Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hypothetical protein, conserved | 0.0028 | 0.0549 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0046 | 0.308 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0098 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.308 | 0.308 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0028 | 0.0549 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0028 | 0.0549 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0098 | 1 | 0.5 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0028 | 0.0549 | 0.1781 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0028 | 0.0549 | 0.5 |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0046 | 0.308 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0028 | 0.0549 | 0.5 |
Onchocerca volvulus | 0.0098 | 1 | 0.5 | |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0028 | 0.0549 | 0.5 |
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0042 | 0.2441 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0098 | 1 | 0.5 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0028 | 0.0549 | 0.5 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0028 | 0.0549 | 0.1781 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 1 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0028 | 0.0549 | 0.5 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0028 | 0.0549 | 0.1781 |
Mycobacterium ulcerans | hypothetical protein | 0.0046 | 0.308 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0549 | 0.5 |
Toxoplasma gondii | MaoC family domain-containing protein | 0.0028 | 0.063 | 0.0432 |
Brugia malayi | maoC like domain containing protein | 0.0046 | 0.308 | 0.308 |
Mycobacterium ulcerans | dehydratase | 0.0046 | 0.308 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.