Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0017 | 0.1354 | 0.2862 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0017 | 0.1354 | 0.5 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0043 | 0.4732 | 1 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0043 | 0.4732 | 0.4732 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0017 | 0.1354 | 0.2862 |
Brugia malayi | methionyl-tRNA synthetase | 0.0043 | 0.4732 | 0.4732 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0017 | 0.1354 | 0.5 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0043 | 0.4732 | 1 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0017 | 0.1354 | 0.5 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0043 | 0.4732 | 1 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0017 | 0.1354 | 0.2862 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0043 | 0.4732 | 1 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0017 | 0.1354 | 0.5 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0043 | 0.4732 | 1 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0043 | 0.4732 | 1 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0017 | 0.1354 | 0.2862 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0043 | 0.4732 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1354 | 0.1354 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0017 | 0.1354 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.2647 | 0.5 | |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0017 | 0.1354 | 0.2862 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0043 | 0.4732 | 0.5 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0043 | 0.4732 | 1 |
Brugia malayi | protein ZK524.3 | 0.0017 | 0.1354 | 0.1354 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0043 | 0.4732 | 1 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0043 | 0.4732 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1354 | 0.1354 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1354 | 0.1354 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0043 | 0.4732 | 1 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0043 | 0.4732 | 1 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0027 | 0.2647 | 0.2647 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0043 | 0.4732 | 0.5 |
Brugia malayi | methionyl-tRNA synthetase | 0.0017 | 0.1354 | 0.1354 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0043 | 0.4732 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 80 % | Inhibition of Class 1 histone deacetylase in human HeLa cells assessed as induction in p21 protein expression at 3 uM incubated for 16 hrs by luciferase reporter gene assay relative to HDAC inhibitor entinostat | ChEMBL. | 23061376 |
CL (ADMET) | = 41 ml/min.kg | Clearance in mouse liver microsomes at 1 uM incubated for 10 mins by LC-MS/MS method | ChEMBL. | 23061376 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.