TDR Targets

Basic information

Technical information

TDR Targets ID: 172210
Name: 4-(4-hydroxyphenyl)butan-2-one
MW: 164.201 | Formula: C10H12O2
H donors: 1 H acceptors: 2 LogP: 1.48 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)CCc1ccc(cc1)O
InChi: 1S/C10H12O2/c1-8(11)2-3-9-4-6-10(12)7-5-9/h4-7,12H,2-3H2,1H3
InChiKey: NJGBTKGETPDVIK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-(4-hydroxyphenyl)-2-butanone
raspberry ketone
5471-51-2
1-(4-Hydroxyphenyl)-3-butanone
4-(3-Oxobutyl)phenol
4-(p-Hydroxyphenyl)-2-butanone (natural)
4-08-00-00506 (Beilstein Handbook Reference)
AI3-31812
BRN 0776080
EINECS 226-806-4
FEMA No. 2588
Hydroxyphenylbutanone, p-
NSC 26515
Rasketone
p-Hydroxybenzyl acetone
56110_FLUKA
ZINC00154632
(p-Hydroxybenzyl)acetone
1-(p-Hydroxyphenyl)-3-butanone
2-Butanone, 4-(4-hydroxyphenyl)-
2-Butanone, 4-(p-hydroxyphenyl)-
4-(p-Hydroxyphenyl)-2-butanone
Frambinone
NSC26515
Oxyphenalon
Rheosmin
WLN: QR D2V1
ST5330630
W258806_ALDRICH
W258814_ALDRICH
AE-473/30684056
178519_ALDRICH

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	androgen receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Onchocerca volvulus		0.0418	0.3438	0.3438
Schistosoma mansoni	zinc finger protein	0.0418	0.3438	0.3438
Onchocerca volvulus		0.0418	0.3438	0.3438
Giardia lamblia	Hypothetical protein	0.0021	0	0.5
Leishmania major	hypothetical protein, conserved	0.0418	0.3438	1
Loa Loa (eye worm)	brahma associated protein	0.1175	1	1
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1175	1	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0418	0.3438	0.3438
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0418	0.3438	0.3438
Giardia lamblia	Hypothetical protein	0.0021	0	0.5
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Echinococcus multilocularis	SWI:SNF matrix associated	0.1175	1	1
Giardia lamblia	Zinc finger domain	0.0021	0	0.5
Echinococcus multilocularis	SWI:SNF matrix associated	0.1175	1	1
Leishmania major	hypothetical protein, conserved	0.0418	0.3438	1
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0418	0.3438	1
Loa Loa (eye worm)	hypothetical protein	0.0418	0.3438	0.3438
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0418	0.3438	0.3438
Giardia lamblia	Ser/Thr protein kinase	0.0021	0	0.5
Echinococcus multilocularis	zinc finger protein Ran binding	0.0418	0.3438	0.3438
Giardia lamblia	Hypothetical protein	0.0021	0	0.5
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0418	0.3438	0.3438
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0	0.5
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0	0.5
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0418	0.3438	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0418	0.3438	0.3438
Entamoeba histolytica	hypothetical protein	0.0021	0	0.5
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0418	0.3438	1
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.1175	1	1
Schistosoma mansoni	fusion	0.0418	0.3438	0.3438
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Schistosoma mansoni	hypothetical protein	0.0418	0.3438	0.3438
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0418	0.3438	1
Trypanosoma cruzi	WLM domain containing protein, putative	0.0418	0.3438	1
Loa Loa (eye worm)	hypothetical protein	0.0418	0.3438	0.3438
Schistosoma mansoni	hypothetical protein	0.1175	1	1
Giardia lamblia	Kinase, NEK	0.0021	0	0.5
Giardia lamblia	Hypothetical protein	0.0021	0	0.5
Schistosoma mansoni	RNA binding protein	0.0418	0.3438	0.3438
Giardia lamblia	Hypothetical protein	0.0021	0	0.5
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Leishmania major	hypothetical protein, conserved	0.0418	0.3438	1
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0418	0.3438	0.3438
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Onchocerca volvulus		0.1175	1	1
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0	0.5
Giardia lamblia	Hypothetical protein	0.0021	0	0.5
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0	0.5
Onchocerca volvulus		0.0418	0.3438	0.3438
Entamoeba histolytica	hypothetical protein	0.0021	0	0.5
Plasmodium vivax	hypothetical protein, conserved	0.1175	1	1
Echinococcus granulosus	ring and YY1 binding protein	0.0418	0.3438	0.3438
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.1175	1	1
Trypanosoma cruzi	WLM domain containing protein, putative	0.0418	0.3438	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0418	0.3438	1
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Leishmania major	hypothetical protein, conserved	0.0418	0.3438	1
Giardia lamblia	Kinase	0.0021	0	0.5
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0418	0.3438	0.3438
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.1175	1	1
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0418	0.3438	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.1175	1	1
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0418	0.3438	1
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Brugia malayi	brahma associated protein 60 kDa	0.1175	1	1
Giardia lamblia	Zinc finger domain	0.0021	0	0.5
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0418	0.3438	1
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0	0.5
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0	0.5
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0418	0.3438	0.3438
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.1175	1	1
Giardia lamblia	Hypothetical protein	0.0021	0	0.5
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0418	0.3438	1
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Entamoeba histolytica	SPRY domain protein	0.0021	0	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0418	0.3438	1
Chlamydia trachomatis	SWIB complex protein	0.1175	1	0.5
Schistosoma mansoni	hypothetical protein	0.1175	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.1175	1	1
Loa Loa (eye worm)	hypothetical protein	0.0418	0.3438	0.3438
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0418	0.3438	1
Schistosoma mansoni	brg-1 associated factor	0.1175	1	1
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0	0.5
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1175	1	1
Schistosoma mansoni	hypothetical protein	0.1175	1	1
Echinococcus granulosus	Zinc finger RanBP2 type	0.0418	0.3438	0.3438
Leishmania major	hypothetical protein, conserved	0.0418	0.3438	1
Toxoplasma gondii	ran binding protein	0.0418	0.3438	0.3438
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0418	0.3438	1
Entamoeba histolytica	zinc finger domain containing protein	0.0021	0	0.5
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.1175	1	1
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0418	0.3438	0.3438
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0418	0.3438	0.3438
Schistosoma mansoni	TRABID protein (C64 family)	0.0418	0.3438	0.3438
Giardia lamblia	Ribonuclease	0.0021	0	0.5
Echinococcus granulosus	SWI:SNF matrix associated	0.1175	1	1
Brugia malayi	SWIB/MDM2 domain containing protein	0.1175	1	1
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.1175	1	1
Giardia lamblia	E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B	0.0021	0	0.5
Echinococcus granulosus	zinc finger protein Ran binding	0.0418	0.3438	0.3438
Onchocerca volvulus		0.0418	0.3438	0.3438
Giardia lamblia	Protein 21.1	0.0021	0	0.5
Giardia lamblia	Kinase, NEK	0.0021	0	0.5
Brugia malayi	YY1-associated factor 2	0.0418	0.3438	0.3438
Chlamydia trachomatis	DNA topoisomerase I	0.1175	1	0.5
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0418	0.3438	0.3438
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0418	0.3438	0.3438
Echinococcus multilocularis	ring and YY1 binding protein	0.0418	0.3438	0.3438

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 3.6	Antagonist activity at AR in human MDA-kb2 cells co-transfected with MMTV-luc assessed as decrease in DHT-induced luciferase activity by reporter gene assay	ChEMBL.	20226658
IC50 (functional)	> 100 uM	In vitro cell growth inhibitory activity against K562 human chronic myelogenous leukemia cell line	ChEMBL.	No reference
IC50 (functional)	> 100 uM	In vitro cell growth inhibitory activity against K562 human chronic myelogenous leukemia cell line	ChEMBL.	No reference
IC50 (functional)	= 252 uM	Antagonist activity at AR in human MDA-kb2 cells co-transfected with MMTV-luc assessed as decrease in DHT-induced luciferase activity by reporter gene assay	ChEMBL.	20226658
Potency (functional)	6.1645 uM	PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
ChEMBL: CHEMBL105912
PubChem: 21648

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 172210