Detailed information for compound 1681120

Basic information

Technical information
  • TDR Targets ID: 1681120
  • Name: (2R,3R)-2-(carboxymethyl)oxirane-2,3-dicarbox ylic acid
  • MW: 190.108 | Formula: C6H6O7
  • H donors: 3 H acceptors: 6 LogP: -1.57 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C[C@]1(O[C@H]1C(=O)O)C(=O)O
  • InChi: 1S/C6H6O7/c7-2(8)1-6(5(11)12)3(13-6)4(9)10/h3H,1H2,(H,7,8)(H,9,10)(H,11,12)/t3-,6+/m0/s1
  • InChiKey: NEDLLNIZNWRDMG-BBIVZNJYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus ATP-citrate synthase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K01648 ATP citrate (pro-S)-lyase [EC2.3.3.8], putative Get druggable targets OG5_129655 All targets in OG5_129655
Schistosoma japonicum ATP-citrate synthase, putative Get druggable targets OG5_129655 All targets in OG5_129655
Schistosoma japonicum ATP-citrate synthase, putative Get druggable targets OG5_129655 All targets in OG5_129655
Toxoplasma gondii ATP-citrate lyase, putative Get druggable targets OG5_129655 All targets in OG5_129655
Brugia malayi ATP-citrate synthase Get druggable targets OG5_129655 All targets in OG5_129655
Schistosoma mansoni ATP-citrate synthase Get druggable targets OG5_129655 All targets in OG5_129655
Neospora caninum cDNA FLJ55447, highly similar to ATP-citrate synthase (EC 2.3.3.8), related Get druggable targets OG5_129655 All targets in OG5_129655
Loa Loa (eye worm) ATP-citrate synthase Get druggable targets OG5_129655 All targets in OG5_129655
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase homolog ATP-citrate synthase   1100 aa 1117 aa 60.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis 0.0028 0.3306 0.3037
Schistosoma mansoni hypothetical protein 0.0028 0.3306 0.3037
Schistosoma mansoni tyrosine kinase 0.0063 0.9727 1
Echinococcus multilocularis transfer RNA-Ala 0.0027 0.3179 0.2899
Schistosoma mansoni cell polarity protein 0.0027 0.3179 0.2899
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0028 0.3306 0.3037
Echinococcus granulosus suppressor of cytokine signaling 6 0.0028 0.3306 0.3037
Brugia malayi Protein kinase domain containing protein 0.0036 0.4741 0.4461
Loa Loa (eye worm) TK/ABL protein kinase 0.0036 0.4741 0.4741
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.4741 0.4741
Brugia malayi Protein kinase domain containing protein 0.0036 0.4741 0.4461
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0036 0.4741 0.4593
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0063 0.9727 1
Schistosoma mansoni vav2 0.0028 0.3306 0.3037
Echinococcus multilocularis c src tyrosine kinase 0.0063 0.9727 1
Onchocerca volvulus 0.0028 0.3306 0.6611
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0055 0.8292 0.8292
Schistosoma mansoni C-fyn 0.0027 0.3179 0.2899
Loa Loa (eye worm) STAT protein 0.0028 0.3306 0.3306
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0028 0.3306 0.3037
Echinococcus multilocularis tyrosine kinase 0.0036 0.4741 0.4593
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.3306 0.295
Echinococcus multilocularis tyrosine protein kinase Abl 0.0063 0.9727 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0063 0.9727 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.3179 0.3179
Brugia malayi Variant SH3 domain containing protein 0.0028 0.3306 0.295
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0027 0.3179 0.2899
Loa Loa (eye worm) hypothetical protein 0.0027 0.3179 0.3179
Loa Loa (eye worm) ATP-citrate synthase 0.0064 1 1
Schistosoma mansoni shc transforming protein 0.0028 0.3306 0.3037
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0028 0.3306 0.3037
Schistosoma mansoni growth factor receptor-bound protein 0.0055 0.8292 0.8443
Schistosoma mansoni suppressor of cytokine signaling 0.0028 0.3306 0.3037
Brugia malayi Variant SH3 domain containing protein 0.0055 0.8292 0.8201
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0027 0.3179 0.2899
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0055 0.8292 0.8443
Loa Loa (eye worm) thyroid receptor interactor 0.0027 0.3179 0.3179
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0028 0.3306 0.3306
Brugia malayi Myosin tail family protein 0.0027 0.3179 0.2816
Brugia malayi SH2 domain containing protein 0.0036 0.4741 0.4461
Echinococcus granulosus tyrosine protein kinase Src42A 0.0063 0.9727 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0063 0.9727 1
Brugia malayi Peripheral plasma membrane protein CASK 0.0027 0.3179 0.2816
Loa Loa (eye worm) hypothetical protein 0.0028 0.3306 0.3306
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.4741 0.4741
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0027 0.3179 0.3179
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0027 0.3179 1
Echinococcus multilocularis nostrin 0.0027 0.3179 0.2899
Echinococcus multilocularis tyrosine protein kinase Srms 0.0036 0.4741 0.4593
Brugia malayi Protein kinase domain containing protein 0.0036 0.4741 0.4461
Echinococcus granulosus suppressor of cytokine signaling 7 0.0028 0.3306 0.3037
Brugia malayi SH2 domain containing protein 0.0036 0.4741 0.4461
Echinococcus multilocularis expressed protein 0.0027 0.3179 0.2899
Brugia malayi Src substrate cortactin 0.0027 0.3179 0.2816
Loa Loa (eye worm) guanylate kinase 0.0027 0.3179 0.3179
Echinococcus granulosus intersectin 2 0.0027 0.3179 0.2899
Loa Loa (eye worm) hypothetical protein 0.0027 0.3179 0.3179
Schistosoma mansoni SH2A 0.0028 0.3306 0.3037
Loa Loa (eye worm) SRC-1 0.0063 0.9727 0.9727
Schistosoma mansoni tyrosine kinase 0.0036 0.4741 0.4593
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0027 0.3179 0.2899
Brugia malayi SH2 domain containing protein 0.0028 0.3306 0.295
Schistosoma mansoni suppressor of cytokine signaling 0.0028 0.3306 0.3037
Brugia malayi hypothetical protein 0.0028 0.3306 0.295
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0028 0.3306 0.3037
Schistosoma mansoni signal transduction protein lnk-related 0.0028 0.3306 0.3037
Echinococcus granulosus growth factor receptor bound protein 2 0.0055 0.8292 0.8443
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.4741 0.4741
Onchocerca volvulus 0.0028 0.3306 0.6611
Brugia malayi Fes/CIP4 homology domain containing protein 0.0027 0.3179 0.2816
Onchocerca volvulus 0.0028 0.3306 0.6611
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0028 0.3306 0.3306
Loa Loa (eye worm) hypothetical protein 0.0027 0.3179 0.3179
Schistosoma mansoni tensin 0.0028 0.3306 0.3037
Schistosoma mansoni hypothetical protein 0.0028 0.3306 0.3037
Loa Loa (eye worm) hypothetical protein 0.0036 0.4741 0.4741
Brugia malayi SH2 domain containing protein 0.0028 0.3306 0.295
Echinococcus multilocularis SH2 motif 0.0028 0.3306 0.3037
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0028 0.3306 0.3037
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0027 0.3179 0.2899
Brugia malayi SH2 domain containing protein 0.0028 0.3306 0.295
Echinococcus granulosus tyrosine protein kinase Src42A 0.0028 0.3306 0.3037
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0055 0.8292 0.8292
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.4741 0.4741
Echinococcus multilocularis endophilin A3 0.0027 0.3179 0.2899
Echinococcus multilocularis intersectin 2 0.0027 0.3179 0.2899
Echinococcus granulosus tyrosine protein kinase Lyn 0.0063 0.9727 1
Brugia malayi Variant SH3 domain containing protein 0.0055 0.8292 0.8201
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0027 0.3179 0.2899
Loa Loa (eye worm) hypothetical protein 0.0028 0.3306 0.3306
Schistosoma mansoni run and tbc1 domain containing 0.0027 0.3179 0.2899
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.3179 1
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.3179 1
Onchocerca volvulus 0.0036 0.4741 1
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0027 0.3179 1
Loa Loa (eye worm) p53BP2 0.0027 0.3179 0.3179
Echinococcus multilocularis SH2 motif 0.0028 0.3306 0.3037
Leishmania major hypothetical protein, conserved 0.0027 0.3179 1
Schistosoma mansoni tensin-related 0.0028 0.3306 0.3037
Schistosoma mansoni tyrosine kinase 0.0063 0.9727 1
Onchocerca volvulus 0.0028 0.3306 0.6611
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0028 0.3306 0.3037
Schistosoma mansoni Dab2-interacting protein-like 0.0027 0.3179 0.2899
Echinococcus granulosus expressed protein 0.0027 0.3179 0.2899
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.3179 1
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0027 0.3179 0.2899
Echinococcus multilocularis SH2 domain containing protein 7 0.0028 0.3306 0.3037
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0027 0.3179 0.2899
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0028 0.3306 0.3306
Brugia malayi RhoGAP domain containing protein 0.0028 0.3306 0.295
Onchocerca volvulus 0.0036 0.4741 1
Entamoeba histolytica protein kinase, putative 0.0028 0.3306 0.0812
Brugia malayi Spectrin alpha chain 0.0027 0.3179 0.2816
Onchocerca volvulus 0.0027 0.3179 0.6312
Echinococcus granulosus SH2 motif 0.0028 0.3306 0.3037
Echinococcus granulosus SH2 domain containing adapter protein F 0.0028 0.3306 0.3037
Loa Loa (eye worm) hypothetical protein 0.0055 0.8292 0.8292
Wolbachia endosymbiont of Brugia malayi succinyl-CoA synthetase, alpha subunit 0.0013 0.0505 0.5
Brugia malayi SH2 domain containing protein 0.0028 0.3306 0.295
Brugia malayi SRC-1 0.0063 0.9727 0.9713
Echinococcus granulosus fch and double sh3 domains protein 2 0.0027 0.3179 0.2899
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0028 0.3306 0.3037
Brugia malayi Variant SH3 domain containing protein 0.0027 0.3179 0.2816
Schistosoma mansoni adapter molecule crk 0.0055 0.8292 0.8443
Loa Loa (eye worm) hypothetical protein 0.0027 0.3179 0.3179
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.4614 0.4456
Schistosoma mansoni eps8-related protein 0.0027 0.3179 0.2899
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0063 0.9727 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.3179 1
Echinococcus granulosus SH2 motif 0.0028 0.3306 0.3037
Echinococcus granulosus tyrosine protein kinase Srms 0.0036 0.4741 0.4593
Schistosoma mansoni apoptosis stimulating of P53 0.0027 0.3179 0.2899
Loa Loa (eye worm) hypothetical protein 0.0028 0.3306 0.3306
Echinococcus granulosus tyrosine kinase 0.0036 0.4741 0.4593
Brugia malayi Guanylate kinase family protein 0.0027 0.3179 0.2816
Loa Loa (eye worm) hypothetical protein 0.0028 0.3306 0.3306
Loa Loa (eye worm) hypothetical protein 0.0028 0.3306 0.3306
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.3179 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.3306 0.3306
Schistosoma mansoni ATP-citrate synthase 0.0055 0.8193 0.8337
Brugia malayi Variant SH3 domain containing protein 0.0027 0.3179 0.2816
Brugia malayi Protein kinase domain containing protein 0.0036 0.4741 0.4461
Schistosoma mansoni dynamin-associated protein 0.0027 0.3179 0.2899
Loa Loa (eye worm) hypothetical protein 0.0027 0.3179 0.3179
Schistosoma mansoni nck2/grb4 0.0055 0.8292 0.8443
Loa Loa (eye worm) hypothetical protein 0.0027 0.3179 0.3179
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0028 0.3306 0.3037
Schistosoma mansoni tyrosine kinase 0.0036 0.4741 0.4593
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0027 0.3179 0.2899
Trypanosoma brucei conserved protein 0.0027 0.3179 1
Chlamydia trachomatis succinyl-CoA ligase subunit alpha 0.0013 0.0505 0.5
Echinococcus granulosus signal transduction protein lnk realted 0.0028 0.3306 0.3037
Echinococcus granulosus tyrosine protein kinase Blk 0.0036 0.4741 0.4593
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0028 0.3306 0.3037
Loa Loa (eye worm) hypothetical protein 0.0028 0.3306 0.3306
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0063 0.9727 1
Echinococcus multilocularis NCK adaptor protein 0.0055 0.8292 0.8443
Onchocerca volvulus 0.0027 0.3179 0.6312
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0027 0.3179 0.2899
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0027 0.3179 0.2899
Brugia malayi Variant SH3 domain containing protein 0.0028 0.3306 0.295
Echinococcus granulosus tyrosine protein kinase shark 0.0036 0.4741 0.4593
Toxoplasma gondii ATP-citrate lyase, putative 0.0064 1 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0063 0.9727 1
Onchocerca volvulus 0.0028 0.3306 0.6611
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0036 0.4741 0.4593
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0028 0.3306 0.6611
Brugia malayi Tensin 0.0028 0.3306 0.295
Echinococcus multilocularis SHC transforming protein 3 0.0028 0.3306 0.3037
Entamoeba histolytica SH2 domain containing protein 0.0028 0.3306 0.0812
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0028 0.3306 0.6611
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0028 0.3306 0.3037
Onchocerca volvulus Putative cortactin 0.0027 0.3179 0.6312
Mycobacterium ulcerans succinyl-CoA synthetase subunit alpha 0.0013 0.0505 0.5
Brugia malayi Variant SH3 domain containing protein 0.0027 0.3179 0.2816
Loa Loa (eye worm) TK protein kinase 0.0036 0.4741 0.4741
Schistosoma mansoni tensin 0.0028 0.3306 0.3037
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0027 0.3179 0.3179
Echinococcus granulosus epidermal growth factor receptor kinase 0.0027 0.3179 0.2899
Echinococcus multilocularis Spectrin alpha actinin 0.0027 0.3179 0.2899
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.3179 1
Onchocerca volvulus 0.0028 0.3306 0.6611
Loa Loa (eye worm) succinate-CoA ligase 0.0013 0.0505 0.0505
Echinococcus granulosus expressed conserved protein 0.0028 0.3306 0.3037
Onchocerca volvulus 0.0027 0.3179 0.6312
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0028 0.3306 0.3037
Echinococcus multilocularis tensin 0.0028 0.3306 0.3037
Echinococcus granulosus tensin 0.0028 0.3306 0.3037
Schistosoma mansoni tensin-related 0.0028 0.3306 0.3037
Echinococcus granulosus NCK adaptor protein 0.0055 0.8292 0.8443
Schistosoma mansoni tensin 0.0028 0.3306 0.3037
Loa Loa (eye worm) SH2 domain-containing protein 0.0028 0.3306 0.3306
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0063 0.9727 1
Onchocerca volvulus 0.0036 0.4741 1
Onchocerca volvulus 0.0036 0.4741 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0063 0.9727 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0063 0.9727 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.3179 0.3179
Schistosoma mansoni sorting nexin 0.0027 0.3179 0.2899
Schistosoma mansoni dreadlocks/dock 0.0027 0.3179 0.2899
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0027 0.3179 0.6312
Loa Loa (eye worm) hypothetical protein 0.0028 0.3306 0.3306
Brugia malayi cytokine inducible SH2-containing protein 5 0.0028 0.3306 0.295
Plasmodium vivax succinyl-CoA synthetase alpha subunit, putative 0.0013 0.0505 0.5
Onchocerca volvulus 0.0027 0.3179 0.6312
Brugia malayi Variant SH3 domain containing protein 0.0027 0.3179 0.2816
Schistosoma mansoni growth factor receptor-bound protein 0.0055 0.8292 0.8443
Onchocerca volvulus 0.0036 0.4741 1
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0027 0.3179 0.2899
Echinococcus granulosus tyrosine protein kinase ABL1 0.0036 0.4741 0.4593
Loa Loa (eye worm) SH2 domain-containing protein 0.0028 0.3306 0.3306
Loa Loa (eye worm) hypothetical protein 0.0028 0.3306 0.3306
Brugia malayi Protein kinase domain containing protein 0.0036 0.4741 0.4461
Loa Loa (eye worm) hypothetical protein 0.0027 0.3179 0.3179
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.4741 0.4741
Echinococcus granulosus N chimaerin 0.0028 0.3306 0.3037
Echinococcus multilocularis SH2 motif 0.0028 0.3306 0.3037
Brugia malayi Tyrosine-protein kinase abl-1 0.0063 0.9727 0.9713
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0027 0.3179 0.2899
Schistosoma mansoni tyrosine kinase 0.0063 0.9727 1
Schistosoma mansoni sorbin 0.0027 0.3179 0.2899
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.4741 0.4741
Schistosoma mansoni tyrosine kinase 0.0063 0.9727 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0036 0.4741 0.4593
Echinococcus granulosus src region 0.0027 0.3179 0.2899
Echinococcus granulosus tyrosine protein kinase Fyn 0.0063 0.9727 1
Echinococcus granulosus SH2 domain containing protein 7 0.0028 0.3306 0.3037
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0028 0.3306 0.3037
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.3179 1
Onchocerca volvulus 0.0036 0.4741 1
Onchocerca volvulus 0.0027 0.3179 0.6312
Echinococcus granulosus endophilin A3 0.0027 0.3179 0.2899
Plasmodium falciparum succinyl-CoA synthetase alpha subunit, putative 0.0013 0.0505 0.5
Echinococcus multilocularis N chimaerin 0.0028 0.3306 0.3037
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.4741 0.4741
Echinococcus multilocularis growth factor receptor bound protein 2 0.0055 0.8292 0.8443
Echinococcus granulosus Spectrin alpha actinin 0.0027 0.3179 0.2899
Trichomonas vaginalis p67phox protein, putative 0.0027 0.3179 1
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0027 0.3179 0.2899
Echinococcus granulosus tyrosine protein kinase Src64B 0.0063 0.9727 1
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.4741 0.4741
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0028 0.3306 0.0812
Mycobacterium leprae Probable succinyl-CoA synthetase (alpha chain) SucD (SCS-alpha) 0.0013 0.0505 0.5
Brugia malayi Variant SH3 domain containing protein 0.0027 0.3179 0.2816
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.3306 0.3306
Loa Loa (eye worm) SH2 domain-containing protein 0.0028 0.3306 0.3306
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.4741 0.4741
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.4741 0.4593
Loa Loa (eye worm) hypothetical protein 0.0028 0.3306 0.3306
Brugia malayi SH2 domain containing protein 0.0028 0.3306 0.295
Echinococcus granulosus SHC transforming protein 3 0.0028 0.3306 0.3037
Echinococcus multilocularis signal transduction protein lnk realted 0.0028 0.3306 0.3037
Echinococcus granulosus tyrosine protein kinase Fyn 0.0063 0.9727 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0063 0.9727 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0028 0.3306 0.3037
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0036 0.4741 0.4593
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0036 0.4741 0.4593
Loa Loa (eye worm) hypothetical protein 0.0028 0.3306 0.3306
Echinococcus granulosus tyrosine kinase 0.0036 0.4741 0.4593
Schistosoma mansoni GTPase activating protein 0.0028 0.3306 0.3037
Schistosoma mansoni formin binding protein and related proteins 0.0027 0.3179 0.2899
Echinococcus granulosus c src tyrosine kinase 0.0063 0.9727 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0028 0.3306 0.3037
Brugia malayi SH2 domain containing protein 0.0028 0.3306 0.295
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0027 0.3179 0.2899
Mycobacterium tuberculosis Probable succinyl-CoA synthetase (alpha chain) SucD (SCS-alpha) 0.0013 0.0505 0.5
Schistosoma mansoni hypothetical protein 0.0027 0.3179 0.2899
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0027 0.3179 0.2899
Echinococcus multilocularis tensin 0.0028 0.3306 0.3037
Brugia malayi SH2 domain containing protein 0.0028 0.3306 0.295
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0063 0.9727 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0063 0.9727 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.3179 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.3306 0.3306
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.4741 0.4741
Brugia malayi Sex muscle abnormal protein 5 0.0055 0.8292 0.8201
Echinococcus granulosus hypothetical protein 0.0028 0.3306 0.3037
Brugia malayi STAT protein, DNA binding domain containing protein 0.0028 0.3306 0.295
Echinococcus granulosus tyrosine protein kinase Fyn 0.0063 0.9727 1
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.3179 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0063 0.9727 1
Brugia malayi protein-tyrosine kinase 0.0036 0.4741 0.4461
Echinococcus granulosus nostrin 0.0027 0.3179 0.2899
Echinococcus multilocularis tyrosine protein kinase shark 0.0036 0.4741 0.4593
Loa Loa (eye worm) hypothetical protein 0.0028 0.3306 0.3306
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.3179 1
Brugia malayi hypothetical protein 0.0036 0.4741 0.4461
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0028 0.3306 0.3037
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0063 0.9727 1
Brugia malayi SH3 domain containing protein 0.0027 0.3179 0.2816
Brugia malayi Variant SH3 domain containing protein 0.0027 0.3179 0.2816
Brugia malayi protein-tyrosine kinase 0.0027 0.3179 0.2816
Brugia malayi tRNA modification GTPase TrmE family protein 0.0028 0.3306 0.295
Loa Loa (eye worm) protein-tyrosine kinase 0.0027 0.3179 0.3179
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0028 0.3306 0.3037
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0036 0.4741 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0028 0.3306 0.3037
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0027 0.3179 0.2899
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0028 0.3306 0.3037
Schistosoma mansoni hypothetical protein 0.0027 0.3179 0.2899
Loa Loa (eye worm) hypothetical protein 0.0028 0.3306 0.3306

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 18 uM Inhibition of rat liver ACLY ChEMBL. 21726077

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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