Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0151 | 0.8892 | 0.8892 |
Loa Loa (eye worm) | alpha amylase | 0.0151 | 0.8892 | 0.8892 |
Loa Loa (eye worm) | alpha amylase | 0.0151 | 0.8892 | 0.8892 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.0151 | 0.8892 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.1468 | 0.1468 |
Mycobacterium tuberculosis | Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas | 0.0151 | 0.8892 | 0.5 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0151 | 0.8892 | 0.5 |
Mycobacterium tuberculosis | Trehalose synthase TreS | 0.0151 | 0.8892 | 0.5 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0151 | 0.8892 | 0.8892 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 10 % | Inhibition of 17beta-HSD1 in human placental cytosolic fraction using [3H]E1 as substrate after 10 mins at 1 uM by HPLC analysis | ChEMBL. | 23145773 |
Inhibition (binding) | = 53 % | Inhibition of 17beta-HSD2 in human placental microsomal fraction using [3H]E2 as substrate at 1 uM after 20 mins by HPLC analysis | ChEMBL. | 23145773 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.