Detailed information for compound 1692253

Basic information

Technical information
  • TDR Targets ID: 1692253
  • Name: 4-diethylaminobut-2-ynyl (2S)-2-cyclohexyl-2- hydroxy-2-phenylacetate hydrochloride
  • MW: 393.947 | Formula: C22H32ClNO3
  • H donors: 1 H acceptors: 2 LogP: 4.98 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CC#CCOC(=O)[C@@](c1ccccc1)(C1CCCCC1)O)CC.Cl
  • InChi: 1S/C22H31NO3.ClH/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20;/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3;1H/t22-;/m1./s1
  • InChiKey: SWIJYDAEGSIQPZ-VZYDHVRKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-diethylaminobut-2-ynyl (2S)-2-cyclohexyl-2-hydroxy-2-phenyl-acetate hydrochloride
  • (2S)-2-cyclohexyl-2-hydroxy-2-phenylacetic acid 4-diethylaminobut-2-ynyl ester hydrochloride
  • (2S)-2-cyclohexyl-2-hydroxy-2-phenyl-acetic acid 4-diethylaminobut-2-ynyl ester hydrochloride
  • 4-diethylaminobut-2-ynyl (2S)-2-cyclohexyl-2-hydroxy-2-phenyl-ethanoate hydrochloride
  • 230949-16-3
  • Esoxybutynin Chloride
  • Esoxybutynin Chloride [USAN]
  • 4-[(2S)-2-cyclohexyl-2-hydroxy-2-phenylacetyl]oxybut-2-ynyl-diethylazanium chloride
  • 4-[(2S)-2-cyclohexyl-2-hydroxy-2-phenyl-acetyl]oxybut-2-ynyl-diethyl-ammonium chloride
  • 4-[(2S)-2-cyclohexyl-2-hydroxy-1-oxo-2-phenylethoxy]but-2-ynyl-diethylammonium chloride
  • 4-[(2S)-2-cyclohexyl-2-hydroxy-2-phenyl-ethanoyl]oxybut-2-ynyl-diethyl-azanium chloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dna polymerase kappa 0.0023 0.0169 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Brugia malayi CXXC zinc finger family protein 0.0035 0.0299 0.0297
Echinococcus multilocularis cpg binding protein 0.0037 0.0322 0.0322
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0223 0.0223
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0295 0.3289 0.3195
Leishmania major cathepsin L-like protease 0.0879 1 1
Leishmania major cathepsin L-like protease 0.0879 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0172 0.188 0.1878
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0172 0.188 0.1766
Plasmodium vivax vivapain-3 0.0459 0.5172 0.5104
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0009 0.0002 0.0002
Leishmania major cysteine peptidase A (CPA) 0.0879 1 1
Loa Loa (eye worm) hypothetical protein 0.0287 0.3193 0.3192
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0295 0.3289 0.3289
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0172 0.188 0.1878
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0002 0.0002
Plasmodium vivax unspecified product 0.0459 0.5172 0.5104
Schistosoma mansoni cpg binding protein 0.0037 0.0322 0.0322
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0395 0.0312
Trichomonas vaginalis ran, putative 0.0021 0.0138 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Schistosoma mansoni cathepsin B (C01 family) 0.0172 0.188 0.188
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.3415 0.3323
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0169 0.0031
Plasmodium vivax vivapain-2 0.0879 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0459 0.5172 0.5172
Trypanosoma cruzi cysteine peptidase, putative 0.0287 0.3193 0.3098
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0459 0.5172 0.5104
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0746 0.0746
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Toxoplasma gondii cathepsin B 0.0295 0.3289 0.3195
Entamoeba histolytica hypothetical protein 0.0023 0.0162 0.0024
Trypanosoma cruzi cysteine protease, putative 0.0459 0.5172 0.5104
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.012 0.0118
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0169 0.0031
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.6315 0.6315
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0009 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0879 1 1
Entamoeba histolytica cysteine protease, putative 0.0879 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.012 0.0118
Brugia malayi hypothetical protein 0.0119 0.1269 0.1267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Loa Loa (eye worm) hypothetical protein 0.0593 0.6708 0.6707
Onchocerca volvulus Huntingtin homolog 0.0119 0.1269 0.0999
Trypanosoma cruzi cysteine peptidase, putative 0.0459 0.5172 0.5104
Mycobacterium ulcerans hypothetical protein 0.0161 0.1752 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0172 0.188 0.1766
Schistosoma mansoni cathepsin C 0.0172 0.188 0.188
Echinococcus multilocularis cathepsin L cysteine protease 0.0879 1 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0172 0.188 0.1766
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.012 0.012
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0172 0.188 0.1766
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0169 0.0169
Echinococcus multilocularis cathepsin L cysteine protease 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0169 0.0084
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.0167
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0569 0.6436 0.6436
Brugia malayi RNA, U transporter 1 0.008 0.0816 0.0814
Plasmodium falciparum serine repeat antigen 7 0.0172 0.188 0.1766
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0169 0.0169
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172 0.188 0.188
Plasmodium vivax vivapain-1 0.0459 0.5172 0.5104
Onchocerca volvulus Huntingtin homolog 0.0119 0.1269 0.0999
Entamoeba histolytica cysteine proteinase 1, putative 0.0459 0.5172 0.5104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0172 0.188 0.1878
Schistosoma mansoni DNA polymerase eta 0.0023 0.0169 0.0169
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0592 0.059
Plasmodium vivax vivapain-2 0.0879 1 1
Leishmania major cathepsin L-like protease 0.0879 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0287 0.3193 0.3192
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.012 0.012
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0024 0.0022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0303 0.0303
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.046 0.046
Trypanosoma cruzi cysteine proteinase, putative 0.0459 0.5172 0.5104
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.188 0.1878
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0169 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0172 0.188 0.1878
Trypanosoma cruzi cruzipain precursor, putative 0.0879 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Schistosoma mansoni cathepsin F (C01 family) 0.0593 0.6708 0.6708
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5574 0.5574
Trypanosoma cruzi cysteine proteinase, putative 0.0459 0.5172 0.5104
Onchocerca volvulus 0.0879 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.006 0.0592 0.059
Onchocerca volvulus 0.0879 1 1
Schistosoma mansoni hypothetical protein 0.0205 0.2251 0.2251
Plasmodium vivax unspecified product 0.0287 0.3193 0.3098
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1564 0.1446
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0169 0.0031
Leishmania major mitochondrial DNA polymerase beta 0.0306 0.3415 0.3323
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Loa Loa (eye worm) hypothetical protein 0.0287 0.3193 0.3192
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0223 0.0138
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.188 0.1878
Leishmania major cathepsin L-like protease 0.0879 1 1
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Schistosoma mansoni hypothetical protein 0.0205 0.2251 0.2251
Echinococcus multilocularis geminin 0.0205 0.2251 0.2251
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0049 0.0049
Brugia malayi cathepsin L precursor 0.0172 0.188 0.1878
Leishmania major cathepsin L-like protease 0.0879 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0879 1 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0569 0.6436 0.6435
Trypanosoma brucei cysteine peptidase C (CPC) 0.0295 0.3289 0.3231
Giardia lamblia Cysteine protease 0.0172 0.188 0.5528
Echinococcus granulosus GPCR family 2 0.0019 0.012 0.012
Echinococcus multilocularis cathepsin b 0.0569 0.6436 0.6436
Onchocerca volvulus Cathepsin L homolog 0.0879 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0592 0.059
Giardia lamblia Encystation-specific protease 0.0172 0.188 0.5528
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0459 0.5172 0.5104
Plasmodium vivax unspecified product 0.0172 0.188 0.1766
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0172 0.188 0.1766
Loa Loa (eye worm) hypothetical protein 0.0019 0.012 0.0118
Giardia lamblia Cathepsin B precursor 0.0172 0.188 0.5528
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Brugia malayi Papain family cysteine protease containing protein 0.0459 0.5172 0.5171
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0879 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0413 0.0413
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Schistosoma mansoni importin beta-1 0.0028 0.0223 0.0223
Onchocerca volvulus Cathepsin L homolog 0.0172 0.188 0.1629
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Echinococcus multilocularis cathepsin L 0.0459 0.5172 0.5172
Echinococcus multilocularis cathepsin b 0.0569 0.6436 0.6436
Loa Loa (eye worm) hypothetical protein 0.0287 0.3193 0.3192
Loa Loa (eye worm) ctsf protein 0.0879 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.012 0.012
Schistosoma mansoni hypothetical protein 0.0019 0.012 0.012
Echinococcus granulosus microtubule associated protein 2 0.0699 0.7931 0.7931
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Plasmodium falciparum serine repeat antigen 5 0.0172 0.188 0.1766
Brugia malayi cathepsin L-like precursor 0.0593 0.6708 0.6707
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0569 0.6436 0.6436
Echinococcus granulosus cysteine protease 0.0459 0.5172 0.5172
Giardia lamblia Cathepsin B precursor 0.0172 0.188 0.5528
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172 0.188 0.188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Echinococcus granulosus cathepsin l1 0.0593 0.6708 0.6708
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0303 0.0303
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.3337 0.3336
Onchocerca volvulus Cathepsin L homolog 0.0879 1 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0172 0.188 0.1766
Onchocerca volvulus 0.0593 0.6708 0.6606
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0459 0.5172 0.5171
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0169 0.0084
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Toxoplasma gondii cathepsin CPL 0.0879 1 1
Echinococcus multilocularis microtubule associated protein 2 0.0699 0.7931 0.7931
Onchocerca volvulus 0.0879 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.012 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0172 0.188 0.1878
Loa Loa (eye worm) hypothetical protein 0.0119 0.1269 0.1267
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0172 0.188 0.5528
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0306 0.3415 0.3359
Brugia malayi hypothetical protein 0.0035 0.0303 0.03
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0002 0.0002
Giardia lamblia Cysteine protease 0.0172 0.188 0.5528
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0049 0.0049
Trypanosoma cruzi cysteine peptidase, putative 0.0879 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0049 0.0049
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0172 0.188 0.1766
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.6315 0.6315
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0413 0.041
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0169 0.0169
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0223 0.0086
Schistosoma mansoni cpg binding protein 0.0037 0.0322 0.0322
Plasmodium falciparum cysteine proteinase falcipain 3 0.0879 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0002 0.0002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172 0.188 0.188
Echinococcus granulosus cpg binding protein 0.0037 0.0322 0.0322
Plasmodium falciparum serine repeat antigen 9 0.0172 0.188 0.1766
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0172 0.188 0.5528
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Plasmodium vivax serine-repeat antigen (SERA) 0.0172 0.188 0.1766
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0172 0.188 0.1766
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0172 0.188 0.1878
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.8954 0.8954
Schistosoma mansoni cathepsin S (C01 family) 0.0172 0.188 0.188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0172 0.188 0.1766
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0041 0.0374 0.0372
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Echinococcus multilocularis cysteine protease 0.0879 1 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0162 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0879 1 1
Toxoplasma gondii hypothetical protein 0.0049 0.0468 0.0335
Loa Loa (eye worm) cathepsin B 0.0295 0.3289 0.3287
Schistosoma mansoni ran 0.0021 0.0138 0.0138
Entamoeba histolytica cysteine proteinase, putative 0.0879 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0169 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0169 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0593 0.6708 0.6707
Trypanosoma cruzi cysteine peptidase, putative 0.0879 1 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0169 0.0166
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Brugia malayi Papain family cysteine protease containing protein 0.0172 0.188 0.1878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0169 0.0169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Giardia lamblia Cathepsin B precursor 0.0295 0.3289 1
Echinococcus granulosus cathepsin L 0.0172 0.188 0.188
Trypanosoma cruzi cruzipain precursor, putative 0.0287 0.3193 0.3098
Plasmodium falciparum serine repeat antigen 6 0.0172 0.188 0.1766
Brugia malayi Cathepsin L-like precursor 0.0879 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0459 0.5172 0.5104
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Loa Loa (eye worm) hypothetical protein 0.0879 1 1
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Onchocerca volvulus 0.0879 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0879 1 1
Toxoplasma gondii cathepsin CPC2 0.0172 0.188 0.1766
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0459 0.5172 0.5172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.046 0.046
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0172 0.188 0.1766
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0593 0.6708 0.6707
Brugia malayi Cathepsin L-like precursor 0.0879 1 1
Brugia malayi fibroinase precursor 0.0172 0.188 0.1878
Loa Loa (eye worm) hypothetical protein 0.0593 0.6708 0.6707
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0047
Loa Loa (eye worm) fibroinase 0.0879 1 1
Plasmodium falciparum importin beta, putative 0.0028 0.0223 0.0086
Giardia lamblia Cathepsin B precursor 0.0172 0.188 0.5528
Giardia lamblia Cathepsin L-like protease 0.0172 0.188 0.5528
Schistosoma mansoni microtubule-associated protein tau 0.0699 0.7931 0.7931
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0879 1 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.012 0.012
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0169 0.0166
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0172 0.188 0.1766
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0172 0.188 0.1766
Brugia malayi cathepsin Z-like cysteine proteinase 0.0172 0.188 0.1878
Plasmodium vivax serine-repeat antigen (SERA) 0.0172 0.188 0.1766
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0172 0.188 0.188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0459 0.5172 0.5171
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0413 0.041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0172 0.188 0.1766
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.188 0.1878
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0395 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0287 0.3193 0.3192
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0379 0.0377
Brugia malayi Cathepsin L-like precursor 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0172 0.188 0.1878
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172 0.188 0.188
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0172 0.188 0.1878
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0374 0.0372
Plasmodium falciparum serine repeat antigen 2 0.0172 0.188 0.1766
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0503 0.037
Giardia lamblia Cathepsin B precursor 0.0172 0.188 0.5528
Schistosoma mansoni cathepsin F (C01 family) 0.0879 1 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0162 0.0024
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0049 0.0049
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0172 0.188 0.1878
Giardia lamblia Cathepsin B precursor 0.0172 0.188 0.5528
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0223 0.0138
Giardia lamblia Cathepsin B precursor 0.0295 0.3289 1
Echinococcus multilocularis cathepsin L 0.0172 0.188 0.188
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0169 0.0169
Schistosoma mansoni hypothetical protein 0.0019 0.012 0.012
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.3415 0.3323
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0172 0.188 0.1878
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5574 0.5574
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Plasmodium falciparum serine repeat antigen 4 0.0172 0.188 0.1766
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0656 0.0525
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0169 0.0084
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0049 0.0049
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0169 0.0031
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0395 0.0261
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Schistosoma mansoni hypothetical protein 0.0299 0.3337 0.3337
Onchocerca volvulus 0.0879 1 1
Giardia lamblia Cysteine protease 0.0172 0.188 0.5528
Giardia lamblia Hypothetical protein 0.0172 0.188 0.5528
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0172 0.188 0.1878
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0138 0.0138
Entamoeba histolytica hypothetical protein 0.0172 0.188 0.1766
Leishmania major cathepsin L-like protease 0.0879 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0879 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0569 0.6436 0.6386
Loa Loa (eye worm) hypothetical protein 0.0039 0.0345 0.0343
Echinococcus granulosus cathepsin b 0.0569 0.6436 0.6436
Entamoeba histolytica cysteine proteinase, putative 0.0459 0.5172 0.5104
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0295 0.3289 0.3195
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Trypanosoma cruzi major cysteine proteinase, putative 0.0172 0.188 0.1766
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0172 0.188 0.188
Trypanosoma cruzi cysteine peptidase, putative 0.0879 1 1
Trypanosoma brucei unspecified product 0.0023 0.0169 0.0084
Brugia malayi cathepsin F-like cysteine proteinase 0.0287 0.3193 0.3192
Giardia lamblia Cathepsin B precursor 0.0295 0.3289 1
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.1564 0.1491
Onchocerca volvulus 0.0879 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0879 1 1
Schistosoma mansoni hypothetical protein 0.0035 0.0303 0.0303
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0299 0.0297
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0379 0.0377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Giardia lamblia Cysteine protease 0.0172 0.188 0.5528
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0879 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1564 0.1446
Entamoeba histolytica cysteine protease, putative 0.0172 0.188 0.1766
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0138 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Onchocerca volvulus 0.0172 0.188 0.1629
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0023 0.002
Entamoeba histolytica cysteine proteinase, putative 0.0459 0.5172 0.5104
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0295 0.3289 0.3287
Echinococcus multilocularis snurportin 1 0.0299 0.3337 0.3337
Echinococcus granulosus cathepsin b 0.0569 0.6436 0.6436
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0002 0.0002
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0569 0.6436 0.6436
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0162 0.016
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.012 0.012
Entamoeba histolytica cysteine proteinase, putative 0.0593 0.6708 0.6662
Plasmodium vivax importin-beta 2, putative 0.0028 0.0223 0.0086
Echinococcus granulosus importin subunit beta 1 0.0028 0.0223 0.0223
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0172 0.188 0.188
Brugia malayi Cathepsin L-like precursor 0.0593 0.6708 0.6707
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5172 0.513
Echinococcus granulosus cathepsin L cysteine protease 0.0459 0.5172 0.5172
Brugia malayi Papain family cysteine protease containing protein 0.0172 0.188 0.1878
Giardia lamblia Hypothetical protein 0.0172 0.188 0.5528
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0172 0.188 0.1766
Plasmodium falciparum serine repeat antigen 8 0.0172 0.188 0.1766
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0569 0.6436 0.6435
Brugia malayi cathepsin Z-like cysteine proteinase 0.0172 0.188 0.1878
Leishmania major DNA polymerase eta, putative 0.0023 0.0169 0.0031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0166
Leishmania major cathepsin L-like protease 0.0879 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0002 0.0002
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0009 0.0002 0.0002
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0169 0.0031
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0169 0.0166
Brugia malayi cathepsin F-like cysteine proteinase 0.0172 0.188 0.1878
Brugia malayi cathepsin L-like cysteine proteinase 0.0172 0.188 0.1878
Schistosoma mansoni hypothetical protein 0.0494 0.5574 0.5574
Schistosoma mansoni ran 0.0021 0.0138 0.0138
Plasmodium falciparum serine repeat antigen 1 0.0172 0.188 0.1766
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.0002 0.0002
Leishmania major DNA polymerase kappa, putative 0.0023 0.0169 0.0031
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0395 0.0261
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.012 0.012
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0169 0.0166
Echinococcus granulosus dna polymerase eta 0.0023 0.0169 0.0169
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0172 0.188 0.1766
Giardia lamblia Cathepsin L-like protease 0.0172 0.188 0.5528
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0879 1 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0162 0.016
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0049 0.0047
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0169 0.0084
Echinococcus granulosus snurportin 1 0.0299 0.3337 0.3337
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0002 0.0002
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0303 0.0303
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0592 0.059
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1752 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Echinococcus granulosus geminin 0.0205 0.2251 0.2251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0172 0.188 0.5528
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0138 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0459 0.5172 0.5172
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0172 0.188 0.188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Brugia malayi Importin beta-1 subunit 0.0028 0.0223 0.0221
Loa Loa (eye worm) hypothetical protein 0.0028 0.0223 0.0221
Schistosoma mansoni hypothetical protein 0.0041 0.0374 0.0374
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0172 0.188 0.1878
Echinococcus granulosus cathepsin L 0.0459 0.5172 0.5172
Echinococcus granulosus neuropeptide s receptor 0.0558 0.6315 0.6315
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.188 0.1878
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0879 1 1
Toxoplasma gondii cathepsin CPC1 0.0172 0.188 0.1766
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Schistosoma mansoni cathepsin s 0.0287 0.3193 0.3193
Brugia malayi Cathepsin L-like precursor 0.0287 0.3193 0.3192
Entamoeba histolytica cysteine proteinase, putative 0.0879 1 1
Brugia malayi Cathepsin L-like precursor 0.0593 0.6708 0.6707
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.188 0.1878
Loa Loa (eye worm) cysteine protease 0.0879 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0459 0.5172 0.5104
Schistosoma mansoni cathepsin F (C01 family) 0.0879 1 1
Schistosoma mansoni cpg binding protein 0.0035 0.0299 0.0299
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0169 0.0166
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.0167
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Giardia lamblia Cathepsin L precursor 0.0172 0.188 0.5528
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0593 0.6708 0.6662
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0879 1 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.188 0.1878
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0569 0.6436 0.6436
Loa Loa (eye worm) hypothetical protein 0.0119 0.1269 0.1267
Entamoeba histolytica cysteine proteinase 2 0.0459 0.5172 0.5104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0459 0.5172 0.5171
Echinococcus granulosus cathepsin l cysteine peptidase 0.0879 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0593 0.6708 0.6707
Leishmania major cathepsin L-like protease 0.0879 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0002 0.0002
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0172 0.188 0.188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5172 0.513
Onchocerca volvulus 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Echinococcus multilocularis dna polymerase eta 0.0023 0.0169 0.0169
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Brugia malayi Latrophilin receptor protein 2 0.0019 0.012 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0172 0.188 0.5528
Giardia lamblia DINP protein human, muc B family 0.0023 0.0169 0.0098
Entamoeba histolytica cysteine protease, putative 0.0459 0.5172 0.5104
Echinococcus multilocularis cysteine protease 0.0879 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0162 0.016
Echinococcus granulosus cathepsin l1 0.0879 1 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0138 0.0138
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0138 0.0136
Onchocerca volvulus Cathepsin F homolog 0.0879 1 1
Plasmodium falciparum serine repeat antigen 3 0.0172 0.188 0.1766
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0172 0.188 0.1878
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0024 0.0024
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0172 0.188 0.1766
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.6315 0.6315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0593 0.6708 0.6707
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0879 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.188 0.1878
Brugia malayi Cathepsin L-like precursor 0.0879 1 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0172 0.188 0.1766
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0049 0.0049

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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