Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 4 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-C motif) receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | chemokine (C-C motif) receptor 4 | 360 aa | 316 aa | 22.1 % |
Brugia malayi | hypothetical protein | chemokine (C-C motif) receptor 1 | 355 aa | 289 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0139 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0139 | 1 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0017 | 0.0393 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 1 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0044 | 0.2551 | 0.2551 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0017 | 0.0393 | 0.0393 |
Plasmodium vivax | calpain, putative | 0.0017 | 0.0393 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0139 | 1 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0044 | 0.2551 | 0.2246 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2158 | 0.2158 |
Brugia malayi | calpain family protein 1 | 0.0044 | 0.2551 | 0.2551 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0046 | 0.2688 | 0.2389 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0017 | 0.0393 | 0.1462 |
Trypanosoma brucei | calpain-like protein, putative | 0.0017 | 0.0393 | 0.1462 |
Echinococcus granulosus | cathepsin b | 0.0139 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0046 | 0.2688 | 0.2688 |
Echinococcus multilocularis | calpain A | 0.0046 | 0.2708 | 0.2409 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1637 | 0.1637 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0032 | 0.1637 | 0.1295 |
Trypanosoma brucei | calpain-like protein, putative | 0.0017 | 0.0393 | 0.1462 |
Trypanosoma brucei | calpain-like protein, putative | 0.0017 | 0.0393 | 0.1462 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0017 | 0.0393 | 0.0393 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0046 | 0.2708 | 0.2409 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0017 | 0.0393 | 0.0393 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0046 | 0.2688 | 1 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0046 | 0.2708 | 0.2409 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0017 | 0.0393 | 0.0393 |
Leishmania major | calpain, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0017 | 0.0393 | 0.1462 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.0017 | 0.0393 | 0.1462 |
Echinococcus granulosus | calpain A | 0.0046 | 0.2708 | 0.2409 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0017 | 0.0393 | 0.1462 |
Brugia malayi | calpain 7 | 0.0017 | 0.0393 | 0.0393 |
Onchocerca volvulus | 0.0027 | 0.1244 | 0.5 | |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.0017 | 0.0393 | 0.0393 |
Giardia lamblia | Cathepsin B precursor | 0.0046 | 0.2688 | 0.5 |
Trypanosoma brucei | antigen, putative | 0.0017 | 0.0393 | 0.1462 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0017 | 0.0393 | 0.1462 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0017 | 0.0393 | 0.0393 |
Echinococcus granulosus | cathepsin b | 0.0139 | 1 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0032 | 0.1637 | 0.1637 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0046 | 0.2688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2551 | 0.2551 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0017 | 0.0393 | 0.0393 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0046 | 0.2688 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0139 | 1 | 1 |
Loa Loa (eye worm) | calpain | 0.0017 | 0.0393 | 0.0393 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0139 | 1 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0017 | 0.0393 | 0.0393 |
Giardia lamblia | Cathepsin B precursor | 0.0046 | 0.2688 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1244 | 0.1244 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0046 | 0.2708 | 0.2409 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0017 | 0.0393 | 0.0393 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0139 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0012 | 0 | 0.5 |
Trypanosoma brucei | calpain-like protein, putative | 0.0017 | 0.0393 | 0.1462 |
Loa Loa (eye worm) | cathepsin B | 0.0046 | 0.2688 | 0.2688 |
Toxoplasma gondii | cathepsin B | 0.0046 | 0.2688 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0046 | 0.2708 | 0.2409 |
Giardia lamblia | Cathepsin B precursor | 0.0046 | 0.2688 | 0.5 |
Entamoeba histolytica | calpain large subunit domain III containing protein | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0139 | 1 | 1 |
Brugia malayi | calpain family protein 1 | 0.0044 | 0.2551 | 0.2551 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.1 | Binding affinity to CCR1 by 35S-gamma-GTP membrane assay | ChEMBL. | 23079519 |
Ki (binding) | = 5.5 | Binding affinity to CCR4 by 35S-gamma-GTP membrane assay | ChEMBL. | 23079519 |
Ki (binding) | = 5.8 | Binding affinity to CCR2 by 35S-gamma-GTP membrane assay | ChEMBL. | 23079519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.