Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis | 4'-phosphopantetheinyl transferase ffp | Starlite/ChEMBL | No references |
Homo sapiens | hydroxysteroid (17-beta) dehydrogenase 4 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | aminoadipate-semialdehyde dehydrogenase small subunit | 4'-phosphopantetheinyl transferase ffp | 224 aa | 183 aa | 27.3 % |
Candida albicans | aminoadipate-semialdehyde dehydrogenase small subunit | 4'-phosphopantetheinyl transferase ffp | 224 aa | 183 aa | 27.3 % |
Entamoeba histolytica | hypothetical protein | 4'-phosphopantetheinyl transferase ffp | 224 aa | 198 aa | 28.3 % |
Trichomonas vaginalis | conserved hypothetical protein | 4'-phosphopantetheinyl transferase ffp | 224 aa | 197 aa | 22.3 % |
Onchocerca volvulus | 4'-phosphopantetheinyl transferase ffp | 224 aa | 186 aa | 26.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0043 | 0.2002 | 1 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0049 | 0.2906 | 0.0311 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | Serotonin receptor | 0.0049 | 0.2906 | 0.0311 |
Onchocerca volvulus | 0.01 | 1 | 1 | |
Toxoplasma gondii | MaoC family domain-containing protein | 0.0029 | 0.0087 | 0.0432 |
Brugia malayi | G-protein coupled receptor | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | Melatonin receptor type 1A | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | neuropeptide F receptor | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | Dopamine receptor protein 2 | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0048 | 0.2678 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | Dopamine receptor protein 1 | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | AKH receptor | 0.0049 | 0.2906 | 0.0311 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | neuropeptide F receptor | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0049 | 0.2906 | 0.0311 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.01 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.01 | 1 | 1 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0049 | 0.2906 | 0.0311 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | putative neuropeptide receptor | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | G-protein coupled receptor | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0048 | 0.2678 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | sulfakinin receptor protein | 0.0049 | 0.2906 | 0.0311 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | follicle stimulating hormone receptor | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | Dopamine receptor | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0049 | 0.2906 | 0.0311 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | larval opioid receptor | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | RE15519p | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | GnHR receptor homolog | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Mycobacterium ulcerans | dehydratase | 0.0048 | 0.2678 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Mycobacterium ulcerans | hypothetical protein | 0.0048 | 0.2678 | 1 |
Brugia malayi | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | Serotonin receptor | 0.0049 | 0.2906 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2906 | 0.0311 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.01 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0028 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0049 | 0.2906 | 0.0311 |
Brugia malayi | ORL1-like opioid receptor | 0.0049 | 0.2906 | 0.0311 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PubChem BioAssay. Gel-Based Assay for Inhibitos of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase): Chemistry Optimization Follow up. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.6138 uM | PubChem BioAssay. Extended Characterization of HPGD Inhibitors: Counterscreen Against HSD17b4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.