Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.043 | 0.2664 | 1 |
Leishmania major | hypothetical protein, conserved | 0.043 | 0.2664 | 1 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.043 | 0.2664 | 0.2664 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.043 | 0.2664 | 0.2664 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.043 | 0.2664 | 0.2664 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.043 | 0.2664 | 1 |
Schistosoma mansoni | RNA binding protein | 0.043 | 0.2664 | 0.2664 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.1208 | 1 | 1 |
Schistosoma mansoni | fusion | 0.043 | 0.2664 | 0.2664 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.043 | 0.2664 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.1208 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.1208 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.2664 | 0.2664 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.2664 | 0.2664 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.2664 | 0.2664 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.043 | 0.2664 | 0.2664 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.043 | 0.2664 | 1 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.043 | 0.2664 | 0.2664 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1208 | 1 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.1208 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.043 | 0.2664 | 0.2664 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.1208 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.043 | 0.2664 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.1208 | 1 | 0.5 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.043 | 0.2664 | 0.2664 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1208 | 1 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.043 | 0.2664 | 0.2664 |
Onchocerca volvulus | 0.1208 | 1 | 1 | |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1208 | 1 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.043 | 0.2664 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.043 | 0.2664 | 0.2664 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.1208 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.043 | 0.2664 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1208 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.043 | 0.2664 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.043 | 0.2664 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.043 | 0.2664 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.043 | 0.2664 | 1 |
Leishmania major | hypothetical protein, conserved | 0.043 | 0.2664 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.043 | 0.2664 | 1 |
Schistosoma mansoni | hypothetical protein | 0.043 | 0.2664 | 0.2664 |
Leishmania major | hypothetical protein, conserved | 0.043 | 0.2664 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.1208 | 1 | 0.5 |
Loa Loa (eye worm) | brahma associated protein | 0.1208 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1208 | 1 | 1 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.043 | 0.2664 | 0.2664 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.043 | 0.2664 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1208 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.1208 | 1 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.1208 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.043 | 0.2664 | 0.2664 |
Schistosoma mansoni | hypothetical protein | 0.1208 | 1 | 1 |
Echinococcus granulosus | ring and YY1 binding protein | 0.043 | 0.2664 | 0.2664 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.2664 | 0.2664 |
Schistosoma mansoni | hypothetical protein | 0.1208 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.043 | 0.2664 | 1 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.043 | 0.2664 | 1 |
Schistosoma mansoni | zinc finger protein | 0.043 | 0.2664 | 0.2664 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.043 | 0.2664 | 0.2664 |
Schistosoma mansoni | brg-1 associated factor | 0.1208 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.043 | 0.2664 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.2664 | 0.2664 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.1208 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1208 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.1208 | 1 | 1 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.043 | 0.2664 | 0.2664 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change from control (functional) | = -24 % | Tested in vivo for the IOP(intraocular pressure) recovery after 50 uL dose of 2% concentration in albino rabbits. | ChEMBL. | 1920359 |
I50 (functional) | = 30 nM | Inhibitory activity against human carbonic anhydrase II using pH stat assay | ChEMBL. | 1920359 |
IC50 (functional) | = 30 nM | Inhibitory activity against human carbonic anhydrase II using pH stat assay | ChEMBL. | 1920359 |
logD (ADMET) | = 0.34 | Partition coefficient (logD7.4) | ChEMBL. | 1920359 |
Max fall in IOP (functional) | = -6.3 mmHg | Maximum fall in IOP after 50 uL dose of 0.5% concentration of the compound in alpha-CT rabbit model | ChEMBL. | 1920359 |
pKa | = 9.2 | Dissociation constant (pKa) (determined in 30% EtOH/water) | ChEMBL. | 1920359 |
S | = 33.4 mg ml-1 | Solubility (buffer pH 7.4) | ChEMBL. | 1920359 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.