TDR Targets

Basic information

Technical information

TDR Targets ID: 172239
Name: 2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]p yridin-3-yl]-1-piperidin-1-ylethanone
MW: 388.29 | Formula: C20H19Cl2N3O
H donors: 0 H acceptors: 2 LogP: 4.96 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc2n(c1)c(CC(=O)N1CCCCC1)c(n2)c1ccc(cc1)Cl
InChi: 1S/C20H19Cl2N3O/c21-15-6-4-14(5-7-15)20-17(12-19(26)24-10-2-1-3-11-24)25-13-16(22)8-9-18(25)23-20/h4-9,13H,1-3,10-12H2
InChiKey: FQRMHEHVTLSROY-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-1-(1-piperidyl)ethanone
2-[6-chloro-2-(4-chlorophenyl)-3-imidazo[1,2-a]pyridinyl]-1-(1-piperidyl)ethanone
2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-1-piperidin-1-yl-ethanone
2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-1-piperidino-ethanone
2-[6-chloro-2-(4-chlorophenyl)imidazo[3,2-a]pyridin-3-yl]-1-piperidin-1-ylethanone
2-[6-chloro-2-(4-chlorophenyl)imidazo[3,2-a]pyridin-3-yl]-1-(1-piperidyl)ethanone
2-[6-chloro-2-(4-chlorophenyl)-3-imidazo[3,2-a]pyridinyl]-1-(1-piperidyl)ethanone
2-[6-chloro-2-(4-chlorophenyl)imidazo[3,2-a]pyridin-3-yl]-1-piperidino-ethanone
2-[6-chloro-2-(4-chlorophenyl)imidazo[3,2-a]pyridin-3-yl]-1-piperidin-1-yl-ethanone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Peripheral-type benzodiazepine receptor	Starlite/ChEMBL	References
Rattus norvegicus	GABA-A receptor; anion channel	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542
Echinococcus granulosus	translocator protein	Get druggable targets OG5_129542	All targets in OG5_129542
Schistosoma mansoni	peripheral-type benzodiazepine receptor	Get druggable targets OG5_129542	All targets in OG5_129542
Echinococcus multilocularis	translocator protein	Get druggable targets OG5_129542	All targets in OG5_129542
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542
Mycobacterium ulcerans	tryptophan-rich sensory protein	Get druggable targets OG5_129542	All targets in OG5_129542
Brugia malayi	TspO/MBR family protein	Get druggable targets OG5_129542	All targets in OG5_129542
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	435 aa	29.7 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	GABA-A receptor; anion channel	467 aa	418 aa	19.6 %
Echinococcus granulosus	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	447 aa	25.7 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	446 aa	29.1 %
Brugia malayi	Cation transporter family protein	GABA-A receptor; anion channel	467 aa	453 aa	28.5 %
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	GABA-A receptor; anion channel	467 aa	384 aa	19.5 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	454 aa	30.4 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	468 aa	28.6 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	375 aa	21.9 %
Echinococcus granulosus	vacuolar h atpase	Peripheral-type benzodiazepine receptor	169 aa	137 aa	25.5 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	461 aa	27.8 %
Echinococcus multilocularis	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	478 aa	28.7 %
Onchocerca volvulus	Large subunit GTPase 1 homolog	GABA-A receptor; anion channel	467 aa	496 aa	26.0 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	441 aa	33.8 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	GABA-A receptor; anion channel	467 aa	379 aa	19.3 %
Onchocerca volvulus	Eukaryotic initiation factor 4A-III homolog	GABA-A receptor; anion channel	467 aa	453 aa	26.9 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	446 aa	28.0 %
Onchocerca volvulus		Peripheral-type benzodiazepine receptor	169 aa	156 aa	25.6 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	494 aa	25.5 %
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	GABA-A receptor; anion channel	467 aa	479 aa	29.2 %
Onchocerca volvulus	Gamma-aminobutyric acid receptor subunit beta homolog	GABA-A receptor; anion channel	467 aa	433 aa	34.6 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	434 aa	26.7 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	454 aa	29.5 %
Echinococcus multilocularis	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Echinococcus granulosus	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	439 aa	29.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Ribonuclease	0.0025	0.0017	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0159	0.0142
Schistosoma mansoni	multidrug resistance protein	0.0044	0.0159	0.0159
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0159	0.0142
Onchocerca volvulus		0.0489	0.345	0.345
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Brugia malayi	Zinc finger, C2H2 type family protein	0.0025	0.0017	0.0017
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0489	0.345	1
Brugia malayi	B-box zinc finger family protein	0.0025	0.0017	0.0017
Brugia malayi	RING finger protein 20	0.0025	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0025	0.0017	0.0017
Onchocerca volvulus		0.0489	0.345	0.345
Giardia lamblia	Hypothetical protein	0.0025	0.0017	0.5
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0025	0.0017	0.0017
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0489	0.345	0.345
Echinococcus granulosus	ring finger protein 113a	0.0025	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0025	0.0017	0.0017
Onchocerca volvulus		0.0322	0.2212	0.2212
Giardia lamblia	Kinase, NEK	0.0025	0.0017	0.5
Loa Loa (eye worm)	hypothetical protein	0.0489	0.345	0.345
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0044	0.0159	0.0142
Brugia malayi	hypothetical protein	0.013	0.0794	0.0794
Entamoeba histolytica	P-glycoprotein-2	0.0044	0.0159	1
Brugia malayi	brahma associated protein 60 kDa	0.1376	1	1
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0489	0.345	1
Onchocerca volvulus		0.1376	1	1
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0044	0.0155	0.0155
Brugia malayi	hypothetical protein	0.0025	0.0017	0.0017
Schistosoma mansoni	TRABID protein (C64 family)	0.0489	0.345	0.345
Echinococcus multilocularis	SWI:SNF matrix associated	0.1376	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0044	0.0159	0.0159
Echinococcus granulosus	ring finger protein 170	0.0025	0.0017	0.0017
Trypanosoma cruzi	hypothetical protein, conserved	0.0489	0.345	1
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0025	0.0017	0.0017
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0489	0.345	1
Giardia lamblia	Hypothetical protein	0.0025	0.0017	0.5
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0044	0.0159	0.0142
Brugia malayi	hypothetical protein	0.0025	0.0017	0.0017
Entamoeba histolytica	P-glycoprotein-2	0.0044	0.0159	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0159	0.0142
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0044	0.0159	0.0159
Entamoeba histolytica	P-glycoprotein 5, putative	0.0044	0.0159	1
Schistosoma mansoni	smdr2	0.0044	0.0159	0.0159
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Onchocerca volvulus		0.0025	0.0017	0.0017
Echinococcus multilocularis	multidrug resistance protein 1	0.0031	0.006	0.006
Schistosoma mansoni	ring finger protein 151	0.0025	0.0017	0.0017
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.1376	1	1
Giardia lamblia	Zinc finger domain	0.0025	0.0017	0.5
Echinococcus granulosus	multidrug resistance protein 1	0.0044	0.0159	0.0159
Schistosoma mansoni	multidrug resistance protein	0.0044	0.0159	0.0159
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Entamoeba histolytica	P-glycoprotein-2, putative	0.0044	0.0159	1
Mycobacterium ulcerans	tryptophan-rich sensory protein	0.0322	0.2212	0.5
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0044	0.0159	0.0142
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0017	0.0017
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0044	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0489	0.345	0.345
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0017	0.0017
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0025	0.0017	0.0017
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Chlamydia trachomatis	SWIB complex protein	0.1376	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0044	0.0159	0.0142
Schistosoma mansoni	zinc finger protein	0.0025	0.0017	0.0017
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0025	0.0017	0.0017
Schistosoma mansoni	RNA binding protein	0.0489	0.345	0.345
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0017	0.0017
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.1376	1	1
Loa Loa (eye worm)	hypothetical protein	0.0322	0.2212	0.2212
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0025	0.0017	0.0017
Leishmania major	hypothetical protein, conserved	0.0489	0.345	1
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0025	0.0017	0.0017
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0489	0.345	0.345
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0044	0.0159	0.0159
Trichomonas vaginalis	conserved hypothetical protein	0.1376	1	1
Toxoplasma gondii	ran binding protein	0.0489	0.345	0.3438
Echinococcus granulosus	translocator protein	0.0322	0.2212	0.2212
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0044	0.0159	0.0159
Giardia lamblia	Hypothetical protein	0.0025	0.0017	0.5
Loa Loa (eye worm)	hypothetical protein	0.0489	0.345	0.345
Onchocerca volvulus		0.0489	0.345	0.345
Schistosoma mansoni	rnf5	0.0025	0.0017	0.0017
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0025	0.0017	0.0017
Echinococcus multilocularis	multidrug resistance protein 1	0.0044	0.0159	0.0159
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0044	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0017	0.0017
Onchocerca volvulus		0.0489	0.345	0.345
Loa Loa (eye worm)	brahma associated protein	0.1376	1	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0044	0.0159	0.0142
Brugia malayi	hypothetical protein	0.0025	0.0017	0.0017
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Schistosoma mansoni	peter pan-related	0.0025	0.0017	0.0017
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0489	0.345	0.345
Echinococcus granulosus	multidrug resistance protein 1	0.0031	0.006	0.006
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0489	0.345	1
Loa Loa (eye worm)	hypothetical protein	0.0489	0.345	0.345
Onchocerca volvulus	Putative RING finger protein 207	0.0025	0.0017	0.0017
Brugia malayi	Neuralized family protein	0.0025	0.0017	0.0017
Trichomonas vaginalis	taga, putative	0.0044	0.0159	0.0142
Echinococcus multilocularis	ATP binding cassette sub family B	0.0044	0.0155	0.0155
Onchocerca volvulus		0.0025	0.0017	0.0017
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0159	0.0142
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0489	0.345	0.345
Entamoeba histolytica	P-glycoprotein-1	0.0044	0.0159	1
Trichomonas vaginalis	abcb9, putative	0.0044	0.0159	0.0142
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Onchocerca volvulus	Protein neuralized homolog	0.0025	0.0017	0.0017
Giardia lamblia	Kinase, NEK	0.0025	0.0017	0.5
Onchocerca volvulus		0.0025	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0322	0.2212	0.2212
Brugia malayi	YY1-associated factor 2	0.0489	0.345	0.345
Giardia lamblia	E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B	0.0025	0.0017	0.5
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Schistosoma mansoni	peter pan-related	0.0025	0.0017	0.0017
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0044	0.0159	0.0142
Echinococcus granulosus	ring and YY1 binding protein	0.0489	0.345	0.345
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.1376	1	1
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0025	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0025	0.0017	0.0017
Chlamydia trachomatis	DNA topoisomerase I	0.1376	1	1
Loa Loa (eye worm)	RING finger protein 20	0.0025	0.0017	0.0017
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0489	0.345	0.345
Leishmania major	hypothetical protein, conserved	0.0489	0.345	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0489	0.345	1
Loa Loa (eye worm)	hypothetical protein	0.0322	0.2212	0.2212
Loa Loa (eye worm)	hypothetical protein	0.0322	0.2212	0.2212
Onchocerca volvulus		0.0322	0.2212	0.2212
Echinococcus granulosus	multidrug resistance protein 1	0.0044	0.0159	0.0159
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0044	0.0159	0.5
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0489	0.345	0.3438
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Leishmania major	p-glycoprotein	0.0044	0.0159	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.1376	1	1
Echinococcus granulosus	SWI:SNF matrix associated	0.1376	1	1
Onchocerca volvulus	RING finger protein 141 homolog	0.0025	0.0017	0.0017
Trypanosoma cruzi	hypothetical protein, conserved	0.0489	0.345	1
Brugia malayi	multidrug resistance protein 3	0.0044	0.0159	0.0159
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0044	0.0159	0.0142
Trypanosoma cruzi	WLM domain containing protein, putative	0.0489	0.345	1
Giardia lamblia	Hypothetical protein	0.0025	0.0017	0.5
Echinococcus granulosus	multidrug resistance protein 1	0.0031	0.006	0.006
Echinococcus granulosus	zinc finger protein Ran binding	0.0489	0.345	0.345
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0044	0.0159	0.0413
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.1376	1	1
Echinococcus multilocularis		0.0025	0.0017	0.0017
Loa Loa (eye worm)	RiNg Finger protein family member	0.0025	0.0017	0.0017
Brugia malayi	Zinc finger protein 183 homolog	0.0025	0.0017	0.0017
Schistosoma mansoni	multidrug resistance protein	0.0044	0.0159	0.0159
Brugia malayi	RING zinc finger protein	0.0025	0.0017	0.0017
Echinococcus granulosus	Zinc finger RanBP2 type	0.0489	0.345	0.345
Plasmodium falciparum	multidrug resistance protein 1	0.0044	0.0159	0.0142
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0044	0.0159	0.0159
Brugia malayi	ABC transporter family protein	0.0044	0.0159	0.0159
Brugia malayi	hypothetical protein	0.0025	0.0017	0.0017
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0159	0.0142
Onchocerca volvulus		0.0322	0.2212	0.2212
Echinococcus multilocularis	SWI:SNF matrix associated	0.1376	1	1
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0025	0.0017	0.0017
Echinococcus multilocularis	SWI:SNF matrix associated	0.1376	1	1
Plasmodium vivax	multidrug resistance protein 1, putative	0.0044	0.0159	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0489	0.345	0.345
Schistosoma mansoni	hypothetical protein	0.0025	0.0017	0.0017
Schistosoma mansoni	peripheral-type benzodiazepine receptor	0.0322	0.2212	0.2212
Trichomonas vaginalis	ABC transporter, putative	0.0044	0.0159	0.0142
Echinococcus multilocularis	zinc finger protein Ran binding	0.0489	0.345	0.345
Schistosoma mansoni	fusion	0.0489	0.345	0.345
Onchocerca volvulus		0.0025	0.0017	0.0017
Onchocerca volvulus		0.0025	0.0017	0.0017
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Brugia malayi	SWIB/MDM2 domain containing protein	0.1376	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0044	0.0159	0.0142
Echinococcus multilocularis	translocator protein	0.0322	0.2212	0.2212
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0044	0.0159	0.0142
Trichomonas vaginalis	ABC transporter, putative	0.0044	0.0159	0.0142
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0017	0.0017
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0044	0.0159	0.0159
Giardia lamblia	Kinase	0.0025	0.0017	0.5
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0044	0.0159	0.0142
Leishmania major	hypothetical protein, conserved	0.0489	0.345	1
Trichomonas vaginalis	abcb9, putative	0.0044	0.0159	0.0142
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0489	0.345	0.345
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1376	1	1
Brugia malayi	hypothetical protein	0.0025	0.0017	0.0017
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Trypanosoma cruzi	WLM domain containing protein, putative	0.0489	0.345	1
Schistosoma mansoni	brg-1 associated factor	0.1376	1	1
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0044	0.0159	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0017	0.0017
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0031	0.006	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0155	0.0155
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0044	0.0159	0.0142
Trypanosoma brucei	hypothetical protein, conserved	0.0489	0.345	1
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0044	0.0159	0.0142
Echinococcus granulosus	multidrug resistance protein 1	0.0044	0.0159	0.0159
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0489	0.345	1
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0489	0.345	1
Trichomonas vaginalis	ABC transporter, putative	0.0044	0.0159	0.0142
Plasmodium vivax	hypothetical protein, conserved	0.1376	1	1
Entamoeba histolytica	P-glycoprotein-5	0.0044	0.0159	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0159	0.0142
Schistosoma mansoni	hypothetical protein	0.1376	1	1
Giardia lamblia	Hypothetical protein	0.0025	0.0017	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0017	0.0017
Leishmania major	hypothetical protein, conserved	0.0489	0.345	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0159	0.0142
Leishmania major	hypothetical protein, conserved	0.0489	0.345	1
Trichomonas vaginalis	ABC transporter, putative	0.0044	0.0159	0.0142
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0044	0.0159	0.0142
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0044	0.0159	0.0142
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0489	0.345	1
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0025	0.0017	0.0017
Brugia malayi	TspO/MBR family protein	0.0322	0.2212	0.2212
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0489	0.345	0.345
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.1376	1	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0044	0.0159	0.0142
Echinococcus multilocularis	ring finger protein 170	0.0025	0.0017	0.0017
Onchocerca volvulus		0.0025	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.1376	1	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0159	0.0159
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0489	0.345	0.3438
Schistosoma mansoni	mind bomb	0.0025	0.0017	0.0017
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0489	0.345	0.345
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1376	1	1
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0025	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0159	0.0159
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0025	0.0017	0.0017
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0489	0.345	1
Schistosoma mansoni	inhibitor of apoptosis 1 diap1	0.0025	0.0017	0.0017
Echinococcus multilocularis	ring finger protein 113a	0.0025	0.0017	0.0017
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0025	0.0017	0.0017
Echinococcus multilocularis	RING finger protein 185	0.0025	0.0017	0.0017
Echinococcus multilocularis	multidrug resistance protein 1	0.0044	0.0159	0.0159
Giardia lamblia	Ser/Thr protein kinase	0.0025	0.0017	0.5
Giardia lamblia	Hypothetical protein	0.0025	0.0017	0.5
Entamoeba histolytica	P-glyco protein 6, putative	0.0044	0.0159	1
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.1376	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0044	0.0159	0.0159
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0044	0.0159	0.0142
Schistosoma mansoni	zinc finger protein	0.0489	0.345	0.345
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0017	0.0017
Trichomonas vaginalis	abcb9, putative	0.0044	0.0159	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0017	0.0017
Giardia lamblia	Zinc finger domain	0.0025	0.0017	0.5
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Giardia lamblia	Protein 21.1	0.0025	0.0017	0.5
Echinococcus multilocularis	ring and YY1 binding protein	0.0489	0.345	0.345
Schistosoma mansoni	hypothetical protein	0.0489	0.345	0.345
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0044	0.0159	0.0159
Onchocerca volvulus		0.0322	0.2212	0.2212
Giardia lamblia	Hypothetical protein	0.0025	0.0017	0.5
Echinococcus granulosus	RING finger protein 185	0.0025	0.0017	0.0017
Onchocerca volvulus		0.0044	0.0159	0.0159
Loa Loa (eye worm)	multidrug resistance protein 3	0.0044	0.0159	0.0159

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 18.7 nM	Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor	ChEMBL.	9301675
IC50 (binding)	= 18.7 nM	Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor	ChEMBL.	9301675
IC50 (binding)	= 240 nM	Displacement of [3H]-flunitrazepam from rat brain GABA-A Benzodiazepine receptor	ChEMBL.	9301675
IC50 (binding)	= 240 nM	Displacement of [3H]-flunitrazepam from rat brain GABA-A Benzodiazepine receptor	ChEMBL.	9301675

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL104993
PubChem: 10834121

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 172239