Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma brucei | methionyl-tRNA synthetase, putative | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Methionyl-tRNA synthetase | 0.0066 | 1 | 0.5 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0066 | 1 | 1 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0066 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.7556 | 0.7546 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0066 | 1 | 0.5 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0066 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.7556 | 0.7546 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0066 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.7556 | 0.7556 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0066 | 1 | 0.5 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0066 | 1 | 0.5 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0066 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 1 | 0.5 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0066 | 1 | 0.5 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0066 | 1 | 1 |
Onchocerca volvulus | 0.0041 | 0 | 0.5 | |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0066 | 1 | 0.5 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0066 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.7556 | 0.7556 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0066 | 1 | 0.5 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0066 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.004 | 0.004 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0.67214 uM | PubChem BioAssay. Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 1.341 uM | PubChem BioAssay. Counterscreen Fluorescent Polarization-based biochemical high throughput orthogonal dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.