Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cysteine proteinase, putative | 0.0135 | 0.086 | 1 |
Onchocerca volvulus | 0.0135 | 0.086 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0092 | 0.0196 | 0.0196 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0097 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0135 | 0.086 | 0.086 |
Plasmodium vivax | vivapain-2 | 0.0135 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Brugia malayi | cathepsin L-like precursor | 0.0097 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0097 | 0.0274 | 0.0274 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0252 | 0.2688 | 0.2688 |
Giardia lamblia | Cathepsin B precursor | 0.0252 | 0.2688 | 0.5 |
Onchocerca volvulus | 0.0135 | 0.086 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0274 | 0.008 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0722 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.086 | 0.086 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0135 | 0.086 | 0.0678 |
Brugia malayi | Cathepsin L-like precursor | 0.0097 | 0.0274 | 0.0274 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0135 | 0.086 | 0.086 |
Onchocerca volvulus | Cathepsin L homolog | 0.0135 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0135 | 0.086 | 0.086 |
Plasmodium vivax | vivapain-2 | 0.0135 | 0.086 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0097 | 0.0274 | 0.0274 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0252 | 0.2688 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0274 | 0.008 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0135 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0274 | 0.008 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0135 | 0.086 | 0.0678 |
Echinococcus granulosus | cathepsin l1 | 0.0135 | 0.086 | 0.086 |
Onchocerca volvulus | 0.0135 | 0.086 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0135 | 0.086 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0135 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0135 | 0.086 | 0.3201 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0092 | 0.0196 | 0.0196 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0135 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0135 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0252 | 0.2688 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0135 | 0.086 | 0.086 |
Onchocerca volvulus | 0.0097 | 0.0274 | 0.1176 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0135 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Loa Loa (eye worm) | ctsf protein | 0.0135 | 0.086 | 0.0678 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0135 | 0.086 | 0.086 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0722 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0097 | 0.0274 | 0.3182 |
Loa Loa (eye worm) | fibroinase | 0.0135 | 0.086 | 0.0678 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Entamoeba histolytica | cysteine protease, putative | 0.0135 | 0.086 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0722 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0092 | 0.0196 | 0.0196 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin b | 0.0722 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0135 | 0.086 | 0.3201 |
Onchocerca volvulus | Cathepsin L homolog | 0.0135 | 0.086 | 1 |
Onchocerca volvulus | 0.0135 | 0.086 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0135 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0722 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0135 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0135 | 0.086 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0097 | 0.0274 | 0.0274 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0135 | 0.086 | 0.086 |
Onchocerca volvulus | 0.0135 | 0.086 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin b | 0.0722 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0092 | 0.0196 | 0.0196 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0135 | 0.086 | 0.3201 |
Loa Loa (eye worm) | cathepsin B | 0.0252 | 0.2688 | 0.2542 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.086 | 0.0678 |
Onchocerca volvulus | 0.0135 | 0.086 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0097 | 0.0274 | 0.0274 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0092 | 0.0196 | 0.0196 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0135 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0135 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0722 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0135 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0135 | 0.086 | 0.3201 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0092 | 0.0196 | 0.0196 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0135 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0252 | 0.2688 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0135 | 0.086 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0722 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0135 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.086 | 0.086 |
Giardia lamblia | Cathepsin B precursor | 0.0252 | 0.2688 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0252 | 0.2688 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Loa Loa (eye worm) | cysteine protease | 0.0135 | 0.086 | 0.0678 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0135 | 0.086 | 1 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0135 | 0.086 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0092 | 0.0196 | 0.0196 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0097 | 0.0274 | 0.1018 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0135 | 0.086 | 0.3201 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0135 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0135 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Echinococcus multilocularis | cathepsin b | 0.0722 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0722 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0135 | 0.086 | 0.3201 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0135 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0097 | 0.0274 | 0.1018 |
Echinococcus multilocularis | cysteine protease | 0.0135 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Toxoplasma gondii | cathepsin B | 0.0252 | 0.2688 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0252 | 0.2688 | 0.2688 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0135 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.086 | 0.086 |
Brugia malayi | ShTK domain containing protein | 0.0092 | 0.0196 | 0.0196 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.601 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.415 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.377 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.156 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.123 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.096 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.068 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.031 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.941 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.826 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
P | = 15.7 M l-1 | Partition coefficient(P) of the compound in octanol/water system | ChEMBL. | 10571171 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.