Detailed information for compound 1689126

Basic information

Technical information
  • TDR Targets ID: 1689126
  • Name: 9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxol an-2-yl]purine-6-sulfonamide
  • MW: 315.306 | Formula: C10H13N5O5S
  • H donors: 3 H acceptors: 7 LogP: -1.68 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1cnc2c1ncnc2S(=O)(=O)N
  • InChi: 1S/C10H13N5O5S/c11-21(18,19)10-8-9(12-3-13-10)15(4-14-8)7-1-5(17)6(2-16)20-7/h3-7,16-17H,1-2H2,(H2,11,18,19)/t5-,6+,7+/m0/s1
  • InChiKey: ILAVFZUCFZBBQF-RRKCRQDMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]purine-6-sulfonamide
  • 9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-6-purinesulfonamide
  • 9-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]purine-6-sulfonamide
  • 9H-Purine-6-sulfonamide, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-
  • AIDS-348386
  • AIDS348386

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA binding protein 0.0066 0.0292 0.1225
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0156 0.2128
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0292 0.1225
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1716 0.371
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1716 0.371
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0024 0.0016
Echinococcus granulosus RUN 0.0021 0.0024 0.0016
Treponema pallidum penicillin-binding protein (pbp-1) 0.1715 1 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0105 0.0162
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0024 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0156 0.2201
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.1716 1
Entamoeba histolytica hypothetical protein 0.0025 0.0046 0.021
Echinococcus granulosus dna polymerase kappa 0.0043 0.0156 0.0166
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0258 0.028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1716 0.371
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0032 0.0404
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0156 0.0166
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0046 0.0042
Schistosoma mansoni ap endonuclease 0.0019 0.0011 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0156 0.2201
Echinococcus granulosus lamin dm0 0.0031 0.0086 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0156 0.2201
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0046 0.0061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1716 0.371
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0024 0.0016
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0046 0.0036
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0156 0.0317
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0156 0.0169
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0292 0.0319
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.025 0.9687
Brugia malayi TAR-binding protein 0.0066 0.0292 0.1225
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0094 0.1304
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0117 0.0591 0.0674
Echinococcus granulosus transcription factor Dp 1 0.0078 0.0361 0.0396
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0046 0.1452
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0135 0.0695 0.4012
Trichomonas vaginalis set domain proteins, putative 0.048 0.2729 0.5913
Echinococcus multilocularis lamin 0.0031 0.0086 0.0086
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0315 0.1756 0.2025
Echinococcus granulosus lamin 0.0031 0.0086 0.0086
Schistosoma mansoni lamin 0.0031 0.0086 0.0086
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0129 0.1733
Brugia malayi follicle stimulating hormone receptor 0.0269 0.1486 0.6228
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0258 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0024 0.0016
Loa Loa (eye worm) inositol-1 0.0039 0.0129 0.0541
Loa Loa (eye worm) hypothetical protein 0.0061 0.0258 0.1079
Trichomonas vaginalis glutaminase, putative 0.0288 0.1599 0.3455
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.025 0.052
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0156 0.0169
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0156 0.2201
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0135 0.0695 0.0773
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0129 0.0258
Echinococcus multilocularis microtubule associated protein 2 0.1525 0.8883 1
Mycobacterium ulcerans penicillin-binding protein PbpA 0.1013 0.5869 0.6797
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.055 0.3141 0.3632
Onchocerca volvulus 0.0088 0.0418 0.1456
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0129 0.0135
Onchocerca volvulus 0.048 0.2729 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0117 0.0591 0.8481
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0024 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1716 0.371
Schistosoma mansoni inositol monophosphatase 0.0039 0.0129 0.0135
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0258 0.028
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0156 0.2201
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.025 0.1047
Loa Loa (eye worm) hypothetical protein 0.0088 0.0418 0.175
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0292 0.1225
Brugia malayi Inositol-1 0.0039 0.0129 0.0541
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0156 0.0317
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.025 0.3496
Echinococcus multilocularis RUN 0.0021 0.0024 0.0016
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0135 0.0695 0.0773
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0129 0.0695
Treponema pallidum penicillin-binding protein (pbp-3) 0.1482 0.863 0.8628
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0129 0.0119
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0129 0.181
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1716 0.371
Schistosoma mansoni intermediate filament proteins 0.0031 0.0086 0.0086
Giardia lamblia DINP protein human, muc B family 0.0022 0.0032 0.0126
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0799 0.4608 0.7834
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0046 0.1452
Brugia malayi glutaminase DH11.1 0.0288 0.1599 0.6702
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0242 0.1015
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0151 0.0788 0.0902
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0046 0.0612
Brugia malayi hypothetical protein 0.0021 0.0024 0.0099
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0038
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0011 0.0002
Echinococcus granulosus intermediate filament protein 0.0031 0.0086 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0292 0.0319
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0117 0.0591 0.0656
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.1716 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0418 0.175
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0046 0.0042
Giardia lamblia Fructose-bisphosphate aldolase 0.0308 0.1716 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0151 0.0788 0.1273
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.025 0.0271
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0258 0.028
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.025 0.0271
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0418 0.046
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0292 0.0319
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1716 0.371
Chlamydia trachomatis transglycolase/transpeptidase 0.0781 0.4499 0.4473
Brugia malayi Pre-SET motif family protein 0.0061 0.0258 0.1079
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0109 0.0545 0.2282
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0011 0.0092
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0032 0.0314
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0009 0.0038
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0135 0.0695 0.2913
Schistosoma mansoni lamin 0.0031 0.0086 0.0086
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0418 0.046
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.0634 0.0704
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0117 0.0591 0.2477
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0359
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0032 0.0037
Leishmania major DNA polymerase kappa, putative 0.0022 0.0032 0.0314
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.025 0.0271
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0156 0.2201
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0117 0.0591 0.0656
Echinococcus granulosus microtubule associated protein 2 0.1525 0.8883 1
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0799 0.4608 0.5334
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0156 0.2201
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0129 0.1733
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0134 0.0563
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0086 0.0359
Onchocerca volvulus 0.0031 0.0086 0.0229
Loa Loa (eye worm) glutaminase 2 0.0288 0.1599 0.6702
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0046 1
Treponema pallidum penicillin-binding protein (pbp-2) 0.0799 0.4608 0.4603
Loa Loa (eye worm) hypothetical protein 0.0033 0.0094 0.0395
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0094 0.1304
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.025 0.3496
Loa Loa (eye worm) glutaminase 0.0288 0.1599 0.6702
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0117 0.0591 0.0656
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0695 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0156 0.2201
Trichomonas vaginalis conserved hypothetical protein 0.0799 0.4608 1
Brugia malayi intermediate filament protein 0.0031 0.0086 0.0359
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0258 0.028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1716 0.371
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0046 0.0036
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.0634 0.0704
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0115 0.1608
Schistosoma mansoni ap endonuclease 0.0019 0.0011 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0292 0.0319
Schistosoma mansoni hypothetical protein 0.0021 0.0024 0.0016
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.1013 0.5869 1
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0466 0.2645 0.4462
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.025 0.1403
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0129 0.0258
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0249 0.1368 0.2317
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0242 0.1015
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0011 0.0002
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0024 0.0016
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0086 0.0359
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.055 0.3141 0.5344
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0422 0.2386 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0129 0.4802
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0117 0.0591 0.0991
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0129 0.0138
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.025 0.3556
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0011 0.0044
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0011 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0156 0.2201
Trypanosoma brucei unspecified product 0.0036 0.0115 0.1608
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0258 0.028
Schistosoma mansoni loxhd1 0.0021 0.0024 0.0016
Onchocerca volvulus 0.0061 0.0258 0.0865
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0117 0.0591 0.0674
Echinococcus granulosus tar DNA binding protein 0.0066 0.0292 0.0319
Trypanosoma brucei protein kinase, putative 0.0059 0.025 0.3556
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0292 0.0319
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0129 0.0135
Schistosoma mansoni inositol monophosphatase 0.0039 0.0129 0.0135
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0105 0.0101
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.025 0.0271
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.025 0.0271
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.1013 0.5869 1
Plasmodium vivax SET domain protein, putative 0.0061 0.0258 1
Loa Loa (eye worm) RNA binding protein 0.0066 0.0292 0.1225
Echinococcus multilocularis musashi 0.0031 0.0086 0.0086
Brugia malayi MAP kinase sur-1 0.0059 0.025 0.1047
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0151 0.0788 0.1327
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.1482 0.863 1
Onchocerca volvulus 0.0031 0.0086 0.0229
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0258 0.028
Schistosoma mansoni microtubule-associated protein tau 0.1525 0.8883 1
Mycobacterium ulcerans glutaminase 0.0288 0.1599 0.1843
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0009 0.0038
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0024 0.3651
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0129 0.1733
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0156 0.2128
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.1715 1 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0695 1
Brugia malayi Pre-SET motif family protein 0.0422 0.2386 1
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0086 0.0359
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0292 0.1225
Schistosoma mansoni hypothetical protein 0.004 0.0134 0.0141
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0156 0.2128
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0129 0.0258
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0156 0.2128
Schistosoma mansoni lipoxygenase 0.0124 0.0634 0.0704
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.025 0.052
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.025 0.3496
Loa Loa (eye worm) hypothetical protein 0.004 0.0134 0.0563
Schistosoma mansoni polycystin 1-related 0.0021 0.0024 0.0016
Brugia malayi Doublecortin family protein 0.0021 0.0024 0.0099
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.025 0.052
Loa Loa (eye worm) hypothetical protein 0.0058 0.0242 0.1015
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0135 0.0695 1
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0024 0.0099
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.025 0.3496
Schistosoma mansoni rab6-interacting 0.0021 0.0024 0.0016
Brugia malayi hypothetical protein 0.0021 0.0024 0.0099
Echinococcus multilocularis lamin dm0 0.0031 0.0086 0.0086
Schistosoma mansoni rab6-interacting 0.0021 0.0024 0.0016
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0244 0.0265
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0135 0.0695 0.2913
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0156 0.2201
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0024 0.053
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0135 0.0695 0.0773
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.025 0.3496
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.025 0.3496
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0242 0.1015
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.025 0.052
Schistosoma mansoni glutaminase 0.0288 0.1599 0.1792
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0315 0.1756 0.2935
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0315 0.1756 0.2979
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0258 0.028
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0418 0.046
Loa Loa (eye worm) hypothetical protein 0.0031 0.0082 0.0345
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0269 0.1486 0.6228
Schistosoma mansoni lipoxygenase 0.0087 0.0413 0.0455
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0156 0.2201
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0099
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.055 0.3141 0.5315
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0009 0.0038
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0466 0.2645 0.4496
Echinococcus multilocularis transcription factor Dp 1 0.0078 0.0361 0.0396
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0046 0.1452
Brugia malayi polk-prov protein 0.0033 0.0094 0.0395
Treponema pallidum fructose-bisphosphate aldolase 0.0308 0.1716 0.1708
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0695 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0292 0.0319
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0099
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0046 0.0524

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.