Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Janus kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0098 | 0.2822 | 0.2682 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1047 | 0.3253 |
Brugia malayi | cathepsin L-like precursor | 0.0038 | 0.0464 | 0.0461 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Plasmodium vivax | vivapain-2 | 0.0053 | 0.1047 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0098 | 0.2822 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0189 | 0.0189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0053 | 0.1047 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0031 | 0.0191 | 0.0188 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0053 | 0.1047 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1047 | 0.3253 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.044 | 0.044 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0026 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0093 | 0.2642 | 1 | |
Echinococcus granulosus | cysteine protease | 0.0031 | 0.0191 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0053 | 0.1047 | 0.0872 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0026 | 0.0003 | 0.0003 |
Plasmodium vivax | vivapain-2 | 0.0053 | 0.1047 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1047 | 0.3253 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0053 | 0.1047 | 0.0872 |
Onchocerca volvulus | 0.0053 | 0.1047 | 0.3963 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0093 | 0.2642 | 0.264 |
Onchocerca volvulus | 0.0053 | 0.1047 | 0.3963 | |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0044 | 0.0705 | 0.0702 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.2642 | 0.2642 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0038 | 0.0464 | 0.3182 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0026 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0038 | 0.0464 | 0.1755 | |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Onchocerca volvulus | 0.0053 | 0.1047 | 0.3963 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0053 | 0.1047 | 0.1047 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Entamoeba histolytica | cysteine protease, putative | 0.0053 | 0.1047 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Echinococcus granulosus | calpain A | 0.0044 | 0.0705 | 0.0702 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0098 | 0.2822 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0053 | 0.1047 | 0.1044 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0053 | 0.1047 | 0.1044 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0026 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0053 | 0.1047 | 0.3963 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0053 | 0.1047 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Onchocerca volvulus | 0.0053 | 0.1047 | 0.3963 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Onchocerca volvulus | 0.0085 | 0.2314 | 0.8761 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0031 | 0.0191 | 0.0188 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Giardia lamblia | Cathepsin B precursor | 0.0098 | 0.2822 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0053 | 0.1047 | 0.0872 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Toxoplasma gondii | cathepsin B | 0.0098 | 0.2822 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0053 | 0.1047 | 0.1047 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0053 | 0.1047 | 0.1044 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0464 | 0.1035 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1047 | 0.3253 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.2642 | 0.2642 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0053 | 0.1047 | 0.1047 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Onchocerca volvulus | Cathepsin F homolog | 0.0053 | 0.1047 | 0.3963 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Echinococcus multilocularis | cathepsin L | 0.0031 | 0.0191 | 0.0188 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0031 | 0.0191 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0053 | 0.1047 | 0.0872 |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1047 | 0.3253 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.1047 | 0.1044 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0044 | 0.0705 | 0.0702 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0026 | 0.0003 | 0.0003 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1047 | 0.3253 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0053 | 0.1047 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0031 | 0.0189 | 0.0186 |
Giardia lamblia | Cathepsin B precursor | 0.0098 | 0.2822 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.0464 | 0.0461 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.1047 | 0.1044 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0093 | 0.2642 | 0.264 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | fibroinase | 0.0053 | 0.1047 | 0.1047 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0098 | 0.2822 | 0.282 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0044 | 0.0705 | 0.0702 |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.1047 | 0.1044 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0026 | 0.0003 | 0.0011 |
Echinococcus multilocularis | cysteine protease | 0.0053 | 0.1047 | 0.1044 |
Echinococcus multilocularis | calpain A | 0.0044 | 0.0705 | 0.0702 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0053 | 0.1047 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Brugia malayi | Trypsin family protein | 0.0093 | 0.2642 | 0.264 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0026 | 0.0003 | 0.0003 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0038 | 0.0464 | 0.0461 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0098 | 0.2822 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0098 | 0.2822 | 0.2822 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1047 | 0.3253 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0053 | 0.1047 | 0.0872 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0042 | 0.0629 | 0.0627 |
Onchocerca volvulus | 0.0053 | 0.1047 | 0.3963 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Echinococcus multilocularis | cysteine protease | 0.0053 | 0.1047 | 0.1044 |
Loa Loa (eye worm) | cysteine protease | 0.0053 | 0.1047 | 0.1047 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Echinococcus granulosus | cathepsin L | 0.0031 | 0.0191 | 0.0188 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.1047 | 0.1044 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0053 | 0.1047 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0038 | 0.0464 | 0.0278 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0031 | 0.0191 | 0.0188 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.0464 | 0.0461 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0031 | 0.0191 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1047 | 0.3253 |
Brugia malayi | calpain family protein 1 | 0.0042 | 0.0629 | 0.0627 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0053 | 0.1047 | 0.1044 |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Brugia malayi | Papain family cysteine protease containing protein | 0.0031 | 0.0191 | 0.0188 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0031 | 0.0189 | 0.0189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1047 | 0.3253 |
Onchocerca volvulus | Cathepsin L homolog | 0.0053 | 0.1047 | 0.3963 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0464 | 0.1035 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0464 | 0.0464 |
Echinococcus granulosus | cathepsin l1 | 0.0053 | 0.1047 | 0.1044 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0053 | 0.1047 | 0.1044 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0026 | 0.0003 | 0.0003 |
Brugia malayi | calpain family protein 1 | 0.0042 | 0.0629 | 0.0627 |
Echinococcus granulosus | cathepsin l1 | 0.0038 | 0.0464 | 0.0461 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0038 | 0.0464 | 0.0461 |
Onchocerca volvulus | Cathepsin L homolog | 0.0053 | 0.1047 | 0.3963 |
Giardia lamblia | Cathepsin B precursor | 0.0098 | 0.2822 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0053 | 0.1047 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0053 | 0.1047 | 0.3963 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0026 | 0.0003 | 0.0011 |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0042 | 0.0629 | 0.0629 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1047 | 0.3253 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0026 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0026 | 0.0003 | 0.0003 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1047 | 0.3253 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0003 | 0.0003 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.1047 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0629 | 0.0629 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1047 | 0.3253 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0464 | 0.0464 |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1047 | 0.1047 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0053 | 0.1047 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0053 | 0.1047 | 1 |
Onchocerca volvulus | 0.0026 | 0.0003 | 0.0011 | |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.1047 | 0.1044 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0044 | 0.0705 | 0.0702 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.