Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma brucei | methionyl-tRNA synthetase, putative | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.2304 | 0.2304 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0025 | 0.0906 | 0.5 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0066 | 0.3397 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.1175 | 0.3458 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0297 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.2304 | 0.2304 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0066 | 0.3397 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0906 | 0.0906 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0066 | 0.3397 | 1 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0025 | 0.0906 | 0.7714 |
Loa Loa (eye worm) | SMO-1 protein | 0.003 | 0.1175 | 0.1175 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0297 | 0.0874 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0066 | 0.3397 | 0.5 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0025 | 0.0906 | 0.5 |
Brugia malayi | protein ZK524.3 | 0.0025 | 0.0906 | 0.0906 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0297 | 0.0874 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0297 | 0.0874 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0066 | 0.3397 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0297 | 0.0297 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0025 | 0.0906 | 0.1965 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0297 | 0.0297 |
Toxoplasma gondii | small ubiquitin family modifier, putative | 0.003 | 0.1175 | 0.1078 |
Plasmodium falciparum | small ubiquitin-related modifier | 0.003 | 0.1175 | 0.1078 |
Echinococcus multilocularis | Small ubiquitin modifier 2 | 0.003 | 0.1175 | 0.3458 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0025 | 0.0906 | 0.2667 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.2304 | 0.2304 |
Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.3397 | 0.3397 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0906 | 0.0906 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0025 | 0.0906 | 0.2667 |
Brugia malayi | Ubiquitin-like protein SMT3 | 0.003 | 0.1175 | 0.1175 |
Brugia malayi | methionyl-tRNA synthetase | 0.0025 | 0.0906 | 0.0906 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0041 | 0.1859 | 0.1859 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1375 | 0.1375 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0066 | 0.3397 | 1 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0066 | 0.3397 | 1 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0025 | 0.0906 | 0.2667 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0906 | 0.0906 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0175 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0297 | 0.0874 |
Leishmania major | small ubiquitin protein, putative | 0.003 | 0.1175 | 0.1078 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0066 | 0.3397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1375 | 0.1375 |
Entamoeba histolytica | ubiquitin like protein | 0.003 | 0.1175 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0297 | 0.0297 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0066 | 0.3397 | 0.3397 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2304 | 0.2304 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0066 | 0.3397 | 1 |
Plasmodium vivax | small ubiquitin-related modifier, putative | 0.003 | 0.1175 | 0.1078 |
Echinococcus granulosus | Small ubiquitin modifier 2 | 0.003 | 0.1175 | 0.3458 |
Onchocerca volvulus | 0.0041 | 0.1859 | 0.1859 | |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0066 | 0.3397 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0297 | 0.0874 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1375 | 0.3477 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.3397 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0297 | 0.0297 |
Giardia lamblia | Sentrin | 0.003 | 0.1175 | 0.1078 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0025 | 0.0906 | 0.1965 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0066 | 0.3397 | 1 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0025 | 0.0906 | 0.5 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0066 | 0.3397 | 1 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0066 | 0.3397 | 1 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0066 | 0.3397 | 1 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0025 | 0.0906 | 0.5 |
Schistosoma mansoni | ubiquitin-like protein sumo/smt3-related | 0.003 | 0.1175 | 0.2831 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 13.451 uM | PubChem BioAssay. Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 23.777 uM | PubChem BioAssay. Counterscreen Fluorescent Polarization-based biochemical high throughput orthogonal dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.