Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | UDP-glucose ceramide glucosyltransferase | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ceramide glucosyltransferase | 0.0288 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.104 | 0.0976 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0181 | 0.0111 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5437 | 0.5405 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0288 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.011 | 0.0039 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.104 | 0.0976 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0131 | 0.4176 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0764 | 0.051 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0288 | 1 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0677 | 0.061 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0181 | 0.0111 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5437 | 0.5405 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.104 | 0.104 |
Brugia malayi | Bromodomain containing protein | 0.0075 | 0.2124 | 0.1906 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.169 | 0.163 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0181 | 0.0111 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.104 | 0.0976 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.104 | 0.0976 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.1557 | 0.1497 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0855 | 0.0855 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.104 | 0.0976 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0677 | 0.061 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.011 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0767 | 0.0767 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1965 | 0.1965 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.104 | 0.0976 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0288 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.104 | 0.0793 |
Echinococcus multilocularis | geminin | 0.0165 | 0.5437 | 0.5405 |
Echinococcus granulosus | geminin | 0.0165 | 0.5437 | 0.5405 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0925 | 0.0925 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.104 | 0.0976 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 1 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.1557 | 0.1497 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 nM | Inhibition of GCS assessed as amount of UDP glucose after 3 hrs by Fluorometry analysis | ChEMBL. | 22497444 |
IC50 (binding) | = 120 nM | Inhibition of GCS in human A549 cells assessed as decrease in GM1 synthesis after 72 hrs by Fluorescence assay | ChEMBL. | 22497444 |
IC50 (ADMET) | = 1530 nM | Inhibition of human CYP3A4 using testosterone as substrate after 45 mins | ChEMBL. | 22497444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.