Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0056 | 0.3093 | 0.5868 |
Brugia malayi | Cathepsin L-like precursor | 0.0047 | 0.2438 | 0.2438 |
Schistosoma mansoni | cathepsin s | 0.0021 | 0.0425 | 0.0425 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0021 | 0.0425 | 0.0425 |
Plasmodium vivax | vivapain-2 | 0.0069 | 0.41 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0069 | 0.41 | 1 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0021 | 0.0425 | 0.0425 |
Entamoeba histolytica | cysteine protease, putative | 0.0037 | 0.1662 | 0.4054 |
Toxoplasma gondii | cathepsin CPL | 0.0069 | 0.41 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.2438 | 0.5946 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.2438 | 0.5946 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0037 | 0.1662 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.41 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0037 | 0.1662 | 0.1662 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0037 | 0.1662 | 0.1662 |
Giardia lamblia | Cathepsin B precursor | 0.0056 | 0.3093 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0037 | 0.1662 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.41 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.1786 | 0.1786 |
Brugia malayi | Cathepsin L-like precursor | 0.0069 | 0.41 | 0.41 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0069 | 0.41 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.1532 | 0.1532 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0056 | 0.3093 | 0.3093 |
Brugia malayi | Cathepsin L-like precursor | 0.0047 | 0.2438 | 0.2438 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0037 | 0.1662 | 0.4054 |
Onchocerca volvulus | 0.0069 | 0.41 | 1 | |
Brugia malayi | cathepsin L-like precursor | 0.0047 | 0.2438 | 0.2438 |
Entamoeba histolytica | cysteine protease, putative | 0.0037 | 0.1662 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0069 | 0.41 | 0.41 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.41 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0037 | 0.1662 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0069 | 0.41 | 0.41 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0021 | 0.0425 | 0.0425 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.41 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0021 | 0.0425 | 0.0425 |
Leishmania major | cysteine peptidase A (CPA) | 0.0069 | 0.41 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0069 | 0.41 | 0.41 |
Toxoplasma gondii | cathepsin B | 0.0056 | 0.3093 | 0.7543 |
Entamoeba histolytica | cysteine protease, putative | 0.0037 | 0.1662 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.41 | 0.41 |
Entamoeba histolytica | cysteine protease, putative | 0.0037 | 0.1662 | 0.4054 |
Giardia lamblia | Cathepsin B precursor | 0.0056 | 0.3093 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0069 | 0.41 | 0.41 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Onchocerca volvulus | 0.0047 | 0.2438 | 0.5946 | |
Loa Loa (eye worm) | cysteine protease | 0.0069 | 0.41 | 0.41 |
Plasmodium vivax | vivapain-3 | 0.0037 | 0.1662 | 0.4054 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0069 | 0.41 | 0.41 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0069 | 0.41 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0145 | 1 | 1 |
Echinococcus granulosus | cathepsin L | 0.0037 | 0.1662 | 0.1662 |
Echinococcus granulosus | cathepsin b | 0.0145 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.41 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.1532 | 0.1532 |
Onchocerca volvulus | 0.0069 | 0.41 | 1 | |
Brugia malayi | Papain family cysteine protease containing protein | 0.0037 | 0.1662 | 0.1662 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.41 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0037 | 0.1662 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0037 | 0.1662 | 0.4054 |
Echinococcus granulosus | cysteine protease | 0.0037 | 0.1662 | 0.1662 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0145 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.41 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2438 | 0.2438 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.41 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0037 | 0.1662 | 0.4054 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0056 | 0.3093 | 0.3093 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0069 | 0.41 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0047 | 0.2438 | 0.5946 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.41 | 0.41 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.41 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.41 | 0.41 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.41 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0037 | 0.1662 | 0.1662 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0037 | 0.1662 | 0.1662 |
Onchocerca volvulus | 0.0069 | 0.41 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.1662 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0037 | 0.1662 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0069 | 0.41 | 0.41 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0069 | 0.41 | 0.41 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0056 | 0.3093 | 0.7543 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0069 | 0.41 | 0.41 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0425 | 0.0425 |
Trypanosoma cruzi | cysteine protease, putative | 0.0037 | 0.1662 | 0.1662 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0425 | 0.0425 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.41 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0069 | 0.41 | 0.41 |
Echinococcus granulosus | cathepsin b | 0.0145 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0145 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.1532 | 0.1532 |
Onchocerca volvulus | Cathepsin L homolog | 0.0069 | 0.41 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0056 | 0.3093 | 0.3093 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0069 | 0.41 | 0.41 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2438 | 0.2438 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0037 | 0.1662 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.41 | 0.41 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0069 | 0.41 | 0.41 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.1662 | 0.4054 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0069 | 0.41 | 0.41 |
Plasmodium vivax | unspecified product | 0.0021 | 0.0425 | 0.1037 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.41 | 0.41 |
Giardia lamblia | Cathepsin B precursor | 0.0056 | 0.3093 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0037 | 0.1662 | 0.4054 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0145 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0069 | 0.41 | 0.41 |
Onchocerca volvulus | 0.0069 | 0.41 | 1 | |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.1532 | 0.1532 |
Echinococcus multilocularis | cysteine protease | 0.0069 | 0.41 | 0.41 |
Entamoeba histolytica | cysteine protease, putative | 0.0037 | 0.1662 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Plasmodium vivax | vivapain-2 | 0.0069 | 0.41 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0069 | 0.41 | 0.41 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0037 | 0.1662 | 0.4054 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0037 | 0.1662 | 0.1662 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0037 | 0.1662 | 0.4054 |
Onchocerca volvulus | 0.0069 | 0.41 | 1 | |
Plasmodium vivax | vivapain-1 | 0.0037 | 0.1662 | 0.4054 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0037 | 0.1662 | 0.1662 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.41 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0047 | 0.2438 | 0.2438 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.41 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0069 | 0.41 | 0.41 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0145 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0069 | 0.41 | 1 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.41 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0037 | 0.1662 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0425 | 0.0425 |
Plasmodium vivax | unspecified product | 0.0037 | 0.1662 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0047 | 0.2438 | 0.2438 |
Onchocerca volvulus | Cathepsin F homolog | 0.0069 | 0.41 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0069 | 0.41 | 0.41 |
Loa Loa (eye worm) | fibroinase | 0.0069 | 0.41 | 0.41 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0069 | 0.41 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.1786 | 0.1786 |
Onchocerca volvulus | 0.0069 | 0.41 | 1 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0033 | 0.135 | 0.3292 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0037 | 0.1662 | 0.1662 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0047 | 0.2438 | 0.2438 |
Entamoeba histolytica | cysteine protease, putative | 0.0037 | 0.1662 | 0.4054 |
Echinococcus multilocularis | cathepsin b | 0.0145 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.41 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0145 | 1 | 1 |
Onchocerca volvulus | 0.0069 | 0.41 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1166 | 0.1166 |
Brugia malayi | Cathepsin L-like precursor | 0.0069 | 0.41 | 0.41 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0037 | 0.1662 | 0.1662 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.41 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0069 | 0.41 | 0.41 |
Echinococcus granulosus | cathepsin l1 | 0.0047 | 0.2438 | 0.2438 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0021 | 0.0425 | 0.0425 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0037 | 0.1662 | 0.4054 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0037 | 0.1662 | 0.1662 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0069 | 0.41 | 0.41 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2438 | 0.2438 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.41 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.41 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.41 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0021 | 0.0425 | 0.0425 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0033 | 0.135 | 0.3292 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0069 | 0.41 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0037 | 0.1662 | 0.1662 |
Entamoeba histolytica | cysteine protease, putative | 0.0069 | 0.41 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0069 | 0.41 | 0.41 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 61.59 % | Cytotoxicity against HEK293T cells assessed as cellular growth at 100 uM by MTT assay | ChEMBL. | 23137434 |
MIC (functional) | = 28.52 uM | Antitubercular activity against log phase culture of Mycobacterium tuberculosis H37Rv ATCC 27294 by agar dilution method | ChEMBL. | 23137434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.