Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nAChR subunit | 0.0038 | 0.0162 | 0.0162 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0382 | 0.3427 | 0.3427 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0038 | 0.0162 | 0.0162 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0382 | 0.3427 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0382 | 0.3427 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0376 | 0.0376 |
Onchocerca volvulus | Putative nachr subunit | 0.0038 | 0.0162 | 0.0162 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0061 | 0.0376 | 0.0376 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0382 | 0.3427 | 1 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0038 | 0.0162 | 0.0162 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.1074 | 1 | 1 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Schistosoma mansoni | fusion | 0.0382 | 0.3427 | 0.3427 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0382 | 0.3427 | 0.3427 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0038 | 0.0162 | 0.0162 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1074 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0.0376 | 0.0376 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0038 | 0.0162 | 0.0162 |
Schistosoma mansoni | hypothetical protein | 0.0382 | 0.3427 | 0.3427 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0376 | 0.0376 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0382 | 0.3427 | 0.5 |
Schistosoma mansoni | RNA binding protein | 0.0382 | 0.3427 | 0.3427 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0038 | 0.0162 | 0.0162 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0038 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0382 | 0.3427 | 0.3427 | |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1074 | 1 | 1 |
Brugia malayi | Cation transporter family protein | 0.0038 | 0.0162 | 0.0162 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.1074 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1074 | 1 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.1074 | 1 | 1 |
Echinococcus granulosus | nAChR subunit | 0.0038 | 0.0162 | 0.0162 |
Brugia malayi | Cation transporter family protein | 0.0038 | 0.0162 | 0.0162 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | brahma associated protein | 0.1074 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.1074 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0061 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0038 | 0.0162 | 0.0162 | |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.1074 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Schistosoma mansoni | nAChR subunit | 0.0038 | 0.0162 | 0.0162 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0382 | 0.3427 | 0.3427 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0038 | 0.0162 | 0.0162 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1074 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0038 | 0.0162 | 0.0162 |
Chlamydia trachomatis | DNA topoisomerase I | 0.1074 | 1 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0038 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0382 | 0.3427 | 0.3427 | |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0038 | 0.0162 | 0.0162 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.1074 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1074 | 1 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0038 | 0.0162 | 0.0162 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0382 | 0.3427 | 0.3427 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0382 | 0.3427 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0382 | 0.3427 | 0.3427 |
Schistosoma mansoni | nAChR subunit | 0.0038 | 0.0162 | 0.0162 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0061 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0376 | 0.0376 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0382 | 0.3427 | 0.3427 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0038 | 0.0162 | 0.0162 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0038 | 0.0162 | 0.0162 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0382 | 0.3427 | 0.3427 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0038 | 0.0162 | 0.0162 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0038 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0038 | 0.0162 | 0.0162 | |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.1074 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.3427 | 0.3427 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0038 | 0.0162 | 0.0162 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0038 | 0.0162 | 0.0162 |
Plasmodium falciparum | zinc finger Ran-binding domain-containing protein 2, putative | 0.0382 | 0.3427 | 0.3427 |
Schistosoma mansoni | hypothetical protein | 0.1074 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0382 | 0.3427 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0382 | 0.3427 | 0.3427 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0038 | 0.0162 | 0.0162 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0038 | 0.0162 | 0.0162 |
Toxoplasma gondii | ran binding protein | 0.0382 | 0.3427 | 0.3427 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1074 | 1 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0038 | 0.0162 | 0.0162 |
Leishmania major | hypothetical protein, conserved | 0.0382 | 0.3427 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0038 | 0.0162 | 0.0162 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0382 | 0.3427 | 1 |
Echinococcus multilocularis | nAChR subunit | 0.0038 | 0.0162 | 0.0162 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0382 | 0.3427 | 0.3427 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.3427 | 0.3427 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0038 | 0.0162 | 0.0162 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0382 | 0.3427 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0038 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0382 | 0.3427 | 0.3427 | |
Loa Loa (eye worm) | ACC-1 protein | 0.0038 | 0.0162 | 0.0162 |
Schistosoma mansoni | nAChR subunit | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.3427 | 0.3427 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0038 | 0.0162 | 0.0162 |
Chlamydia trachomatis | SWIB complex protein | 0.1074 | 1 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0061 | 0.0376 | 0.0376 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0038 | 0.0162 | 0.0162 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0382 | 0.3427 | 0.3427 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0038 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0038 | 0.0162 | 0.0162 | |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0382 | 0.3427 | 0.3427 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0038 | 0.0162 | 0.0162 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0382 | 0.3427 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0038 | 0.0162 | 0.0162 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0038 | 0.0162 | 0.0162 |
Schistosoma mansoni | nAChR subunit | 0.0038 | 0.0162 | 0.0162 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0038 | 0.0162 | 0.0162 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0038 | 0.0162 | 0.0162 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0382 | 0.3427 | 0.3427 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.1074 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0061 | 0.0376 | 0.0376 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0382 | 0.3427 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0382 | 0.3427 | 1 |
Loa Loa (eye worm) | LGC-31 protein | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0382 | 0.3427 | 1 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.3427 | 0.3427 |
Onchocerca volvulus | 0.0038 | 0.0162 | 0.0162 | |
Loa Loa (eye worm) | serotonin transporter b | 0.0061 | 0.0376 | 0.0376 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0382 | 0.3427 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0061 | 0.0376 | 0.0376 |
Plasmodium vivax | hypothetical protein, conserved | 0.1074 | 1 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0038 | 0.0162 | 0.0162 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0382 | 0.3427 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0061 | 0.0376 | 0.0376 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0038 | 0.0162 | 0.0162 |
Brugia malayi | Cation transporter family protein | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0061 | 0.0376 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0038 | 0.0162 | 0.0162 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0038 | 0.0162 | 0.0162 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.1074 | 1 | 1 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0382 | 0.3427 | 0.3427 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0382 | 0.3427 | 0.3427 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0038 | 0.0162 | 0.0162 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0038 | 0.0162 | 0.0162 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0382 | 0.3427 | 0.3427 |
Onchocerca volvulus | 0.0382 | 0.3427 | 0.3427 | |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0038 | 0.0162 | 0.0162 |
Schistosoma mansoni | nAChR subunit | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0038 | 0.0162 | 0.0162 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0038 | 0.0162 | 0.0162 |
Leishmania major | hypothetical protein, conserved | 0.0382 | 0.3427 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.3427 | 0.3427 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | ACC-1 protein | 0.0038 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0038 | 0.0162 | 0.0162 | |
Schistosoma mansoni | hypothetical protein | 0.1074 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0038 | 0.0162 | 0.0162 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0382 | 0.3427 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0038 | 0.0162 | 0.0162 |
Schistosoma mansoni | nAChR subunit | 0.0038 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Leishmania major | hypothetical protein, conserved | 0.0382 | 0.3427 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0162 | 0.0162 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0038 | 0.0162 | 0.0162 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0038 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0038 | 0.0162 | 0.0162 | |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0382 | 0.3427 | 0.3427 |
Brugia malayi | brahma associated protein 60 kDa | 0.1074 | 1 | 1 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0038 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.1074 | 1 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0382 | 0.3427 | 1 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0382 | 0.3427 | 0.3427 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0038 | 0.0162 | 0.0162 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1074 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.19 nM | Binding affinity to human thrombin. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.