Detailed information for compound 16979

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 454.713 | Formula: C23H40N3O2S2+
  • H donors: 2 H acceptors: 4 LogP: 5.82 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC[N+](C)(C)C.CCSc1nnc(s1)c1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C
  • InChi: 1S/C18H26N2OS2.C5H14NO/c1-8-22-16-20-19-15(23-16)11-9-12(17(2,3)4)14(21)13(10-11)18(5,6)7;1-6(2,3)4-5-7/h9-10,21H,8H2,1-7H3;7H,4-5H2,1-3H3/q;+1
  • InChiKey: QMBKNLJAXCEMIQ-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0053 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0142 0.0564 0.2022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Trypanosoma brucei cysteine peptidase C (CPC) 0.0566 0.2612 0.87
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0142 0.0564 0.1995
Trypanosoma cruzi oligopeptidase b 0.013 0.0506 0.0704
Entamoeba histolytica hypothetical protein 0.0142 0.0564 0.255
Trypanosoma brucei chrX additional, unordered contigs 0.0036 0.0053 0.0178
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0142 0.0564 0.255
Onchocerca volvulus 0.0065 0.0194 0.084
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0142 0.0564 0.2707
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0214 0.0914 0.0894
Mycobacterium ulcerans peptide deformylase 0.0456 0.2084 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Toxoplasma gondii histone deacetylase HDAC1 0.0043 0.0085 0.0324
Brugia malayi Cathepsin L-like precursor 0.0455 0.208 0.2894
Trypanosoma brucei unspecified product 0.008 0.0267 0.089
Echinococcus granulosus neuropeptide receptor 0.0065 0.0194 0.0173
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0142 0.0564 0.0544
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0066 0.0198 0.0177
Brugia malayi Cathepsin L-like cysteine proteinase 0.0403 0.1827 0.2542
Loa Loa (eye worm) hypothetical protein 0.0214 0.0914 0.1272
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0146 0.0584 0.0812
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Trypanosoma brucei histone deacetylase 3 0.0043 0.0085 0.0282
Onchocerca volvulus Prolyl endopeptidase homolog 0.0284 0.1251 0.5972
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0456 0.2084 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.0564 0.2022
Onchocerca volvulus 0.0065 0.0194 0.084
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0142 0.0564 0.2707
Brugia malayi GnHR receptor homolog 0.0065 0.0194 0.0271
Onchocerca volvulus 0.0065 0.0194 0.084
Plasmodium falciparum serine repeat antigen 5 0.0142 0.0564 0.2707
Plasmodium falciparum serine repeat antigen 1 0.0142 0.0564 0.2707
Schistosoma mansoni myosin xvIII 0.0065 0.0194 0.0173
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0045 0.015
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0065 0.0194 0.0173
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.0817 0.3795
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Brugia malayi Smad1 0.0066 0.0198 0.0276
Loa Loa (eye worm) hypothetical protein 0.0403 0.1827 0.2542
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Loa Loa (eye worm) transcription factor SMAD2 0.0971 0.4572 0.6362
Leishmania major trypanothione reductase 0.0047 0.0104 0.0347
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0239 0.1031 0.1012
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0065 0.0194 0.0271
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.013 0.0506 0.1685
Loa Loa (eye worm) hypothetical protein 0.0057 0.0155 0.0216
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.0817 0.3795
Schistosoma mansoni amine GPCR 0.0065 0.0194 0.0173
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0442 0.0615
Loa Loa (eye worm) RNA binding protein 0.0132 0.0518 0.0721
Brugia malayi Cathepsin L-like precursor 0.0455 0.208 0.2894
Brugia malayi Bromodomain containing protein 0.0074 0.0235 0.0327
Echinococcus multilocularis smad 0.0066 0.0198 0.0177
Echinococcus multilocularis prolyl endopeptidase 0.0284 0.1251 0.1232
Plasmodium vivax hypothetical protein, conserved 0.0055 0.0144 0.0691
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0455 0.208 0.2063
Echinococcus granulosus cathepsin b 0.1512 0.7186 0.718
Trypanosoma brucei oligopeptidase b 0.013 0.0506 0.1685
Echinococcus multilocularis sex peptide receptor 0.0065 0.0194 0.0173
Brugia malayi RE15519p 0.0065 0.0194 0.0271
Echinococcus granulosus snurportin 1 0.0611 0.283 0.2814
Echinococcus granulosus 7TM GPCR rhodopsin 0.0065 0.0194 0.0173
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0053 0.0205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Echinococcus multilocularis Smad4 0.0066 0.0198 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0267 0.089
Schistosoma mansoni biogenic amine (5HT) receptor 0.0065 0.0194 0.0173
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0034 0.0045 0.015
Entamoeba histolytica hypothetical protein 0.0036 0.005 0.0026
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0393 0.146
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0164 0.0143
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0065 0.0194 0.0173
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Schistosoma mansoni alpha-1 adrenergic receptor 0.0065 0.0194 0.0173
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0155 0.0594
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0146 0.0584 0.0563
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0164 0.0143
Brugia malayi putative neuropeptide receptor NPR1 0.0065 0.0194 0.0271
Brugia malayi G-protein coupled receptor 0.0065 0.0194 0.0271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Onchocerca volvulus 0.0065 0.0194 0.084
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0142 0.0564 0.2022
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0363 0.1635 0.2275
Giardia lamblia Cathepsin L precursor 0.0142 0.0564 0.1995
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.003
Trypanosoma brucei prolyl oligopeptidase, putative 0.013 0.0506 0.1685
Onchocerca volvulus 0.0065 0.0194 0.084
Brugia malayi cathepsin F-like cysteine proteinase 0.0052 0.0132 0.0183
Trypanosoma cruzi cysteine peptidase, putative 0.0646 0.3002 0.4178
Brugia malayi neuropeptide F receptor 0.0065 0.0194 0.0271
Toxoplasma gondii cathepsin B 0.0566 0.2612 1
Leishmania major cathepsin L-like protease 0.0455 0.208 0.6928
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Plasmodium vivax importin-beta 2, putative 0.0057 0.0155 0.0744
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Loa Loa (eye worm) fibroinase 0.0455 0.208 0.2894
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0142 0.0564 0.0785
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Leishmania major cathepsin L-like protease 0.0646 0.3002 1
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0381 0.1719 0.1702
Mycobacterium tuberculosis Probable peptidase 0.013 0.0506 0.203
Giardia lamblia Cathepsin B precursor 0.0566 0.2612 1
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0146 0.0584 0.1944
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0132 0.0183
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.0194 0.0173
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0065 0.0194 0.0271
Echinococcus multilocularis cysteine protease 0.0455 0.208 0.2063
Echinococcus granulosus acylamino acid releasing enzyme 0.0055 0.0144 0.0123
Plasmodium falciparum cysteine proteinase falcipain 3 0.0455 0.208 0.9982
Entamoeba histolytica cysteine protease, putative 0.0142 0.0564 0.255
Entamoeba histolytica prolyl oligopeptidase family protein 0.0055 0.0144 0.0486
Echinococcus granulosus g-protein coupled receptor 0.0065 0.0194 0.0173
Schistosoma mansoni biogenic amine (5HT) receptor 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Schistosoma mansoni adenoreceptor 0.0065 0.0194 0.0173
Plasmodium falciparum serine repeat antigen 6 0.0142 0.0564 0.2707
Plasmodium vivax histone deacetylase, putative 0.0043 0.0085 0.0406
Onchocerca volvulus 0.0065 0.0194 0.084
Echinococcus granulosus neuropeptide s receptor 0.0065 0.0194 0.0173
Entamoeba histolytica deoxycytidyl transferase, putative 0.0117 0.0442 0.1951
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Trypanosoma cruzi DNA damage repair protein, putative 0.0036 0.0053 0.0074
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.0194 0.0173
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0142 0.0564 0.1995
Schistosoma mansoni neuropeptide receptor 0.0065 0.0194 0.0173
Onchocerca volvulus 0.0065 0.0194 0.084
Onchocerca volvulus Cathepsin L homolog 0.0455 0.208 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0065 0.0194 0.0173
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0036 0.0053 0.0205
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0053 0.0074
Onchocerca volvulus 0.0034 0.0045 0.0114
Toxoplasma gondii prolyl endopeptidase 0.0284 0.1251 0.4789
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Echinococcus multilocularis cysteine protease 0.0455 0.208 0.2063
Onchocerca volvulus Cathepsin F homolog 0.0455 0.208 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0194 0.0817 0.0797
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0518 0.0498
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0142 0.0564 0.2707
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0403 0.1827 0.6941
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0214 0.0914 0.1272
Brugia malayi Cathepsin L-like precursor 0.0455 0.208 0.2894
Loa Loa (eye worm) G-protein coupled receptor 0.0065 0.0194 0.0271
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0065 0.0194 0.0173
Trypanosoma brucei Peptide deformylase 2 0.0174 0.072 0.2398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Brugia malayi cathepsin Z-like cysteine proteinase 0.0142 0.0564 0.0785
Echinococcus granulosus G protein coupled receptor 139 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0455 0.208 0.2894
Onchocerca volvulus 0.0142 0.0564 0.2635
Brugia malayi ImpB/MucB/SamB family protein 0.0117 0.0442 0.0615
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0055 0.0144 0.0486
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0082 0.0114
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0214 0.0914 0.1272
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0183
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0442 0.1473
Schistosoma mansoni biogenic amine receptor 0.0065 0.0194 0.0173
Echinococcus granulosus neuropeptide receptor 0.0065 0.0194 0.0173
Brugia malayi MH2 domain containing protein 0.0066 0.0198 0.0276
Loa Loa (eye worm) hypothetical protein 0.0284 0.1251 0.1741
Loa Loa (eye worm) nuclear factor I 0.0037 0.0055 0.0077
Brugia malayi larval opioid receptor 0.0065 0.0194 0.0271
Schistosoma mansoni inhibitor of apoptosis protein 0.0214 0.0914 0.0894
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0142 0.0564 0.1995
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0055 0.0144 0.0479
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0442 0.1473
Echinococcus granulosus apoptotic protease activating factor 1 0.0123 0.0471 0.0451
Trypanosoma brucei unspecified product 0.0117 0.0442 0.1473
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0065 0.0194 0.0173
Plasmodium vivax vivapain-2 0.0455 0.208 0.9982
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0065 0.0194 0.084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0146 0.0584 0.1944
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.0564 0.2022
Schistosoma mansoni cathepsin s 0.0052 0.0132 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0442 0.0615
Echinococcus granulosus serotonin receptor 0.0065 0.0194 0.0173
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) MH1 domain-containing protein 0.003 0.0022 0.003
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.013 0.0506 0.0704
Trypanosoma cruzi DNA polymerase eta, putative 0.0117 0.0442 0.0615
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Echinococcus granulosus cathepsin b 0.1512 0.7186 0.718
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0239 0.1031 0.1012
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0174 0.072 0.1002
Schistosoma mansoni importin beta-1 0.0057 0.0155 0.0134
Brugia malayi Serotonin receptor 0.0065 0.0194 0.0271
Echinococcus granulosus Dipeptidyl peptidase 9 0.0146 0.0584 0.0563
Onchocerca volvulus 0.0455 0.208 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0049 0.0028
Onchocerca volvulus Cathepsin L homolog 0.0142 0.0564 0.2635
Brugia malayi hypothetical protein 0.0091 0.0318 0.0443
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0085 0.0063
Schistosoma mansoni Smad4 0.0066 0.0198 0.0177
Trypanosoma cruzi DNA damage repair protein, putative 0.0036 0.0053 0.0074
Echinococcus multilocularis orexin receptor type 2 0.0065 0.0194 0.0173
Brugia malayi TAR-binding protein 0.0132 0.0518 0.0721
Brugia malayi Papain family cysteine protease containing protein 0.0142 0.0564 0.0785
Brugia malayi sulfakinin receptor protein 0.0065 0.0194 0.0271
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0142 0.0564 0.2707
Echinococcus granulosus cathepsin L cysteine protease 0.0194 0.0817 0.0797
Schistosoma mansoni cathepsin F (C01 family) 0.0455 0.208 0.2063
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0142 0.0564 0.2022
Leishmania major DNA polymerase kappa, putative 0.0036 0.0053 0.0178
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni smad1 5 8 and 0.0066 0.0198 0.0177
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1512 0.7186 0.718
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0817 0.3008
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0142 0.0564 0.2707
Mycobacterium tuberculosis Probable reductase 0.0106 0.0393 0.146
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Loa Loa (eye worm) hypothetical protein 0.0123 0.0471 0.0656
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1512 0.7186 0.718
Echinococcus granulosus histone deacetylase 6 0.0043 0.0085 0.0063
Trypanosoma cruzi cysteine peptidase, putative 0.0646 0.3002 0.4178
Brugia malayi cathepsin L precursor 0.0142 0.0564 0.0785
Toxoplasma gondii cathepsin CPC1 0.0142 0.0564 0.2159
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0142 0.0564 0.0544
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Echinococcus granulosus caspase 2 0.0123 0.0471 0.0451
Brugia malayi Cell death protein 3 precursor 0.0123 0.0471 0.0656
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0284 0.1251 0.1232
Trichomonas vaginalis conserved hypothetical protein 0.0142 0.0564 0.2022
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1512 0.7186 0.718
Onchocerca volvulus 0.0065 0.0194 0.084
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0142 0.0564 0.2707
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0611 0.283 0.3938
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0142 0.0564 0.2707
Entamoeba histolytica hypothetical protein 0.0036 0.005 0.0026
Echinococcus multilocularis fmrfamide receptor 0.0065 0.0194 0.0173
Chlamydia trachomatis peptide deformylase 0.0456 0.2084 0.5
Leishmania major DNA polymerase eta, putative 0.0117 0.0442 0.1473
Trypanosoma cruzi cysteine peptidase, putative 0.0455 0.208 0.2894
Schistosoma mansoni neuropeptide receptor 0.0065 0.0194 0.0173
Loa Loa (eye worm) neuropeptide F receptor 0.0065 0.0194 0.0271
Schistosoma mansoni terminal deoxycytidyl transferase 0.0117 0.0442 0.0422
Trypanosoma cruzi Peptide deformylase 2, putative 0.0174 0.072 0.1002
Schistosoma mansoni smad1 5 8 and 0.0066 0.0198 0.0177
Echinococcus multilocularis tar DNA binding protein 0.0132 0.0518 0.0498
Brugia malayi ORL1-like opioid receptor 0.0065 0.0194 0.0271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Brugia malayi prolyl oligopeptidase family protein 0.0055 0.0144 0.02
Brugia malayi glutathione reductase 0.0047 0.0104 0.0145
Leishmania major DNA polymerase eta, putative 0.0036 0.0053 0.0178
Schistosoma mansoni amine GPCR 0.0065 0.0194 0.0173
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0155 0.0516
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0053 0.0178
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0042 0.0081 0.0113
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0085 0.0063
Loa Loa (eye worm) hypothetical protein 0.0043 0.0085 0.0118
Plasmodium vivax serine-repeat antigen (SERA) 0.0142 0.0564 0.2707
Plasmodium falciparum serine repeat antigen 9 0.0142 0.0564 0.2707
Plasmodium falciparum serine repeat antigen 2 0.0142 0.0564 0.2707
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Echinococcus granulosus importin subunit beta 1 0.0057 0.0155 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Trypanosoma cruzi cysteine peptidase, putative 0.0194 0.0817 0.1137
Plasmodium falciparum importin beta, putative 0.0057 0.0155 0.0744
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0146 0.0584 0.1944
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Mycobacterium ulcerans hypothetical protein 0.0036 0.0053 0.0042
Schistosoma mansoni cathepsin B (C01 family) 0.0142 0.0564 0.0544
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0239 0.1031 0.1012
Loa Loa (eye worm) hypothetical protein 0.0403 0.1827 0.2542
Brugia malayi Dopamine receptor protein 1 0.0065 0.0194 0.0271
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.0132 0.0183
Echinococcus multilocularis somatostatin receptor 0.0065 0.0194 0.0173
Plasmodium falciparum glutathione reductase 0.0047 0.0104 0.05
Echinococcus granulosus cathepsin L cysteine proteinase 0.0455 0.208 0.2063
Plasmodium vivax unspecified product 0.0142 0.0564 0.2707
Echinococcus multilocularis neuropeptide FF receptor 2 0.0065 0.0194 0.0173
Echinococcus granulosus inhibitor of apoptosis protein 0.0214 0.0914 0.0894
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0214 0.0914 0.0894
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Trichomonas vaginalis DNA polymerase eta, putative 0.0117 0.0442 0.1547
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0065 0.0194 0.0173
Echinococcus granulosus fmrfamide receptor 0.0065 0.0194 0.0173
Echinococcus multilocularis neuropeptide receptor A26 0.0065 0.0194 0.0173
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Brugia malayi hypothetical protein 0.0123 0.0471 0.0656
Trichomonas vaginalis conserved hypothetical protein 0.0142 0.0564 0.2022
Toxoplasma gondii cathepsin CPC2 0.0142 0.0564 0.2159
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni neuropeptide receptor 0.0065 0.0194 0.0173
Brugia malayi Papain family cysteine protease containing protein 0.0455 0.208 0.2894
Schistosoma mansoni hypothetical protein 0.2094 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0117 0.0442 0.1473
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.0564 0.2022
Loa Loa (eye worm) hypothetical protein 0.0186 0.0776 0.108
Leishmania major GTP-binding protein, putative 0.0042 0.0082 0.0273
Brugia malayi putative neuropeptide receptor 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.01
Plasmodium vivax vivapain-1 0.0194 0.0817 0.3922
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0518 0.0498
Toxoplasma gondii preprocathepsin c precursor, putative 0.0142 0.0564 0.2159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.0564 0.2022
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0045 0.015
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0038 0.0061 0.0085
Echinococcus multilocularis cathepsin L cysteine protease 0.0455 0.208 0.2063
Trypanosoma cruzi cysteine proteinase, putative 0.0194 0.0817 0.1137
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0085 0.0118
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.0194 0.0173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0239 0.1031 0.1012
Echinococcus granulosus aminopeptidase N 0.0034 0.0045 0.0024
Mycobacterium tuberculosis Conserved hypothetical protein 0.0117 0.0442 0.1707
Plasmodium vivax vivapain-3 0.0194 0.0817 0.3922
Plasmodium falciparum histone deacetylase, putative 0.0043 0.0085 0.0406
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Trypanosoma brucei unspecified product 0.008 0.0267 0.089
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0456 0.2084 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0065 0.0194 0.0271
Echinococcus multilocularis cathepsin L cysteine protease 0.0455 0.208 0.2063
Leishmania major C-8 sterol isomerase-like protein 0.0363 0.1635 0.5446
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0065 0.0194 0.0173
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Schistosoma mansoni smad 0.0066 0.0198 0.0177
Brugia malayi RNA binding protein 0.0132 0.0518 0.0721
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Brugia malayi hypothetical protein 0.0034 0.0045 0.0063
Echinococcus multilocularis cathepsin b 0.1512 0.7186 0.718
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0055 0.0144 0.0385
Leishmania major importin beta-1 subunit, putative 0.0046 0.0103 0.0342
Echinococcus granulosus Smad4 0.0066 0.0198 0.0177
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0117 0.0442 0.1707
Leishmania major cathepsin L-like protease 0.0646 0.3002 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0142 0.0564 0.2707
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.005 0.0029
Echinococcus granulosus histone deacetylase 7 0.0043 0.0085 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Loa Loa (eye worm) histone deacetylase 0.0043 0.0085 0.0118
Echinococcus multilocularis g protein coupled receptor 0.0065 0.0194 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Plasmodium vivax histone deacetylase 2, putative 0.0043 0.0085 0.0406
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Echinococcus multilocularis neuropeptide Y receptor 0.0065 0.0194 0.0173
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0104 0.05
Echinococcus granulosus neuropeptide FF receptor 2 0.0065 0.0194 0.0173
Giardia lamblia Encystation-specific protease 0.0142 0.0564 0.1995
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni cathepsin C 0.0142 0.0564 0.0544
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0065 0.0194 0.0173
Echinococcus granulosus cathepsin l cysteine peptidase 0.0455 0.208 0.2063
Leishmania major cathepsin L-like protease 0.0455 0.208 0.6928
Schistosoma mansoni hypothetical protein 0.0065 0.0194 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Giardia lamblia Hypothetical protein 0.0142 0.0564 0.1995
Brugia malayi MH2 domain containing protein 0.0066 0.0198 0.0276
Brugia malayi Cathepsin L-like precursor 0.0455 0.208 0.2894
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.013 0.0506 0.0668
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Giardia lamblia Cathepsin L precursor 0.0142 0.0564 0.1995
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0082 0.0314
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0214 0.0914 0.0894
Brugia malayi Cathepsin L-like precursor 0.0403 0.1827 0.2542
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0085 0.0063
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.0518 0.0721
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0455 0.208 0.7927
Echinococcus granulosus neuropeptides capa receptor 0.0065 0.0194 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Entamoeba histolytica prolyl oligopeptidase family protein 0.0055 0.0144 0.0486
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0451 0.175
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0082 0.0112
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0049 0.0028
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0034 0.0045 0.0024
Onchocerca volvulus 0.0065 0.0194 0.084
Trypanosoma brucei histone deacetylase 4 0.0043 0.0085 0.0282
Schistosoma mansoni hypothetical protein 0.0036 0.005 0.0029
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0393 0.146
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.0194 0.0173
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Trichomonas vaginalis ran, putative 0.0042 0.0082 0.0144
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0194 0.0817 0.0797
Echinococcus multilocularis cathepsin b 0.1512 0.7186 0.718
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0455 0.208 0.9982
Echinococcus granulosus TGF beta signal transducer SmadC 0.0066 0.0198 0.0177
Echinococcus granulosus g protein coupled receptor 0.0065 0.0194 0.0173
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.0194 0.0173
Echinococcus multilocularis aminopeptidase N 0.0034 0.0045 0.0024
Brugia malayi Peptidase family M1 containing protein 0.0034 0.0045 0.0063
Brugia malayi Serotonin receptor 0.0065 0.0194 0.0271
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0065 0.0194 0.0173
Onchocerca volvulus 0.0065 0.0194 0.084
Brugia malayi Cathepsin L-like precursor 0.0403 0.1827 0.2542
Leishmania major oligopeptidase b 0.013 0.0506 0.1685
Trypanosoma cruzi cysteine peptidase, putative 0.0646 0.3002 0.4178
Plasmodium vivax peptide deformylase, putative 0.0456 0.2084 1
Brugia malayi prolyl oligopeptidase family protein 0.0284 0.1251 0.1741
Schistosoma mansoni caspase-7 (C14 family) 0.0123 0.0471 0.0451
Entamoeba histolytica cysteine proteinase, putative 0.0455 0.208 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0284 0.1251 0.4166
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0403 0.1827 0.2542
Schistosoma mansoni hypothetical protein 0.0065 0.0194 0.0173
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Schistosoma mansoni neuropeptide F-like receptor 0.0065 0.0194 0.0173
Trypanosoma cruzi cruzipain precursor, putative 0.0646 0.3002 0.4178
Loa Loa (eye worm) hypothetical protein 0.0142 0.0564 0.0785
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0146 0.0584 0.0812
Schistosoma mansoni opsin-like receptor 0.0065 0.0194 0.0173
Echinococcus granulosus dna polymerase eta 0.0117 0.0442 0.0422
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0065 0.0194 0.0173
Brugia malayi MH1 domain containing protein 0.0037 0.0055 0.0077
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0053 0.0074
Echinococcus multilocularis neuropeptide receptor 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0194 0.0817 0.1137
Loa Loa (eye worm) hypothetical protein 0.0142 0.0564 0.0785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Trypanosoma cruzi cysteine proteinase, putative 0.0194 0.0817 0.1137
Loa Loa (eye worm) hypothetical protein 0.1512 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0183
Onchocerca volvulus 0.0403 0.1827 0.877
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0065 0.0194 0.0173
Giardia lamblia Cathepsin B precursor 0.0142 0.0564 0.1995
Leishmania major histone deacetylase, putative 0.0043 0.0085 0.0282
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0045 0.015
Schistosoma mansoni neuropeptide F-like receptor 0.0065 0.0194 0.0173
Schistosoma mansoni DNA polymerase eta 0.0117 0.0442 0.0422
Loa Loa (eye worm) MH1 domain-containing protein 0.0066 0.0198 0.0276
Giardia lamblia Cysteine protease 0.0142 0.0564 0.1995
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0442 0.0615
Brugia malayi G protein-coupled receptor F59B2.13 0.0065 0.0194 0.0271
Brugia malayi Peptidase family M1 containing protein 0.0034 0.0045 0.0063
Echinococcus multilocularis serotonin receptor 0.0065 0.0194 0.0173
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0065 0.0194 0.0173
Schistosoma mansoni cathepsin S (C01 family) 0.0142 0.0564 0.0544
Onchocerca volvulus 0.0455 0.208 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Trypanosoma brucei C-8 sterol isomerase, putative 0.0363 0.1635 0.5446
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0267 0.089
Schistosoma mansoni cathepsin F (C01 family) 0.0455 0.208 0.2063
Echinococcus multilocularis apoptotic protease activating factor 1 0.0123 0.0471 0.0451
Onchocerca volvulus Neuropeptide F receptor homolog 0.0065 0.0194 0.084
Leishmania major cathepsin L-like protease 0.0455 0.208 0.6928
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0117 0.0442 0.0422
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0363 0.1635 0.2275
Echinococcus granulosus histone deacetylase 6 0.0043 0.0085 0.0063
Loa Loa (eye worm) hypothetical protein 0.0363 0.1635 0.2275
Plasmodium vivax serine-repeat antigen (SERA) 0.0142 0.0564 0.2707
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0162 0.0141
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Echinococcus granulosus tachykinin peptides receptor 99D 0.0065 0.0194 0.0173
Brugia malayi hypothetical protein 0.0036 0.005 0.007
Plasmodium vivax vivapain-2 0.0455 0.208 0.9982
Treponema pallidum polypeptide deformylase (def) 0.0456 0.2084 0.5
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Entamoeba histolytica hypothetical protein 0.0036 0.005 0.0026
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0082 0.0394
Echinococcus multilocularis g protein coupled receptor 0.0065 0.0194 0.0173
Echinococcus multilocularis histone deacetylase 7 0.0043 0.0085 0.0063
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0103 0.0143
Loa Loa (eye worm) glutathione reductase 0.0047 0.0104 0.0145
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Giardia lamblia Cathepsin B precursor 0.0566 0.2612 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0594 0.2749 0.3825
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0103 0.0225
Schistosoma mansoni cathepsin F (C01 family) 0.0403 0.1827 0.1809
Trypanosoma cruzi oligopeptidase b 0.013 0.0506 0.0704
Schistosoma mansoni amine GPCR 0.0065 0.0194 0.0173
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0117 0.0442 0.0615
Echinococcus multilocularis neuropeptides capa receptor 0.0065 0.0194 0.0173
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0518 0.0498
Loa Loa (eye worm) histone deacetylase 7A 0.0043 0.0085 0.0118
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0104 0.0083
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.013 0.0506 0.203
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0442 0.1473
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Trypanosoma cruzi aminopeptidase, putative 0.0034 0.0045 0.0063
Giardia lamblia Cathepsin B precursor 0.0142 0.0564 0.1995
Trypanosoma cruzi Aminopeptidase M1, putative 0.0034 0.0045 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0817 0.3008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0239 0.1031 0.1435
Echinococcus multilocularis acylamino acid releasing enzyme 0.0055 0.0144 0.0123
Echinococcus granulosus alpha 1A adrenergic receptor 0.0065 0.0194 0.0173
Brugia malayi Dopamine receptor protein 2 0.0065 0.0194 0.0271
Brugia malayi MH1 domain containing protein 0.0037 0.0055 0.0077
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0039 0.0069 0.0048
Giardia lamblia Cathepsin L precursor 0.0142 0.0564 0.1995
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.005 0.0029
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Loa Loa (eye worm) MH2 domain-containing protein 0.0971 0.4572 0.6362
Entamoeba histolytica cysteine proteinase 2 0.0194 0.0817 0.3795
Toxoplasma gondii cathepsin CPL 0.0455 0.208 0.7963
Onchocerca volvulus Deterin homolog 0.0214 0.0914 0.4335
Brugia malayi prolyl oligopeptidase family protein 0.0055 0.0144 0.02
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Brugia malayi MH2 domain containing protein 0.003 0.0022 0.003
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0104 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0142 0.0564 0.0785
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.0518 0.0721
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Brugia malayi AKH receptor 0.0065 0.0194 0.0271
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0817 0.1137
Echinococcus multilocularis histone deacetylase 0.0043 0.0085 0.0063
Echinococcus granulosus biogenic amine 5HT receptor 0.0065 0.0194 0.0173
Loa Loa (eye worm) G-protein coupled receptor 0.0065 0.0194 0.0271
Brugia malayi Papain family cysteine protease containing protein 0.0142 0.0564 0.0785
Schistosoma mansoni opsin-like receptor 0.0065 0.0194 0.0173
Leishmania major cathepsin L-like protease 0.0455 0.208 0.6928
Loa Loa (eye worm) hypothetical protein 0.0055 0.0144 0.02
Trypanosoma brucei DNA polymerase eta, putative 0.0117 0.0442 0.1473
Onchocerca volvulus 0.0065 0.0194 0.084
Brugia malayi Histone deacetylase family protein 0.0043 0.0085 0.0118
Echinococcus multilocularis inhibitor of apoptosis protein 0.0214 0.0914 0.0894
Brugia malayi cathepsin Z-like cysteine proteinase 0.0142 0.0564 0.0785
Trypanosoma brucei prolyl endopeptidase 0.0284 0.1251 0.4166
Brugia malayi cathepsin B-like cysteine proteinase 0.1512 0.7186 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0065 0.0194 0.0271
Leishmania major DNA damage repair protein, putative 0.0036 0.0053 0.0178
Plasmodium falciparum serine repeat antigen 3 0.0142 0.0564 0.2707
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0065 0.0194 0.0173
Loa Loa (eye worm) MH2 domain-containing protein 0.003 0.0022 0.003
Onchocerca volvulus 0.0123 0.0471 0.2185
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0142 0.0564 0.0785
Giardia lamblia Cathepsin L precursor 0.0142 0.0564 0.1995
Loa Loa (eye worm) hypothetical protein 0.0142 0.0564 0.0785
Leishmania major cathepsin L-like protease 0.0455 0.208 0.6928
Schistosoma mansoni smad1 5 8 and 0.0066 0.0198 0.0177
Onchocerca volvulus Cathepsin L homolog 0.0455 0.208 1
Schistosoma mansoni hypothetical protein 0.0611 0.283 0.2814
Loa Loa (eye worm) hypothetical protein 0.0123 0.0471 0.0656
Brugia malayi Cathepsin L-like precursor 0.0455 0.208 0.2894
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Echinococcus granulosus neuropeptide Y receptor 0.0065 0.0194 0.0173
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0564 0.0544
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0451 0.175
Schistosoma mansoni growth hormone secretagogue receptor 0.0065 0.0194 0.0173
Brugia malayi neuropeptide F receptor 0.0065 0.0194 0.0271
Plasmodium falciparum cysteine proteinase falcipain 1 0.0194 0.0817 0.3922
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Echinococcus multilocularis allatostatin A receptor 0.0065 0.0194 0.0173
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0284 0.1251 0.1232
Plasmodium vivax DNA repair protein REV1, putative 0.0036 0.0053 0.0257
Loa Loa (eye worm) TAR-binding protein 0.0132 0.0518 0.0721
Echinococcus multilocularis neuropeptide s receptor 0.0065 0.0194 0.0173
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0052 0.0132 0.0183
Brugia malayi follicle stimulating hormone receptor 0.0065 0.0194 0.0271
Plasmodium vivax unspecified product 0.0052 0.0132 0.0632
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0055 0.0144 0.0486
Giardia lamblia Cathepsin B precursor 0.0142 0.0564 0.1995
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0065 0.0194 0.0271
Echinococcus granulosus cathepsin l1 0.0403 0.1827 0.1809
Onchocerca volvulus 0.0455 0.208 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0082 0.0273
Giardia lamblia DINP protein human, muc B family 0.0117 0.0442 0.1519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Loa Loa (eye worm) hypothetical protein 0.0117 0.0442 0.0615
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0034 0.0045 0.0063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0239 0.1031 0.1012
Echinococcus granulosus cathepsin l1 0.0455 0.208 0.2063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Echinococcus granulosus prolyl endopeptidase 0.0284 0.1251 0.1232
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.0817 0.3795
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0117 0.0442 0.1547
Echinococcus granulosus cathepsin L 0.0142 0.0564 0.0544
Onchocerca volvulus 0.0455 0.208 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0066 0.0198 0.0177
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0065 0.0194 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0055 0.0144 0.0486
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni hypothetical protein 0.0214 0.0914 0.0894
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0082 0.0114
Plasmodium falciparum histone deacetylase 2 0.0043 0.0085 0.0406
Brugia malayi mothers against decapentaplegic homolog 3 0.003 0.0022 0.003
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0566 0.2612 0.87
Leishmania major histone deacetylase, putative 0.0043 0.0085 0.0282
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni biogenic amine receptor 0.0065 0.0194 0.0173
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0082 0.0394
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0142 0.0564 0.2022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0045 0.015
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni histone deacetylase hda2 0.0043 0.0085 0.0063
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0065 0.0194 0.0173
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0104 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.0817 0.2722
Onchocerca volvulus 0.0455 0.208 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0564 0.0544
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0144 0.02
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0146 0.0584 0.0563
Schistosoma mansoni hypothetical protein 0.2094 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0117 0.0442 0.0615
Entamoeba histolytica cysteine proteinase 1, putative 0.0194 0.0817 0.3795
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0085 0.0118
Plasmodium falciparum peptidase, putative 0.0055 0.0144 0.0691
Loa Loa (eye worm) cathepsin B 0.0566 0.2612 0.3635
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.005 0.0029
Giardia lamblia Cathepsin B precursor 0.0142 0.0564 0.1995
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0164 0.0548
Schistosoma mansoni amine GPCR 0.0065 0.0194 0.0173
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Brugia malayi Papain family cysteine protease containing protein 0.0142 0.0564 0.0785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0566 0.2612 0.3635
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Giardia lamblia Alanyl dipeptidyl peptidase 0.0055 0.0144 0.0353
Giardia lamblia Alanyl dipeptidyl peptidase 0.0055 0.0144 0.0353
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0117 0.0442 0.0422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Loa Loa (eye worm) hypothetical protein 0.0214 0.0914 0.1272
Giardia lamblia Cathepsin L-like protease 0.0142 0.0564 0.1995
Plasmodium falciparum serine repeat antigen 8 0.0142 0.0564 0.2707
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0082 0.0061
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0817 0.1137
Entamoeba histolytica cysteine protease, putative 0.0142 0.0564 0.255
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni ran 0.0042 0.0082 0.0061
Entamoeba histolytica cysteine protease, putative 0.0455 0.208 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0036 0.0053 0.0257
Echinococcus granulosus orexin receptor type 2 0.0065 0.0194 0.0173
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0381 0.1719 0.1702
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0142 0.0564 0.2707
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0142 0.0564 0.0544
Trypanosoma cruzi Peptide deformylase 2, putative 0.0174 0.072 0.1002
Echinococcus multilocularis mothers against decapentaplegic 5 0.0066 0.0198 0.0177
Toxoplasma gondii thioredoxin reductase 0.0047 0.0104 0.0399
Echinococcus granulosus tar DNA binding protein 0.0132 0.0518 0.0498
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0155 0.0134
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0065 0.0194 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0142 0.0564 0.2022
Loa Loa (eye worm) hypothetical protein 0.0043 0.0085 0.0118
Leishmania major polypeptide deformylase-like protein, putative 0.0174 0.072 0.2398
Entamoeba histolytica cysteine protease, putative 0.0142 0.0564 0.255
Giardia lamblia Cysteine protease 0.0142 0.0564 0.1995
Onchocerca volvulus 0.0455 0.208 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0451 0.175
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0065 0.0194 0.0173
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Echinococcus granulosus cathepsin L 0.0194 0.0817 0.0797
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0065 0.0194 0.0173
Echinococcus multilocularis serotonin receptor 0.0065 0.0194 0.0173
Echinococcus granulosus neuropeptide receptor A26 0.0065 0.0194 0.0173
Echinococcus multilocularis G-protein coupled receptor, putative 0.0065 0.0194 0.0173
Brugia malayi polk-prov protein 0.0036 0.0053 0.0074
Echinococcus multilocularis neuropeptide receptor 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0142 0.0564 0.2022
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0065 0.0194 0.0173
Giardia lamblia Cathepsin L precursor 0.0142 0.0564 0.1995
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0065 0.0194 0.0173
Trypanosoma brucei DNA damage repair protein, putative 0.0036 0.0053 0.0178
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.0194 0.0173
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0456 0.2084 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0142 0.0564 0.2022
Entamoeba histolytica cysteine protease, putative 0.0142 0.0564 0.255
Schistosoma mansoni ran 0.0042 0.0082 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0142 0.0564 0.2022
Plasmodium falciparum peptide deformylase 0.0456 0.2084 1
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0055 0.0144 0.0551
Echinococcus granulosus neuropeptide Y receptor 0.0065 0.0194 0.0173
Trypanosoma brucei Polypeptide deformylase 1 0.0174 0.072 0.2398
Loa Loa (eye worm) hypothetical protein 0.0055 0.0144 0.02
Giardia lamblia Cathepsin L-like protease 0.0142 0.0564 0.1995
Echinococcus granulosus hypothetical protein 0.0065 0.0194 0.0173
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0142 0.0564 0.0785
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1512 0.7186 0.718
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0267 0.089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0065 0.0194 0.0173
Giardia lamblia Cathepsin B precursor 0.0142 0.0564 0.1995
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Plasmodium vivax glutathione reductase, putative 0.0047 0.0104 0.05
Brugia malayi cathepsin L-like cysteine proteinase 0.0142 0.0564 0.0785
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0053 0.0205
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0566 0.2612 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0066 0.0198 0.0177
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0065 0.0194 0.0173
Giardia lamblia Cathepsin L precursor 0.0142 0.0564 0.1995
Brugia malayi Histone deacetylase family protein 0.0043 0.0085 0.0118
Schistosoma mansoni hypothetical protein 0.0123 0.0471 0.0451
Brugia malayi Thioredoxin reductase 0.0047 0.0104 0.0145
Echinococcus multilocularis snurportin 1 0.0611 0.283 0.2814
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0455 0.208 0.7927
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0142 0.0564 0.2707
Echinococcus granulosus smad 0.0066 0.0198 0.0177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0142 0.0564 0.2022
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0144 0.0385
Echinococcus multilocularis g protein coupled receptor 0.0065 0.0194 0.0173
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0194 0.0817 0.0797
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) TYRA-2 protein 0.0065 0.0194 0.0271
Entamoeba histolytica cysteine protease, putative 0.0142 0.0564 0.255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0403 0.1827 0.6941
Giardia lamblia Hypothetical protein 0.0142 0.0564 0.1995
Entamoeba histolytica Ran family GTPase 0.0042 0.0082 0.0182
Leishmania major cathepsin L-like protease 0.0646 0.3002 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0162 0.0141
Loa Loa (eye worm) hypothetical protein 0.0037 0.0055 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0055 0.0144 0.0385
Schistosoma mansoni opsin-like receptor 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Onchocerca volvulus 0.0065 0.0194 0.084
Trypanosoma cruzi cysteine protease, putative 0.0194 0.0817 0.1137
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0065 0.0194 0.0173
Echinococcus granulosus cysteine protease 0.0194 0.0817 0.0797
Plasmodium vivax unspecified product 0.0194 0.0817 0.3922
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0393 0.146
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0085 0.0118
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0055 0.0144 0.0123
Entamoeba histolytica hypothetical protein 0.0046 0.0103 0.0284
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0142 0.0564 0.1995
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Echinococcus granulosus sex peptide receptor 0.0065 0.0194 0.0173
Onchocerca volvulus 0.0065 0.0194 0.084
Echinococcus multilocularis dna polymerase eta 0.0117 0.0442 0.0422
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0103 0.0225
Brugia malayi MH2 domain containing protein 0.0971 0.4572 0.6362
Loa Loa (eye worm) melatonin receptor type 1A 0.0065 0.0194 0.0271
Entamoeba histolytica cysteine proteinase, putative 0.0403 0.1827 0.8756
Trypanosoma brucei histone deacetylase, putative 0.0043 0.0085 0.0282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.0564 0.2022
Loa Loa (eye worm) hypothetical protein 0.0455 0.208 0.2894
Plasmodium falciparum serine repeat antigen 4 0.0142 0.0564 0.2707
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Schistosoma mansoni biogenic amine receptor 0.0065 0.0194 0.0173
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0082 0.0114
Brugia malayi Dopamine receptor 0.0065 0.0194 0.0271
Echinococcus granulosus g protein coupled receptor 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0142 0.0564 0.2022
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0142 0.0564 0.2707
Echinococcus multilocularis dna polymerase kappa 0.0117 0.0442 0.0422
Schistosoma mansoni bromodomain containing protein 0.0062 0.0179 0.0158
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) aminopeptidase N 0.0034 0.0045 0.0063
Schistosoma mansoni neuropeptide f receptor 76f 0.0065 0.0194 0.0173
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0164 0.0586
Echinococcus multilocularis neuropeptide Y receptor 0.0065 0.0194 0.0173
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0455 0.208 0.2063
Echinococcus multilocularis cathepsin L 0.0194 0.0817 0.0797
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Onchocerca volvulus 0.0065 0.0194 0.084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0239 0.1031 0.1012
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0142 0.0564 0.2022
Echinococcus granulosus somatostatin receptor 0.0065 0.0194 0.0173
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0564 0.0544
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Echinococcus granulosus 7tm_1 domain containing protein 0.0065 0.0194 0.0173
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0164 0.0304
Onchocerca volvulus Cell death protein 3 homolog 0.0123 0.0471 0.2185
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0229 0.0986 0.4452
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Entamoeba histolytica hypothetical protein 0.0036 0.005 0.0026
Loa Loa (eye worm) prolyl oligopeptidase 0.0055 0.0144 0.02
Brugia malayi G-protein coupled receptor 0.0065 0.0194 0.0271
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0085 0.0063
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0393 0.146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0065 0.0194 0.0173
Brugia malayi prolyl oligopeptidase family protein 0.0146 0.0584 0.0812
Brugia malayi fibroinase precursor 0.0142 0.0564 0.0785
Brugia malayi Tachykinin-like peptides receptor 99D 0.0065 0.0194 0.0271
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0085 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0144 0.02
Loa Loa (eye worm) prolyl oligopeptidase 0.0381 0.1719 0.2393
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0053 0.0074
Toxoplasma gondii hypothetical protein 0.0456 0.2084 0.7977
Schistosoma mansoni hypothetical protein 0.0065 0.0194 0.0173
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0564 0.0544
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0142 0.0564 0.2707
Plasmodium falciparum serine repeat antigen 7 0.0142 0.0564 0.2707
Giardia lamblia Cysteine protease 0.0142 0.0564 0.1995
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0104 0.0145
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni DNA polymerase IV / kappa 0.0036 0.0053 0.0032
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0183
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0142 0.0564 0.2707
Echinococcus granulosus allatostatin A receptor 0.0065 0.0194 0.0173
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0082 0.0114
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0518 0.0498
Plasmodium falciparum thioredoxin reductase 0.0047 0.0104 0.05
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0065 0.0194 0.0271
Echinococcus multilocularis cathepsin L 0.0142 0.0564 0.0544
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Mycobacterium ulcerans DNA polymerase IV 0.0117 0.0442 0.1948
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0451 0.034
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.013 0.0506 0.1685
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0155 0.0516
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0381 0.1719 0.8248
Brugia malayi MH1 domain containing protein 0.0066 0.0198 0.0276
Loa Loa (eye worm) hypothetical protein 0.0142 0.0564 0.0785
Onchocerca volvulus 0.0065 0.0194 0.084
Echinococcus granulosus g protein coupled receptor 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0036 0.0053 0.0074
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.013 0.0506 0.2261
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0239 0.1031 0.1012
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0117 0.0442 0.0422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0146 0.0584 0.2234
Brugia malayi RNA, U transporter 1 0.0163 0.0665 0.0925
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0082 0.0061
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0174 0.072 0.1002
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0393 0.146
Echinococcus granulosus histone deacetylase 6 0.0043 0.0085 0.0063
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0142 0.0564 0.0544
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0065 0.0194 0.0271
Brugia malayi cathepsin L-like precursor 0.0403 0.1827 0.2542
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0144 0.0486
Trypanosoma cruzi prolyl endopeptidase 0.0284 0.1251 0.1741
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0142 0.0564 0.0785
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0053 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0053 0.0178
Echinococcus multilocularis caspase 2 0.0123 0.0471 0.0451
Leishmania major DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Loa Loa (eye worm) MH2 domain-containing protein 0.0066 0.0198 0.0276
Echinococcus multilocularis G protein coupled receptor 139 0.0065 0.0194 0.0173
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.013 0.0506 0.0704
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0132 0.0183
Loa Loa (eye worm) cysteine protease 0.0455 0.208 0.2894
Loa Loa (eye worm) hypothetical protein 0.007 0.0215 0.0299
Echinococcus granulosus biogenic amine 5HT receptor 0.0065 0.0194 0.0173
Leishmania major cysteine peptidase A (CPA) 0.0455 0.208 0.6928
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0239 0.1031 0.1435
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0164 0.0586
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0164 0.0629
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0034 0.0045 0.0024
Entamoeba histolytica cysteine protease, putative 0.0142 0.0564 0.255
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0518 0.0498
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0103 0.0225
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0455 0.208 0.2894
Loa Loa (eye worm) neuropeptide F receptor 0.0065 0.0194 0.0271
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0055 0.0144 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.0817 0.2722
Brugia malayi Bromodomain containing protein 0.0038 0.0061 0.0084
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0142 0.0564 0.255
Brugia malayi G protein-coupled receptor 0.0065 0.0194 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0164 0.0143
Echinococcus multilocularis geminin 0.2094 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0442 0.0615
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0564 0.0544
Onchocerca volvulus 0.0065 0.0194 0.084
Echinococcus granulosus histone deacetylase 0.0043 0.0085 0.0063
Giardia lamblia Cathepsin B precursor 0.0566 0.2612 1
Brugia malayi Importin beta-1 subunit 0.0057 0.0155 0.0216
Schistosoma mansoni hypothetical protein 0.0065 0.0194 0.0173
Loa Loa (eye worm) ctsf protein 0.0455 0.208 0.2894
Onchocerca volvulus 0.0065 0.0194 0.084
Schistosoma mansoni amine GPCR 0.0065 0.0194 0.0173
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.0564 0.2022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0566 0.2612 0.2596
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Schistosoma mansoni neuropeptide receptor 0.0065 0.0194 0.0173
Echinococcus granulosus dna polymerase kappa 0.0117 0.0442 0.0422
Echinococcus granulosus neuropeptides capa receptor 0.0065 0.0194 0.0173
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0142 0.0564 0.0785
Echinococcus granulosus peptide allatostatin:somatostatin 0.0065 0.0194 0.0173
Mycobacterium ulcerans DNA polymerase IV 0.0117 0.0442 0.1948
Trypanosoma brucei DNA damage repair protein, putative 0.0036 0.0053 0.0178
Giardia lamblia Cysteine protease 0.0142 0.0564 0.1995
Onchocerca volvulus 0.0455 0.208 1
Echinococcus granulosus dro:myosuppressin receptor 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Echinococcus multilocularis neuropeptides capa receptor 0.0065 0.0194 0.0173
Trypanosoma cruzi major cysteine proteinase, putative 0.0142 0.0564 0.0785
Brugia malayi cathepsin F-like cysteine proteinase 0.0142 0.0564 0.0785
Echinococcus multilocularis fmrfamide receptor 0.0065 0.0194 0.0173
Brugia malayi MH1 domain containing protein 0.0066 0.0198 0.0276
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0164 0.0586
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0091 0.0318 0.0443
Echinococcus multilocularis g-protein coupled receptor 0.0065 0.0194 0.0173
Entamoeba histolytica cysteine proteinase, putative 0.0455 0.208 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0455 0.208 0.9982
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0164 0.0143
Trypanosoma cruzi major cysteine proteinase, putative 0.0333 0.1486 0.2068
Toxoplasma gondii hypothetical protein 0.0055 0.0144 0.0551
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Onchocerca volvulus 0.0214 0.0914 0.4335
Loa Loa (eye worm) Smad1 0.0066 0.0198 0.0276
Brugia malayi Cathepsin L-like precursor 0.0455 0.208 0.2894
Trypanosoma brucei trypanothione reductase 0.0047 0.0104 0.0347
Brugia malayi prolyl oligopeptidase family protein 0.0381 0.1719 0.2393
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.0194 0.0173
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0381 0.1719 0.1702
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.0194 0.0173
Brugia malayi Cathepsin L-like precursor 0.0052 0.0132 0.0183
Brugia malayi Melatonin receptor type 1A 0.0065 0.0194 0.0271
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1512 0.7186 1
Onchocerca volvulus 0.0034 0.0045 0.0114
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.0817 0.3795
Schistosoma mansoni histamine h1 receptor 0.0065 0.0194 0.0173

Activities

Activity type Activity value Assay description Source Reference
Damaged area (functional) = 0.05 % Percentage of gastric damage was measured in rats. ChEMBL. 10197960
ED50 (functional) = 7.1 mg kg-1 ED50 of the compound was measured by CFE assay method. ChEMBL. 10197960
Inhibition (functional) = 77.4 % Percantage inhibition of the prostaglandin synthesis was measured in rats. ChEMBL. 10197960
Lesion frequency (functional) = 12.5 % Lesion frequency of the compound was measured in rats. ChEMBL. 10197960

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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