Detailed information for compound 167144

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 513.584 | Formula: C30H31N3O5
  • H donors: 2 H acceptors: 4 LogP: 3.84 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@H](C(=O)NC1CC(=O)N(CC1=O)CCc1ccccc1)Cc1ccccc1)OCc1ccccc1
  • InChi: 1S/C30H31N3O5/c34-27-20-33(17-16-22-10-4-1-5-11-22)28(35)19-25(27)31-29(36)26(18-23-12-6-2-7-13-23)32-30(37)38-21-24-14-8-3-9-15-24/h1-15,25-26H,16-21H2,(H,31,36)(H,32,37)/t25?,26-/m0/s1
  • InChiKey: WWJXDXQVSFLZSC-AMVUTOCUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0274 0.0222
Chlamydia trachomatis DNA ligase 0.001 0.017 0.5
Trichomonas vaginalis hypothetical protein 0.0033 0.1572 0.3005
Giardia lamblia Cathepsin L precursor 0.0014 0.0411 0.0707
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0274 0.0366
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0722 0.1107
Entamoeba histolytica cysteine protease, putative 0.0014 0.0411 0.0707
Loa Loa (eye worm) hypothetical protein 0.001 0.017 0.017
Giardia lamblia Cysteine protease 0.0014 0.0411 0.0707
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0014 0.0411 0.0411
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0722 0.1323
Onchocerca volvulus 0.0037 0.1774 0.3249
Onchocerca volvulus 0.0052 0.2704 0.5132
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0722 0.1107
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.134 0.1294
Loa Loa (eye worm) cysteine protease 0.0052 0.2704 0.2704
Echinococcus multilocularis smad 0.0008 0.007 0.0017
Schistosoma mansoni smad 0.0008 0.007 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0014 0.0411 0.0708
Leishmania major cysteine peptidase A (CPA) 0.0052 0.2704 0.439
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0014 0.0411 0.1348
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.2505 0.2465
Brugia malayi MH2 domain containing protein 0.0008 0.007 0.0017
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.6563 0.6563
Giardia lamblia Cathepsin L precursor 0.0014 0.0411 0.0707
Plasmodium falciparum serine repeat antigen 7 0.0014 0.0411 0.1348
Brugia malayi Cathepsin L-like precursor 0.0052 0.2704 0.2665
Schistosoma mansoni DNA ligase IV 0.001 0.017 0.0117
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.1066 0.3822
Echinococcus granulosus smad 0.0008 0.007 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0411 0.0708
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.6091 1
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.017 0.0439
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.134 0.1294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.134 0.2132
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.007 0.0017
Leishmania major cathepsin L-like protease 0.0109 0.6091 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0516 0.0465
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.1066 0.1019
Brugia malayi hypothetical protein 0.001 0.017 0.0117
Giardia lamblia Cathepsin B precursor 0.0063 0.3376 0.6574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.6091 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.2704 0.5244
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0516 0.0516
Trichomonas vaginalis conserved hypothetical protein 0.001 0.017 0.0232
Trypanosoma cruzi major cysteine proteinase, putative 0.0014 0.0411 0.0359
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.5108 0.5082
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0516 0.0465
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.2704 0.5244
Brugia malayi hypothetical protein 0.001 0.017 0.0117
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 1 1
Giardia lamblia Cathepsin L-like protease 0.0014 0.0411 0.0707
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0173 0.0362
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0722 0.1107
Brugia malayi Cathepsin L-like precursor 0.0052 0.2704 0.2665
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0014 0.0411 0.1348
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.5108 1
Giardia lamblia Cathepsin L precursor 0.0014 0.0411 0.0707
Loa Loa (eye worm) hypothetical protein 0.0016 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0016 0.0525 0.0525
Schistosoma mansoni cathepsin s 0.0016 0.0525 0.0474
Plasmodium vivax unspecified product 0.0016 0.0525 0.1779
Trypanosoma cruzi major cysteine proteinase, putative 0.007 0.3798 0.3765
Trypanosoma cruzi cruzipain precursor, putative 0.0016 0.0525 0.0474
Loa Loa (eye worm) RecQ helicase 0.0024 0.0996 0.0996
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0068 0.3654 0.362
Entamoeba histolytica cysteine protease, putative 0.0029 0.134 0.2546
Schistosoma mansoni hypothetical protein 0.0015 0.0516 0.0465
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0722 0.1107
Trichomonas vaginalis protein disulfide isomerase, putative 0.0008 0.0053 0.0001
Loa Loa (eye worm) hypothetical protein 0.0049 0.2505 0.2505
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.2505 0.2465
Entamoeba histolytica cysteine protease, putative 0.0029 0.134 0.2546
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0173 0.0121
Trypanosoma brucei cysteine peptidase C (CPC) 0.0063 0.3376 0.5504
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.2704 0.2665
Trypanosoma cruzi cysteine proteinase, putative 0.0029 0.134 0.1294
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.6563 0.6563
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0014 0.0411 0.1348
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0014 0.0411 0.1348
Trichomonas vaginalis protein disulfide isomerase, putative 0.0008 0.0053 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.001 0.017 0.0232
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.2704 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.2704 0.2704
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0014 0.0411 0.1348
Loa Loa (eye worm) hypothetical protein 0.0044 0.2208 0.2208
Leishmania major cathepsin L-like protease 0.0109 0.6091 1
Echinococcus granulosus cathepsin l1 0.0052 0.2704 0.2665
Brugia malayi MH1 domain containing protein 0.0008 0.007 0.0017
Brugia malayi Cathepsin L-like precursor 0.0052 0.2704 0.2665
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.017 0.0117
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0173 0.0121
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0722 0.0672
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0274 0.0222
Brugia malayi hypothetical protein 0.0025 0.1066 0.1019
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.5108 0.5082
Giardia lamblia Cysteine protease 0.0014 0.0411 0.0707
Echinococcus multilocularis cathepsin b 0.0175 1 1
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0344 0.0576
Plasmodium vivax vivapain-2 0.0052 0.2704 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0516 0.0465
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.134 0.1294
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0722 0.1107
Schistosoma mansoni topbp1 0.001 0.017 0.0117
Leishmania major cathepsin L-like protease 0.0052 0.2704 0.439
Loa Loa (eye worm) hypothetical protein 0.001 0.0173 0.0173
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.5108 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0274 0.0222
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0722 0.0672
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0037 0.1774 0.1774
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.1066 0.3049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.2704 0.5244
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0173 0.0362
Loa Loa (eye worm) hypothetical protein 0.0052 0.2704 0.2704
Schistosoma mansoni cathepsin B (C01 family) 0.0014 0.0411 0.0359
Brugia malayi Cathepsin L-like precursor 0.0016 0.0525 0.0474
Leishmania major DNA polymerase eta, putative 0.0044 0.2208 0.3569
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.2704 0.2665
Brugia malayi topoisomerase 0.001 0.017 0.0117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0722 0.0672
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.017 0.0117
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0274 0.0222
Leishmania major hypothetical protein, conserved 0.0022 0.0893 0.1391
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.2704 0.5244
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0014 0.0411 0.0359
Giardia lamblia Hypothetical protein 0.0014 0.0411 0.0707
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0014 0.0411 0.0359
Echinococcus multilocularis replication factor c subunit 1 0.001 0.017 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0411 0.0708
Loa Loa (eye worm) transglutaminase 0.0008 0.0053 0.0053
Loa Loa (eye worm) Smad1 0.0008 0.007 0.007
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.017 0.0351
Plasmodium falciparum serine repeat antigen 1 0.0014 0.0411 0.1348
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.2505 0.2505
Echinococcus granulosus cathepsin L 0.0014 0.0411 0.0359
Giardia lamblia Cathepsin L precursor 0.0014 0.0411 0.0707
Giardia lamblia Cathepsin L precursor 0.0014 0.0411 0.0707
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0893 0.1391
Brugia malayi Cathepsin L-like precursor 0.0052 0.2704 0.2665
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0722 0.5
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0274 0.0222
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.1584 0.1539
Brugia malayi Papain family cysteine protease containing protein 0.0014 0.0411 0.0359
Loa Loa (eye worm) hypothetical protein 0.0014 0.0411 0.0411
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0014 0.0411 0.0708
Brugia malayi fibroinase precursor 0.0014 0.0411 0.0359
Trypanosoma cruzi cysteine proteinase, putative 0.0029 0.134 0.1294
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0722 0.0672
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.5108 1
Schistosoma mansoni kinase 0.0047 0.2397 0.2356
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0722 0.0672
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0014 0.0411 0.0707
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0411 0.0708
Loa Loa (eye worm) cathepsin B 0.0063 0.3376 0.3376
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.5108 0.5082
Treponema pallidum DNA ligase (lig) 0.001 0.017 0.5
Entamoeba histolytica cysteine protease, putative 0.0014 0.0411 0.0707
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.2704 0.2665
Plasmodium falciparum serine repeat antigen 2 0.0014 0.0411 0.1348
Plasmodium falciparum serine repeat antigen 9 0.0014 0.0411 0.1348
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0014 0.0411 0.0707
Trichomonas vaginalis conserved hypothetical protein 0.001 0.017 0.0232
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.1066 0.3822
Giardia lamblia Cathepsin B precursor 0.0014 0.0411 0.0707
Loa Loa (eye worm) hypothetical protein 0.0014 0.0411 0.0411
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.2704 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0014 0.0411 0.0359
Entamoeba histolytica cysteine protease, putative 0.0029 0.134 0.2546
Echinococcus granulosus nibrin 0.001 0.017 0.0117
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0255 0.0203
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0014 0.0411 0.0707
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0411 0.0411
Brugia malayi Cathepsin L-like precursor 0.0037 0.1774 0.173
Echinococcus granulosus cathepsin L 0.0029 0.134 0.1294
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0014 0.0411 0.0359
Plasmodium falciparum serine repeat antigen 8 0.0014 0.0411 0.1348
Leishmania major cathepsin L-like protease 0.0109 0.6091 1
Onchocerca volvulus 0.0052 0.2704 0.5132
Giardia lamblia Cathepsin B precursor 0.0063 0.3376 0.6574
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0014 0.0411 0.0708
Entamoeba histolytica cysteine protease, putative 0.0029 0.134 0.2546
Plasmodium falciparum serine repeat antigen 6 0.0014 0.0411 0.1348
Trichomonas vaginalis conserved hypothetical protein 0.001 0.017 0.0232
Entamoeba histolytica cysteine protease, putative 0.0029 0.134 0.2546
Brugia malayi MH2 domain containing protein 0.0117 0.6563 0.6545
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.2704 0.5244
Echinococcus multilocularis cathepsin L 0.0029 0.134 0.1294
Entamoeba histolytica cysteine protease, putative 0.0029 0.134 0.2546
Brugia malayi Papain family cysteine protease containing protein 0.0014 0.0411 0.0359
Brugia malayi cathepsin F-like cysteine proteinase 0.0014 0.0411 0.0359
Brugia malayi cathepsin Z-like cysteine proteinase 0.0014 0.0411 0.0359
Loa Loa (eye worm) hypothetical protein 0.0033 0.1584 0.1584
Entamoeba histolytica cysteine protease, putative 0.0029 0.134 0.2546
Brugia malayi hypothetical protein 0.0016 0.0545 0.0494
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.5108 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.007 0.007
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0344 0.0292
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0014 0.0411 0.0359
Giardia lamblia Kinase, PLK 0.0092 0.5108 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.2704 0.5244
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.134 0.1294
Echinococcus multilocularis cathepsin L 0.0014 0.0411 0.0359
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.2324 0.4493
Schistosoma mansoni DNA polymerase eta 0.0044 0.2208 0.2167
Giardia lamblia Cathepsin L-like protease 0.0014 0.0411 0.0707
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.2704 0.5244
Toxoplasma gondii cathepsin CPC2 0.0014 0.0411 0.1076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.2704 0.5244
Loa Loa (eye worm) hypothetical protein 0.001 0.017 0.017
Schistosoma mansoni Smad4 0.0008 0.007 0.0017
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.5108 0.5082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.134 0.2547
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.2704 0.2704
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.017 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0274 0.0438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0411 0.0708
Echinococcus granulosus dna polymerase eta 0.0044 0.2208 0.2167
Brugia malayi Cathepsin L-like precursor 0.0052 0.2704 0.2665
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0016 0.0525 0.0474
Entamoeba histolytica hypothetical protein 0.0011 0.0274 0.0437
Plasmodium falciparum serine repeat antigen 3 0.0014 0.0411 0.1348
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0411 0.0708
Entamoeba histolytica cysteine protease, putative 0.0014 0.0411 0.0707
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0996 0.0948
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0173 0.0121
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0014 0.0411 0.0707
Brugia malayi Smad1 0.0008 0.007 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.2704 0.5244
Schistosoma mansoni hypothetical protein 0.0015 0.0516 0.0465
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0516 0.0465
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0996 0.0948
Schistosoma mansoni hypothetical protein 0.0015 0.0516 0.0465
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.1066 0.1019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0722 0.0672
Loa Loa (eye worm) hypothetical protein 0.0016 0.0525 0.0525
Giardia lamblia Cathepsin L precursor 0.0014 0.0411 0.0707
Loa Loa (eye worm) hypothetical protein 0.0014 0.0411 0.0411
Schistosoma mansoni tsg101-related 0.0046 0.2356 0.2315
Brugia malayi Cathepsin L-like precursor 0.0052 0.2704 0.2665
Schistosoma mansoni DNA helicase recq1 0.001 0.0173 0.0121
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.5108 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.6091 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0411 0.0708
Leishmania major DNA polymerase eta, putative 0.0031 0.1432 0.2283
Trypanosoma cruzi cruzipain precursor, putative 0.0109 0.6091 0.607
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0344 0.0481
Echinococcus granulosus cathepsin b 0.0175 1 1
Giardia lamblia Encystation-specific protease 0.0014 0.0411 0.0707
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0701 0.0652
Giardia lamblia DINP protein human, muc B family 0.0019 0.0722 0.1322
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0063 0.3376 0.5504
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.134 0.2546
Loa Loa (eye worm) hypothetical protein 0.0015 0.0516 0.0516
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.5108 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.1066 0.3822
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0722 0.0672
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.5108 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.007 0.0017
Echinococcus granulosus replication factor c subunit 1 0.001 0.017 0.0117
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.017 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.2704 0.5244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0411 0.0708
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0274 0.0222
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.1066 0.1678
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.1774 0.3405
Entamoeba histolytica cysteine protease, putative 0.0052 0.2704 0.5244
Echinococcus granulosus cysteine protease 0.0029 0.134 0.1294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.6091 1
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0274 0.0222
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.2704 0.2665
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0274 0.0222
Toxoplasma gondii cathepsin B 0.0063 0.3376 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.2704 0.5244
Echinococcus multilocularis GPCR, family 2 0.0015 0.0516 0.0465
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.2704 0.2665
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.1774 0.173
Schistosoma mansoni cathepsin S (C01 family) 0.0014 0.0411 0.0359
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.2208 0.3569
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.007 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0722 0.1107
Entamoeba histolytica hypothetical protein 0.0014 0.0411 0.0707
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0722 0.1107
Plasmodium vivax vivapain-1 0.0029 0.134 0.4856
Brugia malayi Cathepsin L-like precursor 0.0037 0.1774 0.173
Plasmodium vivax vivapain-3 0.0029 0.134 0.4856
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.2704 0.5244
Echinococcus granulosus GPCR family 2 0.0015 0.0516 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0411 0.0708
Giardia lamblia Cathepsin B precursor 0.0014 0.0411 0.0707
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0274 0.0222
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.007 0.0017
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0996 0.1866
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0344 0.0574
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0722 1
Echinococcus granulosus cathepsin b 0.0175 1 1
Brugia malayi MH2 domain containing protein 0.0008 0.007 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.2704 0.5244
Echinococcus multilocularis cysteine protease 0.0052 0.2704 0.2665
Schistosoma mansoni hypothetical protein 0.0033 0.1584 0.1539
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0525 0.0474
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.134 0.1294
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0722 1
Entamoeba histolytica cysteine protease, putative 0.0029 0.134 0.2546
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.134 0.2546
Onchocerca volvulus 0.0052 0.2704 0.5132
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.007 0.0017
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0014 0.0411 0.1348
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0014 0.0411 0.1348
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0014 0.0411 0.0708
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0826 0.2915
Entamoeba histolytica cysteine protease, putative 0.0029 0.134 0.2546
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0344 0.0481
Onchocerca volvulus Cathepsin L homolog 0.0052 0.2704 0.5132
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0255 0.0203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.6091 1
Entamoeba histolytica cysteine protease, putative 0.0014 0.0411 0.0707
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.017 0.0232
Echinococcus granulosus bloom syndrome protein 0.0024 0.0996 0.0948
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0274 0.0222
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0722 0.1107
Schistosoma mansoni DNA helicase recq5 0.001 0.0173 0.0121
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.2208 0.2167
Giardia lamblia Cathepsin B precursor 0.0014 0.0411 0.0707
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0014 0.0411 0.0707
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.5108 0.5108
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0014 0.0411 0.0708
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.5108 0.8372
Giardia lamblia Replication factor C, subunit 1 0.001 0.017 0.023
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0014 0.0411 0.0708
Brugia malayi STAT protein, DNA binding domain containing protein 0.0129 0.7272 0.7257
Echinococcus granulosus cathepsin L cysteine protease 0.0029 0.134 0.1294
Loa Loa (eye worm) hypothetical protein 0.0014 0.0411 0.0411
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.017 0.0117
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0175 1 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.017 0.0232
Schistosoma mansoni smad1 5 8 and 0.0008 0.007 0.0017
Echinococcus granulosus dna polymerase kappa 0.0019 0.0722 0.0672
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0722 0.1107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0411 0.0411
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.6091 0.607
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0014 0.0411 0.0411
Toxoplasma gondii ATPase, AAA family protein 0.001 0.017 0.0351
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0175 1 1
Giardia lamblia Hypothetical protein 0.0014 0.0411 0.0707
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.134 0.2132
Leishmania major hypothetical protein, conserved 0.0025 0.1066 0.1678
Schistosoma mansoni tsg101-related 0.0057 0.2975 0.2938
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0722 0.1107
Entamoeba histolytica cysteine protease, putative 0.0029 0.134 0.2546
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.2704 0.5244
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0014 0.0411 0.0707
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0722 0.1322
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0722 0.0672
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.6091 1
Trypanosoma cruzi cysteine protease, putative 0.0029 0.134 0.1294
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.2704 0.5244
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.017 0.0232
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.2208 0.2167
Brugia malayi hypothetical protein 0.0068 0.3654 0.362
Schistosoma mansoni cathepsin C 0.0014 0.0411 0.0359
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.6091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.2704 0.5244
Loa Loa (eye worm) hypothetical protein 0.0037 0.1774 0.1774
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0063 0.3376 0.6574
Giardia lamblia Cysteine protease 0.0014 0.0411 0.0707
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0372 0.0528
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0274 0.0222
Loa Loa (eye worm) Pdia4 protein 0.0008 0.0053 0.0053
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.017 0.0117
Leishmania major cathepsin L-like protease 0.0052 0.2704 0.439
Loa Loa (eye worm) STAT protein 0.0129 0.7272 0.7272
Entamoeba histolytica cysteine proteinase 2 0.0029 0.134 0.2546
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.2704 0.5244
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.1432 0.4147
Brugia malayi cathepsin L precursor 0.0014 0.0411 0.0359
Trypanosoma brucei unspecified product 0.0013 0.0372 0.0528
Plasmodium vivax vivapain-2 0.0052 0.2704 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0014 0.0411 0.1348
Loa Loa (eye worm) ctsf protein 0.0052 0.2704 0.2704
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0722 0.1107
Onchocerca volvulus 0.0014 0.0411 0.0488
Trichomonas vaginalis protein disulfide isomerase, putative 0.0008 0.0053 0.0001
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0722 0.0672
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0014 0.0411 0.0359
Onchocerca volvulus Cathepsin F homolog 0.0052 0.2704 0.5132
Echinococcus multilocularis nibrin 0.001 0.017 0.0117
Schistosoma mansoni hypothetical protein 0.0015 0.0516 0.0465
Trypanosoma brucei unspecified product 0.0013 0.0372 0.0528
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.2704 0.5244
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0014 0.0411 0.1348
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0093 0.5161 0.5136
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0274 0.0222
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0173 0.0173
Giardia lamblia Cathepsin B precursor 0.0014 0.0411 0.0707
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.2704 0.5244
Trypanosoma brucei polo-like protein kinase 0.0092 0.5108 0.8372
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.017 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.017 0.0117
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.6091 0.607
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.134 0.1294
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0372 0.0528
Echinococcus multilocularis cathepsin b 0.0175 1 1
Entamoeba histolytica cysteine protease, putative 0.0014 0.0411 0.0707
Entamoeba histolytica cysteine protease, putative 0.0029 0.134 0.2546
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.017 0.0117
Echinococcus multilocularis dna polymerase eta 0.0044 0.2208 0.2167
Leishmania major cathepsin L-like protease 0.0052 0.2704 0.439
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0173 0.0238
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.017 0.0232
Toxoplasma gondii preprocathepsin c precursor, putative 0.0014 0.0411 0.1076
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.2324 0.4493
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0531 0.1438
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0411 0.0708
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.2704 0.5244
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.5108 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.6091 1
Brugia malayi DKFZp564C0469 protein 0.001 0.017 0.0117
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.007 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.6091 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0722 0.0672
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0014 0.0411 0.0359
Loa Loa (eye worm) hypothetical protein 0.0118 0.6648 0.6648
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.5108 0.5082
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.2704 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.017 0.0232
Brugia malayi Cathepsin L-like cysteine proteinase 0.0037 0.1774 0.173
Loa Loa (eye worm) hypothetical protein 0.001 0.017 0.017
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.017 0.023
Onchocerca volvulus Cathepsin L homolog 0.0052 0.2704 0.5132
Entamoeba histolytica cysteine proteinase 1, putative 0.0029 0.134 0.2546
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0014 0.0411 0.1348
Brugia malayi MH1 domain containing protein 0.0008 0.007 0.0017
Brugia malayi cathepsin L-like precursor 0.0037 0.1774 0.173
Loa Loa (eye worm) hypothetical protein 0.001 0.017 0.017
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.2704 0.5244
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0014 0.0411 0.1348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.134 0.2547
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0274 0.0438
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0014 0.0411 0.0359
Entamoeba histolytica cysteine protease, putative 0.0014 0.0411 0.0707
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.6091 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.6091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.2704 0.5244
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.017 0.0193
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.2704 0.2665
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0029 0.134 0.1294
Entamoeba histolytica cysteine protease, putative 0.0029 0.134 0.2546
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0722 0.1107
Schistosoma mansoni topbp1 0.001 0.017 0.0117
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.2704 0.2665
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0014 0.0411 0.1348
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0014 0.0411 0.0708
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.017 0.0232
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0722 0.0722
Loa Loa (eye worm) hypothetical protein 0.0068 0.3654 0.3654
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1774 0.3405
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0068 0.3654 0.362
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.134 0.2546
Entamoeba histolytica hypothetical protein 0.0011 0.0274 0.0437
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0173 0.0121
Onchocerca volvulus 0.0052 0.2704 0.5132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0411 0.0708
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0722 0.1107
Onchocerca volvulus 0.0052 0.2704 0.5132
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.5108 0.5082
Plasmodium falciparum serine repeat antigen 5 0.0014 0.0411 0.1348
Echinococcus granulosus Smad4 0.0008 0.007 0.0017
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0722 0.1107
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0525 0.0525
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0014 0.0411 0.0359
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0722 0.1323
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0996 0.1866
Echinococcus granulosus cathepsin l1 0.0037 0.1774 0.173
Entamoeba histolytica hypothetical protein 0.0011 0.0274 0.0437
Loa Loa (eye worm) hypothetical protein 0.0175 1 1
Entamoeba histolytica hypothetical protein 0.0011 0.0274 0.0437
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0014 0.0411 0.0359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0411 0.0708
Plasmodium vivax unspecified product 0.0029 0.134 0.4856
Leishmania major cathepsin L-like protease 0.0052 0.2704 0.439
Brugia malayi Papain family cysteine protease containing protein 0.0014 0.0411 0.0359
Echinococcus multilocularis Smad4 0.0008 0.007 0.0017
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0014 0.0411 0.1348
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0173 0.0454
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0173 0.0121
Plasmodium vivax serine-repeat antigen (SERA) 0.0014 0.0411 0.1348
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.2704 0.2665
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0542 0.1846
Leishmania major DNA polymerase kappa, putative 0.0019 0.0722 0.1107
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.2704 0.2665
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.017 0.0117
Toxoplasma gondii cathepsin CPL 0.0052 0.2704 0.7977
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0173 0.0121
Brugia malayi cathepsin Z-like cysteine proteinase 0.0014 0.0411 0.0359
Toxoplasma gondii cathepsin CPC1 0.0014 0.0411 0.1076
Plasmodium vivax unspecified product 0.0014 0.0411 0.1348
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0372 0.0528
Loa Loa (eye worm) fibroinase 0.0052 0.2704 0.2704
Loa Loa (eye worm) hypothetical protein 0.001 0.017 0.017
Giardia lamblia Cathepsin B precursor 0.0014 0.0411 0.0707
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.1432 0.1386
Loa Loa (eye worm) hypothetical protein 0.0025 0.1066 0.1066
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0516 0.0465
Entamoeba histolytica cysteine protease, putative 0.0029 0.134 0.2546
Loa Loa (eye worm) hypothetical protein 0.0037 0.1774 0.1774
Onchocerca volvulus 0.0052 0.2704 0.5132
Leishmania major cathepsin L-like protease 0.0052 0.2704 0.439
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.134 0.2546
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0274 0.0222
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0722 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.2704 0.5244
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0893 0.0844
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0063 0.3376 0.3341
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0014 0.0411 0.0411
Loa Loa (eye worm) protein disulfide isomerase 0.0008 0.0053 0.0053
Schistosoma mansoni smad1 5 8 and 0.0008 0.007 0.0017
Schistosoma mansoni tsg101-related 0.0057 0.2975 0.2938
Plasmodium falciparum serine repeat antigen 4 0.0014 0.0411 0.1348
Giardia lamblia Cysteine protease 0.0014 0.0411 0.0707
Loa Loa (eye worm) hypothetical protein 0.001 0.017 0.017
Echinococcus multilocularis cysteine protease 0.0052 0.2704 0.2665
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0014 0.0411 0.0708
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0014 0.0411 0.0359
Plasmodium falciparum cysteine proteinase falcipain 1 0.0029 0.134 0.4856
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0063 0.3376 0.3341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.2704 0.5244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1774 0.3405
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0516 0.0465
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.2704 0.2665
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.2704 0.5244
Trypanosoma brucei unspecified product 0.0019 0.0722 0.1107
Entamoeba histolytica hypothetical protein 0.001 0.017 0.023
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.5108 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0014 0.0411 0.1348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.2704 0.5244
Brugia malayi cathepsin F-like cysteine proteinase 0.0016 0.0525 0.0474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.2704 0.5244
Onchocerca volvulus Cathepsin L homolog 0.0014 0.0411 0.0488
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0046 0.2356 0.4555
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.6091 0.607
Onchocerca volvulus 0.0052 0.2704 0.5132
Giardia lamblia Cathepsin B precursor 0.0063 0.3376 0.6574
Schistosoma mansoni hypothetical protein 0.0011 0.0255 0.0203

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 53 nM Affinity for cysteine protease (Cruzipain) of Chagas' disease ChEMBL. 12270191
Ki (binding) = 53 nM Affinity for cysteine protease (Cruzipain) of Chagas' disease ChEMBL. 12270191
Ki (binding) = 53.2 nM Affinity for cysteine protease (Cruzipain) of Chagas' disease ChEMBL. 12270191
Ki (binding) = 53.2 nM Affinity for cysteine protease (Cruzipain) of Chagas' disease ChEMBL. 12270191
Ki (binding) = 93 nM Affinity for human Cathepsin L ChEMBL. 12270191
Ki (binding) = 93 nM Affinity for human Cathepsin L ChEMBL. 12270191
Ki (binding) = 6170 nM Affinity for human Cathepsin B ChEMBL. 12270191
Ki (binding) = 6170 nM Affinity for human Cathepsin B ChEMBL. 12270191

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.