Detailed information for compound 1705107

Basic information

Technical information
  • TDR Targets ID: 1705107
  • Name: 6-chloro-N,N-bis(2-methoxyethyl)pyridine-3-su lfonamide
  • MW: 308.782 | Formula: C11H17ClN2O4S
  • H donors: 0 H acceptors: 3 LogP: 0.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCN(S(=O)(=O)c1ccc(nc1)Cl)CCOC
  • InChi: 1S/C11H17ClN2O4S/c1-17-7-5-14(6-8-18-2)19(15,16)10-3-4-11(12)13-9-10/h3-4,9H,5-8H2,1-2H3
  • InChiKey: YDLKBAYEVYIHCM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-chloro-N,N-bis(2-methoxyethyl)-3-pyridinesulfonamide
  • 6-Chloro-pyridine-3-sulfonic acid bis-(2-methoxy-ethyl)-amide
  • MLS000778616
  • SMR000415410
  • ZINC02177726
  • AF-399/42309725
  • STOCK4S-53657

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Loa Loa (eye worm) C2 domain-containing protein 0.0057 0.3491 0.3491
Onchocerca volvulus 0.0057 0.3491 0.5
Schistosoma mansoni fer-1-related 0.0057 0.3491 0.3491
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0057 0.3491 0.3491
Trypanosoma brucei synaptotagmin, putative 0.0057 0.3491 0.5
Echinococcus multilocularis neural cell expressed, developmentally 0.0057 0.3491 0.3491
Schistosoma mansoni protein kinase C 0.0057 0.3491 0.3491
Schistosoma mansoni Mername-AA248 (C02 family) 0.0057 0.3491 0.3491
Echinococcus granulosus extended synaptotagmin 2 0.0057 0.3491 0.3491
Entamoeba histolytica DENN domain protein 0.0057 0.3491 0.5
Schistosoma mansoni hypothetical protein 0.0057 0.3491 0.3491
Brugia malayi C2 domain containing protein 0.0057 0.3491 0.3491
Entamoeba histolytica protein kinase, putative 0.0057 0.3491 0.5
Brugia malayi C2 domain containing protein 0.0057 0.3491 0.3491
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0057 0.3491 0.3491
Loa Loa (eye worm) RNA binding protein 0.0062 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0057 0.3491 0.5
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0057 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Echinococcus granulosus synaptotagmin 0.0057 0.3491 0.3491
Schistosoma mansoni tar DNA-binding protein 0.0062 1 1
Entamoeba histolytica C2 domain containing protein 0.0057 0.3491 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0057 0.3491 0.3491
Onchocerca volvulus Putative cc2d1b protein 0.0057 0.3491 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.3491 0.3491
Trichomonas vaginalis synaptotagmin, putative 0.0057 0.3491 0.5
Onchocerca volvulus 0.0057 0.3491 0.5
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0057 0.3491 0.3491
Echinococcus granulosus copine 9 0.0057 0.3491 0.3491
Trichomonas vaginalis calcium-dependent lipid-binding protein, putative 0.0057 0.3491 0.5
Plasmodium falciparum double C2-like domain-containing protein 0.0057 0.3491 0.5
Brugia malayi Variant SH3 domain containing protein 0.0057 0.3491 0.3491
Brugia malayi phospholipase C homolog 0.0057 0.3491 0.3491
Echinococcus granulosus neural cell expressed developmentally 0.0057 0.3491 0.3491
Entamoeba histolytica hypothetical protein 0.0057 0.3491 0.5
Entamoeba histolytica C2 domain containing protein 0.0057 0.3491 0.5
Trypanosoma brucei C2 domain/Ankyrin repeats (3 copies), putative 0.0057 0.3491 0.5
Leishmania major hypothetical protein, conserved 0.0057 0.3491 0.5
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0057 0.3491 0.5
Entamoeba histolytica C2 domain containing protein 0.0057 0.3491 0.5
Trypanosoma brucei predicted C2 domain protein 0.0057 0.3491 0.5
Echinococcus granulosus copine 9 0.0057 0.3491 0.3491
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0057 0.3491 0.5
Onchocerca volvulus 0.0057 0.3491 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Echinococcus multilocularis copine 9 0.0057 0.3491 0.3491
Echinococcus granulosus myoferlin 0.0057 0.3491 0.3491
Echinococcus granulosus tar DNA binding protein 0.0062 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0057 0.3491 0.3491
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0057 0.3491 0.3491
Brugia malayi C2 domain containing protein 0.0057 0.3491 0.3491
Echinococcus granulosus NEDD4 E3 ubiquitin protein ligase WWP1 0.0057 0.3491 0.3491
Trichomonas vaginalis copine, putative 0.0057 0.3491 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.3491 0.5
Echinococcus multilocularis synaptotagmin 0.0057 0.3491 0.3491
Leishmania major copine i-like protein 0.0057 0.3491 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Echinococcus granulosus protein kinase c epsilon type 0.0057 0.3491 0.3491
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.3491 0.3491
Brugia malayi C2 domain containing protein 0.0057 0.3491 0.3491
Brugia malayi C2 domain containing protein 0.0057 0.3491 0.3491
Schistosoma mansoni mctp-related 0.0057 0.3491 0.3491
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0057 0.3491 0.3491
Trichomonas vaginalis annexin VII, putative 0.0057 0.3491 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Echinococcus granulosus synaptotagmin 0.0057 0.3491 0.3491
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0057 0.3491 0.3491
Schistosoma mansoni unc-13 (munc13) 0.0057 0.3491 0.3491
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0057 0.3491 0.3491
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.3491 0.5
Echinococcus multilocularis calpain 5 0.0057 0.3491 0.3491
Trypanosoma brucei C2 domain containing protein, putative 0.0057 0.3491 0.5
Schistosoma mansoni synaptotagmin 0.0057 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0057 0.3491 0.3491
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0057 0.3491 0.3491
Schistosoma mansoni synaptotagmin 12 0.0057 0.3491 0.3491
Echinococcus granulosus synaptotagmin protein 4 0.0057 0.3491 0.3491
Loa Loa (eye worm) copine family protein 0.0057 0.3491 0.3491
Leishmania major hypothetical protein, conserved 0.0057 0.3491 0.5
Schistosoma mansoni E3 ubiquitin-protein ligase nedd-4 0.0057 0.3491 0.3491
Brugia malayi C2 domain containing protein 0.0057 0.3491 0.3491
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Brugia malayi C2 domain containing protein 0.0057 0.3491 0.3491
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0057 0.3491 0.5
Leishmania major hypothetical protein, conserved 0.0057 0.3491 0.5
Brugia malayi Synaptotagmin protein 3 0.0057 0.3491 0.3491
Trichomonas vaginalis ion channel nompc, putative 0.0057 0.3491 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Schistosoma mansoni glut4 vesicle protein-related 0.0057 0.3491 0.3491
Leishmania major hypothetical protein, conserved 0.0057 0.3491 0.5
Leishmania major hypothetical protein, conserved 0.0057 0.3491 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Leishmania major hypothetical protein, conserved 0.0057 0.3491 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Echinococcus granulosus synaptotagmin 2 0.0057 0.3491 0.3491
Loa Loa (eye worm) C2 domain-containing protein 0.0057 0.3491 0.3491
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0057 0.3491 0.3491
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0057 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Plasmodium vivax double C2-like domain-containing protein, putative 0.0057 0.3491 0.5
Onchocerca volvulus 0.0057 0.3491 0.5
Trichomonas vaginalis synaptotagmin, putative 0.0057 0.3491 0.5
Schistosoma mansoni unc-13 (munc13) 0.0057 0.3491 0.3491
Entamoeba histolytica calcium-binding protein, putative 0.0057 0.3491 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Onchocerca volvulus Multiple C2 domain and transmembrane region protein homolog 0.0057 0.3491 0.5
Trypanosoma brucei C2 domain containing protein, putative 0.0057 0.3491 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Entamoeba histolytica hypothetical protein 0.0057 0.3491 0.5
Brugia malayi Synapse defective protein 1 0.0057 0.3491 0.3491
Trichomonas vaginalis splicing factor 3A subunit, putative 0.0057 0.3491 0.5
Leishmania major hypothetical protein, conserved 0.0057 0.3491 0.5
Entamoeba histolytica C2 domain containing protein 0.0057 0.3491 0.5
Schistosoma mansoni copine 0.0057 0.3491 0.3491
Leishmania major phospholipase c-like protein 0.0057 0.3491 0.5
Echinococcus granulosus intersectin 2 0.0057 0.3491 0.3491
Echinococcus granulosus protein piccolo 0.0057 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Schistosoma mansoni synaptotagmin 0.0057 0.3491 0.3491
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Schistosoma mansoni tar DNA-binding protein 0.0062 1 1
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0057 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Brugia malayi NEDD4.2 0.0057 0.3491 0.3491
Echinococcus multilocularis copine 9 0.0057 0.3491 0.3491
Brugia malayi C2 domain containing protein 0.0057 0.3491 0.3491
Toxoplasma gondii Elicitor-responsive protein, putative 0.0057 0.3491 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.3491 0.5
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0057 0.3491 0.5
Echinococcus granulosus Protein kinase C brain isozyme 0.0057 0.3491 0.3491
Schistosoma mansoni synaptotagmin 0.0057 0.3491 0.3491
Echinococcus multilocularis synaptotagmin 2 0.0057 0.3491 0.3491
Echinococcus granulosus Immunoglobulin E set 0.0057 0.3491 0.3491
Trichomonas vaginalis copine, putative 0.0057 0.3491 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Schistosoma mansoni synaptotagmin 0.0057 0.3491 0.3491
Trypanosoma cruzi C2 domain/Ankyrin repeats (3 copies), putative 0.0057 0.3491 0.5
Echinococcus multilocularis synaptotagmin 0.0057 0.3491 0.3491
Trichomonas vaginalis Proline-rich protein, putative 0.0057 0.3491 0.5
Entamoeba histolytica hypothetical protein 0.0057 0.3491 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.3491 0.5
Leishmania major c2 domain protein, putative 0.0057 0.3491 0.5
Entamoeba histolytica C2 domain containing protein 0.0057 0.3491 0.5
Brugia malayi Copine VIII 0.0057 0.3491 0.3491
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Trypanosoma brucei C2 domain containing protein, putative 0.0057 0.3491 0.5
Echinococcus granulosus synaptotagmin 0.0057 0.3491 0.3491
Loa Loa (eye worm) synaptotagmin-1 0.0057 0.3491 0.3491
Trypanosoma brucei C2 domain containing protein, putative 0.0057 0.3491 0.5
Echinococcus granulosus unc 13 munc13 0.0057 0.3491 0.3491
Brugia malayi C2 domain containing protein 0.0057 0.3491 0.3491
Loa Loa (eye worm) TAR-binding protein 0.0062 1 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0057 0.3491 0.3491
Entamoeba histolytica hypothetical protein, conserved 0.0057 0.3491 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.3491 0.5
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0057 0.3491 0.3491
Schistosoma mansoni hypothetical protein 0.0057 0.3491 0.3491
Loa Loa (eye worm) C2 domain-containing protein 0.0057 0.3491 0.3491
Entamoeba histolytica C2 domain containing protein 0.0057 0.3491 0.5
Plasmodium vivax ferlin, putative 0.0057 0.3491 0.5
Schistosoma mansoni tar DNA-binding protein 0.0062 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 1 1
Toxoplasma gondii ferlin family protein 0.0057 0.3491 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Leishmania major c2 domain protein, putative 0.0057 0.3491 0.5
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0057 0.3491 0.5
Trypanosoma cruzi synaptotagmin, putative 0.0057 0.3491 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Echinococcus multilocularis synaptotagmin 0.0057 0.3491 0.3491
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Entamoeba histolytica Rap/Ran GTPase activating protein, putative 0.0057 0.3491 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Toxoplasma gondii hypothetical protein 0.0057 0.3491 0.5
Entamoeba histolytica hypothetical protein 0.0057 0.3491 0.5
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0057 0.3491 0.3491
Trypanosoma cruzi Coiled-coil and C2 domain-containing protein 0.0057 0.3491 0.5
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0057 0.3491 0.3491
Plasmodium falciparum ferlin, putative 0.0057 0.3491 0.5
Onchocerca volvulus 0.0057 0.3491 0.5
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0057 0.3491 0.3491
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0057 0.3491 0.3491
Brugia malayi TAR-binding protein 0.0062 1 1
Onchocerca volvulus 0.0057 0.3491 0.5
Echinococcus granulosus protein kinase C gamma type 0.0057 0.3491 0.3491
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0057 0.3491 0.3491
Plasmodium vivax hypothetical protein, conserved 0.0057 0.3491 0.5
Loa Loa (eye worm) C2 domain-containing protein 0.0057 0.3491 0.3491
Echinococcus granulosus active breakpoint cluster region 0.0057 0.3491 0.3491
Brugia malayi calpain 5 0.0057 0.3491 0.3491
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0057 0.3491 0.5
Trypanosoma brucei predicted C2 domain protein 0.0057 0.3491 0.5
Trichomonas vaginalis synaptotagmin, putative 0.0057 0.3491 0.5
Echinococcus multilocularis protein piccolo 0.0057 0.3491 0.3491
Trichomonas vaginalis synaptotagmin, putative 0.0057 0.3491 0.5
Brugia malayi Synaptotagmin I 0.0057 0.3491 0.3491
Entamoeba histolytica C2 domain protein, putative 0.0057 0.3491 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Plasmodium falciparum ferlin, putative 0.0057 0.3491 0.5
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0057 0.3491 0.5
Trichomonas vaginalis synaptotagmin, putative 0.0057 0.3491 0.5
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0057 0.3491 0.3491
Schistosoma mansoni rabphilin-3a 0.0057 0.3491 0.3491
Echinococcus multilocularis myoferlin 0.0057 0.3491 0.3491
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.3491 0.5
Trypanosoma cruzi C2 domain containing protein, putative 0.0057 0.3491 0.5
Schistosoma mansoni unc-13 (munc13) 0.0057 0.3491 0.3491
Schistosoma mansoni hypothetical protein 0.0057 0.3491 0.3491
Loa Loa (eye worm) C2 domain-containing protein 0.0057 0.3491 0.3491
Trypanosoma brucei Coiled-coil and C2 domain-containing protein 0.0057 0.3491 0.5
Schistosoma mansoni synaptotagmin 0.0057 0.3491 0.3491
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0057 0.3491 0.3491
Echinococcus multilocularis UNCoordinated family member (unc 13) 0.0057 0.3491 0.3491
Entamoeba histolytica protein kinase, putative 0.0057 0.3491 0.5
Trypanosoma cruzi cAMP binding protein, putative 0.0057 0.3491 0.5
Brugia malayi C2 domain containing protein 0.0057 0.3491 0.3491
Echinococcus multilocularis tar DNA binding protein 0.0062 1 1
Echinococcus multilocularis 0.0057 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Schistosoma mansoni tar DNA-binding protein 0.0062 1 1
Onchocerca volvulus 0.0057 0.3491 0.5
Trichomonas vaginalis copine, putative 0.0057 0.3491 0.5
Entamoeba histolytica C2 domain containing protein 0.0057 0.3491 0.5
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0057 0.3491 0.5
Loa Loa (eye worm) C2 domain-containing protein 0.0057 0.3491 0.3491
Echinococcus multilocularis protein kinase c epsilon type 0.0057 0.3491 0.3491
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Onchocerca volvulus 0.0057 0.3491 0.5
Echinococcus multilocularis serine threonine protein kinase 0.0057 0.3491 0.3491
Loa Loa (eye worm) Nedd4-PD 0.0057 0.3491 0.3491
Brugia malayi Protein kinase c protein 2 0.0057 0.3491 0.3491
Schistosoma mansoni hypothetical protein 0.0057 0.3491 0.3491
Echinococcus multilocularis extended synaptotagmin 2 0.0057 0.3491 0.3491
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0057 0.3491 0.5
Echinococcus granulosus synaptotagmin 15 0.0057 0.3491 0.3491
Echinococcus granulosus synaptotagmin 0.0057 0.3491 0.3491
Schistosoma mansoni synaptotagmin 12 0.0057 0.3491 0.3491
Trypanosoma brucei cAMP binding protein, putative 0.0057 0.3491 0.5
Trichomonas vaginalis copine, putative 0.0057 0.3491 0.5
Trichomonas vaginalis copine, putative 0.0057 0.3491 0.5
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0057 0.3491 0.3491
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.3491 0.3491
Toxoplasma gondii hypothetical protein 0.0057 0.3491 0.5
Entamoeba histolytica hypothetical protein 0.0057 0.3491 0.5
Echinococcus granulosus otoferlin 0.0057 0.3491 0.3491
Brugia malayi C2 domain containing protein 0.0057 0.3491 0.3491
Echinococcus granulosus calpain 5 0.0057 0.3491 0.3491
Schistosoma mansoni otoferlin 0.0057 0.3491 0.3491
Echinococcus multilocularis synaptotagmin 0.0057 0.3491 0.3491
Brugia malayi C2 domain containing protein 0.0057 0.3491 0.3491
Trypanosoma brucei predicted C2 domain protein 0.0057 0.3491 0.5
Trichomonas vaginalis synaptotagmin, putative 0.0057 0.3491 0.5
Leishmania major hypothetical protein, conserved 0.0057 0.3491 0.5
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0057 0.3491 0.5
Trichomonas vaginalis synaptotagmin, putative 0.0057 0.3491 0.5
Echinococcus multilocularis synaptotagmin 0.0057 0.3491 0.3491
Echinococcus granulosus UNCoordinated family member unc 13 0.0057 0.3491 0.3491
Schistosoma mansoni synaptic ras gtpase activating protein syngap 0.0057 0.3491 0.3491
Schistosoma mansoni tar DNA-binding protein 0.0062 1 1
Brugia malayi WW domain containing protein 0.0057 0.3491 0.3491
Brugia malayi Synapse defective protein 1 0.0057 0.3491 0.3491
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.3491 0.3491
Echinococcus multilocularis synaptotagmin 15 0.0057 0.3491 0.3491
Trichomonas vaginalis vab10 spectraplakin, putative 0.0057 0.3491 0.5
Schistosoma mansoni nedd-4-like E3 ubiquitin-protein ligase 0.0057 0.3491 0.3491
Schistosoma mansoni synaptotagmin 0.0057 0.3491 0.3491
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Trichomonas vaginalis Circumsporozoite protein precursor, putative 0.0057 0.3491 0.5
Brugia malayi protein kinase C II. 0.0057 0.3491 0.3491
Entamoeba histolytica hypothetical protein 0.0057 0.3491 0.5
Echinococcus multilocularis unc 13 (munc13) 0.0057 0.3491 0.3491
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0057 0.3491 0.3491
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0057 0.3491 0.3491
Plasmodium vivax ferlin, putative 0.0057 0.3491 0.5
Entamoeba histolytica C2 domain containing protein 0.0057 0.3491 0.5
Entamoeba histolytica C2 domain containing protein 0.0057 0.3491 0.5
Echinococcus multilocularis synaptotagmin protein 4 0.0057 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Schistosoma mansoni hypothetical protein 0.0057 0.3491 0.3491
Brugia malayi C2 domain containing protein 0.0057 0.3491 0.3491
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.3491 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Echinococcus multilocularis intersectin 2 0.0057 0.3491 0.3491
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0057 0.3491 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Echinococcus granulosus synaptotagmin 0.0057 0.3491 0.3491
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.3491 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.3491 0.5
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0057 0.3491 0.5
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0057 0.3491 0.3491
Toxoplasma gondii Sma protein 0.0057 0.3491 0.5
Echinococcus multilocularis NEDD4 E3 ubiquitin protein ligase WWP1 0.0057 0.3491 0.3491
Brugia malayi LD23056p 0.0057 0.3491 0.3491
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Echinococcus multilocularis active breakpoint cluster region 0.0057 0.3491 0.3491
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.3491 0.5
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0057 0.3491 0.3491
Toxoplasma gondii C2 domain-containing protein 0.0057 0.3491 0.5
Schistosoma mansoni rho gtpase activating protein 0.0057 0.3491 0.3491
Trypanosoma cruzi synaptotagmin, putative 0.0057 0.3491 0.5
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0057 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0057 0.3491 0.3491
Brugia malayi Copine family protein 0.0057 0.3491 0.3491
Schistosoma mansoni synaptotagmin-like protein 0.0057 0.3491 0.3491
Brugia malayi C2 domain containing protein 0.0057 0.3491 0.3491
Toxoplasma gondii hypothetical protein 0.0057 0.3491 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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