Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.2565 | 0.254 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.0904 | 0.0872 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0117 | 0.069 | 0.069 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0046 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0117 | 0.069 | 0.0658 |
Onchocerca volvulus | 0.0341 | 0.2755 | 0.5 | |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0631 | 0.5433 | 0.5433 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0046 | 0.0034 | 0.0034 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1125 | 1 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1125 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1125 | 1 | 0.5 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0349 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.28 | 0.2775 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0046 | 0.0034 | 0.0034 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0366 | 0.299 | 0.299 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0046 | 0.0034 | 0.0034 |
Echinococcus granulosus | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1125 | 1 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.008 | 0.0349 | 0.0349 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.1125 | 1 | 0.5 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.1125 | 1 | 0.5 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.1125 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0046 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.2565 | 0.254 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.0904 | 0.0872 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.2565 | 0.254 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0046 | 0.0034 | 0.0034 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.1125 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.1125 | 1 | 0.5 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.0904 | 0.0904 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.1125 | 1 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0631 | 0.5433 | 0.5433 |
Plasmodium falciparum | adenosylhomocysteinase | 0.1125 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.069 | 0.0658 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.1125 | 1 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0046 | 0.0034 | 0.0034 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0046 | 0.0034 | 0.0034 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0046 | 0.0034 | 0.0034 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.1125 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0117 | 0.069 | 0.069 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0349 | 0.0349 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.1125 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1125 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0696 | 0.604 | 0.604 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.0564 nM | The compound was tested In vitro for the ability to inhibit electrically induced contractions of the mouse vas deferens | ChEMBL. | 2536436 |
IC50 (functional) | = 0.0745 nM | The compound was tested In vitro for the ability to inhibit electrically induced contractions of the mouse vas deferens | ChEMBL. | 2536436 |
IC50 (functional) | = 13.3 nM | The compound was tested In vitro for the ability to inhibit electrically induced contractions of the guinea pig ileum | ChEMBL. | 2536436 |
IC50 (functional) | = 13.7 nM | The compound was tested In vitro for the ability to inhibit electrically induced contractions of the guinea pig ileum | ChEMBL. | 2536436 |
Ki (binding) | = 0.63 nM | The compound was tested for the ability to displace opioid receptor delta specific radioligand [3H]-DPDPE | ChEMBL. | 2536436 |
Ki (binding) | = 0.94 nM | The compound was tested for the ability to displace delta-receptor specific radioligand [3H]-DPDPE | ChEMBL. | 2536436 |
Ki (binding) | = 2.3 nM | The compound was tested for the ability to displace opioid receptor delta specific radioligand [3H]-DSLET | ChEMBL. | 2536436 |
Ki (binding) | = 3.27 nM | The compound was tested for the ability to displace delta-receptor specific radioligand [3H]-DSLET | ChEMBL. | 2536436 |
Ki (binding) | = 14.4 nM | The compound was tested for the ability to displace Opioid receptor mu 1 specific radioligand [3H]-DAGO | ChEMBL. | 2536436 |
Ki (binding) | = 20.9 nM | The compound was tested for the ability to displace mu-receptor specific radioligand [3H]-DAGO | ChEMBL. | 2536436 |
Ratio (binding) | = 178 | Ratio of inhibition of electrically induced contractions in GPI and MVD | ChEMBL. | 2536436 |
Ratio (functional) | = 242 | Ratio of inhibition of electrically induced contractions in GPI and MVD | ChEMBL. | 2536436 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.