467	0.5467
Echinococcus granulosus	cathepsin L cysteine protease	0.0061	0.2216	0.2216
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.5467	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.5467	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0113	0.5467	0.5467
Brugia malayi	Papain family cysteine protease containing protein	0.0061	0.2216	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0077	0.325	0.325
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0186	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.5467	1
Onchocerca volvulus		0.0113	0.5467	1
Echinococcus multilocularis	cysteine protease	0.0113	0.5467	0.5467
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.5467	0.5467
Entamoeba histolytica	cysteine protease, putative	0.0061	0.2216	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0113	0.5467	0.5467
Brugia malayi	Cathepsin L-like precursor	0.0036	0.067	0.067
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.5467	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0113	0.5467	1
Trypanosoma cruzi	cysteine protease, putative	0.0061	0.2216	0.2216
Echinococcus granulosus	cathepsin l1	0.0113	0.5467	0.5467
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.5467	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.5467	1
Echinococcus multilocularis	cathepsin L	0.0061	0.2216	0.2216
Entamoeba histolytica	cysteine protease, putative	0.0113	0.5467	1
Brugia malayi	Cathepsin L-like precursor	0.0113	0.5467	0.5467
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.104	0.1903
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.5467	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.5467	0.5467
Brugia malayi	Cathepsin L-like precursor	0.0113	0.5467	0.5467
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.5467	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.067	0.067
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.5467	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0113	0.5467	0.5467
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.5467	1
Brugia malayi	Cathepsin L-like precursor	0.0113	0.5467	0.5467
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0075	0.3093	0.2697
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.1477	0.1477
Toxoplasma gondii	cathepsin B	0.0075	0.3093	0.5658
Entamoeba histolytica	cysteine protease, putative	0.0061	0.2216	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0061	0.2216	0.4054
Trypanosoma cruzi	cruzipain precursor, putative	0.0036	0.067	0.067
Schistosoma mansoni	cathepsin F (C01 family)	0.0113	0.5467	0.5467
Echinococcus multilocularis	cathepsin b	0.0186	1	1
Leishmania major	cathepsin L-like protease	0.0113	0.5467	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0075	0.3093	0.3093
Plasmodium vivax	unspecified product	0.0061	0.2216	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.5467	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0857	0.0857
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	1	1
Onchocerca volvulus		0.0113	0.5467	1
Entamoeba histolytica	cysteine proteinase 2	0.0061	0.2216	0.4054
Loa Loa (eye worm)	fibroinase	0.0113	0.5467	0.5467
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0113	0.5467	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.104	0.1903
Trypanosoma cruzi	cysteine peptidase, putative	0.0061	0.2216	0.2216
Onchocerca volvulus		0.0113	0.5467	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0036	0.067	0.067
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.2216	0.2216
Brugia malayi	Cathepsin L-like precursor	0.0113	0.5467	0.5467
Onchocerca volvulus	Cathepsin F homolog	0.0113	0.5467	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0077	0.325	0.325

Activities

Activity type	Activity value	Assay description	Source	Reference
Fu (ADMET)	= 17 %	Fraction unbound in human plasma	ChEMBL.	22858142
IC50 (ADMET)	> 4.5	Inhibition of CYP3A4	ChEMBL.	22858142
IC50 (ADMET)	> 4.5	Inhibition of CYP2D6	ChEMBL.	22858142
IC50 (ADMET)	> 4.5	Inhibition of CYP2C9	ChEMBL.	22858142
IC50 (ADMET)	> 4.5	Inhibition of CYP2C19	ChEMBL.	22858142
IC50 (ADMET)	> 4.5	Inhibition of CYP1A2	ChEMBL.	22858142
IC50 (binding)	> 5.1	Inhibition of human recombinant cathepsin L using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay	ChEMBL.	22858142
IC50 (binding)	= 5.1	Inhibition of human ERG	ChEMBL.	22858142
IC50 (binding)	= 5.8	Inhibition of human recombinant cathepsin B using Z-Arg-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay	ChEMBL.	22858142
IC50 (binding)	= 6.2	Inhibition of human recombinant cathepsin S using Z-Val-Val-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay	ChEMBL.	22858142
IC50 (binding)	= 8	Inhibition of human recombinant cathepsin K using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay	ChEMBL.	22858142
IC50 (binding)	= 0.018 uM	Inhibition of dog recombinant cathepsin K using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay	ChEMBL.	22858142

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2070937

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1668756