Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | diacylglycerol O-acyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | exocyst complex component 2 | 0.0103 | 0.0899 | 0.0899 |
Echinococcus multilocularis | hypothetical protein | 0.0236 | 0.3088 | 0.3088 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0135 | 0.142 | 1 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0103 | 0.0899 | 0.5 |
Brugia malayi | hypothetical protein | 0.0236 | 0.3088 | 0.2405 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.3088 | 0.3088 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.3088 | 0.3088 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.3088 | 0.3088 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.3088 | 0.3088 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0.0899 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0899 | 0.0899 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0103 | 0.0899 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.8293 | 0.8293 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.3088 | 0.3088 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0182 | 0.2192 | 0.0845 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0153 | 0.1724 | 0.1724 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.4398 | 0.4398 |
Brugia malayi | Sema domain containing protein | 0.0236 | 0.3088 | 0.2405 |
Schistosoma mansoni | semaphorin 5-related | 0.0236 | 0.3088 | 0.296 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0.0899 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0899 | 0.0899 |
Schistosoma mansoni | hypothetical protein | 0.0236 | 0.3088 | 0.296 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0622 | 0.9459 | 0.9459 |
Schistosoma mansoni | hypothetical protein | 0.0315 | 0.4398 | 0.4732 |
Onchocerca volvulus | 0.0236 | 0.3088 | 0.2189 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0.0899 | 0.5 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0135 | 0.142 | 1 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0103 | 0.0899 | 0.5 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0153 | 0.1724 | 0.5 |
Brugia malayi | diacylglycerol acyltransferase | 0.0153 | 0.1724 | 0.0906 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0153 | 0.1724 | 0.1115 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0.0899 | 0.5 |
Echinococcus multilocularis | semaphorin 5B | 0.0236 | 0.3088 | 0.3088 |
Brugia malayi | Plexin repeat family protein | 0.0551 | 0.8293 | 0.8125 |
Brugia malayi | Sema domain containing protein | 0.0236 | 0.3088 | 0.2405 |
Echinococcus granulosus | transcription factor collier | 0.0103 | 0.0899 | 0.0899 |
Schistosoma mansoni | plexin | 0.0315 | 0.4398 | 0.4732 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0226 | 0.2915 | 0.2915 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0236 | 0.3088 | 0.3088 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0899 | 0.0899 |
Echinococcus granulosus | semaphorin 1A | 0.0236 | 0.3088 | 0.3088 |
Schistosoma mansoni | plexin | 0.0551 | 0.8293 | 1 |
Echinococcus multilocularis | exocyst complex component 2 | 0.0103 | 0.0899 | 0.0899 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0.0899 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0.0899 | 0.5 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0103 | 0.0899 | 0.5 |
Echinococcus multilocularis | transcription factor collier | 0.0103 | 0.0899 | 0.0899 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0153 | 0.1724 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0899 | 0.0899 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0153 | 0.1724 | 0.1724 |
Schistosoma mansoni | hypothetical protein | 0.0236 | 0.3088 | 0.296 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0236 | 0.3088 | 0.3088 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0103 | 0.0899 | 0.5 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.0153 | 0.1724 | 0.1724 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0153 | 0.1724 | 0.5 |
Brugia malayi | hypothetical protein | 0.0236 | 0.3088 | 0.2405 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0153 | 0.1724 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0.0899 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.3088 | 0.3088 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1298 | 0.1298 |
Onchocerca volvulus | 0.0551 | 0.8293 | 1 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0226 | 0.2915 | 0.2215 |
Echinococcus granulosus | semaphorin 5B | 0.0236 | 0.3088 | 0.3088 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Fu (ADMET) | = 3.5 % | Fraction unbound in human plasma at 37 degC by LC-UV/MS method based equilibrium dialysis method | ChEMBL. | 23116186 |
IC50 (binding) | = 1.9 uM | Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillography | ChEMBL. | 23116186 |
IC50 (binding) | > 100 uM | Inhibition of human ACAT1 by liquid scintillography | ChEMBL. | 23116186 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.