Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Rattus norvegicus | Thromboxane-A synthase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 530 aa | 22.6 % |
Leishmania infantum | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 473 aa | 22.2 % |
Trypanosoma cruzi | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 448 aa | 20.5 % |
Trypanosoma cruzi | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 450 aa | 20.7 % |
Loa Loa (eye worm) | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 480 aa | 20.8 % |
Dictyostelium discoideum | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 456 aa | 22.4 % |
Trypanosoma brucei | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 450 aa | 20.9 % |
Leishmania braziliensis | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 477 aa | 20.3 % |
Dictyostelium discoideum | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 544 aa | 19.9 % |
Leishmania donovani | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 473 aa | 22.2 % |
Onchocerca volvulus | Thromboxane-A synthase | 533 aa | 507 aa | 21.7 % | |
Trypanosoma brucei gambiense | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 450 aa | 20.9 % |
Trypanosoma congolense | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 453 aa | 20.3 % |
Leishmania major | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 468 aa | 22.0 % |
Leishmania mexicana | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 469 aa | 22.0 % |
Candida albicans | cytochrome P450 56 | Thromboxane-A synthase | 533 aa | 507 aa | 22.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.0058 | 0.0058 |
Schistosoma mansoni | Hyaluronidase | 0.7473 | 1 | 1 |
Loa Loa (eye worm) | hyaluronidase | 0.7473 | 1 | 1 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.7473 | 1 | 1 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.7473 | 1 | 1 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.7473 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.09 uM | Inhibitory activity against the production of leukotriene B4 (LTB4) in glycogen-induced peritoneal cells of rat | ChEMBL. | 7932529 |
IC50 (functional) | = 0.09 uM | Inhibitory activity against the production of leukotriene B4 (LTB4) in glycogen-induced peritoneal cells of rat | ChEMBL. | 7932529 |
IC50 (functional) | = 5.5 uM | Inhibitory activity against the production of thromboxane B2 (TXB2) in glycogen-induced peritoneal cells of rat | ChEMBL. | 7932529 |
IC50 (functional) | = 5.5 uM | Inhibitory activity against the production of thromboxane B2 (TXB2) in glycogen-induced peritoneal cells of rat | ChEMBL. | 7932529 |
IC50 (functional) | > 100 uM | Inhibitory activity against the production of prostaglandin E2 (PGE2) in glycogen-induced peritoneal cells of rat | ChEMBL. | 7932529 |
IC50 (functional) | > 100 uM | Inhibitory activity against the production of prostaglandin E2 (PGE2) in glycogen-induced peritoneal cells of rat | ChEMBL. | 7932529 |
Suppression ratio (functional) | = 10 % | Tested for the suppression ratio, the difference between the amount of PGE-2 produced in the test groups and the control group at the dosage of 100 mg/kg | ChEMBL. | 7932529 |
Suppression ratio (functional) | = 19 % | Tested for the suppression ratio, the difference between the amount of LTB4 produced in the test groups and the control group at the dosage of 100 mg/kg | ChEMBL. | 7932529 |
Suppression ratio (functional) | = 55 % | Tested for the suppression ratio, the difference between the amount of TXB2 produced in the test groups and the control group at the dosage of 100 mg/kg | ChEMBL. | 7932529 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.