TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 622.033 | Formula: C33H27ClF3N3O4
H donors: 2 H acceptors: 4 LogP: 7.06 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)C(F)(F)F
InChi: 1S/C33H27ClF3N3O4/c1-19(20-3-5-21(6-4-20)32(43)38-12-11-31(41)42)40-30(24-8-7-23-16-28(44-2)10-9-22(23)13-24)18-29(39-40)25-14-26(33(35,36)37)17-27(34)15-25/h3-10,13-19H,11-12H2,1-2H3,(H,38,43)(H,41,42)/t19-/m0/s1
InChiKey: QHYLLMYQPXZQNA-IBGZPJMESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon receptor	Starlite/ChEMBL	References
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	References
Homo sapiens	vasoactive intestinal peptide receptor 2	Starlite/ChEMBL	References
Homo sapiens	gastric inhibitory polypeptide receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	vasoactive intestinal peptide receptor 2	438 aa	411 aa	24.3 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon receptor	477 aa	457 aa	25.4 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	gastric inhibitory polypeptide receptor	466 aa	425 aa	24.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	DNA-directed RNA polymerase III subunit C1, putative	0.0009	0.018	0.399
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0076	0.2455	0.2455
Leishmania major	RNA polymerase I second largest subunit, putative	0.0012	0.0289	0.6392
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0268	0.0268
Plasmodium falciparum	DNA-directed RNA polymerase alpha chain, putative	0.0032	0.0942	1
Loa Loa (eye worm)	guanylate kinase	0.0012	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0241	0.803	0.803
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0012	0.0278	0.0278
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0012	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0268	0.0268
Mycobacterium leprae	DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT)	0.025	0.8341	1
Trypanosoma brucei	DNA-directed rna polymerase I largest subunit, putative	0.0007	0.0111	0.2465
Plasmodium falciparum	DNA-directed RNA polymerase II subunit RPB2, putative	0.0017	0.0452	0.4797
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.0012	0.0268	0.5926
Echinococcus multilocularis	nostrin	0.0012	0.0268	0.0268
Schistosoma mansoni	apoptosis stimulating of P53	0.0012	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0268	0.0268
Entamoeba histolytica	hypothetical protein	0.0012	0.0268	0.5926
Leishmania major	DNA-directed RNA polymerase polypeptide, putative	0.0017	0.0452	1
Echinococcus granulosus	tyrosine kinase	0.0012	0.0278	0.0278
Plasmodium falciparum	DNA-directed RNA polymerase I subunit RPA2, putative	0.0012	0.0289	0.3066
Echinococcus granulosus	growth factor receptor bound protein 2	0.0299	1	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0012	0.0278	0.0278
Schistosoma mansoni	hypothetical protein	0.0076	0.2455	0.2455
Schistosoma mansoni	suppressor of cytokine signaling	0.0012	0.0278	0.0278
Giardia lamblia	DNA-directed RNA polymerase subunit A	0.0009	0.018	0.399
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0268	0.0268
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0012	0.0268	0.0268
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0012	0.0278	0.0278
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0012	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0278	0.0278
Loa Loa (eye worm)	RNA polymerase Rpb1	0.0009	0.018	0.018
Echinococcus granulosus	tyrosine kinase	0.0012	0.0278	0.0278
Plasmodium vivax	DNA-directed RNA polymerase I subunit RPA2, putative	0.0012	0.0289	0.3066
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0278	0.0278
Brugia malayi	SH2 domain containing protein	0.0012	0.0278	0.0278
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0024	0.0672	0.0672
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0012	0.0268	0.0268
Brugia malayi	SH2 domain containing protein	0.0012	0.0278	0.0278
Leishmania major	hypothetical protein, conserved	0.0012	0.0268	0.5926
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0012	0.0278	0.0278
Brugia malayi	SH2 domain containing protein	0.0012	0.0278	0.0278
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0012	0.0268	0.0268
Entamoeba histolytica	hypothetical protein	0.0012	0.0268	0.5926
Schistosoma mansoni	tensin	0.0012	0.0278	0.0278
Echinococcus granulosus	DNA directed RNA polymerase II subunit	0.0009	0.018	0.018
Trypanosoma cruzi	DNA-directed RNA polymerase III subunit, putative	0.0006	0.007	0.1552
Echinococcus multilocularis	tensin	0.0012	0.0278	0.0278
Echinococcus granulosus	SH2 motif	0.0012	0.0278	0.0278
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0012	0.0278	0.0278
Brugia malayi	Spectrin alpha chain	0.0012	0.0268	0.0268
Echinococcus multilocularis	SH2 domain containing protein 7	0.0012	0.0278	0.0278
Schistosoma mansoni	tyrosine kinase	0.0024	0.0672	0.0672
Echinococcus multilocularis	transfer RNA-Ala	0.0012	0.0268	0.0268
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0299	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0278	0.0278
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.0012	0.0268	0.5926
Echinococcus multilocularis	DNA directed RNA polymerase III subunit RPC1	0.0009	0.018	0.018
Echinococcus multilocularis	endophilin A3	0.0012	0.0268	0.0268
Plasmodium vivax	DNA-directed RNA polymerase alpha chain, putative	0.0032	0.0942	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0278	0.0278
Trichomonas vaginalis	DNA-directed RNA polymerase I subunit, putative	0.0017	0.0452	1
Brugia malayi	Variant SH3 domain containing protein	0.0024	0.0672	0.0672
Entamoeba histolytica	hypothetical protein	0.0012	0.0268	0.5926
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0278	0.0278
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0278	0.0278
Echinococcus granulosus	tyrosine protein kinase Srms	0.0012	0.0278	0.0278
Schistosoma mansoni	nck2/grb4	0.0024	0.0672	0.0672
Schistosoma mansoni	tensin	0.0012	0.0278	0.0278
Wolbachia endosymbiont of Brugia malayi	DNA-directed RNA polymerase subunit beta/beta'	0.0259	0.8648	1
Echinococcus granulosus	SH2 motif	0.0012	0.0278	0.0278
Brugia malayi	Tyrosine-protein kinase abl-1	0.0024	0.0672	0.0672
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0012	0.0278	0.0278
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0278	0.0278
Loa Loa (eye worm)	SH2 domain-containing protein	0.0012	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0278	0.0278
Schistosoma mansoni	shc transforming protein	0.0012	0.0278	0.0278
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0012	0.0278	0.0278
Loa Loa (eye worm)	TK protein kinase	0.0012	0.0278	0.0278
Brugia malayi	RhoGAP domain containing protein	0.0012	0.0278	0.0278
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0024	0.0672	0.0672
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0012	0.0278	0.0278
Brugia malayi	Protein kinase domain containing protein	0.0012	0.0278	0.0278
Brugia malayi	Tensin	0.0012	0.0278	0.0278
Plasmodium falciparum	DNA-directed RNA polymerase III subunit RPC2, putative	0.0017	0.0452	0.4797
Echinococcus granulosus	hypothetical protein	0.0012	0.0278	0.0278
Plasmodium vivax	DNA-directed RNA polymerase I 190 kDa polypeptide, putative	0.0009	0.018	0.1914
Leishmania major	DNA-directed RNA polymerase III largest subunit , putative	0.0009	0.018	0.399
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0268	0.0268
Onchocerca volvulus		0.0012	0.0278	1
Brugia malayi	Latrophilin receptor protein 2	0.0076	0.2455	0.2455
Plasmodium vivax	DNA-directed RNA polymerase II subunit RPB1, putative	0.0009	0.018	0.1914
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0012	0.0278	0.0278
Echinococcus multilocularis	DNA directed RNA polymerase I subunit RPA2	0.0017	0.0452	0.0452
Toxoplasma gondii	DNA-directed RNA polymerase I RPA2	0.0012	0.0289	0.3046
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0672	0.0672
Echinococcus multilocularis	tyrosine protein kinase shark	0.0012	0.0278	0.0278
Leishmania major	RNA polymerase ii largest subunit	0.0009	0.018	0.399
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0012	0.0268	0.0268
Brugia malayi	protein-tyrosine kinase	0.0012	0.0278	0.0278
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0268	0.5926
Plasmodium vivax	DNA-directed RNA polymerase III largest subunit, putative	0.0009	0.018	0.1914
Plasmodium falciparum	DNA-directed RNA polymerase subunit beta, putative	0.0009	0.018	0.1905
Onchocerca volvulus		0.0012	0.0278	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0024	0.0672	0.0672
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0012	0.0278	0.0278
Brugia malayi	DNA-directed RNA polymerase II largest subunit, putative	0.0009	0.018	0.018
Entamoeba histolytica	DNA-directed RNA polymerase I largest subunit, putative	0.0009	0.018	0.399
Echinococcus granulosus	DNA directed RNA polymerase I subunit RPA1	0.0007	0.0111	0.0111
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0012	0.0268	0.0268
Brugia malayi	Protein kinase domain containing protein	0.0012	0.0278	0.0278
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0268	0.0268
Entamoeba histolytica	protein kinase, putative	0.0012	0.0268	0.5926
Echinococcus granulosus	tensin	0.0012	0.0278	0.0278
Onchocerca volvulus		0.0012	0.0278	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0012	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0278	0.0278
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0012	0.0278	0.0278
Brugia malayi	hypothetical protein	0.0012	0.0278	0.0278
Entamoeba histolytica	hypothetical protein	0.0012	0.0268	0.5926
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0012	0.0278	0.0278
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0076	0.2455	0.2455
Schistosoma mansoni	GTPase activating protein	0.0012	0.0278	0.0278
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0241	0.803	0.803
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0024	0.0672	0.0672
Loa Loa (eye worm)	protein-tyrosine kinase	0.0012	0.0268	0.0268
Plasmodium vivax	DNA-directed RNA polymerase II subunit RPB2, putative	0.0017	0.0452	0.4797
Schistosoma mansoni	sorbin	0.0012	0.0268	0.0268
Trypanosoma brucei	DNA-directed RNA polymerase II subunit 2, putative	0.0017	0.0452	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0278	0.0278
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0024	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0268	0.0268
Entamoeba histolytica	DNA-directed RNA polymerase III largest subunit, putative	0.0009	0.018	0.399
Echinococcus multilocularis		0.0012	0.0278	0.0278
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0012	0.0278	0.0278
Schistosoma mansoni	DNA-directed RNA polymerase II largest subunit	0.0009	0.018	0.018
Wolbachia endosymbiont of Brugia malayi	DNA-directed RNA polymerase subunit alpha	0.01	0.3256	0.3765
Echinococcus multilocularis	tyrosine kinase	0.0012	0.0278	0.0278
Loa Loa (eye worm)	STAT protein	0.0012	0.0278	0.0278
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0012	0.0278	0.0278
Echinococcus multilocularis	DNA directed RNA polymerase II subunit	0.0009	0.018	0.018
Echinococcus granulosus	DNA directed RNA polymerase I subunit RPA2	0.0017	0.0452	0.0452
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0024	0.0672	0.0672
Brugia malayi	Variant SH3 domain containing protein	0.0024	0.0672	0.0672
Toxoplasma gondii	DNA-directed RNA polymerase II RPB2	0.0017	0.0452	0.4765
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0012	0.0278	0.0278
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0024	0.0672	0.0672
Chlamydia trachomatis	DNA-directed RNA polymerase subunit beta	0.025	0.8341	1
Entamoeba histolytica	SH2 domain containing protein	0.0012	0.0278	0.6148
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0012	0.0278	0.6148
Schistosoma mansoni	hypothetical protein	0.0165	0.5449	0.5449
Toxoplasma gondii	DNA-directed RNA polymerase III RPC2	0.0017	0.0452	0.4765
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0268	0.5926
Brugia malayi	Protein kinase domain containing protein	0.0012	0.0278	0.0278
Mycobacterium ulcerans	DNA-directed RNA polymerase subunit beta'	0.0009	0.018	0.0216
Trichomonas vaginalis	DNA-directed RNA polymerase I largest subunit, putative	0.0009	0.018	0.399
Echinococcus granulosus	NCK adaptor protein	0.0024	0.0672	0.0672
Trypanosoma brucei	DNA-directed RNA polymerase I largest subunit	0.0007	0.0111	0.2465
Plasmodium falciparum	DNA-directed RNA polymerase III subunit RPC1, putative	0.0009	0.018	0.1914
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0268	0.5926
Loa Loa (eye worm)	DNA-directed RNA polymerase	0.0014	0.0349	0.0349
Schistosoma mansoni	hypothetical protein	0.0012	0.0268	0.0268
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0012	0.0278	0.0278
Brugia malayi	hypothetical protein	0.0012	0.0278	0.0278
Trichomonas vaginalis	DNA-directed RNA polymerase I largest subunit, putative	0.0009	0.018	0.399
Schistosoma mansoni	hypothetical protein	0.0076	0.2455	0.2455
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0024	0.0672	0.0672
Schistosoma mansoni	DNA-directed RNA polymerase I	0.0009	0.018	0.018
Schistosoma mansoni	run and tbc1 domain containing	0.0012	0.0268	0.0268
Entamoeba histolytica	hypothetical protein, conserved	0.0012	0.0268	0.5926
Treponema pallidum	DNA-directed RNA polymerase subunit alpha	0.01	0.3256	0.3903
Brugia malayi	protein-tyrosine kinase	0.0012	0.0268	0.0268
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0024	0.0672	0.0672
Schistosoma mansoni	eps8-related protein	0.0012	0.0268	0.0268
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0024	0.0672	0.0672
Echinococcus granulosus	DNA directed RNA polymerase II subunit RPB2	0.0017	0.0452	0.0452
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0012	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0278	0.0278
Plasmodium falciparum	RNA polymerase I	0.0009	0.018	0.1914
Trypanosoma cruzi	DNA-directed RNA polymerase II subunit 2, putative	0.0011	0.0256	0.5662
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0278	0.0278
Schistosoma mansoni	hypothetical protein	0.0012	0.0268	0.0268
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0024	0.0672	0.0672
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0268	0.0268
Schistosoma mansoni	hypothetical protein	0.0076	0.2455	0.2455
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0012	0.0268	0.0268
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0268	0.5926
Mycobacterium tuberculosis	Probable DNA-directed RNA polymerase (alpha chain) RpoA (transcriptase alpha chain) (RNA polymerase alpha subunit) (DNA-directed	0.01	0.3256	0.5
Entamoeba histolytica	DNA-directed RNA polymerase subunit, putative	0.0017	0.0452	1
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0012	0.0268	0.0268
Chlamydia trachomatis	DNA-directed RNA polymerase subunit alpha	0.01	0.3256	0.3769
Onchocerca volvulus		0.0012	0.0278	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0012	0.0278	0.0278
Entamoeba histolytica	unconventional myosin IB	0.0012	0.0268	0.5926
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0012	0.0268	0.0268
Echinococcus granulosus	tyrosine protein kinase Blk	0.0012	0.0278	0.0278
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0278	0.0278
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0278	0.0278
Trypanosoma brucei	DNA-directed RNA polymerase III, putative	0.0017	0.0452	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0268	0.0268
Loa Loa (eye worm)	thyroid receptor interactor	0.0012	0.0268	0.0268
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0241	0.803	0.803
Echinococcus multilocularis	signal transduction protein lnk realted	0.0012	0.0278	0.0278
Schistosoma mansoni	dynamin-associated protein	0.0012	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0165	0.5449	0.5449
Schistosoma mansoni	tensin-related	0.0012	0.0278	0.0278
Schistosoma mansoni	sorting nexin	0.0012	0.0268	0.0268
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0268	0.5926
Echinococcus multilocularis	expressed protein	0.0012	0.0268	0.0268
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0012	0.0268	0.0268
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0012	0.0278	0.0278
Echinococcus multilocularis	Spectrin alpha actinin	0.0012	0.0268	0.0268
Brugia malayi	Protein kinase domain containing protein	0.0012	0.0278	0.0278
Giardia lamblia	DNA-directed RNA polymerase subunit B	0.0017	0.0452	1
Schistosoma mansoni	RNA polymerase Rpb1	0.0009	0.018	0.018
Entamoeba histolytica	hypothetical protein, conserved	0.0012	0.0268	0.5926
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0012	0.0278	0.0278
Trichomonas vaginalis	p67phox protein, putative	0.0012	0.0268	0.5926
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0012	0.0278	0.0278
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0024	0.0672	0.0672
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0278	0.0278
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0268	0.5926
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0076	0.2455	0.2455
Brugia malayi	Guanylate kinase family protein	0.0012	0.0268	0.0268
Trypanosoma brucei	RNA polymerase I second largest subunit	0.0012	0.0289	0.6392
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0278	0.0278
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0012	0.0268	0.0268
Giardia lamblia	DNA-directed RNA polymerase RPB2	0.0017	0.0452	1
Echinococcus multilocularis	tensin	0.0012	0.0278	0.0278
Trypanosoma brucei	DNA-directed RNA polymerase II subunit RPB1	0.0009	0.018	0.399
Onchocerca volvulus		0.0012	0.0278	1
Trichomonas vaginalis	DNA-directed RNA polymerase III subunit, putative	0.0017	0.0452	1
Trypanosoma cruzi	DNA-directed rna polymerase I largest subunit, putative	0.0007	0.0111	0.2465
Schistosoma mansoni	vav2	0.0012	0.0278	0.0278
Brugia malayi	SH2 domain containing protein	0.0012	0.0278	0.0278
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0024	0.0672	0.0672
Entamoeba histolytica	DNA-directed RNA polymerase subunit, putative	0.0017	0.0452	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0012	0.0278	0.0278
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0012	0.0268	0.0268
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0024	0.0672	0.0672
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0024	0.0672	0.0672
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0012	0.0278	0.0278
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0012	0.0278	0.0278
Entamoeba histolytica	protein kinase, putative	0.0012	0.0278	0.6148
Echinococcus granulosus	DNA directed RNA polymerase III subunit RPC2	0.0017	0.0452	0.0452
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0268	0.5926
Brugia malayi	SH3 domain containing protein	0.0012	0.0268	0.0268
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0012	0.0278	0.0278
Trypanosoma brucei	DNA-directed RNA polymerase III subunit C1	0.0009	0.018	0.399
Entamoeba histolytica	hypothetical protein	0.0012	0.0268	0.5926
Echinococcus granulosus	tyrosine protein kinase shark	0.0012	0.0278	0.0278
Echinococcus granulosus	GPCR family 2	0.0076	0.2455	0.2455
Mycobacterium ulcerans	DNA-directed RNA polymerase subunit alpha	0.01	0.3256	0.3903
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0278	0.0278
Giardia lamblia	DNA-directed RNA polymerase subunit B	0.0012	0.0289	0.6392
Toxoplasma gondii	DNA-directed RNA polymerase alpha chain rpoA	0.0032	0.0949	1
Schistosoma mansoni	tyrosine kinase	0.0024	0.0672	0.0672
Onchocerca volvulus		0.0012	0.0278	1
Brugia malayi	DNA-directed RNA polymerase II second largest subunit, putative	0.0017	0.0452	0.0452
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0012	0.0278	0.0278
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0268	0.5926
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0012	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0278	0.0278
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0024	0.0672	0.0672
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0012	0.0268	0.0268
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0012	0.0268	0.5926
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0012	0.0278	0.0278
Entamoeba histolytica	hypothetical protein	0.0012	0.0268	0.5926
Trichomonas vaginalis	DNA-directed RNA polymerase I subunit, putative	0.0017	0.0452	1
Echinococcus granulosus	Spectrin alpha actinin	0.0012	0.0268	0.0268
Loa Loa (eye worm)	DNA-directed RNA polymerase II largest subunit	0.0009	0.018	0.018
Trypanosoma cruzi	RNA polymerase IIA largest subunit, putative	0.0009	0.018	0.399
Echinococcus multilocularis	SH2 motif	0.0012	0.0278	0.0278
Schistosoma mansoni	DNA-directed RNA polymerase III subunit	0.0017	0.0452	0.0452
Schistosoma mansoni	tensin-related	0.0012	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0278	0.0278
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0268	0.0268
Echinococcus multilocularis	intersectin 2	0.0012	0.0268	0.0268
Echinococcus granulosus	signal transduction protein lnk realted	0.0012	0.0278	0.0278
Brugia malayi	DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide	0.0017	0.0452	0.0452
Echinococcus multilocularis	DNA directed RNA polymerase III subunit RPC2	0.0017	0.0452	0.0452
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0012	0.0278	1
Schistosoma mansoni	tensin	0.0012	0.0278	0.0278
Brugia malayi	Myosin tail family protein	0.0012	0.0268	0.0268
Echinococcus granulosus	DNA directed RNA polymerase III subunit RPC1	0.0009	0.018	0.018
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0012	0.0278	0.0278
Schistosoma mansoni	growth factor receptor-bound protein	0.0299	1	1
Brugia malayi	SH2 domain containing protein	0.0012	0.0278	0.0278
Brugia malayi	Src substrate cortactin	0.0012	0.0268	0.0268
Loa Loa (eye worm)	RNA polymerase III 128kD subunit-PA	0.0017	0.0452	0.0452
Echinococcus granulosus	nostrin	0.0012	0.0268	0.0268
Echinococcus multilocularis	DNA directed RNA polymerase II subunit RPB2	0.0017	0.0452	0.0452
Toxoplasma gondii	DNA-directed RNA polymerase III RPC1	0.0009	0.018	0.1901
Echinococcus multilocularis	SH2 motif	0.0012	0.0278	0.0278
Echinococcus granulosus	expressed protein	0.0012	0.0268	0.0268
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0024	0.0672	0.0672
Echinococcus multilocularis	DNA directed RNA polymerase I subunit RPA1	0.0007	0.0111	0.0111
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0012	0.0268	0.0268
Entamoeba histolytica	hypothetical protein	0.0012	0.0268	0.5926
Schistosoma mansoni	Dab2-interacting protein-like	0.0012	0.0268	0.0268
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0278	0.0278
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0012	0.0268	0.0268
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0024	0.0672	0.0672
Onchocerca volvulus		0.0012	0.0278	1
Echinococcus granulosus	N chimaerin	0.0012	0.0278	0.0278
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0278	0.0278
Trypanosoma cruzi	DNA-directed RNA polymerase III, putative	0.0017	0.0452	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0012	0.0278	0.0278
Echinococcus multilocularis	SH2 motif	0.0012	0.0278	0.0278
Loa Loa (eye worm)	SRC-1	0.0024	0.0672	0.0672
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0012	0.0268	0.0268
Trypanosoma brucei	RNA polymerase IIA largest subunit	0.0009	0.018	0.399
Schistosoma mansoni	adapter molecule crk	0.0024	0.0672	0.0672
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0024	0.0672	0.0672
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0024	0.0672	0.0672
Brugia malayi	RNA polymerase Rpb1, domain 2 family protein	0.0009	0.018	0.018
Schistosoma mansoni	formin binding protein and related proteins	0.0012	0.0268	0.0268
Schistosoma mansoni	serine/threonine protein kinase	0.0012	0.0268	0.0268
Echinococcus multilocularis	N chimaerin	0.0012	0.0278	0.0278
Trichomonas vaginalis	RNA polymerase A, putative	0.0007	0.0111	0.2465
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0012	0.0278	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0278	0.0278
Echinococcus multilocularis	c src tyrosine kinase	0.0024	0.0672	0.0672
Schistosoma mansoni	DNA-directed RNA polymerase I subunit	0.0012	0.0289	0.0289
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0012	0.0268	0.5926
Schistosoma mansoni	SH2A	0.0012	0.0278	0.0278
Schistosoma mansoni	DNA-directed RNA polymerase III subunit	0.0017	0.0452	0.0452
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0012	0.0268	0.0268
Brugia malayi	DNA-directed RNA polymerase, beta subunit family protein	0.0017	0.0452	0.0452
Schistosoma mansoni	hypothetical protein	0.0012	0.0278	0.0278
Mycobacterium ulcerans	DNA-directed RNA polymerase subunit beta	0.025	0.8341	1
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0012	0.0268	0.0268
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0012	0.0278	0.6148
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0076	0.2455	0.2455
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0268	0.5926
Loa Loa (eye worm)	TK/ABL protein kinase	0.0012	0.0278	0.0278
Onchocerca volvulus		0.0012	0.0278	1
Brugia malayi	SH2 domain containing protein	0.0012	0.0278	0.0278
Giardia lamblia	RNA polymerase AI large subunit	0.0009	0.018	0.399
Onchocerca volvulus		0.0012	0.0278	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0012	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0278	0.0278
Schistosoma mansoni	tyrosine kinase	0.0024	0.0672	0.0672
Leishmania major	DNA-directed rna polymerase I largest subunit, putative	0.0007	0.0111	0.2465
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0012	0.0268	0.0268
Echinococcus multilocularis	GPCR, family 2	0.0076	0.2455	0.2455
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0278	0.0278
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0076	0.2455	0.2455
Schistosoma mansoni	tyrosine kinase	0.0012	0.0278	0.0278
Schistosoma mansoni	tyrosine kinase	0.0012	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0268	0.0268
Echinococcus granulosus	expressed conserved protein	0.0012	0.0278	0.0278
Brugia malayi	Protein kinase domain containing protein	0.0012	0.0278	0.0278
Schistosoma mansoni	C-fyn	0.0012	0.0268	0.0268
Schistosoma mansoni	tyrosine kinase	0.0024	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0278	0.0278
Echinococcus granulosus	c src tyrosine kinase	0.0024	0.0672	0.0672
Schistosoma mansoni	hypothetical protein	0.0076	0.2455	0.2455
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0268	0.0268
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0024	0.0672	0.0672
Onchocerca volvulus		0.0012	0.0278	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0012	0.0278	0.0278
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0012	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0268	0.0268
Trypanosoma cruzi	RNA polymerase I second largest subunit, putative	0.0012	0.0289	0.6392
Loa Loa (eye worm)	hypothetical protein	0.0076	0.2455	0.2455
Echinococcus multilocularis	SHC transforming protein 3	0.0012	0.0278	0.0278
Treponema pallidum	DNA-directed RNA polymerase subunit beta'	0.0009	0.018	0.0216
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0268	0.0268
Schistosoma mansoni	DNA-directed rna polymerase II subunit	0.0017	0.0452	0.0452
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0012	0.0268	0.0268
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0012	0.0268	0.0268
Toxoplasma gondii	DNA-directed RNA polymerase II RPB1	0.0009	0.018	0.1901
Giardia lamblia	DNA-directed RNA polymerase II largest subunit RPB1	0.0009	0.018	0.399
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0012	0.0278	0.0278
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0278	0.0278
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0076	0.2455	0.2455
Schistosoma mansoni	suppressor of cytokine signaling	0.0012	0.0278	0.0278
Loa Loa (eye worm)	p53BP2	0.0012	0.0268	0.0268
Echinococcus multilocularis	NCK adaptor protein	0.0024	0.0672	0.0672
Schistosoma mansoni	cell polarity protein	0.0012	0.0268	0.0268
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0012	0.0278	0.0278
Trypanosoma brucei	conserved protein	0.0012	0.0268	0.5926
Onchocerca volvulus		0.0012	0.0278	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0012	0.0278	0.0278
Plasmodium vivax	DNA-directed RNA polymerase III subunit, putative	0.0017	0.0452	0.4797
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0024	0.0672	0.0672
Entamoeba histolytica	DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide, putative	0.0017	0.0452	1
Entamoeba histolytica	DNA-directed RNA polymerase II large subunit, putative	0.0009	0.018	0.399
Toxoplasma gondii	DNA-directed RNA polymerase I RPA1	0.0009	0.018	0.1901
Onchocerca volvulus		0.0012	0.0278	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0024	0.0672	0.0672
Brugia malayi	SH2 domain containing protein	0.0012	0.0278	0.0278
Echinococcus granulosus	intersectin 2	0.0012	0.0268	0.0268
Brugia malayi	SH2 domain containing protein	0.0012	0.0278	0.0278
Entamoeba histolytica	hypothetical protein	0.0012	0.0268	0.5926
Echinococcus granulosus	SH2 domain containing protein 7	0.0012	0.0278	0.0278
Echinococcus granulosus	SHC transforming protein 3	0.0012	0.0278	0.0278
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0268	0.0268
Schistosoma mansoni	growth factor receptor-bound protein	0.0299	1	1
Brugia malayi	Peripheral plasma membrane protein CASK	0.0012	0.0268	0.0268
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0268	0.5926
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0012	0.0278	0.0278
Echinococcus granulosus	src region	0.0012	0.0268	0.0268
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0012	0.0278	0.0278
Trypanosoma brucei	DNA-directed RNA polymerase III largest subunit, putative	0.0006	0.0063	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0006	0.007	0.007
Schistosoma mansoni	hypothetical protein	0.0012	0.0278	0.0278
Plasmodium falciparum	DNA-directed RNA polymerase II subunit RPB1	0.0009	0.018	0.1914
Mycobacterium leprae	PROBABLE DNA-DIRECTED RNA POLYMERASE (ALPHA CHAIN) RPOA (TRANSCRIPTASE ALPHA CHAIN) (RNA POLYMERASE ALPHA SUBUNIT) (DNA-DIRECTED	0.01	0.3256	0.3769
Brugia malayi	RNA polymerase Rpb1, domain 1 family protein	0.0009	0.018	0.018
Brugia malayi	latrophilin 2 splice variant baaae	0.0165	0.5449	0.5449
Schistosoma mansoni	dreadlocks/dock	0.0012	0.0268	0.0268
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0012	0.0278	0.0278
Brugia malayi	SRC-1	0.0024	0.0672	0.0672
Brugia malayi	SH2 domain containing protein	0.0012	0.0278	0.0278
Loa Loa (eye worm)	DNA-directed RNA polymerase II second largest subunit	0.0017	0.0452	0.0452
Treponema pallidum	DNA-directed RNA polymerase subunit beta	0.025	0.8341	1
Echinococcus granulosus	endophilin A3	0.0012	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0009	0.018	0.018
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0241	0.803	0.803
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0299	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.9 nM	Displacement of [125I]glucagon from human GCGR expressed in CHO cells after 3 hrs by scintillation proximity assay	ChEMBL.	22708876
IC50 (functional)	= 5.7 nM	Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter	ChEMBL.	22708876
IC50 (functional)	= 1336 nM	Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter	ChEMBL.	22708876
IC50 (functional)	= 2.6 uM	Antagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter	ChEMBL.	22708876
IC50 (functional)	= 3.3 uM	Antagonist activity at human GLP1R expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter	ChEMBL.	22708876

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2159349

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1715997