Detailed information for compound 1706391

Basic information

Technical information
  • TDR Targets ID: 1706391
  • Name: 3-[2-(1,3-benzodioxol-5-yl)-2-oxoethyl]-8-met hyl-1,3-diazaspiro[4.5]decane-2,4-dione
  • MW: 344.362 | Formula: C18H20N2O5
  • H donors: 1 H acceptors: 3 LogP: 2.21 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCC2(CC1)NC(=O)N(C2=O)CC(=O)c1ccc2c(c1)OCO2
  • InChi: 1S/C18H20N2O5/c1-11-4-6-18(7-5-11)16(22)20(17(23)19-18)9-13(21)12-2-3-14-15(8-12)25-10-24-14/h2-3,8,11H,4-7,9-10H2,1H3,(H,19,23)
  • InChiKey: HXPSSRYANGSYLC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-(1,3-benzodioxol-5-yl)-2-oxo-ethyl]-8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione
  • 3-[2-(1,3-benzodioxol-5-yl)-2-keto-ethyl]-8-methyl-1,3-diazaspiro[4.5]decane-2,4-quinone
  • ZT-5308883

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.006 0.5218 0.5218
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.5218 0.5218
Loa Loa (eye worm) hypothetical protein 0.0037 0.2654 0.2654
Brugia malayi YY1-associated factor 2 0.0037 0.2654 0.2654
Schistosoma mansoni TRABID protein (C64 family) 0.0037 0.2654 0.2107
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0037 0.2654 1
Schistosoma mansoni zinc finger protein 0.0037 0.2654 0.2107
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0037 0.2654 0.2654
Plasmodium vivax hypothetical protein, conserved 0.0104 1 0.5
Onchocerca volvulus 0.0104 1 1
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0037 0.2654 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0104 1 1
Brugia malayi SWIB/MDM2 domain containing protein 0.0104 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.3124 0.3124
Leishmania major hypothetical protein, conserved 0.0037 0.2654 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.2654 0.2654
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.4672 0.4672
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.4672 0.4276
Schistosoma mansoni hypothetical protein 0.0037 0.2654 0.2107
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0037 0.2654 0.2107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.4672 0.4276
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0037 0.2654 0.2654
Echinococcus granulosus Zinc finger RanBP2 type 0.0037 0.2654 0.2107
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0104 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.2654 0.2654
Schistosoma mansoni fusion 0.0037 0.2654 0.2107
Loa Loa (eye worm) hypothetical protein 0.0037 0.2654 0.2654
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.2654 1
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0037 0.2654 0.2107
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0037 0.2654 1
Leishmania major hypothetical protein, conserved 0.0037 0.2654 1
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.2654 1
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0104 1 1
Leishmania major hypothetical protein, conserved 0.0037 0.2654 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0037 0.2654 0.2654
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0037 0.2654 1
Trichomonas vaginalis conserved hypothetical protein 0.0104 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0693 0.0693
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.4672 0.4276
Echinococcus multilocularis ring and YY1 binding protein 0.0037 0.2654 0.2107
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0104 1 0.5
Trypanosoma cruzi WLM domain containing protein, putative 0.0037 0.2654 1
Leishmania major hypothetical protein, conserved 0.0037 0.2654 1
Schistosoma mansoni hypothetical protein 0.0104 1 1
Echinococcus granulosus zinc finger protein Ran binding 0.0037 0.2654 0.2107
Echinococcus multilocularis SWI:SNF matrix associated 0.0104 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.2654 0.2654
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0104 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.2654 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.4672 0.4276
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0104 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.2654 1
Schistosoma mansoni hypothetical protein 0.0041 0.3124 0.2611
Echinococcus multilocularis zinc finger protein Ran binding 0.0037 0.2654 0.2107
Schistosoma mansoni RNA binding protein 0.0037 0.2654 0.2107
Schistosoma mansoni brg-1 associated factor 0.0104 1 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0 0.5
Schistosoma mansoni hypothetical protein 0.0104 1 1
Brugia malayi brahma associated protein 60 kDa 0.0104 1 1
Chlamydia trachomatis DNA topoisomerase I 0.0104 1 0.5
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0037 0.2654 0.2107
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.4672 0.4672
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0693 0.0693
Echinococcus multilocularis SWI:SNF matrix associated 0.0104 1 1
Loa Loa (eye worm) brahma associated protein 0.0104 1 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0037 0.2654 1
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0037 0.2654 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0037 0.2654 0.2654
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0693 0.0693
Chlamydia trachomatis SWIB complex protein 0.0104 1 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.5218 0.5218
Echinococcus granulosus ring and YY1 binding protein 0.0037 0.2654 0.2107
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0104 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.3124 0.3124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.4672 0.4276
Trypanosoma cruzi WLM domain containing protein, putative 0.0037 0.2654 1
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0104 1 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0104 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0693 0.0693
Echinococcus granulosus SWI:SNF matrix associated 0.0104 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.4672 0.4276
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.5218 0.5218
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0037 0.2654 1
Schistosoma mansoni hypothetical protein 0.0104 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.4672 0.4276
Leishmania major hypothetical protein, conserved 0.0037 0.2654 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.2654 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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