Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0443 | 0.334 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.1244 | 1 | 0.5 |
Onchocerca volvulus | 0.0443 | 0.334 | 0.3311 | |
Leishmania major | hypothetical protein, conserved | 0.0443 | 0.334 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0443 | 0.334 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0443 | 0.334 | 0.3336 |
Brugia malayi | Animal haem peroxidase family protein | 0.0046 | 0.0043 | 0.0037 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0443 | 0.334 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.1244 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0443 | 0.334 | 0.5 |
Onchocerca volvulus | 0.0443 | 0.334 | 0.3311 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0046 | 0.0043 | 0.0037 |
Schistosoma mansoni | hypothetical protein | 0.1244 | 1 | 1 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0443 | 0.334 | 0.3311 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0043 | 0.0037 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0062 | 0.0179 | 0.0137 |
Brugia malayi | hypothetical protein | 0.0046 | 0.0043 | 0.0037 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1244 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0043 | 0.0037 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0443 | 0.334 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.1244 | 1 | 1 |
Onchocerca volvulus | 0.1244 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0043 | 0.0037 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1244 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0443 | 0.334 | 0.5 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0443 | 0.334 | 0.3311 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0147 | 0.088 | 0.088 |
Schistosoma mansoni | peroxidasin | 0.0046 | 0.0043 | 0.0043 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0062 | 0.0179 | 0.0137 |
Schistosoma mansoni | zinc finger protein | 0.0443 | 0.334 | 0.334 |
Brugia malayi | Peroxidasin | 0.0046 | 0.0043 | 0.0037 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0443 | 0.334 | 0.3336 |
Schistosoma mansoni | hypothetical protein | 0.1244 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.1244 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0443 | 0.334 | 0.5 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0443 | 0.334 | 0.3311 |
Echinococcus multilocularis | tumor protein p63 | 0.1002 | 0.7983 | 0.7974 |
Echinococcus granulosus | tumor protein p63 | 0.1002 | 0.7983 | 0.7974 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0043 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.334 | 0.3336 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0443 | 0.334 | 0.5 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0443 | 0.334 | 0.3311 |
Brugia malayi | Animal haem peroxidase family protein | 0.0046 | 0.0043 | 0.0037 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1244 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.1244 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0043 | 0.0037 |
Leishmania major | hypothetical protein, conserved | 0.0443 | 0.334 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0043 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.334 | 0.3336 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.088 | 0.0875 |
Brugia malayi | Blistered cuticle protein 3 | 0.0046 | 0.0043 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0043 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.334 | 0.3336 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.334 | 0.3336 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0443 | 0.334 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0443 | 0.334 | 0.3336 |
Onchocerca volvulus | 0.0147 | 0.088 | 0.0841 | |
Schistosoma mansoni | RNA binding protein | 0.0443 | 0.334 | 0.334 |
Schistosoma mansoni | hypothetical protein | 0.1244 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0046 | 0.0043 | 0.0037 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0443 | 0.334 | 0.3336 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0443 | 0.334 | 0.5 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0443 | 0.334 | 0.3311 |
Schistosoma mansoni | peroxidasin | 0.0046 | 0.0043 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.334 | 0.3336 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.1244 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0046 | 0.0043 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0043 | 0.0037 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1244 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.1244 | 1 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0443 | 0.334 | 0.3336 |
Brugia malayi | Animal haem peroxidase family protein | 0.0046 | 0.0043 | 0.0037 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0443 | 0.334 | 0.3311 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0443 | 0.334 | 0.3311 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0043 | 0.0037 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.1244 | 1 | 1 |
Onchocerca volvulus | 0.0443 | 0.334 | 0.3311 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0443 | 0.334 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0443 | 0.334 | 0.5 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0443 | 0.334 | 0.3311 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.1244 | 1 | 1 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0443 | 0.334 | 0.3311 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0046 | 0.0043 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0043 | 0.0037 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0443 | 0.334 | 0.334 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0043 | 0.0037 |
Brugia malayi | brahma associated protein 60 kDa | 0.1244 | 1 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.1244 | 1 | 1 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.1244 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0043 | 0.0037 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0443 | 0.334 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0046 | 0.0043 | 0.0037 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0443 | 0.334 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0046 | 0.0043 | 0.0037 |
Loa Loa (eye worm) | brahma associated protein | 0.1244 | 1 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0443 | 0.334 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0443 | 0.334 | 0.334 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0043 | 0.0037 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0443 | 0.334 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0043 | 0.0037 |
Schistosoma mansoni | fusion | 0.0443 | 0.334 | 0.334 |
Leishmania major | hypothetical protein, conserved | 0.0443 | 0.334 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1244 | 1 | 1 |
Onchocerca volvulus | 0.0443 | 0.334 | 0.3311 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0046 | 0.0043 | 0.0037 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1244 | 1 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.1244 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Duration (functional) | = 291 min | Duration of action at which functional detrusor muscle contraction strength was measured using guinea pig model of cystometrogram | ChEMBL. | 1920357 |
Kb (functional) | = 24 nM | Antimuscarinic effect determined by comparing ability to inhibit carbachol-induced guinea pig detrusor muscle contractions | ChEMBL. | 1920357 |
Potency (functional) | = 0.28 | Effect on in vivo functional detrusor muscle contraction strength using guinea pig model of cystometrogram | ChEMBL. | 1920357 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.