Detailed information for compound 1707724

Basic information

Technical information
  • TDR Targets ID: 1707724
  • Name: 1-methyl-8,10-diazaspiro[5.5]undecane-7,9,11- trione
  • MW: 210.23 | Formula: C10H14N2O3
  • H donors: 2 H acceptors: 3 LogP: 1.24 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)C2(C(=O)N1)CCCCC2C
  • InChi: 1S/C10H14N2O3/c1-6-4-2-3-5-10(6)7(13)11-9(15)12-8(10)14/h6H,2-5H2,1H3,(H2,11,12,13,14,15)
  • InChiKey: MOJQTXMYIYJFBE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 67196-32-1
  • 7-Methyl-2,4-diazaspiro(5.5)undecane-1,3,5-trione
  • BRN 0209445
  • 2,4-Diazaspiro[5.5]undecane-1,3,5-trione, 7-methyl-
  • NSC117435
  • 2,4-Diazaspiro(5.5)undecane-1,3,5-trione, 7-methyl-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0478 0.1006
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0029 0.0076 0.7225
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0105 0.0073
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.1946 0.1953
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Brugia malayi Pre-SET motif family protein 0.0218 0.3011 0.734
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Onchocerca volvulus 0.0087 0.0974 0.2638
Toxoplasma gondii protein kinase domain-containing protein 0.0029 0.0076 0.7225
Trypanosoma brucei Pseudokinase, putative 0.0029 0.0076 0.1096
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0974 0.6128
Brugia malayi polk-prov protein 0.0033 0.0125 0.0123
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0093 0.8778
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0105 0.0073
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0029 0.0076 0.0174
Entamoeba histolytica hypothetical protein 0.0029 0.0076 0.0174
Schistosoma mansoni lipoxygenase 0.0086 0.0963 0.2217
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0029 0.0076 0.7225
Loa Loa (eye worm) hypothetical protein 0.0031 0.0105 0.0073
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0093 1
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0695 0.1547
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0029 0.0076 0.0174
Plasmodium vivax protein kinase, putative 0.0029 0.0076 0.7225
Plasmodium vivax SET domain protein, putative 0.0031 0.0105 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0974 0.6128
Entamoeba histolytica hypothetical protein 0.0029 0.0076 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.4148
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.0665 0.9962 1
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0137 0.1752 0.3185
Entamoeba histolytica serine/threonine kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Treponema pallidum penicillin-binding protein (pbp-1) 0.0667 1 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0695 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0306 0.4382 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0288 0.3427
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0029 0.0076 0.0174
Brugia malayi Protein kinase domain containing protein 0.0029 0.0076 0.000000050972
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Entamoeba histolytica serine/threonine kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Brugia malayi hypothetical protein 0.003 0.0093 0.0041
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0288 0.4148
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0288 0.4148
Trichomonas vaginalis TKL family protein kinase 0.0029 0.0076 0.000000036818
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0093 1
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Trichomonas vaginalis TKL family protein kinase 0.0029 0.0076 0.000000036818
Entamoeba histolytica serine/threonine kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica hypothetical protein 0.0029 0.0076 0.0174
Entamoeba histolytica serine/threonine kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica ankyrin repeat protein 0.0029 0.0076 0.0174
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.4382 0.778
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Trichomonas vaginalis set domain proteins, putative 0.0248 0.348 0.6149
Leishmania major hypothetical protein, conserved 0.0029 0.0076 0.1096
Chlamydia trachomatis transglycolase/transpeptidase 0.0376 0.5464 0.5464
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.4148
Plasmodium falciparum tyrosine kinase-like protein 0.0029 0.0076 0.823
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.4382 0.778
Entamoeba histolytica ankyrin repeat protein 0.0029 0.0076 0.0174
Leishmania major protein kinase, putative 0.0029 0.0076 0.1096
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0029 0.0076 0.0174
Plasmodium falciparum protein kinase, putative 0.0029 0.0076 0.823
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0137 0.1752 0.3122
Plasmodium falciparum tyrosine kinase-like protein 0.0029 0.0076 0.823
Entamoeba histolytica tyrosin kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0029 0.0076 0.0174
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0554 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.0385 0.5611 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0554 0.0556
Trypanosoma brucei Flagellum attachment zone protein 20 0.0029 0.0076 0.1096
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0029 0.0076 0.0174
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0029 0.0076 0.0174
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0137 0.1752 0.1759
Onchocerca volvulus 0.0029 0.0076 0.000000059878
Entamoeba histolytica tyrosin kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0288 0.0289
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Loa Loa (eye worm) glutaminase 0.0286 0.4074 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0491 0.1037
Onchocerca volvulus 0.0248 0.348 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0695 1
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0478 0.1006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.4382 0.778
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0554 0.1195
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.4148
Entamoeba histolytica hypothetical protein 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Plasmodium falciparum protein kinase, putative 0.0029 0.0076 0.823
Plasmodium falciparum protein kinase, putative 0.0029 0.0076 0.823
Treponema pallidum fructose-bisphosphate aldolase 0.0306 0.4382 0.4382
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Leishmania major hypothetical protein, conserved 0.003 0.0093 0.1332
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.1946 0.3537
Entamoeba histolytica receptor protein kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0554 0.1195
Toxoplasma gondii STE kinase 0.0029 0.0076 0.7225
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0029 0.0076 0.000000050972
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0288 0.0289
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0478 0.2746
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0029 0.0076 0.000000050972
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0088 0.0078
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0105 0.02
Plasmodium vivax tyrosine kinase-like protein, putative 0.0029 0.0076 0.7225
Echinococcus multilocularis tyrosine protein kinase shark 0.0029 0.0076 0.00000013911
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0258 0.3627 0.6463
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0974 0.2246
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0554 0.1007
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0181 0.26
Giardia lamblia Protein 21.1 0.0029 0.0076 0.000000047324
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0029 0.0076 0.000000036818
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.1541 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0288 0.3427
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0378 0.5501 1
Entamoeba histolytica hypothetical protein, conserved 0.0029 0.0076 0.0174
Loa Loa (eye worm) hypothetical protein 0.0087 0.0974 0.2246
Echinococcus multilocularis integrin linked protein kinase 0.0029 0.0076 0.00000013911
Treponema pallidum penicillin-binding protein (pbp-3) 0.0665 0.9962 0.9962
Echinococcus granulosus tyrosine protein kinase shark 0.0029 0.0076 0.00000013911
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0258 0.3627 0.364
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.0076 0.1096
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0478 0.1006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0478 0.2746
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0695 0.1585
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0695 0.4223
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0306 0.4382 1
Brugia malayi glutaminase DH11.1 0.0286 0.4074 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0029 0.0076 0.0174
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0093 0.0265
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0288 0.3427
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.3011 0.734
Leishmania major protein kinase, putative 0.0029 0.0076 0.1096
Entamoeba histolytica tyrosin kinase, putative 0.0029 0.0076 0.0174
Schistosoma mansoni protein kinase 0.0029 0.0076 0.000000050972
Entamoeba histolytica hypothetical protein 0.0029 0.0076 0.0174
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0239 0.333 0.6054
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.0667 1 1
Entamoeba histolytica hypothetical protein 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0478 0.2746
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0128 0.1604 0.2915
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.4382 0.778
Mycobacterium ulcerans glutaminase 0.0286 0.4074 0.409
Loa Loa (eye worm) glutaminase 2 0.0286 0.4074 1
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0242 0.113
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.4148
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.4382 0.778
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0478 0.2746
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Brugia malayi integrin-linked kinase 0.0029 0.0076 0.000000050972
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0093 0.1332
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0695 0.1547
Onchocerca volvulus 0.0031 0.0105 0.0086
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0041
Toxoplasma gondii protein kinase 0.0029 0.0076 0.7225
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0125 0.1806
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Treponema pallidum penicillin-binding protein (pbp-2) 0.0385 0.5611 0.5611
Brugia malayi Pre-SET motif family protein 0.0031 0.0105 0.0073
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0288 0.0383
Echinococcus granulosus dna polymerase kappa 0.0043 0.0288 0.1447
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica cysteine surface protein, putative 0.0029 0.0076 0.0174
Trichomonas vaginalis TKL family protein kinase 0.0029 0.0076 0.000000036818
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0093 0.8778
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0288 0.1447
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0093 0.0265
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0378 0.5501 0.9803
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0554 0.3261
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0125 0.1806
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.4148
Trichomonas vaginalis TKL family protein kinase 0.0029 0.0076 0.000000036818
Entamoeba histolytica serine/threonine kinase, putative 0.0029 0.0076 0.0174
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.1541 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0554 0.3261
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0105 0.02
Plasmodium vivax tyrosine kinase-like protein, putative 0.0029 0.0076 0.7225
Giardia lamblia Fructose-bisphosphate aldolase 0.0306 0.4382 1
Echinococcus granulosus transcription factor Dp 1 0.004 0.0242 0.113
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0385 0.5611 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0105 0.02
Entamoeba histolytica serine/threonine kinase, putative 0.0029 0.0076 0.0174
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0695 1
Entamoeba histolytica hypothetical protein 0.0029 0.0076 0.0174
Entamoeba histolytica hypothetical protein 0.0029 0.0076 0.0174
Loa Loa (eye worm) hypothetical protein 0.0033 0.0125 0.0123
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0378 0.5501 0.5522
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0695 0.1547
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0695 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0105 0.0073
Echinococcus granulosus integrin linked protein kinase 0.0029 0.0076 0.00000013911
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.4382 0.778
Schistosoma mansoni lipoxygenase 0.0124 0.1541 0.3664
Trypanosoma brucei unspecified product 0.0036 0.0181 0.26
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0105 0.0073
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0288 0.3427
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0239 0.333 0.5935
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0478 0.1006
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0695 0.4223
Entamoeba histolytica hypothetical protein 0.0029 0.0076 0.0174
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0974 0.2246
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0029 0.0076 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.4148
Entamoeba histolytica hypothetical protein 0.0029 0.0076 0.0174
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0554 0.7972
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0029 0.0076 0.7225
Trichomonas vaginalis glutaminase, putative 0.0286 0.4074 0.7223
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.4382 0.778
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0029 0.0076 0.0174
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0385 0.5611 0.5632
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.4148
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.1946 0.3468
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0105 1
Entamoeba histolytica protein kinase domain containing protein 0.0029 0.0076 0.0174
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0029 0.0076 0.0174
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0288 0.0383
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0029 0.0076 0.0174
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.4382 0.778
Entamoeba histolytica tyrosin kinase, putative 0.0029 0.0076 0.0174
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0029 0.0076 0.1096
Entamoeba histolytica hypothetical protein 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Entamoeba histolytica tyrosine kinase, putative 0.0029 0.0076 0.0174
Schistosoma mansoni tyrosine kinase 0.0029 0.0076 0.000000050972
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174
Giardia lamblia Kinase, NEK 0.0029 0.0076 0.000000047324
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.4148
Schistosoma mansoni protein kinase 0.0029 0.0076 0.000000050972
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0029 0.0076 0.0174
Entamoeba histolytica receptor protein kinase, putative 0.0029 0.0076 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.4148
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0258 0.3627 0.6592
Schistosoma mansoni glutaminase 0.0286 0.4074 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0029 0.0076 0.0174
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0478 0.1006
Trypanosoma brucei protein kinase, putative 0.0029 0.0076 0.1096
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0029 0.0076 0.0174
Entamoeba histolytica protein kinase, putative 0.0029 0.0076 0.0174

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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