TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 462.808 | Formula: C18H18ClF3N4O5
H donors: 4 H acceptors: 4 LogP: 1.94 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(c(c1)C(F)(F)F)Cl)NC[C@H]1O[C@H](C[C@@H]1O)n1cc(C)c(=O)[nH]c1=O
InChi: 1S/C18H18ClF3N4O5/c1-8-7-26(17(30)25-15(8)28)14-5-12(27)13(31-14)6-23-16(29)24-9-2-3-11(19)10(4-9)18(20,21)22/h2-4,7,12-14,27H,5-6H2,1H3,(H2,23,24,29)(H,25,28,30)/t12-,13+,14+/m0/s1
InChiKey: FIFLVFXOJCAQLR-BFHYXJOUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0043	0.0043
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.029	0.1765	0.1765
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Brugia malayi	Papain family cysteine protease containing protein	0.029	0.1765	0.1765
Leishmania major	cathepsin L-like protease	0.029	0.1765	0.5152
Toxoplasma gondii	cathepsin B	0.0523	0.3425	1
Echinococcus multilocularis	geminin	0.0164	0.0865	0.0865
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0043	0.0043
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0312	0.1925	0.1925
Onchocerca volvulus	Cathepsin L homolog	0.011	0.0482	0.0697
Loa Loa (eye worm)	cysteine protease	0.029	0.1765	0.1765
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.011	0.0482	0.0482
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.029	0.1765	0.5152
Loa Loa (eye worm)	fibroinase	0.029	0.1765	0.1765
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Leishmania major	cathepsin L-like protease	0.029	0.1765	0.5152
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0049	0.0047	0.0068
Echinococcus multilocularis	cysteine protease	0.029	0.1765	0.1765
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Giardia lamblia	Cathepsin B precursor	0.011	0.0482	0.1406
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.011	0.0482	0.1406
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.011	0.0482	0.0482
Treponema pallidum	thymidylate kinase (tmk)	0.0087	0.0318	1
Trypanosoma cruzi	cysteine peptidase, putative	0.029	0.1765	0.1765
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.029	0.1765	0.5152
Echinococcus multilocularis	inhibitor of apoptosis protein	0.1012	0.6906	0.6906
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.011	0.0482	0.1406
Onchocerca volvulus	Cathepsin L homolog	0.029	0.1765	0.2555
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.011	0.0482	0.1406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0049	0.0047	0.0267
Giardia lamblia	Cathepsin L-like protease	0.011	0.0482	0.1406
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0067	0.0176	0.0176
Brugia malayi	Cathepsin L-like precursor	0.029	0.1765	0.1765
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.029	0.1765	0.5152
Toxoplasma gondii	cathepsin CPL	0.029	0.1765	0.5152
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Trypanosoma cruzi	major cysteine proteinase, putative	0.011	0.0482	0.0482
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.011	0.0482	0.2729
Echinococcus granulosus	thymidylate kinase	0.0087	0.0318	0.0318
Echinococcus granulosus	cathepsin l cysteine peptidase	0.029	0.1765	0.1765
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.029	0.1765	0.5152
Brugia malayi	cathepsin Z-like cysteine proteinase	0.011	0.0482	0.0482
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.011	0.0482	0.1406
Giardia lamblia	Encystation-specific protease	0.011	0.0482	0.1406
Giardia lamblia	Hypothetical protein	0.011	0.0482	0.1406
Echinococcus multilocularis	histone deacetylase 6	0.0046	0.0029	0.0029
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.029	0.1765	0.5152
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.011	0.0482	0.0482
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.011	0.0482	0.2729
Trypanosoma cruzi	histone deacetylase, putative	0.0046	0.0029	0.0029
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1446	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0482	0.1406
Giardia lamblia	Cathepsin L precursor	0.011	0.0482	0.1406
Echinococcus granulosus	cathepsin l1	0.029	0.1765	0.1765
Plasmodium falciparum	serine repeat antigen 1	0.011	0.0482	0.2729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0482	0.1406
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.011	0.0482	0.0482
Schistosoma mansoni	thymidylate kinase	0.0087	0.0318	0.0318
Onchocerca volvulus		0.1012	0.6906	1
Onchocerca volvulus	Cell death protein 3 homolog	0.0312	0.1925	0.2787
Onchocerca volvulus	Cathepsin F homolog	0.029	0.1765	0.2555
Loa Loa (eye worm)	histone deacetylase 7A	0.0046	0.0029	0.0029
Loa Loa (eye worm)	cathepsin B	0.0523	0.3425	0.3425
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Schistosoma mansoni	cathepsin F (C01 family)	0.029	0.1765	0.1765
Plasmodium falciparum	serine repeat antigen 3	0.011	0.0482	0.2729
Brugia malayi	cathepsin L precursor	0.011	0.0482	0.0482
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.011	0.0482	0.1406
Onchocerca volvulus		0.029	0.1765	0.2555
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.011	0.0482	0.0482
Plasmodium falciparum	serine repeat antigen 2	0.011	0.0482	0.2729
Echinococcus granulosus	cathepsin L cysteine protease	0.011	0.0482	0.0482
Plasmodium vivax	vivapain-2	0.029	0.1765	1
Trypanosoma cruzi	cysteine peptidase, putative	0.029	0.1765	0.1765
Trichomonas vaginalis	thymidylate kinase, putative	0.0087	0.0318	0.0929
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.0135	0.0135
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0043	0.0043
Echinococcus multilocularis	cathepsin b	0.1446	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.011	0.0482	0.2729
Plasmodium vivax	RNA helicase-1, putative	0.0049	0.0047	0.0267
Giardia lamblia	Cathepsin B precursor	0.011	0.0482	0.1406
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.011	0.0482	0.2729
Entamoeba histolytica	Thymidylate kinase, putative	0.0087	0.0318	0.1803
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.011	0.0482	0.0482
Trypanosoma cruzi	cysteine peptidase, putative	0.029	0.1765	0.1765
Plasmodium vivax	serine-repeat antigen (SERA)	0.011	0.0482	0.2729
Entamoeba histolytica	hypothetical protein	0.011	0.0482	0.2729
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0135	0.0135
Plasmodium falciparum	serine repeat antigen 9	0.011	0.0482	0.2729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.029	0.1765	0.5152
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0049	0.0047	0.0047
Plasmodium falciparum	histone deacetylase 2	0.0046	0.0029	0.0166
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0135	0.0135
Onchocerca volvulus		0.029	0.1765	0.2555
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.011	0.0482	0.1406
Schistosoma mansoni	hypothetical protein	0.0087	0.0318	0.0318
Mycobacterium leprae	probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK)	0.0087	0.0318	0.5
Leishmania major	cathepsin L-like protease	0.029	0.1765	0.5152
Brugia malayi	Papain family cysteine protease containing protein	0.011	0.0482	0.0482
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Onchocerca volvulus	Putative thymidylate kinase	0.0087	0.0318	0.0461
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0043	0.0043
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.011	0.0482	0.2729
Brugia malayi	thymidylate kinase	0.0087	0.0318	0.0318
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Toxoplasma gondii	thymidylate kinase	0.0087	0.0318	0.0929
Brugia malayi	MH2 domain containing protein	0.0117	0.0531	0.0531
Echinococcus multilocularis	histone deacetylase 6	0.0046	0.0029	0.0029
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.029	0.1765	0.1765
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.029	0.1765	0.5152
Giardia lamblia	Cathepsin B precursor	0.011	0.0482	0.1406
Plasmodium vivax	histone deacetylase 2, putative	0.0046	0.0029	0.0166
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.0531	0.0531
Echinococcus granulosus	cathepsin L cysteine proteinase	0.029	0.1765	0.1765
Schistosoma mansoni	thymidylate kinase	0.0087	0.0318	0.0318
Echinococcus granulosus	geminin	0.0164	0.0865	0.0865
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.011	0.0482	0.1406
Schistosoma mansoni	cathepsin F (C01 family)	0.029	0.1765	0.1765
Leishmania major	cathepsin L-like protease	0.029	0.1765	0.5152
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.011	0.0482	0.1406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.029	0.1765	0.1765
Echinococcus granulosus	apoptotic protease activating factor 1	0.0312	0.1925	0.1925
Schistosoma mansoni	cathepsin C	0.011	0.0482	0.0482
Giardia lamblia	Cathepsin B precursor	0.011	0.0482	0.1406
Echinococcus multilocularis	caspase 2	0.0312	0.1925	0.1925
Loa Loa (eye worm)	hypothetical protein	0.029	0.1765	0.1765
Giardia lamblia	Hypothetical protein	0.011	0.0482	0.1406
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0043	0.0043
Entamoeba histolytica	cysteine proteinase, putative	0.029	0.1765	1
Trypanosoma cruzi	cysteine protease, putative	0.011	0.0482	0.0482
Brugia malayi	RNA binding protein	0.0061	0.0135	0.0135
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0049	0.0047	0.0047
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0049	0.0047	0.0047
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0049	0.0047	0.0047
Echinococcus granulosus	histone deacetylase 6	0.0046	0.0029	0.0029
Leishmania major	histone deacetylase, putative	0.0046	0.0029	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.0482	0.1406
Onchocerca volvulus		0.029	0.1765	0.2555
Echinococcus granulosus	cathepsin L	0.011	0.0482	0.0482
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.029	0.1765	1
Schistosoma mansoni	hypothetical protein	0.1012	0.6906	0.6906
Loa Loa (eye worm)	hypothetical protein	0.1012	0.6906	0.6906
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0482	0.1406
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Giardia lamblia	Cysteine protease	0.011	0.0482	0.1406
Plasmodium falciparum	histone deacetylase, putative	0.0046	0.0029	0.0166
Mycobacterium ulcerans	thymidylate kinase	0.0087	0.0318	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0482	0.1406
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.011	0.0482	0.0482
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.011	0.0482	0.1406
Schistosoma mansoni	inhibitor of apoptosis protein	0.1012	0.6906	0.6906
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0482	0.1406
Brugia malayi	Cathepsin L-like precursor	0.029	0.1765	0.1765
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0049	0.0047	0.0138
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.011	0.0482	0.1406
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.029	0.1765	0.5152
Giardia lamblia	Cysteine protease	0.011	0.0482	0.1406
Onchocerca volvulus		0.029	0.1765	0.2555
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.1012	0.6906	0.6906
Schistosoma mansoni	hypothetical protein	0.0312	0.1925	0.1925
Echinococcus multilocularis	cysteine protease	0.029	0.1765	0.1765
Echinococcus granulosus	histone deacetylase	0.0046	0.0029	0.0029
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0523	0.3425	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.011	0.0482	0.1406
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0043	0.0043
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.011	0.0482	0.0482
Loa Loa (eye worm)	hypothetical protein	0.011	0.0482	0.0482
Entamoeba histolytica	cysteine proteinase, putative	0.029	0.1765	1
Trypanosoma brucei	thymidylate kinase, putative	0.0087	0.0318	0.0929
Brugia malayi	Cathepsin L-like precursor	0.029	0.1765	0.1765
Loa Loa (eye worm)	hypothetical protein	0.011	0.0482	0.0482
Entamoeba histolytica	cysteine proteinase, putative	0.011	0.0482	0.2729
Giardia lamblia	CDC8	0.0087	0.0318	0.0929
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.011	0.0482	0.0482
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0523	0.3425	0.3425
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1446	1	1
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0049	0.0047	0.0138
Chlamydia trachomatis	thymidylate kinase	0.0087	0.0318	0.5
Schistosoma mansoni	hypothetical protein	0.0164	0.0865	0.0865
Plasmodium falciparum	serine repeat antigen 7	0.011	0.0482	0.2729
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0029	0.0029
Echinococcus granulosus	histone deacetylase 7	0.0046	0.0029	0.0029
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Trypanosoma brucei	thymidylate kinase, putative	0.0087	0.0318	0.0929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.029	0.1765	0.5152
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0049	0.0047	0.0047
Schistosoma mansoni	caspase-7 (C14 family)	0.0312	0.1925	0.1925
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.029	0.1765	0.5152
Schistosoma mansoni	histone deacetylase 4 5	0.0046	0.0029	0.0029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0523	0.3425	1
Echinococcus multilocularis	histone deacetylase 6	0.0046	0.0029	0.0029
Leishmania major	thymidylate kinase-like protein	0.0087	0.0318	0.0929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Loa Loa (eye worm)	hypothetical protein	0.011	0.0482	0.0482
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.029	0.1765	0.5152
Trypanosoma cruzi	cysteine peptidase, putative	0.029	0.1765	0.1765
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Plasmodium falciparum	serine repeat antigen 8	0.011	0.0482	0.2729
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.011	0.0482	0.0482
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.011	0.0482	0.1406
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0523	0.3425	1
Echinococcus multilocularis	thymidylate kinase	0.0087	0.0318	0.0318
Plasmodium vivax	thymidylate kinase, putative	0.0087	0.0318	0.1803
Leishmania major	eukaryotic initiation factor 4a, putative	0.0049	0.0047	0.0138
Brugia malayi	Cathepsin L-like precursor	0.029	0.1765	0.1765
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.029	0.1765	0.5152
Schistosoma mansoni	hypothetical protein	0.0164	0.0865	0.0865
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.0135	0.0135
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.011	0.0482	0.1406
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0049	0.0047	0.0138
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0049	0.0047	0.0138
Echinococcus granulosus	cathepsin b	0.1446	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.011	0.0482	0.0482
Plasmodium vivax	histone deacetylase, putative	0.0046	0.0029	0.0166
Trypanosoma brucei	histone deacetylase, putative	0.0046	0.0029	0.0086
Trypanosoma cruzi	cruzipain precursor, putative	0.029	0.1765	0.1765
Loa Loa (eye worm)	RNA binding protein	0.0061	0.0135	0.0135
Echinococcus granulosus	caspase 2	0.0312	0.1925	0.1925
Schistosoma mansoni	histone deacetylase hda2	0.0046	0.0029	0.0029
Entamoeba histolytica	cysteine proteinase, putative	0.011	0.0482	0.2729
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.029	0.1765	0.5152
Echinococcus granulosus	histone deacetylase 6	0.0046	0.0029	0.0029
Giardia lamblia	Cathepsin L precursor	0.011	0.0482	0.1406
Leishmania major	histone deacetylase, putative	0.0046	0.0029	0.0086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.029	0.1765	0.5152
Schistosoma mansoni	cathepsin S (C01 family)	0.011	0.0482	0.0482
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.011	0.0482	0.2729
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.011	0.0482	0.2729
Plasmodium vivax	unspecified product	0.011	0.0482	0.2729
Plasmodium vivax	serine-repeat antigen (SERA)	0.011	0.0482	0.2729
Plasmodium falciparum	serine repeat antigen 6	0.011	0.0482	0.2729
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.029	0.1765	0.5152
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Echinococcus multilocularis	cathepsin L cysteine protease	0.029	0.1765	0.1765
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.029	0.1765	0.5152
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.011	0.0482	0.2729
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Echinococcus granulosus	histone deacetylase 6	0.0046	0.0029	0.0029
Toxoplasma gondii	histone deacetylase HDAC1	0.0046	0.0029	0.0086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.029	0.1765	0.5152
Brugia malayi	Histone deacetylase family protein	0.0046	0.0029	0.0029
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0043	0.0043
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.011	0.0482	0.2729
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.029	0.1765	1
Leishmania major	cathepsin L-like protease	0.029	0.1765	0.5152
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.0482	0.1406
Giardia lamblia	Cathepsin B precursor	0.011	0.0482	0.1406
Brugia malayi	Cathepsin L-like precursor	0.029	0.1765	0.1765
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0043	0.0043
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0047	0.0047
Leishmania major	cathepsin L-like protease	0.029	0.1765	0.5152
Trypanosoma cruzi	histone deacetylase, putative	0.0046	0.0029	0.0029
Onchocerca volvulus		0.029	0.1765	0.2555
Giardia lamblia	Cysteine protease	0.011	0.0482	0.1406
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.011	0.0482	0.2729
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.029	0.1765	0.5152
Echinococcus granulosus	cathepsin b	0.1446	1	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.011	0.0482	0.0482
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.1012	0.6906	0.6906
Echinococcus multilocularis	cathepsin L	0.011	0.0482	0.0482
Onchocerca volvulus		0.0312	0.1925	0.2787
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.029	0.1765	0.1765
Leishmania major	cathepsin L-like protease	0.029	0.1765	0.5152
Toxoplasma gondii	cathepsin CPC1	0.011	0.0482	0.1406
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.029	0.1765	0.5152
Schistosoma mansoni	cathepsin B (C01 family)	0.011	0.0482	0.0482
Brugia malayi	Cathepsin L-like precursor	0.029	0.1765	0.1765
Brugia malayi	Cell death protein 3 precursor	0.0312	0.1925	0.1925
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0043	0.0043
Plasmodium falciparum	serine repeat antigen 5	0.011	0.0482	0.2729
Entamoeba histolytica	cysteine proteinase, putative	0.029	0.1765	1
Giardia lamblia	Cathepsin L precursor	0.011	0.0482	0.1406
Loa Loa (eye worm)	histone deacetylase	0.0046	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.029	0.1765	0.1765
Giardia lamblia	Cathepsin L precursor	0.011	0.0482	0.1406
Echinococcus multilocularis	histone deacetylase	0.0046	0.0029	0.0029
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.029	0.1765	0.1765
Loa Loa (eye worm)	thymidylate kinase	0.0087	0.0318	0.0318
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0482	0.1406
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.029	0.1765	0.5152
Loa Loa (eye worm)	hypothetical protein	0.029	0.1765	0.1765
Giardia lamblia	Cathepsin B precursor	0.0523	0.3425	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.011	0.0482	0.2729
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.011	0.0482	0.2729
Trypanosoma brucei	histone deacetylase 3	0.0046	0.0029	0.0086
Leishmania major	eukaryotic initiation factor 4a, putative	0.0049	0.0047	0.0138
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0049	0.0047	0.0267
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Loa Loa (eye worm)	hypothetical protein	0.1012	0.6906	0.6906
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.029	0.1765	0.1765
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.0531	0.0531
Onchocerca volvulus		0.029	0.1765	0.2555
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.011	0.0482	0.1406
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Echinococcus granulosus	cathepsin l1	0.029	0.1765	0.1765
Trypanosoma cruzi	cysteine proteinase, putative	0.011	0.0482	0.0482
Echinococcus multilocularis	cathepsin L cysteine protease	0.029	0.1765	0.1765
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Plasmodium falciparum	cysteine proteinase falcipain 3	0.029	0.1765	1
Echinococcus multilocularis	cathepsin L	0.011	0.0482	0.0482
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1446	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.1012	0.6906	0.6906
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.011	0.0482	0.1406
Toxoplasma gondii	cathepsin CPC2	0.011	0.0482	0.1406
Giardia lamblia	Cathepsin L-like protease	0.011	0.0482	0.1406
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1446	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0482	0.1406
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0135	0.0135
Echinococcus multilocularis	histone deacetylase 7	0.0046	0.0029	0.0029
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.011	0.0482	0.1406
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1446	1	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.011	0.0482	0.0482
Plasmodium falciparum	thymidylate kinase	0.0087	0.0318	0.1803
Giardia lamblia	Cathepsin B precursor	0.0523	0.3425	1
Echinococcus granulosus	tar DNA binding protein	0.0061	0.0135	0.0135
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Brugia malayi	Papain family cysteine protease containing protein	0.011	0.0482	0.0482
Trypanosoma brucei	histone deacetylase 4	0.0046	0.0029	0.0086
Schistosoma mansoni	histone deacetylase 4 5	0.0046	0.0029	0.0029
Brugia malayi	Cathepsin L-like precursor	0.029	0.1765	0.1765
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.011	0.0482	0.1406
Echinococcus granulosus	cysteine protease	0.011	0.0482	0.0482
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Trypanosoma cruzi	cysteine proteinase, putative	0.011	0.0482	0.0482
Brugia malayi	cathepsin Z-like cysteine proteinase	0.011	0.0482	0.0482
Onchocerca volvulus	Deterin homolog	0.1012	0.6906	1
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0135	0.0135
Entamoeba histolytica	cysteine protease, putative	0.029	0.1765	1
Plasmodium vivax	vivapain-3	0.011	0.0482	0.2729
Trypanosoma cruzi	thymidylate kinase, putative	0.0087	0.0318	0.0318
Plasmodium falciparum	serine repeat antigen 4	0.011	0.0482	0.2729
Loa Loa (eye worm)	hypothetical protein	0.0312	0.1925	0.1925
Plasmodium vivax	vivapain-2	0.029	0.1765	1
Leishmania major	cysteine peptidase A (CPA)	0.029	0.1765	0.5152
Plasmodium vivax	unspecified product	0.011	0.0482	0.2729
Echinococcus multilocularis	cathepsin b	0.1446	1	1
Loa Loa (eye worm)	ctsf protein	0.029	0.1765	0.1765
Plasmodium falciparum	cysteine proteinase falcipain 1	0.011	0.0482	0.2729
Trichomonas vaginalis	thymidylate kinase, putative	0.0087	0.0318	0.0929
Brugia malayi	hypothetical protein	0.0312	0.1925	0.1925
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.011	0.0482	0.2729
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0312	0.1925	0.1925
Brugia malayi	Papain family cysteine protease containing protein	0.011	0.0482	0.0482
Plasmodium vivax	vivapain-1	0.011	0.0482	0.2729
Brugia malayi	eukaryotic initiation factor 4A	0.0049	0.0047	0.0047
Leishmania major	cathepsin L-like protease	0.029	0.1765	0.5152
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0049	0.0047	0.0138
Echinococcus granulosus	inhibitor of apoptosis protein	0.1012	0.6906	0.6906
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.011	0.0482	0.0482
Entamoeba histolytica	cysteine proteinase 2	0.011	0.0482	0.2729
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.1012	0.6906	0.6906
Echinococcus granulosus	cathepsin L	0.011	0.0482	0.0482
Brugia malayi	cathepsin L-like precursor	0.029	0.1765	0.1765
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0523	0.3425	0.3425
Brugia malayi	Cathepsin L-like cysteine proteinase	0.029	0.1765	0.1765
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0482	0.1406
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.0135	0.0135
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0049	0.0047	0.0047
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0049	0.0047	0.0047
Onchocerca volvulus		0.011	0.0482	0.0697
Giardia lamblia	Cathepsin L precursor	0.011	0.0482	0.1406
Loa Loa (eye worm)	hypothetical protein	0.011	0.0482	0.0482
Trypanosoma cruzi	thymidylate kinase, putative	0.0087	0.0318	0.0318
Giardia lamblia	Cathepsin B precursor	0.0523	0.3425	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.011	0.0482	0.0482
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.1012	0.6906	0.6906
Entamoeba histolytica	cysteine proteinase, putative	0.011	0.0482	0.2729
Onchocerca volvulus		0.029	0.1765	0.2555
Brugia malayi	Cathepsin L-like precursor	0.029	0.1765	0.1765
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Entamoeba histolytica	cysteine proteinase, putative	0.011	0.0482	0.2729
Onchocerca volvulus	Cathepsin L homolog	0.029	0.1765	0.2555
Brugia malayi	TAR-binding protein	0.0061	0.0135	0.0135
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.029	0.1765	0.5152
Schistosoma mansoni	cathepsin F (C01 family)	0.029	0.1765	0.1765
Loa Loa (eye worm)	hypothetical protein	0.011	0.0482	0.0482
Brugia malayi	fibroinase precursor	0.011	0.0482	0.0482
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	0.0087	0.0318	0.5
Giardia lamblia	Cysteine protease	0.011	0.0482	0.1406
Loa Loa (eye worm)	hypothetical protein	0.011	0.0482	0.0482
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0135	0.0135
Trypanosoma cruzi	histone deacetylase, putative	0.0046	0.0029	0.0029
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.011	0.0482	0.0482
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)	0.0087	0.0318	1
Onchocerca volvulus		0.029	0.1765	0.2555
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.011	0.0482	0.0482
Loa Loa (eye worm)	hypothetical protein	0.1446	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.011	0.0482	0.0482
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.011	0.0482	0.0482
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.011	0.0482	0.2729
Entamoeba histolytica	cysteine protease, putative	0.011	0.0482	0.2729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.029	0.1765	0.5152
Brugia malayi	cathepsin F-like cysteine proteinase	0.011	0.0482	0.0482
Brugia malayi	Histone deacetylase family protein	0.0046	0.0029	0.0029
Entamoeba histolytica	cysteine proteinase 1, putative	0.011	0.0482	0.2729
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.011	0.0482	0.2729
Trypanosoma cruzi	cysteine peptidase, putative	0.011	0.0482	0.0482
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0049	0.0047	0.0138
Brugia malayi	Papain family cysteine protease containing protein	0.011	0.0482	0.0482
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.011	0.0482	0.0482
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0049	0.0047	0.0047
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.029	0.1765	0.5152
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.011	0.0482	0.1406
Giardia lamblia	Cathepsin L precursor	0.011	0.0482	0.1406

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 114 uM	Antimalarial activity against erythrocytic stages of Plasmodium falciparum 3D7 infected in human O positive RBC after 48 hrs by SYBR-green assay	ChEMBL.	23240776
Ki (binding)	= 27 uM	Inhibition of recombinant Plasmodium falciparum TMPK using TMP as substrate by pyruvate kinase and lactate dehydrogenase enzyme coupled assay	ChEMBL.	23240776

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2179047

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1716822