TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 383.395 | Formula: C21H21NO6
H donors: 0 H acceptors: 1 LogP: 3.84 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OC)C1CCc2c(C1=NOC(=O)C)cc1c(c2)OCO1
InChi: 1S/C21H21NO6/c1-12(23)28-22-21-15(13-5-7-17(24-2)18(8-13)25-3)6-4-14-9-19-20(10-16(14)21)27-11-26-19/h5,7-10,15H,4,6,11H2,1-3H3
InChiKey: ZLNILMHQBVKPMC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Chlamydia trachomatis	SWIB complex protein	0.1169	1	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0416	0.3472	0.3472
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0416	0.3472	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0066	0.0066
Leishmania major	hypothetical protein, conserved	0.0416	0.3472	1
Brugia malayi	RING zinc finger protein	0.0021	0.0051	0.0051
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0021	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.1169	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0023	0.0066	0.0066
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0066	0.0044
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Schistosoma mansoni	fusion	0.0416	0.3472	0.3472
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0051
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0021	0.0051	0.0051
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1169	1	1
Onchocerca volvulus		0.0416	0.3472	0.3472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0066	0.0066
Schistosoma mansoni	peter pan-related	0.0021	0.0051	0.0051
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0021	0.0051	0.0146
Onchocerca volvulus		0.0023	0.0066	0.0066
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0066	0.0066
Onchocerca volvulus		0.0416	0.3472	0.3472
Echinococcus multilocularis	cathepsin L cysteine protease	0.0023	0.0066	0.0033
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0066	0.0066
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0066	0.0044
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0066	0.0066
Echinococcus multilocularis	SWI:SNF matrix associated	0.1169	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0023	0.0066	0.0015
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0051	0.7729
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0023	0.0066	0.0033
Loa Loa (eye worm)	cysteine protease	0.0023	0.0066	0.0066
Echinococcus multilocularis	SWI:SNF matrix associated	0.1169	1	1
Echinococcus multilocularis	ring finger protein 113a	0.0021	0.0051	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0051
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0051	0.0146
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0023	0.0066	0.0015
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Leishmania major	hypothetical protein, conserved	0.0416	0.3472	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0066	0.0066
Onchocerca volvulus		0.0021	0.0051	0.0051
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0066	0.0066
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0021	0.0051	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0066	0.0066
Onchocerca volvulus		0.0021	0.0051	0.0051
Onchocerca volvulus	Putative RING finger protein 207	0.0021	0.0051	0.0051
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0021	0.0051	0.0051
Echinococcus granulosus	ring finger protein 113a	0.0021	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Echinococcus multilocularis	ring finger protein 170	0.0021	0.0051	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0066	0.0066
Schistosoma mansoni	hypothetical protein	0.0021	0.0051	0.0051
Trypanosoma cruzi	cruzipain precursor, putative	0.0023	0.0066	0.0189
Trichomonas vaginalis	ankyrin, putative	0.0021	0.0051	0.0051
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0051	0.7729
Schistosoma mansoni	TRABID protein (C64 family)	0.0416	0.3472	0.3472
Trypanosoma cruzi	hypothetical protein, conserved	0.0416	0.3472	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0066	0.0066
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0389	0.0389
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Brugia malayi	YY1-associated factor 2	0.0416	0.3472	0.3472
Leishmania major	cathepsin L-like protease	0.0023	0.0066	0.0044
Plasmodium vivax	hypothetical protein, conserved	0.1169	1	1
Loa Loa (eye worm)	RING finger protein 20	0.0021	0.0051	0.0051
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0066	1
Echinococcus granulosus	SWI:SNF matrix associated	0.1169	1	1
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0032	0.0032
Onchocerca volvulus		0.0023	0.0066	0.0066
Echinococcus multilocularis	cathepsin L cysteine protease	0.0023	0.0066	0.0033
Onchocerca volvulus	Cathepsin L homolog	0.0023	0.0066	0.0066
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0416	0.3472	0.3472
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0416	0.3472	0.3472
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0051	0.7729
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0021	0.0051	0.0051
Onchocerca volvulus		0.0021	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0021	0.0051	0.0051
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0066	0.0066
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0066	0.0066
Schistosoma mansoni	peter pan-related	0.0021	0.0051	0.0051
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0051
Leishmania major	cathepsin L-like protease	0.0023	0.0066	0.0044
Brugia malayi	Neuralized family protein	0.0021	0.0051	0.0051
Schistosoma mansoni	serine/threonine protein kinase	0.0021	0.0051	0.0051
Trichomonas vaginalis	cell cycle control protein cwf24, putative	0.0021	0.0051	0.0051
Giardia lamblia	Hypothetical protein	0.0021	0.0051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0066	0.0066
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Giardia lamblia	Hypothetical protein	0.0021	0.0051	0.5
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0021	0.0051	0.0051
Schistosoma mansoni	mind bomb	0.0021	0.0051	0.0051
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0021	0.0051	0.0051
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0051	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0051
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0066	0.0066
Plasmodium vivax	vivapain-2	0.0023	0.0066	0.0015
Echinococcus granulosus	Zinc finger RanBP2 type	0.0416	0.3472	0.3472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0066	0.0066
Leishmania major	cysteine peptidase A (CPA)	0.0023	0.0066	0.0044
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.1169	1	1
Brugia malayi	B-box zinc finger family protein	0.0021	0.0051	0.0051
Entamoeba histolytica	SPRY domain protein	0.0021	0.0051	0.7729
Schistosoma mansoni	hypothetical protein	0.1169	1	1
Trichomonas vaginalis	ankyrin, putative	0.0021	0.0051	0.0051
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0416	0.3472	0.3438
Loa Loa (eye worm)	hypothetical protein	0.0416	0.3472	0.3472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0066	0.0066
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Brugia malayi	RING finger protein 20	0.0021	0.0051	0.0051
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0032	0.0032
Brugia malayi	SWIB/MDM2 domain containing protein	0.1169	1	1
Plasmodium vivax	vivapain-2	0.0023	0.0066	0.0015
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0051
Leishmania major	hypothetical protein, conserved	0.0416	0.3472	1
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Giardia lamblia	Hypothetical protein	0.0021	0.0051	0.5
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Schistosoma mansoni	zinc finger protein	0.0021	0.0051	0.0051
Onchocerca volvulus		0.0023	0.0066	0.0066
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Giardia lamblia	Zinc finger domain	0.0021	0.0051	0.5
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0416	0.3472	0.3438
Schistosoma mansoni	hypothetical protein	0.0041	0.0224	0.0224
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0416	0.3472	0.3472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0066	0.0066
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0066	0.0066
Onchocerca volvulus	Cathepsin F homolog	0.0023	0.0066	0.0066
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0021	0.0051	0.0051
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0416	0.3472	0.3451
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Echinococcus granulosus	RING finger protein 185	0.0021	0.0051	0.0051
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Echinococcus multilocularis	cysteine protease	0.0023	0.0066	0.0033
Loa Loa (eye worm)	brahma associated protein	0.1169	1	1
Giardia lamblia	Hypothetical protein	0.0021	0.0051	0.5
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0032	0.0032
Brugia malayi	Zinc finger, C2H2 type family protein	0.0021	0.0051	0.0051
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0021	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0021	0.0051	0.0051
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Schistosoma mansoni	inhibitor of apoptosis 1 diap1	0.0021	0.0051	0.0051
Schistosoma mansoni	zinc finger protein	0.0416	0.3472	0.3472
Leishmania major	cathepsin L-like protease	0.0023	0.0066	0.0044
Chlamydia trachomatis	DNA topoisomerase I	0.1169	1	0.5
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0021	0.0051	0.0051
Trichomonas vaginalis	ion channel nompc, putative	0.0021	0.0051	0.0051
Loa Loa (eye worm)	RiNg Finger protein family member	0.0021	0.0051	0.0051
Giardia lamblia	Kinase, NEK	0.0021	0.0051	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0416	0.3472	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0051
Trypanosoma cruzi	hypothetical protein	0.0021	0.0051	0.0146
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0032	0.0032
Onchocerca volvulus		0.0023	0.0066	0.0066
Onchocerca volvulus		0.0021	0.0051	0.0051
Schistosoma mansoni	hypothetical protein	0.1169	1	1
Giardia lamblia	Ser/Thr protein kinase	0.0021	0.0051	0.5
Echinococcus granulosus	ring finger protein 170	0.0021	0.0051	0.0051
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0051	0.7729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0066	0.0066
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0021	0.0051	0.0051
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1169	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0066	0.0044
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0066	0.0044
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0021	0.0051	0.0146
Brugia malayi	Zinc finger protein 183 homolog	0.0021	0.0051	0.0051
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Schistosoma mansoni	ring finger protein 151	0.0021	0.0051	0.0051
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Onchocerca volvulus	Protein neuralized homolog	0.0021	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0023	0.0066	0.0066
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0023	0.0066	0.0066
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0066	0.0044
Giardia lamblia	Hypothetical protein	0.0021	0.0051	0.5
Entamoeba histolytica	hypothetical protein	0.0021	0.0051	0.7729
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0066	0.0066
Schistosoma mansoni	hypothetical protein	0.0021	0.0051	0.0051
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Trypanosoma cruzi	WLM domain containing protein, putative	0.0416	0.3472	1
Trichomonas vaginalis	ankyrin, putative	0.0021	0.0051	0.0051
Onchocerca volvulus	Cathepsin L homolog	0.0023	0.0066	0.0066
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.1169	1	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0416	0.3472	0.3472
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0021	0.0051	0.0018
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0051	0.7729
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0066	0.0044
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0032	0.0032
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0416	0.3472	1
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.1169	1	1
Schistosoma mansoni	brg-1 associated factor	0.1169	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0023	0.0066	0.0066
Toxoplasma gondii	cathepsin CPL	0.0023	0.0066	0.0015
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0066	0.0066
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0066	0.0044
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0066	0.0066
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0023	0.0066	0.0066
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0021	0.0051	0.0051
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0066	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0021	0.0051	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0066	0.0066
Schistosoma mansoni	rnf5	0.0021	0.0051	0.0051
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0416	0.3472	0.3451
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0416	0.3472	1
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0051
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0023	0.0066	0.0033
Trypanosoma brucei	hypothetical protein, conserved	0.0416	0.3472	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0023	0.0066	0.0066
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0066	0.0066
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0416	0.3472	0.3472
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Loa Loa (eye worm)	ctsf protein	0.0023	0.0066	0.0066
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0021	0.0051	0.0051
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0051
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0051	0.0146
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0021	0.0051	0.0051
Schistosoma mansoni	hypothetical protein	0.0416	0.3472	0.3472
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Giardia lamblia	Zinc finger domain	0.0021	0.0051	0.5
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0416	0.3472	1
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0021	0.0051	0.0051
Schistosoma mansoni	hypothetical protein	0.0019	0.0032	0.0032
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0066	0.0066
Schistosoma mansoni	hypothetical protein	0.0019	0.0032	0.0032
Echinococcus multilocularis		0.0021	0.0051	0.0018
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0051	0.7729
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Brugia malayi	brahma associated protein 60 kDa	0.1169	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0023	0.0066	0.0066
Toxoplasma gondii	ran binding protein	0.0416	0.3472	0.3438
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0066	0.0066
Echinococcus granulosus	zinc finger protein Ran binding	0.0416	0.3472	0.3472
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0021	0.0051	0.0018
Giardia lamblia	E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B	0.0021	0.0051	0.5
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Leishmania major	cathepsin L-like protease	0.0023	0.0066	0.0044
Schistosoma mansoni	hypothetical protein	0.0019	0.0032	0.0032
Schistosoma mansoni	RNA binding protein	0.0416	0.3472	0.3472
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Giardia lamblia	Kinase	0.0021	0.0051	0.5
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0021	0.0051	0.0018
Leishmania major	cathepsin L-like protease	0.0023	0.0066	0.0044
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0066	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0066	0.0066
Entamoeba histolytica	cysteine protease, putative	0.0023	0.0066	1
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0416	0.3472	0.3472
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0224	0.0224
Giardia lamblia	Kinase, NEK	0.0021	0.0051	0.5
Leishmania major	hypothetical protein, conserved	0.0416	0.3472	1
Trichomonas vaginalis	hypothetical protein	0.0021	0.0051	0.0051
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0416	0.3472	1
Schistosoma mansoni	hypothetical protein	0.1169	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0066	0.0189
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0416	0.3472	0.3472
Onchocerca volvulus		0.0021	0.0051	0.0051
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0021	0.0051	0.0051
Echinococcus granulosus	cathepsin l1	0.0023	0.0066	0.0066
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0066	0.0066
Echinococcus multilocularis	ring and YY1 binding protein	0.0416	0.3472	0.3451
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0066	0.0044
Echinococcus multilocularis	SWI:SNF matrix associated	0.1169	1	1
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.1169	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0389	0.0389
Leishmania major	cathepsin L-like protease	0.0023	0.0066	0.0044
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Trypanosoma cruzi	hypothetical protein	0.0021	0.0051	0.0146
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0023	0.0066	0.0015
Leishmania major	cathepsin L-like protease	0.0023	0.0066	0.0044
Entamoeba histolytica	hypothetical protein	0.0021	0.0051	0.7729
Onchocerca volvulus		0.0023	0.0066	0.0066
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Echinococcus multilocularis	zinc finger protein Ran binding	0.0416	0.3472	0.3451
Echinococcus multilocularis	cysteine protease	0.0023	0.0066	0.0033
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0066	0.0066
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0066	0.0066
Loa Loa (eye worm)	fibroinase	0.0023	0.0066	0.0066
Echinococcus multilocularis	RING finger protein 185	0.0021	0.0051	0.0018
Schistosoma mansoni	hypothetical protein	0.0019	0.0032	0.0032
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0416	0.3472	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0066	0.0044
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0066	0.0189
Onchocerca volvulus		0.0416	0.3472	0.3472
Echinococcus granulosus	GPCR family 2	0.0019	0.0032	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Onchocerca volvulus		0.1169	1	1
Schistosoma mansoni	hypothetical protein	0.0021	0.0051	0.0051
Echinococcus granulosus	ring and YY1 binding protein	0.0416	0.3472	0.3472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0066	0.0066
Onchocerca volvulus		0.0021	0.0051	0.0051
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0416	0.3472	0.3472
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0416	0.3472	1
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Onchocerca volvulus		0.0023	0.0066	0.0066
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0051	0.0146
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0389	0.0389
Trypanosoma cruzi	WLM domain containing protein, putative	0.0416	0.3472	1
Giardia lamblia	Hypothetical protein	0.0021	0.0051	0.5
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.1169	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Onchocerca volvulus		0.0023	0.0066	0.0066
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0416	0.3472	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0051	0.0146
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0051	0.7729
Onchocerca volvulus	RING finger protein 141 homolog	0.0021	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0051
Leishmania major	hypothetical protein, conserved	0.0416	0.3472	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0389	0.0389
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0416	0.3472	1
Giardia lamblia	Ribonuclease	0.0021	0.0051	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0051	0.0051
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0051	0.0146
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0051
Giardia lamblia	Hypothetical protein	0.0021	0.0051	0.5
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0.0051	0.7729
Leishmania major	cathepsin L-like protease	0.0023	0.0066	0.0044
Onchocerca volvulus		0.0416	0.3472	0.3472
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.1169	1	1
Brugia malayi	hypothetical protein	0.0021	0.0051	0.0051
Giardia lamblia	Protein 21.1	0.0021	0.0051	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0066	0.0189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0066	0.0044
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0066	0.0189
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0021	0.0051	0.0146
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0051	0.0146
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0416	0.3472	0.3472

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.1623 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2140558

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1705881