Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | References |
Homo sapiens | glucosidase, beta (bile acid) 2 | Starlite/ChEMBL | References |
Homo sapiens | UDP-glucose ceramide glucosyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.8753 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.8753 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.283 | 0.1027 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0332 | 1 | 1 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0332 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0332 | 1 | 1 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0332 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0332 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0269 | 0.6101 | 0.2159 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0332 | 1 | 1 |
Loa Loa (eye worm) | sodium/hydrogen exchanger 3 family protein | 0.0332 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 (nhe2) | 0.0269 | 0.6101 | 0.2159 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0288 | 0.7287 | 0.4544 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0288 | 0.7287 | 0.6544 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.8753 | 1 |
Schistosoma mansoni | sodium/hydrogen exchanger | 0.0332 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.8753 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0332 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0332 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.8753 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0332 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.283 | 0.1027 |
Schistosoma mansoni | sodium/hydrogen exchanger 2 (nhe2) | 0.0332 | 1 | 1 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0288 | 0.7287 | 0.4544 |
Loa Loa (eye worm) | sodium/hydrogen exchanger | 0.0332 | 1 | 1 |
Loa Loa (eye worm) | NHE-3 | 0.0332 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0332 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0332 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.8753 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.7287 | 0.4544 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0332 | 1 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0312 | 0.8753 | 0.5402 |
Giardia lamblia | Sodium/hydrogen exchanger 3 | 0.0332 | 1 | 0.5 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0332 | 1 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0288 | 0.7287 | 0.7287 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0312 | 0.8753 | 0.8753 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.7287 | 0.4544 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 140 % | Activation of lysosomal beta-glucosidase N370S mutant (unknown origin) at 25 to 75 uM relative to control | ChEMBL. | No reference |
IC50 (binding) | = 9 nM | Inhibition of GBA2 (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | = 500 nM | Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry | ChEMBL. | 25250725 |
IC50 (binding) | = 1 uM | Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide | ChEMBL. | 25250725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.