Detailed information for compound 1719392

Basic information

Technical information
  • TDR Targets ID: 1719392
  • Name: N-[3-(5-bromoindol-1-yl)sulfonylphenyl]-1-met hylpiperidin-4-amine
  • MW: 448.377 | Formula: C20H22BrN3O2S
  • H donors: 1 H acceptors: 2 LogP: 4.5 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCC(CC1)Nc1cccc(c1)S(=O)(=O)n1ccc2c1ccc(c2)Br
  • InChi: 1S/C20H22BrN3O2S/c1-23-10-8-17(9-11-23)22-18-3-2-4-19(14-18)27(25,26)24-12-7-15-13-16(21)5-6-20(15)24/h2-7,12-14,17,22H,8-11H2,1H3
  • InChiKey: LZRVTRCCUYBTJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-(5-bromoindol-1-yl)sulfonylphenyl]-1-methyl-piperidin-4-amine
  • N-[3-[(5-bromo-1-indolyl)sulfonyl]phenyl]-1-methyl-4-piperidinamine
  • [3-(5-bromoindol-1-yl)sulfonylphenyl]-(1-methyl-4-piperidyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0512 0.3707 0.8446
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.016 0.0082
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0299 0.0222
Schistosoma mansoni cathepsin F (C01 family) 0.06 0.4374 0.433
Leishmania major cathepsin L-like protease 0.06 0.4374 1
Brugia malayi calpain family protein 1 0.0054 0.0225 0.0148
Plasmodium falciparum serine repeat antigen 7 0.0141 0.0889 0.1886
Trypanosoma cruzi cysteine proteinase, putative 0.0327 0.2302 0.2241
Loa Loa (eye worm) fibroinase 0.06 0.4374 0.4374
Trypanosoma cruzi major cysteine proteinase, putative 0.0141 0.0889 0.0817
Loa Loa (eye worm) hypothetical protein 0.0414 0.2961 0.2961
Echinococcus multilocularis cysteine protease 0.06 0.4374 0.4361
Trypanosoma cruzi cysteine peptidase, putative 0.06 0.4374 0.433
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.016 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0889 0.1886
Echinococcus multilocularis cathepsin b 0.1341 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.4374 1
Echinococcus multilocularis calpain family protein 1, d 0.0039 0.0118 0.0094
Trypanosoma cruzi cysteine peptidase, putative 0.0327 0.2302 0.2241
Toxoplasma gondii cathepsin CPC1 0.0141 0.0889 0.1886
Echinococcus multilocularis cathepsin L cysteine protease 0.06 0.4374 0.4361
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0299 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0141 0.0889 0.1886
Plasmodium vivax vivapain-3 0.0327 0.2302 0.5176
Schistosoma mansoni microtubule-associated protein tau 0.0709 0.52 0.5162
Schistosoma mansoni cathepsin F (C01 family) 0.06 0.4374 0.433
Leishmania major cathepsin L-like protease 0.06 0.4374 1
Loa Loa (eye worm) hypothetical protein 0.0414 0.2961 0.2961
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.016 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.4374 1
Giardia lamblia Cathepsin L-like protease 0.0141 0.0889 0.2234
Trypanosoma cruzi cysteine peptidase, putative 0.06 0.4374 0.433
Brugia malayi calpain family protein 1 0.0054 0.0225 0.0148
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0141 0.0889 0.0889
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0186 0.1232 0.1162
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0141 0.0889 0.1886
Onchocerca volvulus Cathepsin L homolog 0.06 0.4374 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0141 0.0889 0.0889
Giardia lamblia Cathepsin L precursor 0.0141 0.0889 0.2234
Echinococcus multilocularis cathepsin L 0.0327 0.2302 0.2284
Loa Loa (eye worm) hypothetical protein 0.0141 0.0889 0.0889
Echinococcus multilocularis cysteine protease 0.06 0.4374 0.4361
Brugia malayi Cathepsin L-like precursor 0.06 0.4374 0.433
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.0889 0.0817
Entamoeba histolytica cysteine protease, putative 0.06 0.4374 1
Entamoeba histolytica cysteine protease, putative 0.0327 0.2302 0.5263
Entamoeba histolytica cysteine protease, putative 0.0141 0.0889 0.2032
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.1232 0.1232
Entamoeba histolytica cysteine proteinase, putative 0.06 0.4374 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0141 0.0889 0.1886
Echinococcus granulosus geminin 0.0174 0.114 0.107
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0141 0.0889 0.1886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.4374 1
Entamoeba histolytica cysteine proteinase, putative 0.0327 0.2302 0.5263
Loa Loa (eye worm) hypothetical protein 0.0034 0.0079 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0327 0.2302 0.5176
Echinococcus granulosus cathepsin L cysteine protease 0.0327 0.2302 0.2241
Loa Loa (eye worm) papain family cysteine protease containing protein 0.06 0.4374 0.4374
Giardia lamblia Cysteine protease 0.0141 0.0889 0.2234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.4374 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.016 0.0082
Entamoeba histolytica cysteine protease, putative 0.0327 0.2302 0.5263
Loa Loa (eye worm) hypothetical protein 0.0141 0.0889 0.0889
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0414 0.2961 0.6711
Entamoeba histolytica cysteine protease, putative 0.0327 0.2302 0.5263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.4374 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.0889 0.1886
Entamoeba histolytica cysteine protease, putative 0.0327 0.2302 0.5263
Trypanosoma cruzi cysteine peptidase, putative 0.06 0.4374 0.433
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.4374 1
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0889 0.1886
Brugia malayi cathepsin L-like precursor 0.0414 0.2961 0.2906
Loa Loa (eye worm) hypothetical protein 0.0047 0.0179 0.0179
Brugia malayi Cathepsin L-like precursor 0.06 0.4374 0.433
Giardia lamblia Cathepsin L precursor 0.0141 0.0889 0.2234
Leishmania major cathepsin L-like protease 0.06 0.4374 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.016 0.0082
Giardia lamblia Cysteine protease 0.0141 0.0889 0.2234
Onchocerca volvulus 0.06 0.4374 1
Entamoeba histolytica cysteine protease, putative 0.0327 0.2302 0.5263
Echinococcus granulosus calpain A 0.0056 0.0244 0.0166
Giardia lamblia Cathepsin B precursor 0.0141 0.0889 0.2234
Plasmodium falciparum serine repeat antigen 6 0.0141 0.0889 0.1886
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0056 0.0244 0.0166
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.0889 0.0817
Plasmodium vivax serine-repeat antigen (SERA) 0.0141 0.0889 0.1886
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0054 0.0225 0.0148
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.0889 0.0817
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1341 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0327 0.2302 0.5176
Toxoplasma gondii cathepsin CPL 0.06 0.4374 1
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0079 0.5
Loa Loa (eye worm) hypothetical protein 0.0414 0.2961 0.2961
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0141 0.0889 0.1886
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0141 0.0889 0.2032
Plasmodium falciparum serine repeat antigen 9 0.0141 0.0889 0.1886
Entamoeba histolytica cysteine protease, putative 0.0327 0.2302 0.5263
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0299 0.0222
Brugia malayi Papain family cysteine protease containing protein 0.0141 0.0889 0.0817
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0141 0.0889 0.1886
Brugia malayi Cathepsin L-like precursor 0.06 0.4374 0.433
Toxoplasma gondii preprocathepsin c precursor, putative 0.0141 0.0889 0.1886
Entamoeba histolytica cysteine protease, putative 0.0141 0.0889 0.2032
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0141 0.0889 0.2234
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0141 0.0889 0.2032
Onchocerca volvulus 0.06 0.4374 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0079 0.5
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0079 0.0079
Trypanosoma cruzi cysteine proteinase, putative 0.0327 0.2302 0.2241
Leishmania major cathepsin L-like protease 0.06 0.4374 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0118 0.0118
Plasmodium vivax vivapain-2 0.06 0.4374 1
Brugia malayi Cathepsin L-like precursor 0.06 0.4374 0.433
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.4374 1
Schistosoma mansoni hypothetical protein 0.0174 0.114 0.107
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0512 0.3707 0.8446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.4374 1
Loa Loa (eye worm) hypothetical protein 0.1341 1 1
Giardia lamblia Cysteine protease 0.0141 0.0889 0.2234
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0141 0.0889 0.1886
Schistosoma mansoni cathepsin s 0.0186 0.1232 0.1162
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0141 0.0889 0.1886
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0141 0.0889 0.0817
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0299 0.0222
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0141 0.0889 0.1886
Schistosoma mansoni cathepsin S (C01 family) 0.0141 0.0889 0.0817
Plasmodium vivax unspecified product 0.0327 0.2302 0.5176
Brugia malayi Papain family cysteine protease containing protein 0.0141 0.0889 0.0817
Loa Loa (eye worm) ctsf protein 0.06 0.4374 0.4374
Giardia lamblia Cathepsin L precursor 0.0141 0.0889 0.2234
Entamoeba histolytica cysteine proteinase, putative 0.0414 0.2961 0.677
Schistosoma mansoni hypothetical protein 0.0174 0.114 0.107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.4374 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.06 0.4374 0.433
Trypanosoma brucei cysteine peptidase C (CPC) 0.0512 0.3707 0.8446
Brugia malayi cathepsin L precursor 0.0141 0.0889 0.0817
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.016 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.4374 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0141 0.0889 0.0817
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0244 0.0166
Plasmodium falciparum cysteine proteinase falcipain 1 0.0327 0.2302 0.5176
Plasmodium falciparum cysteine proteinase falcipain 3 0.06 0.4374 1
Echinococcus granulosus cysteine protease 0.0327 0.2302 0.2241
Onchocerca volvulus 0.06 0.4374 1
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0299 0.0299
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0141 0.0889 0.1886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.0889 0.1886
Entamoeba histolytica cysteine proteinase 2 0.0327 0.2302 0.5263
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0079 0.0079
Echinococcus multilocularis cathepsin L cysteine protease 0.06 0.4374 0.4361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.4374 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.0889 0.1886
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0327 0.2302 0.2241
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0512 0.3707 0.3657
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.4374 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.4374 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0299 0.0299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.4374 1
Entamoeba histolytica cysteine protease, putative 0.0141 0.0889 0.2032
Plasmodium vivax vivapain-2 0.06 0.4374 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0512 0.3707 0.3657
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0327 0.2302 0.2241
Brugia malayi cathepsin Z-like cysteine proteinase 0.0141 0.0889 0.0817
Giardia lamblia Cathepsin B precursor 0.0512 0.3707 1
Plasmodium vivax unspecified product 0.0186 0.1232 0.2684
Leishmania major cathepsin L-like protease 0.06 0.4374 1
Giardia lamblia Cathepsin B precursor 0.0512 0.3707 1
Plasmodium falciparum serine repeat antigen 3 0.0141 0.0889 0.1886
Plasmodium vivax vivapain-1 0.0327 0.2302 0.5176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.4374 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.4374 1
Entamoeba histolytica cysteine proteinase, putative 0.0327 0.2302 0.5263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.4374 1
Giardia lamblia Cathepsin B precursor 0.0141 0.0889 0.2234
Giardia lamblia Cysteine protease 0.0141 0.0889 0.2234
Trypanosoma cruzi cruzipain precursor, putative 0.0186 0.1232 0.1162
Echinococcus multilocularis cathepsin L 0.0141 0.0889 0.0867
Loa Loa (eye worm) hypothetical protein 0.0186 0.1232 0.1232
Schistosoma mansoni cathepsin C 0.0141 0.0889 0.0817
Onchocerca volvulus 0.0414 0.2961 0.6716
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0141 0.0889 0.1886
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.016 0.0136
Brugia malayi RNA binding protein 0.0063 0.0299 0.0222
Echinococcus multilocularis pyruvate kinase 0.0034 0.0079 0.0055
Giardia lamblia Cathepsin L-like protease 0.0141 0.0889 0.2234
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0141 0.0889 0.1886
Loa Loa (eye worm) hypothetical protein 0.0186 0.1232 0.1232
Schistosoma mansoni cathepsin B (C01 family) 0.0141 0.0889 0.0817
Plasmodium vivax serine-repeat antigen (SERA) 0.0141 0.0889 0.1886
Trypanosoma cruzi cysteine peptidase, putative 0.06 0.4374 0.433
Brugia malayi Cathepsin L-like precursor 0.0414 0.2961 0.2906
Loa Loa (eye worm) hypothetical protein 0.0141 0.0889 0.0889
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1341 1 1
Onchocerca volvulus Cathepsin L homolog 0.06 0.4374 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0327 0.2302 0.2241
Entamoeba histolytica cysteine protease, putative 0.0327 0.2302 0.5263
Echinococcus multilocularis calpain A 0.0056 0.0244 0.022
Trypanosoma cruzi cysteine peptidase, putative 0.0186 0.1232 0.1162
Giardia lamblia Hypothetical protein 0.0141 0.0889 0.2234
Echinococcus granulosus cathepsin l1 0.0414 0.2961 0.2906
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.4374 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0225 0.0225
Toxoplasma gondii cathepsin CPC2 0.0141 0.0889 0.1886
Loa Loa (eye worm) hypothetical protein 0.0141 0.0889 0.0889
Echinococcus multilocularis geminin 0.0174 0.114 0.1119
Onchocerca volvulus Cathepsin L homolog 0.0141 0.0889 0.1899
Onchocerca volvulus 0.06 0.4374 1
Onchocerca volvulus 0.06 0.4374 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0079 0.0016
Brugia malayi fibroinase precursor 0.0141 0.0889 0.0817
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0244 0.0166
Entamoeba histolytica cysteine proteinase, putative 0.06 0.4374 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0141 0.0889 0.1886
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0141 0.0889 0.0889
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0141 0.0889 0.1886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.0889 0.1886
Brugia malayi Cathepsin L-like precursor 0.06 0.4374 0.433
Entamoeba histolytica cysteine protease, putative 0.0141 0.0889 0.2032
Plasmodium falciparum serine repeat antigen 2 0.0141 0.0889 0.1886
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.06 0.4374 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.4374 1
Entamoeba histolytica cysteine protease, putative 0.0327 0.2302 0.5263
Entamoeba histolytica cysteine protease, putative 0.0141 0.0889 0.2032
Entamoeba histolytica cysteine protease, putative 0.0141 0.0889 0.2032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.4374 1
Loa Loa (eye worm) calpain family protein 1 0.0039 0.0118 0.0118
Loa Loa (eye worm) RNA binding protein 0.0063 0.0299 0.0299
Leishmania major cathepsin L-like protease 0.06 0.4374 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.4374 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1341 1 1
Giardia lamblia Cathepsin B precursor 0.0141 0.0889 0.2234
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.0889 0.0817
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.4374 1
Loa Loa (eye worm) cysteine protease 0.06 0.4374 0.4374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.4374 1
Plasmodium vivax unspecified product 0.0141 0.0889 0.1886
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0141 0.0889 0.1886
Plasmodium falciparum serine repeat antigen 5 0.0141 0.0889 0.1886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.4374 1
Echinococcus granulosus cathepsin L 0.0327 0.2302 0.2241
Echinococcus granulosus cathepsin L 0.0141 0.0889 0.0817
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0141 0.0889 0.2234
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0079 0.0016
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0141 0.0889 0.2234
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.06 0.4374 0.4374
Echinococcus granulosus cathepsin l1 0.06 0.4374 0.433
Echinococcus multilocularis pyruvate kinase 0.0034 0.0079 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.4374 1
Echinococcus granulosus microtubule associated protein 2 0.0709 0.52 0.5162
Plasmodium falciparum serine repeat antigen 1 0.0141 0.0889 0.1886
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0141 0.0889 0.1886
Loa Loa (eye worm) hypothetical protein 0.0141 0.0889 0.0889
Chlamydia trachomatis pyruvate kinase 0.0034 0.0079 0.5
Echinococcus granulosus cathepsin b 0.1341 1 1
Giardia lamblia Cathepsin B precursor 0.0141 0.0889 0.2234
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.4374 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.016 0.0082
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0141 0.0889 0.1886
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0141 0.0889 0.1886
Brugia malayi TAR-binding protein 0.0063 0.0299 0.0222
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0079 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.0889 0.1886
Echinococcus multilocularis cathepsin b 0.1341 1 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0327 0.2302 0.5263
Plasmodium falciparum cysteine proteinase falcipain 2a 0.06 0.4374 1
Giardia lamblia Hypothetical protein 0.0141 0.0889 0.2234
Entamoeba histolytica cysteine protease, putative 0.0327 0.2302 0.5263
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0141 0.0889 0.0817
Leishmania major cathepsin L-like protease 0.06 0.4374 1
Onchocerca volvulus 0.0141 0.0889 0.1899
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.4374 1
Plasmodium falciparum serine repeat antigen 8 0.0141 0.0889 0.1886
Echinococcus multilocularis cathepsin l cysteine peptidase 0.06 0.4374 0.4361
Loa Loa (eye worm) hypothetical protein 0.0141 0.0889 0.0889
Entamoeba histolytica cysteine protease, putative 0.0327 0.2302 0.5263
Echinococcus granulosus cathepsin b 0.1341 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0141 0.0889 0.0817
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0141 0.0889 0.1886
Trypanosoma cruzi cysteine protease, putative 0.0327 0.2302 0.2241
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.06 0.4374 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.4374 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0414 0.2961 0.2906
Trypanosoma cruzi major cysteine proteinase, putative 0.0141 0.0889 0.0817
Loa Loa (eye worm) calpain family protein 1 0.0054 0.0225 0.0225
Brugia malayi Cathepsin L-like precursor 0.06 0.4374 0.433
Leishmania major cathepsin L-like protease 0.06 0.4374 1
Onchocerca volvulus 0.06 0.4374 1
Entamoeba histolytica cysteine proteinase, putative 0.0327 0.2302 0.5263
Entamoeba histolytica cysteine protease, putative 0.0327 0.2302 0.5263
Giardia lamblia Cathepsin L precursor 0.0141 0.0889 0.2234
Plasmodium falciparum cysteine proteinase falcipain 2b 0.06 0.4374 1
Entamoeba histolytica cysteine proteinase, putative 0.0327 0.2302 0.5263
Brugia malayi Papain family cysteine protease containing protein 0.06 0.4374 0.433
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0141 0.0889 0.0817
Echinococcus granulosus cathepsin L cysteine proteinase 0.06 0.4374 0.433
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.2302 0.5176
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.4374 1
Trypanosoma cruzi cruzipain precursor, putative 0.06 0.4374 0.433
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0299 0.0276
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1341 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0141 0.0889 0.1886
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0414 0.2961 0.2906
Giardia lamblia Cathepsin L precursor 0.0141 0.0889 0.2234
Echinococcus multilocularis microtubule associated protein 2 0.0709 0.52 0.5188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.0889 0.1886
Giardia lamblia Cathepsin L precursor 0.0141 0.0889 0.2234
Onchocerca volvulus 0.06 0.4374 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.4374 1
Brugia malayi Papain family cysteine protease containing protein 0.0327 0.2302 0.2241
Brugia malayi cathepsin F-like cysteine proteinase 0.0141 0.0889 0.0817
Loa Loa (eye worm) cathepsin B 0.0512 0.3707 0.3707
Brugia malayi Cathepsin L-like precursor 0.0186 0.1232 0.1162
Loa Loa (eye worm) hypothetical protein 0.0186 0.1232 0.1232
Brugia malayi Cathepsin L-like precursor 0.0414 0.2961 0.2906
Plasmodium falciparum serine repeat antigen 4 0.0141 0.0889 0.1886
Leishmania major cysteine peptidase A (CPA) 0.06 0.4374 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.2302 0.5176
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0141 0.0889 0.2234
Giardia lamblia Cathepsin B precursor 0.0512 0.3707 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0327 0.2302 0.2241
Brugia malayi Papain family cysteine protease containing protein 0.0141 0.0889 0.0817
Brugia malayi cathepsin L-like cysteine proteinase 0.0141 0.0889 0.0817
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0299 0.0222
Giardia lamblia Cathepsin B precursor 0.0141 0.0889 0.2234
Toxoplasma gondii cathepsin B 0.0512 0.3707 0.8446
Echinococcus granulosus tar DNA binding protein 0.0063 0.0299 0.0222
Entamoeba histolytica hypothetical protein 0.0141 0.0889 0.2032
Schistosoma mansoni cathepsin F (C01 family) 0.0414 0.2961 0.2906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.4374 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0299 0.0222
Entamoeba histolytica cysteine protease, putative 0.0327 0.2302 0.5263
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.06 0.4374 0.4374
Onchocerca volvulus Cathepsin F homolog 0.06 0.4374 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0141 0.0889 0.1886
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.0889 0.0817
Brugia malayi cathepsin F-like cysteine proteinase 0.0186 0.1232 0.1162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.06 0.4374 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0056 0.0244 0.022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.016 0.016
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0141 0.0889 0.1886
Echinococcus multilocularis cathepsin l cysteine peptidase 0.06 0.4374 0.4361
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.4374 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.06 0.4374 1
Brugia malayi Papain family cysteine protease containing protein 0.0327 0.2302 0.2241
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0141 0.0889 0.0817
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0141 0.0889 0.1886
Giardia lamblia Encystation-specific protease 0.0141 0.0889 0.2234
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1341 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0414 0.2961 0.6711
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0141 0.0889 0.1886
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0079 0.0016
Entamoeba histolytica cysteine protease, putative 0.0327 0.2302 0.5263

Activities

Activity type Activity value Assay description Source Reference
Imax (functional) = 98 % Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells assessed as inhibition of 5HT-induced luciferase activity after 4 hrs by reporter gene assay relative to control ChEMBL. 23006002
Kb (functional) = 10.3 nM Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells assessed as inhibition of 5HT-induced luciferase activity after 4 hrs by reporter gene assay ChEMBL. 23006002

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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