TDR Targets

Basic information

Technical information

TDR Targets ID: 171710
Name: 2-(3-methoxyphenyl)-6-morpholin-4-ylpyran-4-o ne
MW: 287.31 | Formula: C16H17NO4
H donors: 0 H acceptors: 1 LogP: 1.69 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)c1cc(=O)cc(o1)N1CCOCC1
InChi: 1S/C16H17NO4/c1-19-14-4-2-3-12(9-14)15-10-13(18)11-16(21-15)17-5-7-20-8-6-17/h2-4,9-11H,5-8H2,1H3
InChiKey: OLIONIBTYZDPMY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(3-methoxyphenyl)-6-morpholino-pyran-4-one
2-(3-methoxyphenyl)-6-morpholino-4-pyranone
2-(3-methoxyphenyl)-6-morpholin-4-yl-pyran-4-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase, DNA-activated, catalytic polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Trypanosoma cruzi	WLM domain containing protein, putative	0.0509	0.3457	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0029	0.0084
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0509	0.3457	0.3438
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0509	0.3457	0.3457
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.1432	1	1
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0509	0.3457	0.3457
Trichomonas vaginalis	ankyrin, putative	0.0026	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Leishmania major	hypothetical protein, conserved	0.0026	0.0029	0.0084
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0509	0.3457	1
Giardia lamblia	Hypothetical protein	0.0026	0.0029	1
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.1432	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Leishmania major	hypothetical protein, conserved	0.0509	0.3457	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.1432	1	1
Trichomonas vaginalis	ankyrin, putative	0.0026	0.0029	0.0029
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Entamoeba histolytica	zinc finger domain containing protein	0.0026	0.0029	1
Brugia malayi	Neuralized family protein	0.0026	0.0029	0.0029
Echinococcus multilocularis	ring finger protein 170	0.0026	0.0029	0.0029
Toxoplasma gondii	ran binding protein	0.0509	0.3457	0.3457
Schistosoma mansoni	hypothetical protein	0.1432	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0026	0.0029	0.0029
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0509	0.3457	0.3457
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0026	0.0029	0.0029
Giardia lamblia	Zinc finger domain	0.0026	0.0029	1
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0509	0.3457	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0313	0.2068	0.2068
Trypanosoma cruzi	hypothetical protein, conserved	0.0509	0.3457	1
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0509	0.3457	1
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0313	0.2068	0.2068
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0029	0.0084
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.1432	1	1
Giardia lamblia	Kinase	0.0026	0.0029	1
Leishmania major	hypothetical protein, conserved	0.0509	0.3457	1
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Entamoeba histolytica	zinc finger domain containing protein	0.0026	0.0029	1
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0026	0.0029	0.0029
Trypanosoma brucei	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Trypanosoma brucei	predicted zinc finger protein	0.0026	0.0029	0.0084
Brugia malayi	hypothetical protein	0.0026	0.0029	0.0029
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0026	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0029	0.0029
Chlamydia trachomatis	SWIB complex protein	0.1432	1	0.5
Leishmania major	hypothetical protein, conserved	0.0509	0.3457	1
Onchocerca volvulus		0.0509	0.3457	0.3438
Trypanosoma brucei	SNF2 family N-terminal domain/Ring finger domain containing protein, putative	0.0026	0.0029	0.0084
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0026	0.0029	0.0029
Trichomonas vaginalis	ion channel nompc, putative	0.0026	0.0029	0.0029
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0029	0.0084
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0509	0.3457	0.3457
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0029	0.0029
Echinococcus granulosus	ring finger protein 170	0.0026	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Entamoeba histolytica	zinc finger domain containing protein	0.0026	0.0029	1
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0026	0.0029	0.0029
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.0623	0.1801
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0026	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0029	0.0029
Giardia lamblia	Ribonuclease	0.0026	0.0029	1
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0509	0.3457	0.3457
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0509	0.3457	0.3457
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Onchocerca volvulus		0.0509	0.3457	0.3438
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Trypanosoma cruzi	hypothetical protein	0.0026	0.0029	0.0084
Echinococcus multilocularis	SWI:SNF matrix associated	0.1432	1	1
Onchocerca volvulus		0.0509	0.3457	0.3438
Schistosoma mansoni	mind bomb	0.0026	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0026	0.0029	0.0029
Echinococcus granulosus	RING finger protein 185	0.0026	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0509	0.3457	0.3457
Leishmania major	hypothetical protein, conserved	0.0026	0.0029	0.0084
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0026	0.0029	0.0029
Schistosoma mansoni	zinc finger protein	0.0026	0.0029	0.0029
Entamoeba histolytica	SPRY domain protein	0.0026	0.0029	1
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0026	0.0029	0.0029
Leishmania major	hypothetical protein, conserved	0.0026	0.0029	0.0084
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0026	0.0029	0.0029
Brugia malayi	brahma associated protein 60 kDa	0.1432	1	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Leishmania major	hypothetical protein, conserved	0.0026	0.0029	0.0084
Brugia malayi	hypothetical protein	0.0026	0.0029	0.0029
Giardia lamblia	Ser/Thr protein kinase	0.0026	0.0029	1
Schistosoma mansoni	peter pan-related	0.0026	0.0029	0.0029
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger) containing protein, putative	0.0026	0.0029	0.0084
Schistosoma mansoni	rnf5	0.0026	0.0029	0.0029
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0026	0.0029	0.0029
Giardia lamblia	Hypothetical protein	0.0026	0.0029	1
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0026	0.0029	0.0029
Toxoplasma gondii	hypothetical protein	0.0026	0.0029	0.0029
Brugia malayi	YY1-associated factor 2	0.0509	0.3457	0.3457
Trypanosoma cruzi	hypothetical protein	0.0026	0.0029	0.0084
Brugia malayi	RING zinc finger protein	0.0026	0.0029	0.0029
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0026	0.0029	0.0029
Schistosoma mansoni	hypothetical protein	0.0509	0.3457	0.3457
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Schistosoma mansoni	hypothetical protein	0.1432	1	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0029	0.0084
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.1432	1	1
Entamoeba histolytica	zinc finger domain containing protein	0.0026	0.0029	1
Schistosoma mansoni	ring finger protein 151	0.0026	0.0029	0.0029
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Trypanosoma brucei	hypothetical protein, conserved	0.0509	0.3457	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0029	0.0029
Entamoeba histolytica	hypothetical protein	0.0026	0.0029	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0029	0.0084
Leishmania major	hypothetical protein, conserved	0.0509	0.3457	1
Leishmania major	DNA repair protein-like protein	0.0026	0.0029	0.0084
Entamoeba histolytica	zinc finger domain containing protein	0.0026	0.0029	1
Giardia lamblia	Hypothetical protein	0.0026	0.0029	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0029	0.0084
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0509	0.3457	0.3457
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0029	0.0084
Entamoeba histolytica	zinc finger domain containing protein	0.0026	0.0029	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0029	0.0084
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0509	0.3457	0.3457
Loa Loa (eye worm)	hypothetical protein	0.0509	0.3457	0.3457
Trypanosoma brucei	ring finger containing protein	0.0026	0.0029	0.0084
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0509	0.3457	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Chlamydia trachomatis	DNA topoisomerase I	0.1432	1	0.5
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Schistosoma mansoni	RNA binding protein	0.0509	0.3457	0.3457
Toxoplasma gondii	helicase, putative	0.0026	0.0029	0.0029
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Echinococcus multilocularis	RING finger protein 185	0.0026	0.0029	0.0029
Trypanosoma brucei	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Schistosoma mansoni	hypothetical protein	0.1432	1	1
Leishmania major	hypothetical protein, conserved	0.0509	0.3457	1
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1432	1	1
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Entamoeba histolytica	zinc finger domain containing protein	0.0026	0.0029	1
Giardia lamblia	Hypothetical protein	0.0026	0.0029	1
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0026	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0026	0.0029	0.0029
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0026	0.0029	0.0029
Echinococcus multilocularis	zinc finger protein Ran binding	0.0509	0.3457	0.3457
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0029	0.0029
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Toxoplasma gondii	SWI2/SNF2-containing protein RAD5	0.0026	0.0029	0.0029
Entamoeba histolytica	zinc finger domain containing protein	0.0026	0.0029	1
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0029	0.0029
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Brugia malayi	Zinc finger protein 183 homolog	0.0026	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Toxoplasma gondii	RING zinc finger protein	0.0026	0.0029	0.0029
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0026	0.0029	0.0084
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0026	0.0029	0.0029
Schistosoma mansoni	fusion	0.0509	0.3457	0.3457
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Giardia lamblia	Hypothetical protein	0.0026	0.0029	1
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Onchocerca volvulus		0.1432	1	1
Giardia lamblia	E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B	0.0026	0.0029	1
Echinococcus granulosus	Zinc finger RanBP2 type	0.0509	0.3457	0.3457
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0509	0.3457	1
Schistosoma mansoni	peter pan-related	0.0026	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Leishmania major	hypothetical protein, unknown function	0.0026	0.0029	0.0084
Leishmania major	hypothetical protein, conserved	0.0026	0.0029	0.0084
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0029	0.0084
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Echinococcus multilocularis		0.0026	0.0029	0.0029
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0026	0.0029	0.0029
Schistosoma mansoni	TRABID protein (C64 family)	0.0509	0.3457	0.3457
Giardia lamblia	Zinc finger domain	0.0026	0.0029	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0029	0.0029
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Echinococcus granulosus	zinc finger protein Ran binding	0.0509	0.3457	0.3457
Toxoplasma gondii	Bardet-Biedl syndrome 5, putative	0.0026	0.0029	0.0029
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Echinococcus multilocularis	ring and YY1 binding protein	0.0509	0.3457	0.3457
Schistosoma mansoni	hypothetical protein	0.0026	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0029	0.0029
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0026	0.0029	0.0084
Loa Loa (eye worm)	brahma associated protein	0.1432	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0509	0.3457	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0509	0.3457	0.3457
Brugia malayi	Zinc finger, C2H2 type family protein	0.0026	0.0029	0.0029
Plasmodium vivax	hypothetical protein, conserved	0.1432	1	1
Trichomonas vaginalis	cell cycle control protein cwf24, putative	0.0026	0.0029	0.0029
Brugia malayi	SWIB/MDM2 domain containing protein	0.1432	1	1
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Brugia malayi	hypothetical protein	0.0026	0.0029	0.0029
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0509	0.3457	1
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Toxoplasma gondii	hypothetical protein	0.0026	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Brugia malayi	hypothetical protein	0.0026	0.0029	0.0029
Entamoeba histolytica	hypothetical protein	0.0026	0.0029	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0509	0.3457	1
Brugia malayi	B-box zinc finger family protein	0.0026	0.0029	0.0029
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0509	0.3457	1
Loa Loa (eye worm)	RiNg Finger protein family member	0.0026	0.0029	0.0029
Toxoplasma gondii	hypothetical protein	0.0026	0.0029	0.0029
Trypanosoma brucei	DNA repair protein, putative	0.0026	0.0029	0.0084
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.1432	1	1
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0026	0.0029	0.0029
Giardia lamblia	Hypothetical protein	0.0026	0.0029	1
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0026	0.0029	0.0029
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.1432	1	1
Onchocerca volvulus		0.0509	0.3457	0.3438
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Trichomonas vaginalis	ankyrin, putative	0.0026	0.0029	0.0029
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Echinococcus granulosus	SWI:SNF matrix associated	0.1432	1	1
Echinococcus granulosus	ring and YY1 binding protein	0.0509	0.3457	0.3457
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0509	0.3457	0.3457
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.1432	1	1
Giardia lamblia	Kinase, NEK	0.0026	0.0029	1
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0509	0.3457	0.3438
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0026	0.0029	0.0029
Leishmania major	hypothetical protein, conserved	0.0026	0.0029	0.0084
Leishmania major	hypothetical protein, conserved	0.0026	0.0029	0.0084
Leishmania major	hypothetical protein, conserved	0.0026	0.0029	0.0084
Toxoplasma gondii	hypothetical protein	0.0026	0.0029	0.0029
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0029	0.0084
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Echinococcus multilocularis	ring finger protein 113a	0.0026	0.0029	0.0029
Leishmania major	hypothetical protein, conserved	0.0114	0.0652	0.1887
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0509	0.3457	0.3457
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0026	0.0029	0.0029
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.1432	1	1
Schistosoma mansoni	zinc finger protein	0.0509	0.3457	0.3457
Brugia malayi	hypothetical protein	0.0026	0.0029	0.0029
Trypanosoma cruzi	WLM domain containing protein, putative	0.0509	0.3457	1
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Brugia malayi	RING finger protein 20	0.0026	0.0029	0.0029
Giardia lamblia	Kinase, NEK	0.0026	0.0029	1
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0026	0.0029	0.0029
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1432	1	1
Schistosoma mansoni	brg-1 associated factor	0.1432	1	1
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Schistosoma mansoni	hypothetical protein	0.0026	0.0029	0.0029
Giardia lamblia	Protein 21.1	0.0026	0.0029	1
Schistosoma mansoni	hypothetical protein	0.0026	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0029	0.0029
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0026	0.0029	0.0084
Schistosoma mansoni	inhibitor of apoptosis 1 diap1	0.0026	0.0029	0.0029
Echinococcus granulosus	ring finger protein 113a	0.0026	0.0029	0.0029
Trichomonas vaginalis	hypothetical protein	0.0026	0.0029	0.0029
Brugia malayi	hypothetical protein	0.0026	0.0029	0.0029
Trypanosoma brucei	hypothetical protein, conserved	0.0509	0.3457	1
Loa Loa (eye worm)	RING finger protein 20	0.0026	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0029	0.0029
Leishmania major	hypothetical protein	0.0026	0.0029	0.0084
Giardia lamblia	Hypothetical protein	0.0026	0.0029	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0029	0.0084

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.54 uM	In vitro inhibition of DNA-dependent protein kinase(DNA-PK) from HeLa (human carcinoma) cells.	ChEMBL.	12941339
IC50 (binding)	= 0.54 uM	Inhibition of DNA-PK in HeLa cell nuclear extracts	ChEMBL.	17371003
IC50 (binding)	= 0.54 uM	In vitro inhibition of DNA-dependent protein kinase(DNA-PK) from HeLa (human carcinoma) cells.	ChEMBL.	12941339
IC50 (binding)	= 0.54 uM	Inhibition of DNA-PK in HeLa cell nuclear extracts	ChEMBL.	17371003

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL106543
PubChem: 21106405

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 171710