Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoglyceride lipase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | esterase, putative | monoglyceride lipase | 303 aa | 254 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0103 | 0.3041 | 0.1206 |
Mycobacterium ulcerans | hypothetical protein | 0.0084 | 0.2086 | 0.2086 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0138 | 0.4798 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.2086 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.2086 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2086 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0078 | 0.1769 | 0.1769 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.2086 | 0.5 |
Leishmania major | monoglyceride lipase, putative | 0.0084 | 0.2086 | 0.1046 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0138 | 0.4798 | 1 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0241 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2086 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0206 | 0.8231 | 0.5 |
Loa Loa (eye worm) | ILVBL protein | 0.0146 | 0.5202 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.2086 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0084 | 0.2086 | 0.2086 |
Mycobacterium ulcerans | hypothetical protein | 0.0241 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0138 | 0.4798 | 0.4798 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0241 | 1 | 1 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0084 | 0.2086 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.2086 | 0.5 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0241 | 1 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0241 | 1 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.2086 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0138 | 0.4798 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2086 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0241 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0241 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2086 | 0.5 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0084 | 0.2086 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0206 | 0.8231 | 0.5 |
Mycobacterium ulcerans | lysophospholipase | 0.0084 | 0.2086 | 0.2086 |
Mycobacterium ulcerans | acetolactate synthase | 0.0138 | 0.4798 | 0.4798 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0138 | 0.4798 | 0.4798 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2086 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 141 nM | Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintillation counting | ChEMBL. | 23036333 |
Inhibition (binding) | = 40 % | Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured at 10'-5 M after 10 mins by liquid scintillation counting | ChEMBL. | 23036333 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.