Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 16 uM | Cytostatic concentration test against mock infected human cells of MT-4 cell line | ChEMBL. | 9804703 |
EC50 (functional) | > 8 uM | compound was tested for antiviral activity against HIV-2 (ROB) in MT-4 cell line, activity expressed as concentration required to protect 50% of the virus-infected cells against destruction by the virus. | ChEMBL. | 9804703 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 9804703 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.