Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.5 |
Mycobacterium tuberculosis | Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor | 0.0143 | 0.2189 | 0.1323 |
Trichomonas vaginalis | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0187 | 0.3297 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0075 | 0.0464 | 0.0584 |
Onchocerca volvulus | 0.037 | 0.7931 | 0.783 | |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 1 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0277 | 0.5582 | 0.6348 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0075 | 0.0464 | 0.1406 |
Schistosoma mansoni | nAChR subunit | 0.0075 | 0.0464 | 0.0584 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0075 | 0.0464 | 0.0584 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0075 | 0.0464 | 0.1406 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Mycobacterium leprae | Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho | 0.0143 | 0.2189 | 0.1323 |
Schistosoma mansoni | nAChR subunit | 0.0075 | 0.0464 | 0.0584 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.4157 |
Onchocerca volvulus | 0.0452 | 1 | 1 | |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0075 | 0.0464 | 0.0464 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.014 | 0.2117 | 0.6423 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0075 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0375 | 0.8048 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.7055 | 0.7055 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.037 | 0.7931 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0075 | 0.0464 | 0.0584 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.7931 | 0.7931 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 1 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.4157 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0187 | 0.3297 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0452 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.014 | 0.2117 | 0.5837 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0075 | 0.0464 | 0.1406 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0187 | 0.3297 | 0.5 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0075 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.7931 | 0.7931 |
Leishmania major | xanthine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.5 |
Leishmania major | hypoxanthine-guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.5 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0075 | 0.0464 | 0.1406 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0375 | 0.8048 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.021 | 0.3867 | 0.375 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Plasmodium falciparum | hypoxanthine-guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0075 | 0.0464 | 0.0584 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0187 | 0.3297 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0075 | 0.0464 | 0.0584 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 1 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0075 | 0.0464 | 0.0464 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.014 | 0.2117 | 0.1734 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.014 | 0.2117 | 0.6423 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Onchocerca volvulus | 0.037 | 0.7931 | 0.783 | |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0075 | 0.0464 | 0.1406 |
Loa Loa (eye worm) | LGC-31 protein | 0.0075 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.014 | 0.2117 | 0.5837 |
Onchocerca volvulus | 0.0187 | 0.3297 | 0.2971 | |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 1 |
Brugia malayi | Phosphoribosyl transferase domain containing protein | 0.0187 | 0.3297 | 0.2971 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0075 | 0.0464 | 0.1406 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.0379 | 0.8153 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0075 | 0.0464 | 0.1406 |
Onchocerca volvulus | 0.037 | 0.7931 | 0.783 | |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0187 | 0.3297 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0075 | 0.0464 | 0.0584 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Brugia malayi | Cation transporter family protein | 0.037 | 0.7931 | 0.783 |
Schistosoma mansoni | nAChR subunit | 0.0075 | 0.0464 | 0.0584 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0277 | 0.5582 | 0.6348 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.5 |
Onchocerca volvulus | Putative nachr subunit | 0.014 | 0.2117 | 0.1734 |
Toxoplasma gondii | hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT | 0.0187 | 0.3297 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0075 | 0.0464 | 0.0584 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0277 | 0.5582 | 0.6348 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Schistosoma mansoni | nAChR subunit | 0.0075 | 0.0464 | 0.0584 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0187 | 0.3297 | 0.5 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0075 | 0.0464 | 0.0464 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0379 | 0.8153 | 0.5 |
Loa Loa (eye worm) | ACC-1 protein | 0.0075 | 0.0464 | 0.0464 |
Mycobacterium ulcerans | hypoxanthine-guanine phosphoribosyltransferase Hpt | 0.0187 | 0.3297 | 0.2964 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.2117 | 0.2117 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0379 | 0.8153 | 1 |
Echinococcus multilocularis | nAChR subunit | 0.0075 | 0.0464 | 0.1406 |
Loa Loa (eye worm) | ACC-1 protein | 0.0075 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0375 | 0.8048 | 1 |
Plasmodium vivax | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0187 | 0.3297 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.014 | 0.2117 | 0.6423 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.021 | 0.3867 | 0.3809 |
Loa Loa (eye worm) | hypothetical protein | 0.0452 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.014 | 0.2117 | 0.5837 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.5 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.014 | 0.2117 | 0.2117 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.037 | 0.7931 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0075 | 0.0464 | 0.1406 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0075 | 0.0464 | 0.1406 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.