Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Deoxyhypusine synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | deoxyhypusine synthase, putative | 0.0084 | 1 | 0.5 |
Plasmodium vivax | deoxyhypusine synthase, putative | 0.0084 | 1 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Echinococcus granulosus | deoxyhypusine synthase | 0.0084 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Leishmania major | deoxyhypusine synthase, putative | 0.0084 | 1 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Trichomonas vaginalis | deoxyhypusine synthase, putative | 0.0084 | 1 | 0.5 |
Entamoeba histolytica | deoxyhypusine synthase, putative | 0.0084 | 1 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Echinococcus multilocularis | deoxyhypusine synthase | 0.0084 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0077 | 0 | 0.5 |
Entamoeba histolytica | deoxyhypusine synthase, putative | 0.0084 | 1 | 0.5 |
Plasmodium falciparum | deoxyhypusine synthase | 0.0084 | 1 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Giardia lamblia | Deoxyhypusine synthase, putative | 0.0084 | 1 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Toxoplasma gondii | deoxyhypusine synthase | 0.0084 | 1 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Loa Loa (eye worm) | deoxyhypusine synthase | 0.0084 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Schistosoma mansoni | deoxyhypusine synthase | 0.0084 | 1 | 1 |
Trypanosoma brucei | deoxyhypusine synthase | 0.0084 | 1 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0077 | 0 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Onchocerca volvulus | 0.0077 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 85 % | Effect on spermidine uptake in CHO cells at concentration 10 uM. | ChEMBL. | 7636868 |
Control (functional) | = 100 % | Effect of the compound on Hypusine formation in CHO cells at concentration 3 uM. | ChEMBL. | 7636868 |
Control (functional) | = 100 % | Effect of the compound on Hypusine formation in CHO cells at concentration 10 uM. | ChEMBL. | 7636868 |
Control (functional) | = 100 % | Effect of the compound on hypusine synthesis in CHO cells at concentration 3 uM. | ChEMBL. | 7636868 |
Control (functional) | = 100 % | Effect of the compound on hypusine synthesis in CHO cells at concentration 10 uM. | ChEMBL. | 7636868 |
Control (functional) | = 100 % | Effect of the compound on Hypusine formation in CHO cells at concentration 3 uM. | ChEMBL. | 7636868 |
Control (functional) | = 100 % | Effect of the compound on Hypusine formation in CHO cells at concentration 10 uM. | ChEMBL. | 7636868 |
Control (functional) | = 100 % | Effect of the compound on hypusine synthesis in CHO cells at concentration 3 uM. | ChEMBL. | 7636868 |
Control (functional) | = 100 % | Effect of the compound on hypusine synthesis in CHO cells at concentration 10 uM. | ChEMBL. | 7636868 |
Growth inhibition (functional) | 0 | Growth inhibition was measured against CHO cell line. | ChEMBL. | 7636868 |
IC50 (binding) | = 3.2 uM | In vitro IC50 value by measuring the inhibition of deoxyhypusine synthase. | ChEMBL. | 7636868 |
IC50 (binding) | = 3.2 uM | In vitro IC50 value by measuring the inhibition of deoxyhypusine synthase. | ChEMBL. | 7636868 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.