Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | eukaryotic translation initiation factor 4E | Starlite/ChEMBL | References |
Oryctolagus cuniculus | Eukaryotic translation initiation factor 4E | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.059 uM | Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay | ChEMBL. | 22458568 |
IC50 (binding) | = 1.9 uM | Inhibition of eIF4E in rabbit reticulocyte cell lysate assessed as inhibition of cap-dependent translation after 90 mins by luciferase reporter gene assay | ChEMBL. | 22458568 |
Ratio IC50 (binding) | = 30 | Ratio of m7-GMP IC50 to compound IC50 for eIF4E in rabbit reticulocyte cell lysate | ChEMBL. | 22458568 |
Ratio IC50 (binding) | = 200 | Ratio of m7-GMP IC50 to compound IC50 for human eIF4E | ChEMBL. | 22458568 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.